Boletín médico del Hospital Infantil de México最新文献_第5页

Diagnostic approach and monitoring of chronic kidney disease in the primary care pediatric population. 儿科初级保健中慢性肾病的诊断方法和监测。

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000174

Martha I Carrascal, Karen J Sánchez-Acosta, Lina J Herrera Parra, Juan G Cárdenas-Aguilera, Ana K Serrano-Gayubo, Clímaco A Jiménez-Triana, Lizbeth A Merchán, Ana Ma Valbuena-García, Richard Baquero-Rodríguez

{"title":"Diagnostic approach and monitoring of chronic kidney disease in the primary care pediatric population.","authors":"Martha I Carrascal, Karen J Sánchez-Acosta, Lina J Herrera Parra, Juan G Cárdenas-Aguilera, Ana K Serrano-Gayubo, Clímaco A Jiménez-Triana, Lizbeth A Merchán, Ana Ma Valbuena-García, Richard Baquero-Rodríguez","doi":"10.24875/BMHIM.23000174","DOIUrl":"10.24875/BMHIM.23000174","url":null,"abstract":"Chronic kidney disease (CKD) has severe consequences on the quality and expectancy of life and is considered a major health problem worldwide. This is, especially relevant in pediatric patients, as they have unique characteristics and a mortality rate 30 times higher (in advanced stages) than healthy people. This review aims to define the minimum components for the diagnostic approach and monitoring of CKD in the pediatric population from primary health care to promote comprehensive care and adequate risk management. For this purpose, we performed a systematic review of the literature with a panel of experts. Based on the evidence, to optimize the definition, diagnosis, and timely treatment of CKD in the pediatric population, we formulated 21 recommendations. These were approved by the research team and peer-reviewed by clinical experts. They will facilitate the definition of the diagnostic approach for CKD in the pediatric population in primary health-care settings, allowing for timely treatment intervention, comprehensive care, and monitoring of this disease.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"143-150"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report on activated PI3K-delta syndrome. 活化 PI3K-delta 综合征病例报告。

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000124

Israel E Crisanto-López, Alan A Pérez-Arzola, Yazmin Hernández-Castañeda, Reyna G Carrasco-Trinidad, Aurea Vera-Loaiza, Berenice Jiménez-Pérez, Tania A Guzmán-Santiago, Pablo O Rodríguez-Hurtado, Wilbert Salazar-Bonilla, Daniela Juárez-Melchor

{"title":"Case report on activated PI3K-delta syndrome.","authors":"Israel E Crisanto-López, Alan A Pérez-Arzola, Yazmin Hernández-Castañeda, Reyna G Carrasco-Trinidad, Aurea Vera-Loaiza, Berenice Jiménez-Pérez, Tania A Guzmán-Santiago, Pablo O Rodríguez-Hurtado, Wilbert Salazar-Bonilla, Daniela Juárez-Melchor","doi":"10.24875/BMHIM.23000124","DOIUrl":"10.24875/BMHIM.23000124","url":null,"abstract":"Background: Activated phosphoinositide 3-kinase delta syndrome (APDS) [OMIM 615513] is an inborn error of immunity with autosomal dominant inheritance caused by a pathogenic variant in the PIK3CD gene. The prevalence ratio of APDS is < 1: 1,000,000 newborns. The main clinical features of APDS are sinopulmonary infections, benign lymphoproliferation, autoinflammatory disease, and a major risk of lymphoid neoplasms.Clinical case: A 17-year-old female with a history of pneumonia at 9 months of age subsequently developed recurrent respiratory tract infections, bronchiectasis, perforated otitis media, unilateral tonsillar lymphoid hyperplasia, pansinusitis, recurrent oral candidiasis, and chronic rhinitis. Laboratory studies reported persistent leukopenia and lymphopenia, low CD4 lymphocyte subpopulation, and persistently elevated immunoglobulin M immunoglobulin studies with values up to 692 mg/dL. An inborn error of immunity next-generation sequencing and multiplex ligation-dependent probe amplification analysis detected a heterozygous pathogenic variant in the PIK3CD gene, compatible with APDS. Treatment with monthly injectable gamma globulin and prophylactic antibiotics was started, allowing better control of the infectious processes.Conclusion: This is the second case of APDS reported in Mexico in the literature. It is important to be aware of this condition to make a timely diagnosis, which requires a high clinical suspicion and immunological and genetic studies to provide adequate treatment and prevent complications.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 4","pages":"245-249"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress in parents of preschoolers with Autism Spectrum Disorders: an update review. 自闭症谱系障碍学龄前儿童家长的压力：最新综述。

