Claudia E Peña-Varela, Nancy L Salazar-Flores, Reyna G Ramos-Porras, Karina A Martínez-Cervantes, Lilia T Avena-Portillo, Luisa B Gámez-González
{"title":"Persistent hyperinsulinemic hypoglycemia of infancy treated at the Hospital Infantil de Especialidades de Chihuahua.","authors":"Claudia E Peña-Varela, Nancy L Salazar-Flores, Reyna G Ramos-Porras, Karina A Martínez-Cervantes, Lilia T Avena-Portillo, Luisa B Gámez-González","doi":"10.24875/BMHIM.24000102","DOIUrl":"10.24875/BMHIM.24000102","url":null,"abstract":"<p><strong>Background: </strong>Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) affects between 0.5% and 5% of pediatric patients. This condition is caused by a dysfunction of pancreatic β-cells, leading to tumors and hyperinsulinism, which result in persistent hypoglycemia. These episodes are often resistant to conventional treatment and require interventions to reduce insulin production and increase glucose levels, thereby restoring metabolic balance.</p><p><strong>Clini calcases: </strong>We present three cases of PHHI. The first is a four-day-old Rarámuri patient with persistent hypoglycemia, diagnosed after a pancreatectomy and biopsy. The second case is a three-day-old Rarámuri patient with persistent hypoglycemia and a pancreatic lesion detected by scintigraphy, with PHHI confirmed after pancreatectomy. The third case is a three-day-old female patient with hypoactivity and persistent hypoglycemia, who was also diagnosed with PHHI after a pancreatectomy.</p><p><strong>Conclusions: </strong>While clinical presentation and biochemical findings raise high diagnostic suspicion, histopathological confirmation is essential. Early diagnosis is key to preventing long-term sequelae. PHHI should be considered in the differential diagnosis of hyperinsulinemic hypoglycemia, such as prematurity, intrauterine growth restriction, low birth weight, maternal diabetes, tyrosinemia type 1, or Beckwith-Wiedemann syndrome. These cases highlight the complexity of PHHI and its unusual presentation in the Rarámuri ethnic group, underscoring the importance of culturally sensitive medical care.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 4","pages":"258-262"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lorena Salazar-Cavazos, Jesus J Solis-Flores, Carmen L de Hoyos-Ramón, Marco A Flores-Heredia, Luis G Martínez-Valades, Lucas A Garza-Garza
{"title":"Complications and blood transfusions in newborns are associated with a higher milliliters per kilogram ratio of blood extracted for laboratory studies.","authors":"Lorena Salazar-Cavazos, Jesus J Solis-Flores, Carmen L de Hoyos-Ramón, Marco A Flores-Heredia, Luis G Martínez-Valades, Lucas A Garza-Garza","doi":"10.24875/BMHIM.24000148","DOIUrl":"10.24875/BMHIM.24000148","url":null,"abstract":"<p><strong>Background: </strong>Phlebotomy-associated blood loss is a clinical concern in term and pre-term newborns. Previous reports have associated a higher volume of phlebotomy associated blood loss to a more pre-term status and to the need for blood transfusions. The present study was undertaken to evaluate the amount of phlebotomy-associated blood loss and its associations.</p><p><strong>Methods: </strong>Retrospective, observational, and analytical study conducted through a retrospective chart review. The primary objective was to determine the association between the presence of the endpoint \"any complications\" and the mean phlebotomy-associated blood loss in milliliters/kilograms (mL/kg). Blood loss was quantified using the corresponding documentation sheet in the clinical record, as reported by the nursery service.</p><p><strong>Results: </strong>176 patients were included in the present study. Male: female ratio was 1.67:1.00. Mean gestational weeks was 34.2 with a standard deviation of 3.7. Patients meeting the composite endpoint \"any complications\" had a higher mean mL/kg of phlebotomy-associated blood loss than those who did meet it (10.93 vs. 2.91, p < 0.001). In addition, patients requiring blood transfusions had higher mL/kg of phlebotomy-associated blood loss than those who did not (21.16 vs. 4.21, p < 0.001). Finally, more pre-term status was significantly associated with a higher phlebotomy-associated blood loss (p < 0.001).