Boletín médico del Hospital Infantil de México最新文献

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Risk of alterations in neurodevelopment in infants and preschool children with cancer. 癌症婴儿和学龄前儿童神经发育发生改变的风险。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000011
Liliana Velasco-Hidalgo, Alejandro González-Garay, Antonio Rizzoli-Córdoba, Roberto Rivera-Luna, Alda García-Guzmán, Ana Gabriela Ortiz-Razo, Evereth Alejandra Olmedo-Jiménez, Rocío Cárdenas-Cardós, Kenya Shamira Carmona-Jaimez, Marta Zapata-Tarrés
{"title":"Risk of alterations in neurodevelopment in infants and preschool children with cancer.","authors":"Liliana Velasco-Hidalgo, Alejandro González-Garay, Antonio Rizzoli-Córdoba, Roberto Rivera-Luna, Alda García-Guzmán, Ana Gabriela Ortiz-Razo, Evereth Alejandra Olmedo-Jiménez, Rocío Cárdenas-Cardós, Kenya Shamira Carmona-Jaimez, Marta Zapata-Tarrés","doi":"10.24875/BMHIM.24000011","DOIUrl":"https://doi.org/10.24875/BMHIM.24000011","url":null,"abstract":"<p><strong>Background: </strong>Some cancer survivors experience difficulties with concentration, attention, and memory; however, there are no studies on neurodevelopment in patients under 5 years of age who are undergoing cancer treatment. Our aim was to evaluate neurodevelopment in cancer patients under 5 years of age using the Early Development Instrument (EDI) test, considering factors such as nutritional status, type of cancer, and treatment effect.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from February 2018 to March 2019. Patients with cancer diagnoses outside the central nervous system in any phase of cancer treatment were included.</p><p><strong>Results: </strong>A total of 45 patients were included. Regarding fine motor skills, 28% of patients with retinoblastoma and 23% of patients with leukemia or lymphoma had a risk of developmental delay compared to 0% of patients with solid tumors (p = 0.025). The final results showed that 19 (42.2%) patients had normal neurodevelopment (gray), 7 (15.5%) had a delay in neurodevelopment (light gray), and 19 (42.2%) had a risk of developmental delay (black). Regarding developmental delay, 52% of patients in the leukemia and lymphoma group, 71% in the retinoblastoma group, and 23% in the solid tumor group presented developmental delay (p = 0.06).</p><p><strong>Conclusions: </strong>The risk of delay and lag in neurodevelopment is common in cancer patients under 5 years of age undergoing treatment. However, more studies are required to evaluate the effect of treatment on this group of patients as it may be affected by various factors.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 4","pages":"217-224"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of bacteriuria and bacterial resistance in adolescents from the center of the state of Tlaxcala, Mexico. 墨西哥特拉斯卡拉州中心地区青少年菌尿和细菌耐药性的流行情况。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000062
Daniela Z Méndez-Polonieski, Pablo Méndez-Hernández, Olivier Barbier, Manolo Ortega-Romero, Juan C Rubio-Gutiérrez, Elodia Rojas-Lima, Juana Narvaez-Morales, Margarita Martínez-Gómez, Estela Cuevas-Romero, Rosalba Cerón-Meza, Mara Medeiros
{"title":"Prevalence of bacteriuria and bacterial resistance in adolescents from the center of the state of Tlaxcala, Mexico.","authors":"Daniela Z Méndez-Polonieski, Pablo Méndez-Hernández, Olivier Barbier, Manolo Ortega-Romero, Juan C Rubio-Gutiérrez, Elodia Rojas-Lima, Juana Narvaez-Morales, Margarita Martínez-Gómez, Estela Cuevas-Romero, Rosalba Cerón-Meza, Mara Medeiros","doi":"10.24875/BMHIM.24000062","DOIUrl":"https://doi.org/10.24875/BMHIM.24000062","url":null,"abstract":"<p><p>Urinary tract infections and bacteriuria are common in the pediatric population, and antibiotic resistance is increasing significantly. Recurrent urinary infections, symptomatic or asymptomatic, are a risk factor for developing chronic kidney disease in adolescents and young adults. This study aimed to assess the prevalence of bacteriuria diagnosed by culture to identify the main causal agents and sensitivity to antibiotics in adolescents from the central region of the state of Tlaxcala. A cross-sectional study was carried out among 905 adolescents from 11 to 18 years old who lived in the central region of the state of Tlaxcala, Mexico. Bacteriuria