IF 0.6

Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000182

Nancy Espinosa-Díaz, Maribel Vega-Arce, Maria Ignacia Jara, Francisca Garrido

{"title":"Stress in parents of preschoolers with Autism Spectrum Disorders: an update review.","authors":"Nancy Espinosa-Díaz, Maribel Vega-Arce, Maria Ignacia Jara, Francisca Garrido","doi":"10.24875/BMHIM.23000182","DOIUrl":"https://doi.org/10.24875/BMHIM.23000182","url":null,"abstract":"Background: Parental stress experienced in the context of caring for children with autism spectrum disorder (ASD) in preschool is significant and has been poorly studied; studies tend to focus on more advanced ages of children where parental symptomatology has become chronic. The current study sought to provide new empirical evidence on factors associated with parental stress.Methods: An exhaustive search was conducted in four academic databases: CINAHL Complete, Medline Complete, Web of Science (WoS), and Scopus, limiting the articles to those published between 2017 and 2023.Results: The sample obtained consisted of 24 selected articles, which were produced in 11 countries, and all were in English. In terms of content, the topics addressed were the manifestation of parental stress, factors of the child with ASD and their relationship with parental stress, factors of parents of children with ASD, family factors of parents of children with ASD, social factors of parents of children with ASD, parental stress and access to formal care services, and parental stress and specialized interventions.Conclusions: It is possible to affirm that research reports indicate that the general level of stress among parents of children with ASD is compared to their reference groups, both in relation to child-related stress and other stressors. The variables that affect parental stress exhibit a reciprocal influence among them, so interventions aimed at early childhood should incorporate both the children and their parental figures. This is in consideration of the impact that stress has on the mental health of parents, establishing that parents with better health have early access to support services during the early years of parenting, as well as in later years.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 4","pages":"195-209"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody persistence 7 years after hepatitis-A vaccine in children with human immunodeficiency virus infection. 人类免疫缺陷病毒感染儿童接种甲型肝炎疫苗 7 年后的抗体持续性。

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000125

José G Vázquez-Rosales, Alejandra P Melgoza-Salazar, Mariana G-Sámano-Aviña, Victoria E Montaño-Luna, Ma Rosalía Lira-Carmona, Fortino Solórzano-Santos

{"title":"Antibody persistence 7 years after hepatitis-A vaccine in children with human immunodeficiency virus infection.","authors":"José G Vázquez-Rosales, Alejandra P Melgoza-Salazar, Mariana G-Sámano-Aviña, Victoria E Montaño-Luna, Ma Rosalía Lira-Carmona, Fortino Solórzano-Santos","doi":"10.24875/BMHIM.23000125","DOIUrl":"https://doi.org/10.24875/BMHIM.23000125","url":null,"abstract":"Background: HIV-infected children have a higher risk of presenting infections, including the hepatitis A virus (HAV). The inactivated HAV vaccine is immunogenic in immunocompetent hosts; however, there are insufficient studies on the duration of seroprotection in HIV-infected children.Methods: An analytical cohort study was conducted. HIV-1-infected children who received the inactivated HAV vaccine (2 doses) were included. Blood samples were taken for antibody measurement, the first one 28 days after the second dose and another 7 years after the vaccination schedule. Information on viral load, immunological category, weight, height, and response to antiretroviral treatment from diagnosis to the last assessment was obtained.Results: 19 patients were included, with a mean age of 12.6 years (SD ± 2.29). 58% were male. 80% of the patients presented protective immunoglobulin G antibodies against HAV 7-year post-vaccination. The antibody concentration was found to be between 13 and 80 mIU/mL (median of 80 mIU/mL). 52% showed some degree of immunosuppression. There was no statistically significant relationship between the presence of seroprotection and viral load, treatment failure, immunological category, and malnutrition. Twelve patients presented with antiretroviral treatment failure, and in 33% of them, the antibodies did not offer satisfactory seroprotection.Conclusion: 7-year post-vaccination, 80% of HIV-infected children maintain seroprotection titers against HAV.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"176-181"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in medicine and artificial intelligence. 医学和人工智能的进步。

