María F Carrillo-Vega, Juan M Mireles-Dorantes, Samara Mendienta-Zerón, Guillermo Salinas-Escudero, Filiberto Toledano Toledano, Victor Granados-García
{"title":"Direct medical costs of polyarthritis in a pediatric hospital in Mexico.","authors":"María F Carrillo-Vega, Juan M Mireles-Dorantes, Samara Mendienta-Zerón, Guillermo Salinas-Escudero, Filiberto Toledano Toledano, Victor Granados-García","doi":"10.24875/BMHIM.24000079","DOIUrl":"https://doi.org/10.24875/BMHIM.24000079","url":null,"abstract":"<p><strong>Background: </strong>Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The polyarticular course (polyarthritis) represents 63-66% of patients with JIA. The aim was to determine the direct medical costs (DMC) of JIA of the polyarthritis type in pediatric patients of a tertiary hospital in Mexico.</p><p><strong>Methods: </strong>An analysis of the disease costs was developed from the perspective of the Instituto de Seguridad Social del Estado de México y Municipios Maternal and Child Hospital (HMI). The time horizon was 12 years. All patients diagnosed with JIA with polyarticular course treated by the pediatric rheumatology service of the HMI from January to September 2022 and with an active clinical record were included. Different costing techniques were used. The cost components were consultations, medications, hospitalization, and office and laboratory studies. The costs are reported in USD 2021.</p><p><strong>Results: </strong>Twenty-six records of patients with polyarticular arthritis from the HMI were analyzed, with a mean of 4,555.2 USD (standard deviation [SD] = 1,456.7) and a median of 3,828 USD (SD = 1,492) in the first 10 years of treatment. The components of DMC were medications (82.7%), office and laboratory studies (8.4%), hospitalization (8.0%), and consultations (1.8%). Biological disease-modifying drugs (bDMARDs) accounted for 95.3% of the drug component cost.</p><p><strong>Conclusion: </strong>The cost of bDMARDs represented the most critical cost of polyarticular JIA, reflected in the 2<sup>nd</sup> year of treatment. Including generic bDMARDs and reviewing purchase prices by health institutions in Mexico is necessary.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 6","pages":"356-367"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Casallas-Vega, David Andrade-Fonseca, Jaime J. Pérez-Niño, Jeisson A. Hincapié-Carvajal, Juan P. Castañeda-González, Samanta Del R. Herrera-Valladares, Sandra M. Hernández-Zambrano
{"title":"Quality of life and burnout: children and adolescents in cancer treatment.","authors":"Alexander Casallas-Vega, David Andrade-Fonseca, Jaime J. Pérez-Niño, Jeisson A. Hincapié-Carvajal, Juan P. Castañeda-González, Samanta Del R. Herrera-Valladares, Sandra M. Hernández-Zambrano","doi":"10.24875/BMHIM.24000063","DOIUrl":"10.24875/BMHIM.24000063","url":null,"abstract":"<p><strong>Background: </strong>Pediatric cancer is a complex disease that requires interdisciplinary interventions. This study aims to describe the quality of life and exhaustion levels in children diagnosed with cancer, using validated instruments that reflect the peculiarities of this disease.</p><p><strong>Method: </strong>An observational analytical study was conducted on children and adolescents aged 2 to 18 years with cancer. The PedsQL Cancer Module and FACIT-F instruments were used to assess quality of life and fatigue, respectively, with statistical analysis performed to identify correlations and develop an explanatory model.</p><p><strong>Results: </strong>Notable physical and psychological symptoms such as nausea, fatigue, hyporexia, irritability, and sadness were identified. The PedsQL and FACIT-F indicated a diminished quality of life. There was high concordance between the perceptions of children and their parents, except in the anxiety related to procedures, where children reported higher levels. These symptoms reflect the impact of cancer treatment on children's well-being. The concordance in evaluations suggests that parents have a good understanding of these experiences, highlighting the relevance of psychosocial interventions to improve quality of life through an adequate support network.</p><p><strong>Conclusions: </strong>It is crucial that pediatric cancer treatment addresses not only medical aspects but also the comprehensive support for the emotional and psychosocial well-being of the patients and their families.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 6","pages":"337-345"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mireya Robledo-Aceves, América A Corona-Gutiérrez, Eva E Camarena-Pulido, Alejandro Barrón-Balderas, Carlos Meza-López, Ruth Y Ramos-Gutiérrez, Jesús Gutiérrez-Rojas
{"title":"Epidemiology of acute childhood poisoning in pediatric emergencies in Western Mexico.","authors":"Mireya Robledo-Aceves, América A Corona-Gutiérrez, Eva E Camarena-Pulido, Alejandro Barrón-Balderas, Carlos Meza-López, Ruth Y Ramos-Gutiérrez, Jesús Gutiérrez-Rojas","doi":"10.24875/BMHIM.23000183","DOIUrl":"10.24875/BMHIM.23000183","url":null,"abstract":"<p><strong>Introduction: </strong>The increase in the production of substances to enhance the quality of life, the biodiversity of the different ecosystems in Mexico, and the unique characteristics of pediatric patients, contribute to intoxications within this population.</p><p><strong>Method: </strong>Analytical retrospective study of admissions to pediatric emergency care due to poisoning in < 16-year-old (2016 to 2020). Included variables were age, gender, type of toxic substance, exposure characteristics, and the season of the year. Frequencies, percentages, range, average and standard deviation were obteined. In the bivariate análisis, the Chi square test was used. A p-value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Over 5 years, there were 459 cases, with a prevalence of 3.16%. No gender predominance was observed. The most common was caused by venomous animals (28.5%), followed by medication ingestion (27.6%). Only 5% of cases were suicide attempts, the rest were accidental (95%). Children up to 5 years old were more commonly by medication ingestion, hydrocarbons, or household products (p = 0.03, p = 0.0001), while the causes in older children were contact with venomous animals and ingestion of stimulants drugs (alcohol, amphetamines, cannabis, cocaine) (p = 0.0001, p = 0.006). Intoxication with quaternary ammonium herbicides was lethal in all cases.