</p><p><strong>Conclusions: </strong>The presence of any complications, more pre-term status and need for blood transfusions was significantly associated with a higher mL/kg phlebotomy-associated blood loss. Bigger, prospective studies controlling other variables and temporality are needed to fully grasp the clinical consequences of a high mL/kg phlebotomy-associated blood loss.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 5","pages":"289-294"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enrique G Ortiz-Hernández, Ariadna Vallejo, Diego Guzmán, Melissa León, Natalia Calderón
{"title":"Relación entre genotipo y carga viral de virus del papiloma humano y la gravedad de presentación de la papilomatosis respiratoria recurrente en niños.","authors":"Enrique G Ortiz-Hernández, Ariadna Vallejo, Diego Guzmán, Melissa León, Natalia Calderón","doi":"10.24875/BMHIM.24000145","DOIUrl":"https://doi.org/10.24875/BMHIM.24000145","url":null,"abstract":"<p><strong>Background: </strong>Recurrent respiratory papillomatosis is a condition that occurs mainly in the pediatric population with a rate of 3.62 to 4.3 per 100,000 children. The most common clinical manifestation is dysphonia; however, the disease can progress to more severe forms, generating serious obstruction of the airway.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in which patients diagnosed with laryngeal papillomatosis confirmed by histopathological analysis and polymerase chain reaction were included. The genotype of the virus and its viral load were determined through a search in the clinical records, and the clinical and genetic variables of each case were captured through a structured form.</p><p><strong>Results: </strong>A total of 32 patients were enrolled, of which the prevalence of genotype 6 was found in 41% and the same prevalence in the case of genotype 11, with a percentage of coinfection with both subtypes of 18%. Genotype 11 was found to be associated with a greater number of resections (p = 0.004), a higher score on the Derkay scale (p = 0.02) and greater severity when presenting ≥ 4 surgeries per year and/or ≥ 10 total surgeries (p = 0.04).</p><p><strong>Conclusions: </strong>Human papillomavirus genotype 11 showed a greater association with the presentation of greater severity of recurrent respiratory papillomatosis in pediatric patients; therefore, this population is more susceptible to a poor outcome (which increases the demand for medical services), as well as impact on the quality of life of minors.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 5","pages":"282-288"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Ibarra-Ríos, Alejandra Sánchez-Cruz, Deneb A Morales-Barquet, Eunice V Serpa-Maldonado, Rogelio Guillén-Torres, José G Mantilla-Uresti, Edgar A Jorge-Chang, Carolina Michel-Macías, Federico Franchi, Irma A Coronado-Zarco, Lourdes Ma Del C Jamaica-Balderas, Dillan D Izaguirre-Alcántara, Mario A Mora-Sagrero, Enrique García-Chávez, Alfonso de J Martínez-García, Horacio Márquez-González
{"title":"Guidelines for performing and reporting neonatal lung ultrasound in Mexico.","authors":"Daniel Ibarra-Ríos, Alejandra Sánchez-Cruz, Deneb A Morales-Barquet, Eunice V Serpa-Maldonado, Rogelio Guillén-Torres, José G Mantilla-Uresti, Edgar A Jorge-Chang, Carolina Michel-Macías, Federico Franchi, Irma A Coronado-Zarco, Lourdes Ma Del C Jamaica-Balderas, Dillan D Izaguirre-Alcántara, Mario A Mora-Sagrero, Enrique García-Chávez, Alfonso de J Martínez-García, Horacio Márquez-González","doi":"10.24875/BMHIM.25000084","DOIUrl":"10.24875/BMHIM.25000084","url":null,"abstract":"<p><p>El ultrasonido pulmonar (UP) es una herramienta que ha revolucionado los cuidados intensivos/urgencias pediátricas y de adultos, y en la última década se han publicado cientos de estudios que demuestran su utilidad en neonatología. Programas establecidos de todo el mundo han mostrado que se modifica o ajusta el tratamiento tras realizarlo en más del 50% de las ocasiones y disminuye la