Archives in cancer research最新文献

{"title":"The Impact of Radiotherapy in the Treatment of Recurrent Desmoid Tumor of Neck: A Case Report with Literature Review","authors":"Sarah El-Abbassi, Y. Echchikhi, Asmae Touil, H. Elkacemi, N. Benjaafar","doi":"10.21767/2254-6081.1000155","DOIUrl":"https://doi.org/10.21767/2254-6081.1000155","url":null,"abstract":"Background: Extra-abdominal desmoid tumor of the head and neck in particular commonly infiltrate vital neurovascular structures. we report a case of a large and recurrent extra-abdominal desmoid tumor causing significant morbidity and who was treated successfully by radiotherapy. Case presentation: A 34-year-old male patient presented with a history of right neck mass for 15 months, which was gradually increasing in size. Cervical CT scan revealed a large mass of the posterior soft tissues of the neck extended to the soft tissues of the posterior thoracic wall. The CT density of the mass was that of fat tissue. It was measuring 12.4 × 85.9 mm and enhanced after injection of the contrast product. A biopsy was taken. The histopathological findings were suggestive of desmoid tumor. Discussion: This case was discussed in multidisciplinary oncological team and radiotherapy was planned. The surgery was proposed but not performed due to the recurring character of the tumor and the risk of a high postoperative morbidity. After 4 weeks of treatment, the clinical evaluation showed a good response. Conclusion: Alternative treatment modalities such as primary radiotherapy may be preferable to mutilating surgery.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68113567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Failure in a Patient with Metastatic Lung Cancer after Experiencing Partial Response during Chemotherapy and Immunotherapy","authors":"M. G. Gramaje, C. G. Lorenzo, A. I. D. H. Santabaya, J. Sarto","doi":"10.21767/2254-6081.100163","DOIUrl":"https://doi.org/10.21767/2254-6081.100163","url":null,"abstract":"We present the case of a 62-year-old patient who developed dyspnoea, chest and dorsal pain. The history was taken, finds patients was smoker and has high blood pressure, chronic obstructive pulmonary disease and sleep apnea syndrome. So, the patients followed by Complementary tests (tomography, bronchoscopy and endoscopic ultrasound. he was diagnosed with lung adenocarcinoma stage IV (T4N3M1b bone and pulmonary lesions, no liver masses) without target driver. He was stared chemotherapy and immunotherapy in clinical trial with tumor response but liver failure. We performed a differential diagnosis to discern the etiology of the fulminant hepatitis.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68124323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Flare of Brain Metastases in ALK-Positive Non-Small Cell Lung Cancer after Stopping Crizotinib","authors":"J. Juengsamarn, E. Sirachainan, T. Reungwetwattana","doi":"10.21767/2254-6081.1000146","DOIUrl":"https://doi.org/10.21767/2254-6081.1000146","url":null,"abstract":"The prevalence of Anaplastic lymphoma kinase(ALK) rearrangement in NSCLC is about 7-10%. Currently, there are several ALK inhibitors available in treating this group of patients. Brain metastases occur in approximately 30% of patients with ALK-positive non-small-cell lung cancer (NSCLC), and in patients treated with ALK inhibitor, CNS progression occurs in up to 70% of patients. Patients with brain metastases from ALK-positive NSCLC have a distinct natural history compared with patients with wild-type NSCLC. This article describes the rapid flare of brain metastases in ALK-positive non-small cell lung cancer after stopping Crizotinib.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Leukemias in Khyber Pakhtunkhwa and Afghan Children Visiting to Hayatabad Medical Complex Hospital","authors":"Shahtaj Khan, A. Mir, Baber Rehman Khattak, A. Rehman, A. Zeb","doi":"10.21767/2254-6081.1000149","DOIUrl":"https://doi.org/10.21767/2254-6081.1000149","url":null,"abstract":"Background: Khyber Pakhtoonkhwa and Afghanistan located in South Central Asia which is most prevalent area for childhood leukemia. In this region, no previous data or study was available on estimated cases per year of different types of childhood leukemia. The aim of the present study is to evaluate the frequency of different types of childhood leukemia in the children from different districts of Khyber Pakhtoonkhwa (KP) and Afghanistan presenting to Hayat Abad Medical Complex Hospital, Peshawar. Methods: This descriptive cross-sectional study was conducted in pathology department Hayat Abad Medical Complex hospital, Peshawar, Pakistan. Duration of the present study was, from January 2014 to December 2016. A total number of 605 children were enrolled up to 15 years of age, who were suspected to have leukemia, went through bone marrow examination. 