Bio-medical materials and engineering最新文献_第5页

Polyvinylpyrrolidone hydrogel coating for ureteral stent: Safety and performance evaluation 用于输尿管支架的聚乙烯吡咯烷酮水凝胶涂层：安全性和性能评估

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-23 DOI: 10.3233/bme-230179

Haibin Tang, Dimeng Wu, Zheng Liu, Xi Liu, Heng Yuan, Xiaosong Jin, Shuai Gao, Gang Chen

{"title":"Polyvinylpyrrolidone hydrogel coating for ureteral stent: Safety and performance evaluation","authors":"Haibin Tang, Dimeng Wu, Zheng Liu, Xi Liu, Heng Yuan, Xiaosong Jin, Shuai Gao, Gang Chen","doi":"10.3233/bme-230179","DOIUrl":"https://doi.org/10.3233/bme-230179","url":null,"abstract":"BACKGROUND:Ureteral stents are commonly used in urology. However, complications such as encrustation and infection on the surface of the stent, and injury to the ureteral mucosa can occur after implantation, causing discomfort for patients. OBJECTIVE:We intend to confirm the biosafety of polyvinylpyrrolidone (PVP) hydrophilic coating and its lubrication properties for surface modification of ureteral stents to reduce friction and improve patient comfort. METHODS:Based on our previous studies, we have developed a PVP hydrophilic coating for surface modification of ureteral stents. We firstly investigated the cytotoxicity, intradermal irritation, delayed type hypersensitivity, and acute systemic reactions of stent coating extracts. We further characterized the break strength, retention strength, and dynamic friction of the stent. RESULTS:The cell survival rate of all experimental groups was greater than 70%. No hypersensitivity reaction, systemic toxicity reaction, or obvious intradermal reaction were observed. The above results indicate that the test results of the modified stent meet the requirements of ISO 10993-5: 2009 (Cytotoxicity); ISO 10993-10:2021 (Sensitization and Irritation); ISO 10993-11:2017 (Acute Systemic Toxicity). After soaking in artificial urine for an extended period, there was no obvious change in its super-slip performance. CONCLUSION:Our results confirm the safety and lubrication characteristics of PVP hydrophilic coating for ureteral stent surface modification. The performance of this coating has the potential to reduce complications after stent implantation, thereby improving patient comfort, reducing medical burden, and has a good clinical application prospect.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"171 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139561990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customized design and biomechanical property analysis of 3D-printed tantalum intervertebral cages 3D 打印钽椎间笼的定制设计和生物力学特性分析

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-10 DOI: 10.3233/bme-230154

Yutao Zhang, Shu Du, Wurikaixi Aiyiti, Yong Teng, Ru Jia, Houfeng Jiang

{"title":"Customized design and biomechanical property analysis of 3D-printed tantalum intervertebral cages","authors":"Yutao Zhang, Shu Du, Wurikaixi Aiyiti, Yong Teng, Ru Jia, Houfeng Jiang","doi":"10.3233/bme-230154","DOIUrl":"https://doi.org/10.3233/bme-230154","url":null,"abstract":"BACKGROUND:Intervertebral cages used in clinical applications were often general products with standard specifications, which were challenging to match with the cervical vertebra and prone to cause stress shielding and subsidence. OBJECTIVE:To design and fabricate customized tantalum (Ta) intervertebral fusion cages that meets the biomechanical requirements of the cervical segment. METHODS:The lattice intervertebral cages were customized designed and fabricated by the selective laser melting. The joint and muscle forces of the cervical segment under different movements were analyzed using reverse dynamics method. The stress characteristics of cage, plate, screws and vertebral endplate were analyzed by finite element analysis. The fluid flow behaviors and permeability of three lattice structures were simulated by computational fluid dynamics. Compression tests were executed to investigate the biomechanical properties of the cages. RESULTS:Compared with the solid cages, the lattice-filled structures significantly reduced the stress of cages and anterior fixation system. In comparison to the octahedroid and quaddiametral lattice-filled cages, the bitriangle lattice-filled cage had a lower stress shielding rate, higher permeability, and superior subsidence resistance ability. CONCLUSION:The inverse dynamics simulation combined with finite element analysis is an effective method to investigate the biomechanical properties of the cervical vertebra during movements.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"2 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139459721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial effect of Ag-containing hydroxyapatite thin film fabricated by sputtering 用溅射法制造的含银羟基磷灰石薄膜的抗菌效果