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000007

Leonardo Viniegra-Velázquez

{"title":"Progress in medicine and artificial intelligence.","authors":"Leonardo Viniegra-Velázquez","doi":"10.24875/BMHIM.24000007","DOIUrl":"https://doi.org/10.24875/BMHIM.24000007","url":null,"abstract":"This essay questions, with regard to medicine, the idea of progress as technological development by focusing on people rather than things. It analyzes how the predominance of such an idea of progress converts today's societies to techno-fetishism that degrades community life and medical practice, contributing to the medicalization of social life. It is argued that the realization of technological potentialities depends on their forms of use; that the main motive of technological development is unlimited profit and that priority developments are those that enhance the social control that maintains the status quo. The intelligence as an intelligence quotient is criticized by proposing it as an attribute of the human being as a whole, manifested in the ways of thinking and proceeding of people in their circumstances, where affectivity and critical thinking are essential for their development; it is emphasized that its antecedent is the harmonic concert of planetary life that contrasts with the prevailing human disharmony. It is proposed that artificial intelligence is the most recent creation of techno-fetishism that deposits vital attributes in technology and that its forms of use will accentuate the degradation of human and planetary life. Another idea of medical progress is proposed, based on forms of organization conducive to the development of inquisitive, critical and collaborative skills that promote permanent improvement, whose distant horizon is dignifying progress: spiritual, intellectual, moral and convivial sublimation of collectivities in harmony with the planetary ecosystem.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"121-131"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guía mexicana para el diagnóstico y el tratamiento del hemangioma infantil. 墨西哥婴儿血管瘤诊断和治疗指南。

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000069

Mirna E Toledo-Bahena, Karen A Camargo-Sánchez, Helena Vidaurri-De la Cruz, Adriana M Valencia-Herrera, M Mar Sáez-de Ocáriz, Mario R Duarte-Abdala, Julieta Osuna-Osuna, Jessica Aranda-Mendoza, Gloria M Rosales-Solís, Gibert Maza-Ramos, M Luz Orozco-Covarrubias, Pablo Lezama-Del Valle, Julio R Erdmenger-Orellana, Rocío Enríquez-García, Pilar Dies-Suárez, Alejandro Celis-Jiménez, Carlos A Mena-Cedillos

{"title":"Guía mexicana para el diagnóstico y el tratamiento del hemangioma infantil.","authors":"Mirna E Toledo-Bahena, Karen A Camargo-Sánchez, Helena Vidaurri-De la Cruz, Adriana M Valencia-Herrera, M Mar Sáez-de Ocáriz, Mario R Duarte-Abdala, Julieta Osuna-Osuna, Jessica Aranda-Mendoza, Gloria M Rosales-Solís, Gibert Maza-Ramos, M Luz Orozco-Covarrubias, Pablo Lezama-Del Valle, Julio R Erdmenger-Orellana, Rocío Enríquez-García, Pilar Dies-Suárez, Alejandro Celis-Jiménez, Carlos A Mena-Cedillos","doi":"10.24875/BMHIM.24000069","DOIUrl":"10.24875/BMHIM.24000069","url":null,"abstract":"Infantile hemangioma is a benign vascular tumor, the most common in childhood, whose natural evolution is the disappearance of the lesion in the pediatric age and which has effective and safe treatments that limit its growth and favor its disappearance at younger ages. Infantile hemangioma continues to be a reason for attention to complications, due to erroneous diagnoses, lack of knowledge of the condition, late referral or fear of the effects of the medications used for its treatment. Furthermore, its presence is normalized without taking into account that it can cause uncertainty, anxiety, feelings of guilt and, as a consequence, a significant impact on the quality of life, mainly in the parents or caregivers of the child. The need for a clinical practice guideline in our country arises from the high presentation of late-remitted complications in infantile hemangioma even with the availability of adequate treatments, the continuous evolution of medicine and the appearance of new evidence. Throughout the guide you will find recommendations regarding the diagnosis, treatment and follow-up of patients with infantile hemangioma, taking into account the paraclinical tests that can be performed, topical or systemic management options, as well as adjuvant therapies. For the first time, objective tools for patient follow-up are included in a guide for the management of infantile hemangioma, as well as to help the first contact doctor in timely referral.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 Supl 2","pages":"1-28"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between the KARVI scale and the Child Development Evaluation test (EDI) as a screening tool for suspected neurodevelopmental delay. 将 KARVI 量表与儿童发育评估测试 (EDI) 作为筛查疑似神经发育迟缓的工具进行比较。