3 ml blood was collected in EDTA tube (purple top) and complete blood count was prepared by hematology analyzer (Ruby cell dyne, Abbott, USA). By aseptic techniques bone marrow aspiration and bone marrow trephine biopsy samples were collected from all patients. Slides were papered from Bone marrow aspirates, fixed with methanol and stained with Giemsa, myeloperoxidase and periodic acid Schiff stain. Trephine biopsy slides were stained by Hematoxylene and Eosin and Reticulin stain. Immunohistochemistry was done after initially examining bone marrow aspirate slides. All data was documented and statistical analysis was performed by SPSS-20 software. Findings: Among 605 children suspected to have leukemia, 281 (46.5%) children were diagnosed with different types of childhood leukemia. Out of 281 diagnosed patients, 231(82.2%) were Pakistani children and rest of the 50 (17.8%) were Afghani children. The studied population consist of 173(61.6%) males and 108(38.4) females. Their age ranged from 3 months to 15 years with median age of 9.8 years. Out of 281 cases, 210 (74.73%) were diagnosed to have acute lymphoblastic leukemia and rest of the children were 62 (22.06%) acute myeloid leukemia, 7 (2.44%) chronic myeloid leukemia, 2 (0.71%) had Juvenile Chronic Myelomonocytic Leukemia (JMML) and 1 (0.35%) child was report with Chronic Myelomonocytic leukemia (CMML). There was no significant differences seen in prevalence among Afghan children and Pakistani children except ALL, which is more frequent in Afghan children compared to Pakistani children and no single case of CMML, were diagnosed in Afghan children. Conclusion: In the present study, acute lymphoblastic leukemia is most frequent leukemia in the children of Khyber Pakhtoonkhwa and Afghanistan. Juvenile chronic Myelomonocytic leukemia is found the less common leukemia in the present study.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in Time to Treatment ofHepatocellular Carcinoma in Patients withHepatitis B Virus versus Hepatitis C Virus","authors":"Jennifer D. Wu, T. Hochman, J. Goldberg, J. Al-Mondhiry, B. Perkins, Iulia Giouriu, L. Leichman","doi":"10.21767/2254-6081.1000154","DOIUrl":"https://doi.org/10.21767/2254-6081.1000154","url":null,"abstract":"Background: The most common risk factors for hepatocellular carcinoma (HCC) are hepatitis B (HBV) and C (HCV). Patients with HCV related HCC have biology and outcomes distinct from HBV related HCC. We evaluated whether there is a difference in time from diagnosis to treatment between HCC patients with HBV and HCV. Methods: We conducted a retrospective chart review to identify patients with confirmed HCC, and a known diagnosis of either HBV or HCV at Bellevue Hospital Center between January 2005 and December 2009. Medical records were reviewed for disease and treatment characteristics. Results: Seventy HBV patients and 76 HCV patients were identified. HBV patients were mostly Asian (87%), while the majority of HCV patients were Black and Hispanic (28% and 47%, p<0.0001). At diagnosis, the HBV group presented with larger tumors compared to the HCV group (median 5.3 cm vs. 3.1 cm, p=0.025), and HCV patients were older than HBV patients (median age 61.3 years vs. 50.7 years, p<0.0001). Patients with HBV related HCC received treatment quicker than their HCV counterparts (median 2.1 vs. 3.2 months, p=0.019). Conclusion: Patients with HCV related HCC wait longer for treatment when compared to patients with HBV related HCC in an urban inner-city hospital Efforts to reduce time between outside referral to oncology services may help decrease such disparity.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68113438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Role of Magic Fruit and Honey Bee against Human Hepatocarcinogenesis","authors":"M. M. Selim, F. Kashwaa, M. Mohammed, M. El-Houseini","doi":"10.21767/2254-6081.100159","DOIUrl":"https://doi.org/10.21767/2254-6081.100159","url":null,"abstract":"Background: Hepatitis C is an infectious disease that affects the liver. Its complication is a major high-risk group that may be lead to hepatocellular carcinoma HCC, so natural prevention is required. The combination of magic fruit and honey bee was used in the treatment of HCV patients were treated with 4 g from Magic fruit and 1 g from Honey bee 3 times daily for three months. Methods and findings: Our group study was conducted on 50 patients with chronic hepatitis C (the male number was 35 while the female was 15; the median age was 45 years) was taken from the outpatient clinics of NCI, Egypt. Results: The mean values of virus C level, which was determined by real time PCR and FoxP3 protein which was measured by ELISA in sera of patients with chronic hepatitis infection (CHI), showed highly significant decrease after treatment. Hence the results have shown improvements in liver function, kidney function, and CBC tests for the HCV patients post-treatment. Moreover, the results revealed also that, highly significant decreased of CD4 + CD25 expression by flow cytometric analysis was observed in the mononuclear leukocytes isolated from the patients after treatment. Conclusion: A combination of magic fruit and honey bee could be useful protective natural agents against human hepatocarcinogenesis induced by HCV infection. Further study is strongly recommended for large populations and prolonged treatment for 9-12 months.