was evaluated by positive nitrites and leukocyte esterase, and urine culture with antibiogram. Multivariate logistic regression models were executed to evaluate the risk of presenting bacteriuria, with a confidence level of 95%. A total of 31 participants had a positive urine culture, with a bacteriuria prevalence of 3.4%, of which 29 cases were asymptomatic. The most frequent agent was Escherichia coli) in both sexes (28.6% in men and 29.7% in women) and regarding bacterial resistance: E. coli presented greater resistance to ampicillin, trimethoprim/sulfametoxazol and ceftriaxone. The risk factors associated with bacteriuria were female sex, sexual activity, use of contraceptives, and greater consumption of sweetened beverages. Bacteriuria is common in this adolescent population, so its early identification is necessary to treat it, and to prevent its complications.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 6","pages":"346-355"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 associated transverse myelitis: case report. 与 COVID-19 相关的横贯性脊髓炎:病例报告。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000179
Claudia V Tapia-Fonseca, Omar D Cortés-Enríquez, Laura P Raya-Garza, Diana M Gutiérrez-Cuellar
{"title":"COVID-19 associated transverse myelitis: case report.","authors":"Claudia V Tapia-Fonseca, Omar D Cortés-Enríquez, Laura P Raya-Garza, Diana M Gutiérrez-Cuellar","doi":"10.24875/BMHIM.23000179","DOIUrl":"10.24875/BMHIM.23000179","url":null,"abstract":"<p><strong>Background: </strong>Transverse myelitis (TM) is a demyelinating inflammatory disease that presents with motor, sensory, and autonomic dysfunction, which may be acute or subacute. COVID-19-associated TM has been described in a scarce number of patients.</p><p><strong>Clinical case: </strong>A 15-year-old previously healthy male patient with respiratory disease before his neurological deterioration presented to the emergency room after developing a complete medullary syndrome located at the cervical-dorsal level, with ascending and symmetric paraparesis that rapidly progressed to paraplegia, with sensory dysfunction from the T3 level, sphincter dysfunction and sudden ventilatory deterioration that required mechanical ventilation. Magnetic resonance imaging was compatible with acute TM. Inflammatory and non-inflammatory etiologies were discarded. In addition, a positive severe acute respiratory syndrome coronavirus 2 test was obtained. Treatment included steroid pulses and plasmapheresis, with an insidious evolution.</p><p><strong>Conclusion: </strong>COVID-19 is an infrequent cause of TM and should be suspected when other etiologies have been ruled out.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"191-194"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in medicine and artificial intelligence. 医学和人工智能的进步。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIME.M24000071
Leonardo Viniegra-Velázquez
{"title":"Progress in medicine and artificial intelligence.","authors":"Leonardo Viniegra-Velázquez","doi":"10.24875/BMHIME.M24000071","DOIUrl":"https://doi.org/10.24875/BMHIME.M24000071","url":null,"abstract":"<p><p>This essay challenges the idea of progress as technological development in relation to medicine by focusing on people rather than things. It analyzes how the prevalence of such an idea of progress leads contemporary societies to a technofetishism that degrades community life and medical practice, contributing to the medicalization of social life. It is argued that the realization of technological potentialities depends on their forms of use, that the main motive of technological development is unlimited profit, and the priority developments are those that enhance social control which maintains the status quo. Intelligence as an intelligence quotient is criticized by proposing it as an attribute of the human being as a whole, manifested in the ways of thinking and acting of human beings in their circumstances, where affectivity and critical thinking are essential for their development; it is emphasized that its antecedent is the harmonic concert of planetary life, which contrasts with the prevailing human disharmony. It is proposed that artificial intelligence is the latest creation of technofetishism, which deposits vital attributes in technology, and that its use will accentuate the degradation of human and planetary life. Another idea of medical progress is proposed, based on forms of organization that is conducive to the development of inquisitive, critical, and collaborative skills that promote permanent improvement, whose distant horizon is dignified progress: the spiritual, intellectual, moral, and convivial sublimation of collectivities in harmony with the planetary ecosystem.