radiación al recién nacido. Se convocó a un grupo de expertos con programas nacionales establecidos, integrado por neonatólogos, radiólogos, neumólogos y cardiólogos con experiencia de 3 a 8 años (> 2,000 estudios realizados). Se llevó a cabo una revisión sistemática de la literatura en bases de datos electrónicas, incluyendo PubMed, Embase, Web of Science y Cochrane, con términos específicos y estrategias de búsqueda avanzada adaptadas a cada motor. Se incluyeron artículos que cumplían con criterios de calidad metodológica y relevancia. Además, se complementó la información mediante consulta a expertos internacionales y revisión de literatura local para garantizar la representación de datos en el contexto nacional. Se presentan los hallazgos de la revisión sistemática junto con un consenso para la semiología, terminología, realización y reporte del UP neonatal en México, así como los criterios diagnósticos de cada afección. La transición hacia la incorporación del UP en la práctica clínica habitual requiere una planificación adecuada y unificación de criterios. Se presenta un marco para la práctica, que incluye una metodología estandarizada para la realización y reporte del UP neonatal en el país.</p><p><p>Lung ultrasound (LU) is a tool that has revolutionized pediatric and adult intensive/emergency care; in the last decade, hundreds of studies have been published demonstrating its usefulness in neonatology. Established programs around the world have shown that management is modified or adjusted after performance in more than 50% of the cases and reduces radiation to the newborn. A group of experts with established national programs, consisting of neonatologists, radiologists, pulmonologists and cardiologists with experience of 3 to 8 years (> 2,000 studies conducted) were convened. A systematic review of the literature was conducted in electronic databases, including PubMed, Embase, Web of Science and Cochrane, with specific terms and advanced search strategies adapted to each engine. Articles that met methodological quality and relevance criteria were included. In addition, the information was complemented by consulting international experts and reviewing local literature to ensure that data were represented in the national context. The findings of the systematic review are presented along with a consensus for the semiology, terminology, performance, and reporting of neonatal LU in Mexico, as well as the diagnostic criteria for each pathology. The transition towards the incorporation of LU into routine clinical practice requires adequate planning and unific","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 Supl 5","pages":"4-37"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan A Godínez-Chaparro, Marissa de J Quintal-Ramírez, Baldomero García-Gálvez
{"title":"Clinical and dermoscopic findings of classic-type nevus lipomatosus cutaneous superficialis in an adolescent. Case report.","authors":"Juan A Godínez-Chaparro, Marissa de J Quintal-Ramírez, Baldomero García-Gálvez","doi":"10.24875/BMHIM.24000112","DOIUrl":"10.24875/BMHIM.24000112","url":null,"abstract":"<p><strong>Background: </strong>Nevus Lipomatosus Cutaneous Superficialis (NLCS) is a rare benign tumor characterized by the presence of ectopic adipocytes distributed among the collagen bundles in the dermis. Dermoscopy of this lesion has been poorly documented, but it aids in diagnosis.</p><p><strong>Clinical case: </strong>A female patient, 11 years and 5 months old, presented with lesions in the lumbar region that had gradually increased in size and number since birth. In September 2023, she was evaluated at CMN La Raza, where a lesion in the lumbar region was observed, consisting of a linear plaque measuring 30 × 15 mm in diameter, composed of multiple skin-colored papules and nodules that coalesced. Dermoscopy revealed a cerebriform surface, a web-like pigment network, and the presence of yellowish structureless areas. Histopathology showed a proliferation of mature adipocytes in the reticular and papillary dermis. The adipocytes were located perianexally, perivascularly, and dispersed among the collagen bundles. An increase in the density of collagen bundles was observed. The diagnosis was NLCS. The lesion was completely excised without recurrence.