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-04 DOI: 10.3233/bme-230131

K. Ozeki, Y. Nakajima

{"title":"Antibacterial effect of Ag-containing hydroxyapatite thin film fabricated by sputtering","authors":"K. Ozeki, Y. Nakajima","doi":"10.3233/bme-230131","DOIUrl":"https://doi.org/10.3233/bme-230131","url":null,"abstract":"BACKGROUND:Infections related to joint prosthesis are still a major concern for orthopedic surgeons. Hydroxyapatite (HA) is a useful biocompatible material because of its good osteocompatibility. Antibacterial HA coatings have been fabricated with addition of antibacterial agents such as Ag to HA using the plasma spraying method. However, the plasma-sprayed HA coating suffers from fractures at large thicknesses. The sputter-coated HA thin film has a high density, and has been applied clinically for dental implants. However, there are no extensive studies on Ag-containing HA thin films. OBJECTIVE:The aim of this study was to prepare an Ag-containing HA thin film by sputtering, and evaluate its antibacterial effect and cytotoxicity. METHODS:The Ag-containing HA thin films were prepared by radio-frequency magnetron sputtering. The films were characterized using X-ray photoelectron spectroscopy, X-ray diffractometry, and scanning electron microscopy (SEM). The antibacterial activities and cytotoxicities of the films were also evaluated. RESULTS:The Ag/Ca molar ratio of the films increased with the Ag ratio in the target. The SEM observation of the hydrothermally treated films showed surfaces covered with globular particles. All Ag-containing HA films exhibited an antibacterial effect against E. Coli. The number of cells of the films decreased with the Ag ratio. The films subjected to the hydrothermal treatment exhibited a higher number of cells than the as-sputtered films. CONCLUSION:The Ag-containing HA thin film was effective in terms of antibacterial effect, and had a low cytotoxicity in the proliferation of osteoblast cells at a low Ag ratio in the target.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"13 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139102041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of transjugular intrahepatic portosystemic shunt by hemodynamic simulation. 通过血液动力学模拟分析经颈静脉肝内门体分流术。

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230020

Junjie Cao, Zhichao Yao, Guijun Huo, Zhanao Liu, Yao Tang, Jian Huang, Minxin Chen, Rui Ding, Liming Shen, Dayong Zhou

{"title":"Analysis of transjugular intrahepatic portosystemic shunt by hemodynamic simulation.","authors":"Junjie Cao, Zhichao Yao, Guijun Huo, Zhanao Liu, Yao Tang, Jian Huang, Minxin Chen, Rui Ding, Liming Shen, Dayong Zhou","doi":"10.3233/BME-230020","DOIUrl":"10.3233/BME-230020","url":null,"abstract":"Background: Transjugular intrahepatic portosystemic shunt (TIPS), which artificially creates a portocaval shunt to reduce portal venous pressure, has gradually become the primary treatment for portal hypertension (PH). However, there is no prefect shunting scheme in TIPS to balance the occurrence of postoperative complications and effective haemostasis.Objective: To construct cirrhotic PH models and compare different shunting schemes in TIPS.Methods: Three cases of cirrhotic PH with different liver volumes were selected for enhanced computed tomography scanning. The models for different shunting schemes were created using Mimics software, and following FLUENT calculation, all the models were imported into the software computational fluid dynamic-post for processing. In each shunting scheme, the differences in portal vein pressure, hepatic blood perfusion and blood flow from the superior mesenteric vein in the shunt tract were compared. The coefficient G was adapted to evaluate the advantages and disadvantages.Results: (1) Concerning the precise location of the shunt tract, the wider the diameter of the shunt tract, the lower the pressure of the portal vein and the lesser the hepatic blood perfusion. Meanwhile, the pressure drop objective was not achieved with the 6 mm-diameter shunting scheme. (2) The 8 mm-diameter shunting scheme through the left portal vein (LPV) had the highest coefficient G.Conclusion: The 8 mm-diameter shunting scheme through the LPV may demonstrate a superior effect and prognosis in TIPS procedures.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"27-37"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9912197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release. 与奥萨拉嗪交联的可快速降解魔芋葡甘露聚糖水凝胶用于结肠药物释放。

