Archives in cancer research最新文献

{"title":"Extranodal NK/T-Cell Lymphoma, Nasal Type, Presenting as Facial Cellulitis","authors":"Mouzount A, M. W., Majjaoui Se, K. T, B. N","doi":"10.21767/2254-6081.100176","DOIUrl":"https://doi.org/10.21767/2254-6081.100176","url":null,"abstract":"Background: Checkpoint kinase 1 (CHK1) is a serine/threonine-protein kinase which plays a major role during checkpoint-mediated cell cycle arrest and activation of DNA repair in response to DNA damage. Ultraviolet (UV) irradiation induces DNA damage triggering the cell cycle arrest and the cell may be forced into apoptosis if damage is not repaired. Through phosphorylation mediated activation CHK1, as an effector kinase, responds to this damage by targeting downstream effector proteins. Objective: The objective of the present study was to demonstrate CHK1 methylation in response to UV induced DNA damage. Methods: Expression of CHK1 was detected in a cancer cell line Hct-116. Hct-116 cells, cultured in RPMI-1640 medium supplemented with serum and antibiotics, were transfected with HA-Chk1 plasmid, exposed to UV radiation and incubated for different time intervals. Cell lysis followed by immunoblotting was performed to visualize the signals of methylated CHK1. Result: Methylated CHK1 signals were observed in response to UV induced DNA damage in a cancer cell line Hct-116. Expectedly, it was found that with the increased duration of post UV exposure, methylation level of CHK1 was also amplified. Discussion and Conclusion: Here, for the first time, it is reported that DNA damage induced by UV radiation was associated with elevated methylation of CHK1. This new finding might indicate that cells may have evolved mechanisms to promote CHK1 methylation for reasons not yet known. This study reveals novel modification of CHK1 as a component of the cellular response to DNA damage which may help us understand the importance of such modifications.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of Cerebellar Haemangioblastoma in a 13-Year-OldGirl with Neurofibromatosis Type 2: Reportof a Case and Discussion of the Literature","authors":"J. Ouma, Dereje Mamo, M. Gritzman","doi":"10.21767/2254-6081.100173","DOIUrl":"https://doi.org/10.21767/2254-6081.100173","url":null,"abstract":"Neurofibromatosis is a condition that can occur in a number of forms, the commonest of which are types 1 and 2. As a group, they fall under the phacomatoses family of conditions, otherwise known as neurocutaneous syndromes, owing to the fact that they concurrently have disorders of the nervous system and the integument, which organs share a common ectodermal origin. Other examples include Schwannomatosis and Von Hippel Lindau syndromes. We describe a case of a young girl who presented with features of NF2 and was discovered to have a cerebellar hemangioblastoma at the same time. We are not aware of this association being described in the literature.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68125161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into Tumor Markersin Oral Cancer: A Review","authors":"Taranpreet Kaur, S. Dahiya, Ankit Srivastava","doi":"10.21767/2254-6081.100169","DOIUrl":"https://doi.org/10.21767/2254-6081.100169","url":null,"abstract":"Tumor markers are substances that are produced either by the tumor itself or by the body in response to the presence of cancer or certain benign conditions that can aid in the diagnosis of cancer. These markers may be employed to predict primary or secondary tumor risk. Sometimes, non-cancerous conditions can also cause elevation of some tumor markers to be higher than normal. Besides, not every cancer patient may have raised level of a tumor marker. For these reasons, knowledge about cancer biomarkers is essential. This review highlights potential molecular markers relevant to oral neoplasia in terms of their perspective role of in prevention and detection.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68124277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head and Neck Carcinogenesis","authors":"S. Ajaz","doi":"10.21767/2254-6081.100184","DOIUrl":"https://doi.org/10.21767/2254-6081.100184","url":null,"abstract":"Cancer is caused by mutation(s) in driver gene(s), leading to the transformation of normal cell into malignant one, followed by rapid proliferation. Head and neck cancers (HNCs) comprise epithelial malignancies of the mucosal lining in upper aero-digestive tract. These cancers are heterogeneous in nature. Carcinogenesis therein is correlated with the use of tobacco, chewing of areca nut (betel quid), alcohol consumption and infection with the human papillomavirus (HPV). These factors in conjunction with molecular variations contribute to tumour development, pathology and response to treatment. Thus, the carcinogenesis of head and neck cancers comprise a complex system of gene-gene and geneenvironment interactions.