IF 0.9

Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000062

Carolina Tovar-Moreno, Miguel A Karlis-Rangel, Susana A Villarreal-Guerra, Fernanda P García-Ayón, Jesús Santos-Guzmán, Belinda Carrión-Chavarría

{"title":"Comparison between the KARVI scale and the Child Development Evaluation test (EDI) as a screening tool for suspected neurodevelopmental delay.","authors":"Carolina Tovar-Moreno, Miguel A Karlis-Rangel, Susana A Villarreal-Guerra, Fernanda P García-Ayón, Jesús Santos-Guzmán, Belinda Carrión-Chavarría","doi":"10.24875/BMHIM.23000062","DOIUrl":"10.24875/BMHIM.23000062","url":null,"abstract":"Background: Early detection of suspected neurodevelopmental delay allows for timely diagnosis and appropriate intervention, for which numerous screening tests have been developed. However, most are complex and impractical for health-care workers at the community level. This study aimed to validate the KARVI scale in the neurodevelopment assessment of children under 1 year of age.Methods: We conducted an observational, longitudinal, comparative, inferential, and prospective study. Healthy children without risk factors for developing neurodevelopmental delay from 0 to 12 months of age were evaluated remotely using the Zoom® application. The Child Development Evaluation Test and the KARVI scale were applied once a month for four consecutive months.Results: Fifty individuals were analyzed, with a predominance of males in 52%. Adequate percentages for a screening test were obtained in the first evaluation with a sensitivity of 70% (confidence interval [CI] 95% 34.75-93.33) and a specificity of 75% (CI 95% 58.8-87.31), and in the fourth evaluation with a sensitivity of 100% (CI 95% 29.4-100) and a specificity of 78.72% (CI 95% 64.34-89.3), being significant in both evaluations (p = 0.007 and p = 0.001, respectively).Conclusions: The KARVI scale has the elements to be an effective screening test for suspected neurodevelopmental delay, but more extensive studies are needed to obtain more reliable results.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 1","pages":"36-43"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the changes in the management of preterm newborns born in a Spanish third-level hospital in the past 10 years. 过去 10 年西班牙一家三级医院早产新生儿管理变化分析。

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000093

María Santiago-Souto, Rafael García-Mozo, Marta Costa-Romero

{"title":"Analysis of the changes in the management of preterm newborns born in a Spanish third-level hospital in the past 10 years.","authors":"María Santiago-Souto, Rafael García-Mozo, Marta Costa-Romero","doi":"10.24875/BMHIM.23000093","DOIUrl":"https://doi.org/10.24875/BMHIM.23000093","url":null,"abstract":"Background: Preterm newborns require the use of the best and most current strategies to treat and prevent both acute pathology and associated sequelae. This study aimed to compare the differences in the management of preterm newborns over 10 years in a tertiary hospital in Spain and its impact on height, weight, and neurological development in the medium term.Methods: We conducted a retrospective, observational, and analytical study examining the management and clinical variables in preterm newborns under 32 weeks of gestational age who were born in our hospital in 2011 and 2021.Results: Twenty-six newborns were included in the study. Significant differences in magnesium sulfate use, continuous positive airway pressure immediately after birth, and non-invasive mechanical ventilation during hospitalization were observed. Differences were found in the use of parenteral nutrition and the timing of initiation of enteral feeding. We did not observe differences in the neurological or weight evolution in the medium term.Conclusions: Significant differences in managing preterm newborns in these 10 years were observed. Lower mortality and alterations in central nervous system ultrasound and, significantly, less growth retardation during admission in 2021 have been observed; however, it does not manifest with improvement in long-term somatometrics or neurological prognosis.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 1","pages":"16-22"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drugs and natural products for the treatment of COVID-19 during 2020, the first year of the pandemic. 2020 年，即大流行的第一年，用于治疗 COVID-19 的药物和天然产品。