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230066

Qiao Zhang, Huili Fu, Yunfei Zhang, Liang Li, Guoping Yan

{"title":"Rapidly degradable konjac glucomannan hydrogels cross-linked with olsalazine for colonic drug release.","authors":"Qiao Zhang, Huili Fu, Yunfei Zhang, Liang Li, Guoping Yan","doi":"10.3233/BME-230066","DOIUrl":"10.3233/BME-230066","url":null,"abstract":"Background: Polysaccharide hydrogel is one of the most important materials for the colon target drug release system. However, the degradation time of polysaccharide hydrogel is much longer than the retention time in the colon. The drugs are expelled from the body before being released.Objective: In order to match the degradation of drug carriers and their retention time in the colon, a rapidly degradable konjac glucomannan (KGM) hydrogel was designed for colon target drug release.Methods: A crosslinker containing azo bond, olsalazine, was used to prepare the rapidly degradable KGM hydrogel. The degradation and drug release of the hydrogels with different crosslinking densities in the normal buffer and the human fecal medium were studied to evaluate the efficiency of colon drug release.Results: More than 50% of the KGM hydrogel by weight was degraded and more than 60% of the 5-fluorouracil (5-Fu) was released within 48 h in 5% w/v human fecal medium.Conclusion: The drug was released more rapidly in a simulated colon environment than in a normal buffer. Furthermore, the drug release was controlled by the degradation of the hydrogel. The KGM hydrogel containing azo crosslinker has great potential for colon drug release.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"125-137"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10651986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial preference behavior of robo-pigeons induced by electrical stimulus targeting fear nuclei. 以恐惧核为目标的电刺激诱发机器人鸽的空间偏好行为

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-240048

Yanna Ping, Huanhuan Peng, Yongjun Zhu, Yuhao Feng, Yexin Zhang, Xiaomin Qi, Xinyu Liu

{"title":"Spatial preference behavior of robo-pigeons induced by electrical stimulus targeting fear nuclei.","authors":"Yanna Ping, Huanhuan Peng, Yongjun Zhu, Yuhao Feng, Yexin Zhang, Xiaomin Qi, Xinyu Liu","doi":"10.3233/BME-240048","DOIUrl":"10.3233/BME-240048","url":null,"abstract":"Background: Numerous studies have confirmed that stimulating the mid-brain motor nuclei can regulate movement forcibly for robo-pigeons, but research on behavior modulation using non-motor nuclei is scarce.Objective: In this study, we constructed a spatial preference behavior by stimulating the stratum griseum periventriculare (SGP), a nucleus correlated with fear and escape, for robo-pigeons.Methods: The study was carried out in a square-enclosed experimental field, with a designated box serving as the 'safe' area for the robo-pigeons. If the robo-pigeon exits this area, the SGP will be stimulated. After a brief training period, the robo-pigeons will have a clear spatial preference for the box.Results: The result from five pigeons has shown that, after simple training, the animals develop a spatial preference for the box. They can quickly return to the box in any situation when the SGP is stimulated, with a success rate exceeding 80% (89.0 ± 6.5%). Moreover, this behavior is highly stable and remains consistent, unaffected by changes in the location of the box or the interference box.Conclusion: The results prove that using the electrical stimulus could enable animals to accomplish more complex tasks. It may offer a novel approach to regulating pigeon behavior and further advance the study of cyborg animals.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"465-474"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering. 用于组织工程的聚乳酸同轴系统和聚乳酸与聚（e-己内酯）三层膜所含的芦荟粘液负载明胶电纺纤维。