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"132-142"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing CLABSI through a quality strategy for the implementation of the aseptic non-touch technique in a pediatric ward. 通过在儿科病房实施无菌非接触技术的质量策略,减少 CLABSI。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000134
Ana C Guerrero-Díaz, Daniela De la Rosa-Zamboni, Ma A Martin-Martin, Isabel Rosas-Mateos, Marisol Medina-Pelcastre, Margarita Torres-García, Almudena Laris-González, Martha Avilés-Robles
{"title":"Reducing CLABSI through a quality strategy for the implementation of the aseptic non-touch technique in a pediatric ward.","authors":"Ana C Guerrero-Díaz, Daniela De la Rosa-Zamboni, Ma A Martin-Martin, Isabel Rosas-Mateos, Marisol Medina-Pelcastre, Margarita Torres-García, Almudena Laris-González, Martha Avilés-Robles","doi":"10.24875/BMHIM.23000134","DOIUrl":"https://doi.org/10.24875/BMHIM.23000134","url":null,"abstract":"<p><strong>Background: </strong>Central line-associated bloodstream infections (CLABSIs) are among the most epidemiologically relevant health care-associated infections. The aseptic non-touch technique (ANTT) is a standardized practice used to prevent CLABSIs. In a pediatric hospital, the overall CLABSI rate was 1.92/1000 catheter days (CD). However, in one unit, the rate was 5.7/1000 CD.</p><p><strong>Methods: </strong>Nurses were trained in ANTT. For the implementation, plan-do-study-act (PDSA) cycles were completed. Adherence monitoring of the ANTT and epidemiological surveillance were performed.</p><p><strong>Results: </strong>ANTT adherence of 95% was achieved after 6 PDSA cycles. Hand hygiene and general cleaning reached 100% adherence. Port disinfection and material collection had the lowest adherence rates, with 76.2% and 84.7%, respectively. The CLABSI rate decreased from 5.7 to 1.26/1000 CD.</p><p><strong>Conclusion: </strong>The implementation of ANTT helped reduce the CLABSI rate. Training and continuous monitoring are key to maintaining ANTT adherence.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 3","pages":"182-190"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous fluids in dehydrated children with acute gastroenteritis: evidence is needed. 急性肠胃炎脱水儿童的静脉输液:需要证据。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000036
Elizete Aparecida-Lomazi, Marisa da Silva-Laranjeira, Vera M Santoro-Belangero, Vera L Sdepanian
{"title":"Intravenous fluids in dehydrated children with acute gastroenteritis: evidence is needed.","authors":"Elizete Aparecida-Lomazi, Marisa da Silva-Laranjeira, Vera M Santoro-Belangero, Vera L Sdepanian","doi":"10.24875/BMHIM.24000036","DOIUrl":"https://doi.org/10.24875/BMHIM.24000036","url":null,"abstract":"","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 4","pages":"253-254"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary patterns of Sonoran breastfeeding women are associated to exclusive or partial breastfeeding regimes. 索诺拉哺乳期妇女的饮食模式与纯母乳喂养或部分母乳喂养制度有关。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000084
Alejandra Arguelles-López, Omar A Trujillo-Rivera, Ana M Calderón-de la Barca
{"title":"Dietary patterns of Sonoran breastfeeding women are associated to exclusive or partial breastfeeding regimes.","authors":"Alejandra Arguelles-López, Omar A Trujillo-Rivera, Ana M Calderón-de la Barca","doi":"10.24875/BMHIM.23000084","DOIUrl":"https://doi.org/10.24875/BMHIM.23000084","url":null,"abstract":"<p><strong>Background: </strong>During breastfeeding, the maternal diet ensures mothers and infants health. Therefore, it is necessary to update information about the diet of exclusively or partially breastfeeding women in each population. We evaluated the diet of Sonoran breastfeeding women, identified their dietary patterns, and examined their association with the breastfeeding regime.