</p><p><strong>Conclusions: </strong>The condition may be underdiagnosed due to a lack of medical familiarity. Dermoscopy facilitates a more accurate diagnosis. An increased number of reports will contribute to the creation of a database for future studies and potential associations.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 5","pages":"319-322"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth Hernández-Chávez, Judith Flores-Calderón, Flora Zárate-Mondragón, Miriam Sosa-Arce, Beatriz González-Ortiz, Laura E Flores-Fong, Alejandra Consuelo-Sánchez, Jorge A Macías-Flores, Sindy Ledesma-Ramírez, Fátima A Reynoso-Zarzosa, Abisai Arellano-Tejeda, Yolanda A Castillo-de León, Denis L Martínez-Bejarano, Leticia P Bilbao-Chávez, Guillermina Gómez-Navarro, Carlos P Acosta-Rodríguez Bueno, Karla Miranda-Barbachano, Idalia A Cura-Esquivel, Emma V Estrada-Arce, Renata Aguila-Cano, Juana E Castillo-Calderón, Gabriela Hernández-Vez, Karen R Ignorosa-Arellano, Renata I Alcántara-García, Francisco A Medina-Vega, Martha P Sánchez-Soto, José L Pérez-Hernández
{"title":"Pediatric consensus of autoimmune hepatitis.","authors":"Elizabeth Hernández-Chávez, Judith Flores-Calderón, Flora Zárate-Mondragón, Miriam Sosa-Arce, Beatriz González-Ortiz, Laura E Flores-Fong, Alejandra Consuelo-Sánchez, Jorge A Macías-Flores, Sindy Ledesma-Ramírez, Fátima A Reynoso-Zarzosa, Abisai Arellano-Tejeda, Yolanda A Castillo-de León, Denis L Martínez-Bejarano, Leticia P Bilbao-Chávez, Guillermina Gómez-Navarro, Carlos P Acosta-Rodríguez Bueno, Karla Miranda-Barbachano, Idalia A Cura-Esquivel, Emma V Estrada-Arce, Renata Aguila-Cano, Juana E Castillo-Calderón, Gabriela Hernández-Vez, Karen R Ignorosa-Arellano, Renata I Alcántara-García, Francisco A Medina-Vega, Martha P Sánchez-Soto, José L Pérez-Hernández","doi":"10.24875/BMHIM.25000091","DOIUrl":"https://doi.org/10.24875/BMHIM.25000091","url":null,"abstract":"<p><p>The Mexican Association of Hepatology held this Consensus on Autoimmune Hepatitis in the Pediatric Population with the aim of providing physicians with useful information for diagnosis and treatment. A group of pediatric and hepatology gastroenterologists and a transplant surgeon reviewed the medical literature. The Delphi method was applied sending the statements to the participants to be analyzed and voted on the level of agreement and discussed during virtual sessions, 46 statements were approved with the recommendations for the autoimmune hepatitis diagnosis, early management to prevent disease progression, cirrhosis complications, and for the treatment failure, adverse events detection, alternative therapy and liver transplant indications. Autoimmune hepatitis is a rare entity in pediatrics diagnostic and therapeutic challenge. Updated recommendations for diagnosis and treatment with pediatric doses are presented.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 Supl 4","pages":"1-21"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145767056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Rodriguez-Portilla, Isabel Pinedo-Torres, Claudia C Guerra-Ríos, Angela Parra Del Riego-Freundt-Thurne, Nilton Yhuri-Carreazo
{"title":"Septic shock upon admission to pediatric intensive care units: prognostic analysis of mortality in a retrospective cohort.","authors":"Ricardo Rodriguez-Portilla, Isabel Pinedo-Torres, Claudia C Guerra-Ríos, Angela Parra Del Riego-Freundt-Thurne, Nilton Yhuri-Carreazo","doi":"10.24875/BMHIM.24000056","DOIUrl":"10.24875/BMHIM.24000056","url":null,"abstract":"<p><strong>Background: </strong>Septic shock is a common cause of admission to pediatric intensive care units (PICU) and is associated with significant mortality. Our objective was to analyze the association between septic shock diagnosis at PICU admission and mortality during hospitalization.