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-240050

María Mónica Castillo Ortega, Jesús Manuel Quiroz Castillo, Teresa Del Castillo Castro, Dora Evelia Rodriguez Felix, Hisila Del Carmen Santacruz Ortega, Octavio Manero, Karla Alejandra Lopez Gastelum, Lerma Hanaiy Chan Chan, Diego Hernandez Martinez, Jose Agustin Tapia Hernández, Damian Francisco Plascencia Martínez

{"title":"Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering.","authors":"María Mónica Castillo Ortega, Jesús Manuel Quiroz Castillo, Teresa Del Castillo Castro, Dora Evelia Rodriguez Felix, Hisila Del Carmen Santacruz Ortega, Octavio Manero, Karla Alejandra Lopez Gastelum, Lerma Hanaiy Chan Chan, Diego Hernandez Martinez, Jose Agustin Tapia Hernández, Damian Francisco Plascencia Martínez","doi":"10.3233/BME-240050","DOIUrl":"10.3233/BME-240050","url":null,"abstract":"Background: Polymeric electrospun mats have been used as scaffolds in tissue engineering for the development of novel materials due to its characteristics. The usage of synthetic materials has gone in decline due to environmental problems associated with their synthesis and waste disposal. Biomaterials such as biopolymers have been used recently due to good compatibility on biological applications and sustainability.Objective: The purpose of this work is to obtain novel materials based on synthetic and natural polymers for applications on tissue engineering.Methods: Aloe vera mucilage was obtained, chemically characterized, and used as an active compound contained in electrospun mats. Polymeric scaffolds were obtained in single, coaxial and tri-layer structures, characterized and evaluated in cell culture.Results: Mucilage loaded electrospun fibers showed good compatibility due to formation of hydrogen bonds between polymers and biomolecules from its structure, evidenced by FTIR spectra and thermal properties. Cell viability test showed that most of the obtained mats result on viability higher than 75%, resulting in nontoxic materials, ready to be used on scaffolding applications.Conclusion: Mucilage containing fibers resulted on materials with potential use on scaffolding applications due to their mechanical performance and cell viability results.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"387-399"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions. 通过贻贝启发粘合剂作为骨替代物增强磷酸钙水门汀的力学性能：它们之间相互作用的亮点。

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230017

Rupan Yuan, Sijie Zhou, Xiong Xiong, Dan Yang, Donghu Lin, Taiyi Li, Bin He, Guihua Wei, Shuxin Qu

{"title":"Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions.","authors":"Rupan Yuan, Sijie Zhou, Xiong Xiong, Dan Yang, Donghu Lin, Taiyi Li, Bin He, Guihua Wei, Shuxin Qu","doi":"10.3233/BME-230017","DOIUrl":"10.3233/BME-230017","url":null,"abstract":"Background: Inspired by natural bones, many organic components were added to Calcium Phosphate Cements (CPCs) to improve their mechanical strength. However, the strength of these composite CPCs is limited by the low strength of organic components itself and the weak interaction between organic components and CPCs.Objective: Firstly, a composite CPC containing mussel-inspired adhesive, Poly-(Dopamine Methacrylamide-co-2-methoxy Ethylacrylate) (pDM) was developed. Secondly, the interactions between pDM and CPC and their effect on mechanical properties were investigated.Methods: The interactions between pDM and CPC were performed by Nuclear Magnetic Resonance, Laser Raman, X-ray Photoelectron Spectroscopy, Fourier Transform-Infrared Spectroscopy and X-ray Diffraction Analysis.Results: The toughness and compressive strength of pDM-CPC scaffold were both significantly enhanced, because of the enhanced interface binding strength among CPC and pDM due to their interaction and the improved mechanical strength of pDM owing to its self-oxidation cross-linking. The toughness of pDM-CPC scaffolds increased with the increased contents of pDM, while pDM-CPC scaffold containing 35 wt.% pDM had the highest compressive strength of all, which the latter was more than five times compared to that of CPC.Conclusion: The mechanically strong pDM-CPC scaffolds has potential application in bone regeneration as well as in craniofacial and orthopedic repair.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"13-26"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the efficacy of the punch-out technique in systemic-to-pulmonary shunts: A computational fluid dynamics approach. 评估全身-肺分流术中打孔技术的功效：计算流体动力学方法。