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68124587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete Response of Radiation related Angiosarcoma of the Breast with CMF Chemotherapy","authors":"L. Vohra, T. Siddiqui","doi":"10.21767/2254-6081.1000125","DOIUrl":"https://doi.org/10.21767/2254-6081.1000125","url":null,"abstract":"Angiosarcoma of breast or chest wall is a rare recognized side effect in breast cancer survivors secondary to Adjuvant radiation. The treatment of angiosarcoma of the breast is carried out in number of ways. We would like to report the case of a 50-year old woman. She developed an angiosarcoma of the breast following adjuvant radiation to her conserved breast and was successfully treated with classical Cyclophosphamide, Methotrexate, and 5- fluorouracil (CMF) chemotherapy leading to a successful local surgical salvage.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68109741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Kaposi Sarcoma","authors":"Sarah El-Abbassi, Asmae Touil, T. Kebdani, N. Benjaafar","doi":"10.21767/2254-6081.1000140","DOIUrl":"https://doi.org/10.21767/2254-6081.1000140","url":null,"abstract":"Kaposi sarcoma (KS) is a lymphoangio-proliferative disease often caused by KS associated herpes virus, also known as human herpes virus 8. There are 4 known variants of KS: Epidemic or AIDS-associated KS, Endemic or African KS, iatrogenic post transplantation KS and Mediterranean or classic KS (CKS). We report a case of CKS treated successfully by radiation therapy.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete Genital Prolapse with Cervix Carcinoma: A Case Report andLiterature Review","authors":"Sarah El-Abbassi, S. Elmajjaoui, H. Elkacemi, T. Kebdani, N. Benjaafar","doi":"10.21767/2254-6081.1000141","DOIUrl":"https://doi.org/10.21767/2254-6081.1000141","url":null,"abstract":"Background: Although genital prolapse and carcinoma of the uterine cervix are not rare event, their association is very uncommon. We report a case of this association. Case presentation: A-79-year-old female presented with 11 months history of post-menopausal bleeding, pelvic pain and sensation of heaviness which was increasing in intensity over than 8 months. Physical assessment showed a large genital prolapse third degree and ulcerous and necrotic lesion at the lower part prolapse. Histopathological examination of cervical biopsies revealed well differentiated and invasive squamous cell carcinoma. She was staging according to the International Federation of Gynecology and Obstetrics staging system 2009 as FIGO IIIB. The patient was treated by palliative chemotherapy. After 3 months, the patient died. Conclusion: Genital prolapse with cervical carcinoma is a rare association. In fact, it is necessary to individualize the optimal treatment for each patient to improve life quality and the prognosis.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Utility of Immunohistochemistry in Undifferentiated OvarianCarcinoma","authors":"H. Mouhamed","doi":"10.21767/2254-6081.1000143","DOIUrl":"https://doi.org/10.21767/2254-6081.1000143","url":null,"abstract":"Background: The impact of diagnostic immunohistochemistry (IHC) for the surgical pathology is legendary especially when it provides true identity of undifferentiated tumors. It is very important for the plane of management and prognostication, and it also provides further insights into the pathogenesis of these tumors. So, this study was undertaken to determine the role and significance of IHC for accurate diagnosis and subtyping of undifferentiated ovarian carcinoma as it is essential in guiding therapy and prognosis. Material and methods: IHC staining performed on 20 cases of undifferentiated ovarian carcinomas. A panel of antibodies was chosen to confirm the epithelial origin of these tumors and to exclude the possibility of ovarian metastasis from other sites. Results: IHC staining results showed that: 2 cases were malignant mesothelioma (calretinin+, panCKA1/A3+, CK7+, EMA+, vimentin+). Two other cases were granulosa cell tumor (inhibin+, calertinin+, vimentin+). Sixteen cases were undifferentiated ovarian carcinoma (PAX8+, vimentin+, panCKA1/A3+, CK7+, EMA+). Conclusion: The designed combinations of immunostaining profiles are helpful in the diagnosis of tumor origin and could offer a fast and correct prediction of the primary tumor site. PanCKA1/A3, CK7, CK20, vimentin, EMA, calertinin, inhibin, PAX8, GCDFP15 antibodies were sufficient for classification in most cases, whereas CA125 and CEA may help in supporting the diagnosis.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}