</p><p><strong>Methods: </strong>In this cross-sectional study, 62 women breastfeeding exclusively (n = 43) or partially (n = 19) participated. The diet was assessed using a food frequency questionnaire, and patterns were identified through principal component analysis.</p><p><strong>Results: </strong>Overall, fats and sodium intake were higher, while potassium intake was lower than recommended. Two dietary patterns were identified: \"regional\" (n = 36) and \"prudent\" (n = 26). Women following the \"prudent\" pattern consumed more protein, calcium, and potassium than those following the \"regional\" pattern (p < 0.05). The probability of exclusively breastfeeding women having a \"prudent\" dietary pattern was higher than that of partially breastfeeding women (adjusted odds ratios = 7.29, p = 0.019).</p><p><strong>Conclusions: </strong>Exclusive breastfeeding possibly motivated mothers to follow a more prudent diet than those who partially breastfed. Therefore, it is crucial to promote a healthy diet among breastfeeding mothers.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 1","pages":"3-9"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between skin-to-skin contact during the first hour of life and duration of exclusive breastfeeding. 婴儿出生后一小时内的皮肤接触与纯母乳喂养持续时间之间的关系。
IF 0.9
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.23000160
Alejandra Prian-Gaudiano, Daniela Horta-Carpinteyro, Andrea Sarmiento-Aguilar
{"title":"Relationship between skin-to-skin contact during the first hour of life and duration of exclusive breastfeeding.","authors":"Alejandra Prian-Gaudiano, Daniela Horta-Carpinteyro, Andrea Sarmiento-Aguilar","doi":"10.24875/BMHIM.23000160","DOIUrl":"https://doi.org/10.24875/BMHIM.23000160","url":null,"abstract":"<p><strong>Background: </strong>Exclusive breastfeeding (BF) has the greatest potential impact on child mortality of any preventive intervention. Skin-to-skin contact (SSC) during the first hour of life is beneficial for initiating BF; however, routine separation of mother and infant is still common. This work aimed to demonstrate that SSC during the first hour of life is associated with a greater frequency and duration of exclusive BF.</p><p><strong>Methods: </strong>This is an observational case-control study. We reviewed the medical records of patients born between 2016 and 2022 classified as cases or controls based on the history of SSC in the first hour of life. Statistical analysis was performed using SPSS version 28.</p><p><strong>Results: </strong>We included 362 medical records, of which 200 (55.2%) had SSC and were considered cases; the 162 (44.8%) who did not have SSC were considered controls. Those who received SSC were more likely to receive exclusive BF at 3 (163 [81.5%] vs. 94 [58%], p < 0.001) and 6 months of age (147 [73.5%] vs. 83 [51.2%], p < 0.001).</p><p><strong>Conclusions: </strong>Patients who received SSC in the first hour of life were more likely to receive exclusive BF at 3 and 6 months of age. Promoting and respecting this practice is essential to increase the possibility of a newborn to be exclusively breastfed for the first 6 months of life.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 1","pages":"10-15"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overall manifestations and survival of pediatric patients with Langerhans cell histiocytosis. A middle-income country (mic) national multicenter study. 朗格汉斯细胞组织细胞增生症儿科患者的总体表现和存活率。一项中等收入国家(微型)全国多中心研究。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000061
Liliana Velasco-Hidalgo, Alejandro González-Garay, Roberto Rivera-Luna, Marta Zapata-Tarrés, Cesar Galván-Diaz, Araceli López-Facundo, Farina Arreguín-González, José León-Espitia, Daniel Ortiz-Morales, Luis Juárez-Villegas, Oscar González-Llano, Daniela Covarrubias-Zapata, Alejandro Reséndiz-López, Miguel Palomo-Colli, Luisa Ma Duarte-Arroy, José De J Loeza-Oliva, Isidoro Tejocote-Romero, Laura García-Segura, Pablo González-Montalvo, Silvia Chávez-Gallegos, Eloy Pérez-Rivera, Iris Gallardo-Gallardo, Daniela Olvera-Caraza, Cinthia Cruz-Medina, Lourdes Vega-Vega, Lourdes Romero-Rodríguez, Citlali Simón-González, Diana Reyes-Morales, Rosalba Bellido, Guillermo Gaytán-Fernández, Martha Velázquez-Aviña, Gabriel Peñaloza-González, Kenya S Carmona-Jaimez, Nubia Macías-García