</p><p><strong>Method: </strong>This retrospective cohort study was conducted in the PICU of Hospital Nacional Edgardo Rebagliati Martins (HNERM) in Lima, Peru, from January 2018 to December 2021. The sample size was determined based on annual mortality rates, and randomization was used to create two groups: patients with and without septic shock. To evaluate mortality risk, we performed a Poisson regression with robust variances and 95% confidence intervals (CI) using both crude and adjusted models.</p><p><strong>Results: </strong>Of 1,341 patients admitted to the PICU during the study period, 358 were included in the analysis. The study population was 51.9% female, with a median age of 3.7 years. The largest age group was children under 1 year, comprising 29.6% of participants. The septic shock group showed higher rates of mechanical ventilation requirement, longer hospital stays, and increased mortality. The risk of mortality was 2.73 times higher in patients admitted with septic shock compared to those admitted with other diagnoses (relative risks: 2.73; 95% CI: 1.36-5.46).</p><p><strong>Conclusion: </strong>Patients admitted to the PICU with septic shock demonstrated a 2.73 times higher risk of death compared to those admitted for other reasons.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 1","pages":"28-34"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan I Indo, Zelmira Ríos, Carla de Nicola, Mauro F Andreu
{"title":"Decannulation outcomes in pediatric patients with acquired brain injury: a retrospective study.","authors":"Juan I Indo, Zelmira Ríos, Carla de Nicola, Mauro F Andreu","doi":"10.24875/BMHIM.25000014","DOIUrl":"10.24875/BMHIM.25000014","url":null,"abstract":"<p><strong>Background: </strong>Decanulation in paediatric patients with tracheostomy due to acquired brain injury is a key objective in rehabilitation, and there is a lack of consensus about the optimal protocol and success factors in decannulation. Therefore, the aim of this study is to describe the experience of decannulation in a paediatric neurorehabilitation centre in Buenos Aires.</p><p><strong>Methods: </strong>An observational, retrospective, and descriptive study was conducted on patients under 18 years old with acquired brain injury and tracheostomy, admitted between January 2016 and August 2023. Demographic, clinical data, and fibroendoscopy results were collected. Decannulation was performed according to institutional criteria, and a 48-hour monitoring period was implemented to evaluate post-decannulation complications.</p><p><strong>Results: </strong>Of the 41 patients included in the study, 12 (29.3%) were successfully decannulated, while 29 (70.7%) were discharged with a speaking valve, an occluded cannula, or with the initial tracheostomy configuration. Fibroendoscopy was performed on 13 patients, detecting lesions in 11 cases.</p><p><strong>Conclusions: </strong>The decannulation rate observed falls within the range documented in the literature, although it is closer to the lower end, which may be due to the complexity of the cases and the conservative approach adopted. The presence of disorders of consciousness and comorbidities were important factors in the decannulation process.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 4","pages":"245-251"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luisana Guier-Bonilla, Adriana Yock-Corrales, Marco T Vargas-Acuña, Rolando Ulloa-Gutierrez
{"title":"Hospitalizations due to acute respiratory tract infections caused by human metapneumovirus in Costa Rican children.","authors":"Luisana Guier-Bonilla, Adriana Yock-Corrales, Marco T Vargas-Acuña, Rolando Ulloa-Gutierrez","doi":"10.24875/BMHIM.24000184","DOIUrl":"10.24875/BMHIM.24000184","url":null,"abstract":"<p><strong>Background: </strong>Human metapneumovirus (hMPV) is a leading cause of acute respiratory infection in children, particularly early in life. Despite this, there are few prospective hMPV studies in Latin American children and this is the only of that kind in Costa Rica.</p><p><strong>Methods: </strong>We conducted an observational descriptive prospective study at the only national tertiary referral pediatric hospital of the country. We included children < 13 years of age with a laboratory-confirmed hMPV episode of acute respiratory tract infection requiring hospitalization from September 1, 2015, to September 30, 2017. Diagnosis was confirmed by direct immunofluorescence assay and/or polymerase-chain reaction.