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.100184","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68126493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction of cancer by epigenetics","authors":"M. Verma","doi":"10.21767/2254-6081-C1-001","DOIUrl":"https://doi.org/10.21767/2254-6081-C1-001","url":null,"abstract":"","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"05 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44044408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating microRNAs: novel biomarkers in personalized medicine against breast cancer - breakthroughs in cancer research","authors":"A. Qattan","doi":"10.4172/2153-0645-C1-016","DOIUrl":"https://doi.org/10.4172/2153-0645-C1-016","url":null,"abstract":"Vitamin D deficiency (VDD) has been implicated as an important factor in the development or aggravation of systemic lupus erythematous (SLE). Patients with SLE are especially prone to the development of VDD due to the nature of their illness and avoidance of sun exposure. The prevalence of VD status in Bahraini patients with SLE has not been studied. Our aim is to study the prevalence of VDD in Bahraini cohort with SLE. Fifty-eight Bahraini patients with SLE were included retrospectively in this study. Most of the patients were females 50/58. The patients were followed at the rheumatology department at \"Salmanyia medical complex\". Controls were fifty-eight age-matched healthy Bahraini subjects. Serum levels of 25 (OH) vitamin D were estimated using chemilumenescence immunoassay. Chi Square and T-Test were used for analysis a p value of ≤ 0.05 was considered significant. There was statistically significant difference (P ≤ 0.05) in the mean serum levels of vitamin D between patients (30.67 nmol/l) and controls (39.95 nmom/L). In the SLE patients there were 49.1% deficient, 47.1% insufficient and 3.8% were Optimal. In the controls; 27% was deficient, 52% insufficient and 21% optimal. In conclusion, There was high prevalence of VDD in Bahraini patients with SLE. Both patients and controls had low vitamin D serum levels, however the patients had statistically significant lower levels. Our study also highlights the need for studying the effects of correcting hypovitaminosis on the disease activity in SLE patients.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70235075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of FTO SNPs <i>rs9930506</i> and <i>rs9939609</i> in Prostate Cancer Severity in a Cohort of Puerto Rican Men.","authors":"Jeannette L Salgado-Montilla,&nbsp;Jorge L Rodríguez-Cabán,&nbsp;Jonathan Sánchez-García,&nbsp;Ricardo Sánchez-Ortiz,&nbsp;Margarita Irizarry-Ramírez","doi":"10.21767/2254-6081.1000148","DOIUrl":"https://doi.org/10.21767/2254-6081.1000148","url":null,"abstract":"<p><strong>Background: </strong>Obesity is prevalent in PR and has been associated with prostate cancer (PCa) mortality and aggressiveness. Polymorphisms (SNPs) <i>rs9930506</i> and <i>rs9939609</i> in the FTO gene have been associated with both obesity and PCa. The aim of this work was to ascertain whether the presence of these SNPs is associated with PCa risk and severity in a cohort of Puerto Rican men.</p><p><strong>Methods and findings: </strong>The study population consisted of 513 Puerto Rican men age ranging from 40-79 years old who underwent radical prostatectomy (RP) as the first treatment for PCa and 128 healthy Puerto Rican men age ranging from 40-79 years old. Genomic DNA (gDNA) was extracted and SNPs were determined by Real-Time PCR. PCa severity was defined based on RP stage and Gleason Score. The relationship of FTO SNPs with demographic, clinical characteristics, PCa status and PCa severity were assessed. Logistic regression models with a 95% confidence interval (CI) determined SNPs interaction with PCa risk and severity odds ratio (ORs).