{"title":"Overall manifestations and survival of pediatric patients with Langerhans cell histiocytosis. A middle-income country (mic) national multicenter study.","authors":"Liliana Velasco-Hidalgo, Alejandro González-Garay, Roberto Rivera-Luna, Marta Zapata-Tarrés, Cesar Galván-Diaz, Araceli López-Facundo, Farina Arreguín-González, José León-Espitia, Daniel Ortiz-Morales, Luis Juárez-Villegas, Oscar González-Llano, Daniela Covarrubias-Zapata, Alejandro Reséndiz-López, Miguel Palomo-Colli, Luisa Ma Duarte-Arroy, José De J Loeza-Oliva, Isidoro Tejocote-Romero, Laura García-Segura, Pablo González-Montalvo, Silvia Chávez-Gallegos, Eloy Pérez-Rivera, Iris Gallardo-Gallardo, Daniela Olvera-Caraza, Cinthia Cruz-Medina, Lourdes Vega-Vega, Lourdes Romero-Rodríguez, Citlali Simón-González, Diana Reyes-Morales, Rosalba Bellido, Guillermo Gaytán-Fernández, Martha Velázquez-Aviña, Gabriel Peñaloza-González, Kenya S Carmona-Jaimez, Nubia Macías-García","doi":"10.24875/BMHIM.24000061","DOIUrl":"10.24875/BMHIM.24000061","url":null,"abstract":"<p><strong>Background: </strong>Langerhans cell histiocytosis (LCH) is a rare neoplastic disease characterized by clonal proliferation of den-dritic cells. It is Mexico's ninth most frequent malignancy in patients under 18 years of age. The aim of the study was to determine the clinical characteristics, treatment, and survival of Mexican pediatric patients diagnosed with LCH treated from January 2010 to December 2018.</p><p><strong>Methods: </strong>We conducted a retrospective study of LCH using data from 19 accredited hospitals throughout the Mexican Republic. Patients < 18 years who were diagnosed with LCH between January 2010 and December 2018 were included (253 patients) in the study.</p><p><strong>Results: </strong>All patients had a histopathological diagnosis, and extension studies were performed at their treatment centers. The median age at diagnosis was 19 months. The most frequently affected sites included the bone (178 cases; 70%) and the skin (131 cases; 51.7%). Of the patients in Group 1, 48 (42%) had bone marrow involvement, 62 (53%) had splenomegaly, and 39 (34.8%) had liver involvement. Of the patients who underwent chemotherapy treatment, 61.2% exhibited a complete response, and 36 patients (14.2%) relapsed after complete remission. The most frequent sites of relapse were the skin, bone, lymph nodes, and liver. The overall survival rate was 91.3% and was lower for patients in Group 1 (77%) compared with those in Groups 2 (97%) and 3 (100%), p = 0.001.</p><p><strong>Conclusion: </strong>The current report aims to demonstrate the findings of a multicenter study conducted on Mexican children with LCH; consequently, these treatment results for a relatively infrequent disease merit further research.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 6","pages":"328-336"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Types of statistical analysis in prognostic studies. 预后研究中的统计分析类型。
IF 0.6
Boletín médico del Hospital Infantil de México Pub Date : 2024-01-01 DOI: 10.24875/BMHIM.24000060
Mario E Rendón-Macías, Ana S Castillo-Ivón, Lorena Orozco-Díaz
{"title":"Types of statistical analysis in prognostic studies.","authors":"Mario E Rendón-Macías, Ana S Castillo-Ivón, Lorena Orozco-Díaz","doi":"10.24875/BMHIM.24000060","DOIUrl":"https://doi.org/10.24875/BMHIM.24000060","url":null,"abstract":"<p><p>Prognostic studies may have a descriptive exploratory objective on an outcome or a comparative objective in the search for factors associated with it. A second objective is explanatory to determine the effect of a particular prognostic factor adjusted for its confounders, with or without the intention of establishing causality. The third objective is the construction of a predictive prognostic scale. For each of these objectives, there are recommended statistical methods for clarification and validity. In this article, the methods and application examples are presented. The proper selection of analytical methods allows for clear and valid communication of the results of a prognostic study.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 6","pages":"319-327"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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