</p><p><strong>Results: </strong>One hundred and eighty-eight patients were analyzed. One hundred and sixteen (62%) were male. About 65% were < 15 months of age; median age was 12 months (interquartile range [IQR] = 6-23). Median hospital stay was 5 days (IQR = 3-8). The most common underlying conditions were prematurity (21.8%;41), recurrent wheeze-asthma (22,8%;43), and low birth weight (17%;32). About 52.6% patients received intravenous antibiotics. Complications occurred in 37.5%, among which, ventilatory failure occurred in 17% (32), shock 4.2% (8), and pleural effusion 1.6% (3). Forty-five (23.9%) patients needed high-flow nasal cannula (average of 3.4 days [standard deviation (SD) = 2.08]). Fifty-four (28.7%) children required pediatric intensive care unit admission. Twenty-eight (14.8%) of them were on assisted mechanical ventilation for a mean duration of 6.3 days (SD = 6.03). Ten patients went home with requiring supplementary oxygen; no deaths occurred.</p><p><strong>Conclusions: </strong>hMPV-associated hospitalizations in Costa Rican children are associated with significant morbidity. A concerning finding in our study was the high proportion of patients requiring antibiotic therapy, either on admission or during hospitalization. This should prompt us to antimicrobial stewardship interventions.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 4","pages":"238-244"},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Rizzoli-Córdoba, Hortensia Reyes-Morales, Jesús H Trujillo-Flores, Mario R Paredes-Saldaña, Angélica Ocaña-Zavaleta, Laura A Hernández-Trejo, José A García-Aranda, Daniel Aceves-Villagrán, Miguel Á Villasis-Keever
{"title":"Effect of a federal early education program in Mexico on the developmental level of children aged 13-48 months: national survey.","authors":"Antonio Rizzoli-Córdoba, Hortensia Reyes-Morales, Jesús H Trujillo-Flores, Mario R Paredes-Saldaña, Angélica Ocaña-Zavaleta, Laura A Hernández-Trejo, José A García-Aranda, Daniel Aceves-Villagrán, Miguel Á Villasis-Keever","doi":"10.24875/BMHIM.24000159","DOIUrl":"10.24875/BMHIM.24000159","url":null,"abstract":"<p><strong>Background: </strong>Early childhood development is crucial. The objective of this study was to evaluate, on a national scale, the level of development of children enrolled in the federal childcare program, according to the length of stay in the childcare centers and by geographic area.</p><p><strong>Methods: </strong>A national cross-sectional study was conducted. The study population comprised 231,058 children aged between 13 and 48 months, enrolled in 9200-day care centers across the 32 states of Mexico. The developmental level was measured using the Child Development Evaluation test. The effect of length of stay was analyzed by logistic regression, using odds ratio of prevalence and 95% confidence intervals.</p><p><strong>Results: </strong>Of the total number of participants, 53% were male, and the 37-48 month-old group was the largest (45%, n = 103,976). The length of stay ranged from 1 to > 24 months. The proportion of children with normal developmental outcomes increased alongside the length of stay, from 72.3% for children with < 6 months of stay to 88.7% for those who attended centers for > 24 months. By geographical region, Guerrero and Oaxaca, two low-income states, showed the best results, along with the highest-income states. The distribution for each area of development and geographic area are shown.</p><p><strong>Conclusion: </strong>At the national level, long-term enrollment in daycare centers favors normal development. Particularly important is the high result in low-income regions, and it could be an equalizing strategy as a public policy. The different results among areas could help to improve the curricula.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"82 Supl 1","pages":"73-85"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}