</p><p><strong>Results and discussion: </strong>BMI, age and PSA were considered as confounders. Hardy-Weinberg equilibrium was present for both SNPs. The heterozygous forms (<i>A/G; T/A</i>) were the most prevalent genotypes and the frequency of alleles and genotypes for both SNPs agreed with those published in 1000 genomes. Results suggest an inverse association between the mutated <i>rs9939609</i> and the risk of having PCa (OR: 0.53, 95% CI: 0.31-0.92) and a positive association with overweight (OR: 1.05, 95% CI: 0.68-1.62). Importantly, among the cases that were overweight, those with mutated <i>rs9939609</i> had a greater chance of high severity PCa (OR: 1.39, 95% CI: 0.84-2.32) although these results were not statistical significant upon adjustment. Limitations of the study were the relatively small cohort and lack of access to the weight history of all our subjects.</p><p><strong>Conclusion: </strong>Results offer a research line to be followed with an expanded number of subjects that may provide a better statistical significance, to unravel the high mortality rate in this population.</p>","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35736160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant Reduction in Deaths in Hospital Over a Decade in an Increasingly Elderly Population Dying From Pelvic Cancer in England: A Population Based Study","authors":"Beena A, Pring A, Georgeson B, Sheppard S, Gornall R, Hounsome L, Verne J","doi":"10.21767/2254-6081.1000126","DOIUrl":"https://doi.org/10.21767/2254-6081.1000126","url":null,"abstract":"Background: In England more than 70% of people prefer to die at home. 29% of all deaths have an underlying cause of cancer during 2004-2013. Pelvic cancer (Gynaecological, urological and colorectal) accounts for 18.6% of all cancer deaths. This group of patients have overlapping speciality care needs and similar complications which could lead to multiple hospital admissions and hence many die in hospital. Many people do not receive care which meets their individual needs including where they prefer to die. Aim: To find out where patients with pelvic cancer die as a 'proxy' for quality of care, the variations by geography and demographics and whether this has changed since the publication of the National End of Life Care Strategy in 2008. Design: A national population based study to investigate factors influencing place of death with an underlying cause of death of pelvic cancer. Results: The proportion of pelvic cancers deaths (underlying cause) that occur in hospital declined from 46% in 2004 to 34% in 2013 (p<0.001); deaths occurring at home/care home increased from 33% in 2004 to 46% in 2013 (p<0.001). Three quarters (73%) were aged 70 years or over. 71% of the care home residents, died in a care home but only 36% of those who lived at home died at home (p<0.001). Multivariate regression analysis show age and deprivation quintile are the significant (P<0.001) factors. Conclusion: There has been a highly significant reduction in the proportion of pelvic cancer deaths in hospital in England consistent with aims of the End of Life Care Strategy. Older people, the most deprived and people living in their own home are more likely to die in hospital.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68109834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilonidal Sinus at Lateral Aspect of Neck","authors":"P. Tomas","doi":"10.21767/2254-6081.1000145","DOIUrl":"https://doi.org/10.21767/2254-6081.1000145","url":null,"abstract":"Pilonidal sinus disease is seen most commonly in the sacro-coccigeal area. Umbilical pilonidal sinus is a rare form of the condition with few studies about its clinical course and management. The current review is to highlight the presentation and management of umbilical pilonidal sinus. Literature review revealed 25 papers which contained 385 patients complaining from umbilical pilonidal sinus. Chronic discharging sinus and pain were the two most common presenting symptoms. Both conservative and surgical management were effective methods of therapy.","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal Cancer Associated with a Right Aortic Arch","authors":"K. Yatribi, A. Mouzount, T. Kebdani, N. Benjaafar","doi":"10.21767/2254-6081.1000147","DOIUrl":"https://doi.org/10.21767/2254-6081.1000147","url":null,"abstract":"","PeriodicalId":91204,"journal":{"name":"Archives in cancer research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2254-6081.1000147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68112421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}