IF 0.9

Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000016

Elia G Jaimes-Castelán, Claudia González-Espinosa, Gil A Magos-Guerrero, Isabel Arrieta-Cruz, Manuel Jiménez-Estrada, Ricardo Reyes-Chilpa, Jorge I Castillo-Arellano

{"title":"Drugs and natural products for the treatment of COVID-19 during 2020, the first year of the pandemic.","authors":"Elia G Jaimes-Castelán, Claudia González-Espinosa, Gil A Magos-Guerrero, Isabel Arrieta-Cruz, Manuel Jiménez-Estrada, Ricardo Reyes-Chilpa, Jorge I Castillo-Arellano","doi":"10.24875/BMHIM.23000016","DOIUrl":"https://doi.org/10.24875/BMHIM.23000016","url":null,"abstract":"This work aimed to show which treatments showed efficacy against coronavirus disease 2019 (COVID-19); therefore, the results of 37 clinical trials started in 2020 and completed in 2021 are reviewed and discussed here. These were selected from databases, excluding vaccines, computational studies, in silico, in vitro, and those with hyperimmune sera from recovered patients. We found 34 drugs, one vitamin, and one herbal remedy with pharmacological activity against symptomatic COVID-19. They reduced mortality, disease progression, or recovery time. For each treatment, the identifier and type of trial, the severity of the disease, the sponsor, the country where the trial was conducted, and the trial results are presented. The drugs were classified according to their mechanism of action. Several drugs that reduced mortality also reduced inflammation in the most severe cases. These include some that are not considered anti-inflammatory, such as Aviptadil, pyridostigmine bromide, anakinra, imatinib, baricitinib, and bevacizumab, as well as the combination of ivermectin, aspirin, dexamethasone, and enoxaparin. Nigella sativa seeds with honey have also been reported to have therapeutic activity. On the other hand, tofacitinib, novaferon with ritonavir, and lopinavir were also effective, as well as in combination with antiviral therapies such as danoprevir with ritonavir. The natural products colchicine and Vitamin D3 were only effective in patients with mild-to-moderate COVID-19, as was hydroxychloroquine. Drug repositioning has been the main tool in the search for effective therapies by expanding the pharmacological options available to patients.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 1","pages":"53-72"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of oropharyngeal colostrum administration with decreased inflammatory indices in premature newborns weighing less than 1500 g. 口咽初乳与体重不足 1500 克的早产新生儿炎症指数下降的关系

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Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000048

Guadalupe Gómez-Rodríguez, Juan L Moreno-Saldaña, Evaldo J Rodríguez-Mejía, Marco A Olvera-Olvera

{"title":"Association of oropharyngeal colostrum administration with decreased inflammatory indices in premature newborns weighing less than 1500 g.","authors":"Guadalupe Gómez-Rodríguez, Juan L Moreno-Saldaña, Evaldo J Rodríguez-Mejía, Marco A Olvera-Olvera","doi":"10.24875/BMHIM.23000048","DOIUrl":"10.24875/BMHIM.23000048","url":null,"abstract":"Background: The administration of colostrum through its absorption at the oropharyngeal level stimulates the mucosa-associated lymphoid tissue, providing a local immunological protection barrier. The study aimed to investigate the association of oropharyngeal colostrum administration with the reduction of inflammatory indices.Materials and methods: This was an observational, ambispective, analytical study of newborns < 32 weeks of gestation at risk of sepsis. Oropharyngeal colostrum was administered at 0.2 mL every 4 h for 5 days. Inflammatory indices were analyzed. Statistical analysis included frequencies, percentages, mean and Standard deviation, contingency coefficient, and Kolmogorov-Smirnov test for the distribution curve of the numerical data.Results: There were 50 patients, 33 (66%) female and 17 (34%) male, with a median gestational age of 30-31 weeks (95% confidence interval [CI]). Nineteen patients had sepsis. A lower positivity rate in C-reactive protein was found, with a median of 0.5-0.6 (95% CI) at 5 days of colostrum administration versus 0.5-1.1 (95% CI) as the initial C-reactive protein. Analysis with χ2 yielded a p = 0.13, and the contingency coefficient showed a p = 0.196, indicating an association.Conclusion: Oropharyngeal colostrum administration was associated with a lower C-reactive protein positivity rate and clinical improvement in premature newborns at risk of sepsis.","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"170-175"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0