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-240022

Shiho Yamazaki, Ryosuke Kowatari, Tetsuya Yano, Hanae Sasaki, Kazuyuki Daitoku, Masahito Minakawa

{"title":"Evaluating the efficacy of the punch-out technique in systemic-to-pulmonary shunts: A computational fluid dynamics approach.","authors":"Shiho Yamazaki, Ryosuke Kowatari, Tetsuya Yano, Hanae Sasaki, Kazuyuki Daitoku, Masahito Minakawa","doi":"10.3233/BME-240022","DOIUrl":"10.3233/BME-240022","url":null,"abstract":"Background: Systemic-to-pulmonary shunt is a palliative procedure used to decrease pulmonary blood flow in congenital heart diseases. Shunt stenosis or occlusion has been reported to be associated with mortality; therefore, the management of thrombotic complications remains a challenge for most congenital cardiovascular surgeons. Despite its importance, the optimal method for shunt anastomosis remains unclear.Objective: The study investigates the clinical benefits of the punch-out technique over conventional methods in the anastomosis process of Systemic-to-pulmonary shunt, focusing on its potential to reduce shunt-related complications.Methods: Anastomotic models were created by two different surgeons employing both traditional slit and innovative punch-out techniques. Computational tomography was performed to construct three-dimensional models for computational fluid dynamics (CFD) analysis. We assessed the flow pattern, helicity, magnitude of wall shear stress, and its gradient.Results: The anastomotic flow area was larger in the model using the punch-out technique than in the slit model. In CFD simulation, we found that using the punch-out technique decreases the likelihood of establishing a high wall shear stress distribution around the anastomosis line in the model.Conclusion: The punch-out technique emerges as a promising method in SPS anastomosis, offering a reproducible and less skill-dependent alternative that potentially diminishes the risk of shunt occlusion, thereby enhancing patient outcomes.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"425-437"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcutaneous tissue reaction to a novel nano zinc oxide eugenol dental cement. 新型纳米氧化锌丁香酚牙水泥的皮下组织反应。

IF 1 4区医学

Bio-medical materials and engineering Pub Date : 2024-01-01 DOI: 10.3233/BME-230118

Rohmat Nursin, Masitah Hayati Harun, Dasmawati Mohamad, Siti Khadijah Mohd Bakhori, Shahrom Mahmud

{"title":"Subcutaneous tissue reaction to a novel nano zinc oxide eugenol dental cement.","authors":"Rohmat Nursin, Masitah Hayati Harun, Dasmawati Mohamad, Siti Khadijah Mohd Bakhori, Shahrom Mahmud","doi":"10.3233/BME-230118","DOIUrl":"10.3233/BME-230118","url":null,"abstract":"Background: Zinc oxide eugenol (ZOE) cement is a popular dental material due mainly to its analgesic, antibacterial and anti-inflammatory effects. The formulation of ZOE cement from nano particle-sized zinc oxide (ZnO) has the potential to increase these properties as well as reduce its adverse effects to the surrounding tissues.Objective: This study evaluated the subcutaneous tissue response towards nano ZOE cements (ZOE-A and ZOE-B) in comparison to conventional ZOE (ZOE-K).Methods: Test materials were implanted into 15 New Zealand white rabbits. Tissue samples were obtained after 7, 14, and 30 days (n = 5 per period) for histopathological evaluation of inflammatory cell infiltrate, fibrous tissue condensation, and abscess formation.Results: ZOE-A showed the lowest score for the variable macrophage and lymphocyte at day 7. Both ZOE-A and ZOE-B presented lower fibrous tissue condensation and abscess formation compared to conventional ZOE-K. By day 30, ZOE-A exhibited less lymphocytic and neutrophilic infiltrate compared to the other materials, while ZOE-B had the lowest score for macrophages. ZOE-K exerted higher inflammatory cell response at almost all of the experimental periods. All of the materials resulted in thin fiber condensation after 30 days.Conclusions: Rabbit tissue implanted with ZOE-A and ZOE-B showed better response compared to ZOE-K.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"139-151"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138440236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0