</p><p><strong>Conclusions: </strong>Children under the age of 5 are more susceptible to intoxication from common household products. Older kids tend to be more frequently a combination of stimulants drugs.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 5","pages":"287-293"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elsa M Zúñiga-Lara, César M Zambrano-Virgen, José F Gaytán-Morales, Fredenet O Mendoza-Camargo, Yazmin A Gómez-Domínguez
{"title":"Graft-versus-host disease variety toxic epidermal necrolysis. Case report.","authors":"Elsa M Zúñiga-Lara, César M Zambrano-Virgen, José F Gaytán-Morales, Fredenet O Mendoza-Camargo, Yazmin A Gómez-Domínguez","doi":"10.24875/BMHIM.24000048","DOIUrl":"https://doi.org/10.24875/BMHIM.24000048","url":null,"abstract":"<p><strong>Background: </strong>We present the case of a patient who underwent hematopoietic progenitor cell transplantation from a fully compatible unrelated donor and subsequently developed Grade IV skin graft-versus-host disease (GVHD) resembling toxic epidermal necrolysis (TEN).</p><p><strong>Clinical case: </strong>An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD.</p><p><strong>Conclusion: </strong>The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 6","pages":"368-371"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan A Godínez-Chaparro, Helena Vidaurri-de la Cruz, Karen Oyorzabal-Serrano, Ixchel R Ramírez-Ricarte
{"title":"Clinical and epidemiological characteristics of pilomatricomas in a Mexican pediatric population.","authors":"Juan A Godínez-Chaparro, Helena Vidaurri-de la Cruz, Karen Oyorzabal-Serrano, Ixchel R Ramírez-Ricarte","doi":"10.24875/BMHIM.24000067","DOIUrl":"10.24875/BMHIM.24000067","url":null,"abstract":"<p><strong>Background: </strong>Pilomatricoma is a common benign adnexal neoplasm in children. There are few epidemiological studies on this subject, with most relying solely on descriptive statistics.</p><p><strong>Methods: </strong>A cross-sectional study conducted in two tertiary hospitals in Mexico City from January 2017 to December 2023. Clinical and electronic records of patients with histopathological diagnosis of pilomatricoma, both sexes, under 18 years old, with any type of present comorbidity were selected. Records of patients with diagnosis not confirmed by histopathology or incomplete records were not included in the study.</p><p><strong>Results: </strong>Fifty-two cases with pilomatrixoma were included in the study, showing a total of 74 lesions. About 23.1% of the cases had multiple pilomatrixomas. 40.4% of the cases experienced pain; this symptom was associated with lesions > 15 mm in diameter and with multiple pilomatrixomas. Risk factors for lesions > 15 mm included age under 8 years, positive tent sign, tumor evolution longer than a year, and a non-classical clinical variety. The head and neck were the most commonly affected areas. The left upper extremity presented larger pilomatrixomas (median 18.5 mm) and occurred more frequently in adolescent patients (mean age 12.1 years) compared to other body areas.</p><p><strong>Conclusions: </strong>Pilomatrixoma in children shows clinical diversity, with specific findings based on size, number, and anatomical location.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 5","pages":"263-271"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José F Mier-de Leija, Daniela de la Rosa-Zamboni, Juan J L Sienra-Monge, Horacio Márquez-González, Solange G Koretzky
{"title":"Frequency of hand contact with hospital surfaces in hospitalized pediatric patients.","authors":"José F Mier-de Leija, Daniela de la Rosa-Zamboni, Juan J L Sienra-Monge, Horacio Márquez-González, Solange G Koretzky","doi":"10.24875/BMHIM.23000143","DOIUrl":"https://doi.org/10.24875/BMHIM.23000143","url":null,"abstract":"<p><strong>Background: </strong>Hand hygiene (HH) is an important strategy for preventing health-care-associated infections (HAIs). Few programs focus on HH for family members and primary caregivers but fewer for patients. This study aimed to estimate the frequency with which hospitalized pediatric patients have hand contact with hospital surfaces.</p><p><strong>Methods: </strong>We conducted a cross-sectional descriptive observational study consisting of three phases: the first was the creation of an observation and data collection tool, the second was the training of the monitors, and the third was the observational study of hand contact and HH opportunities in hospitalized pediatric patients.</p><p><strong>Results: </strong>Over 3600 minutes of observation, 2032 HH opportunities were detected, averaging 33.8/h (SD 4.7) as determined by hand contact with hospital surfaces of hospitalized pediatric patients. In our study, infants and preschool children had the highest frequency of hand contact.</p><p><strong>Conclusion: </strong>The high frequency of hand contact of hospital surfaces by children suggests that hourly hand disinfection of patients and caregivers, objects and surfaces around the patients may be prevention measures that could be incorporated to reduce HAIs in pediatric hospitals.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 1","pages":"44-52"},"PeriodicalIF":0.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drugs and natural products for the treatment of COVID-19 during 2020: comment.","authors":"Hineptch Daungsupawong, Viroj Wiwanitkit","doi":"10.24875/BMHIM.24000042","DOIUrl":"10.24875/BMHIM.24000042","url":null,"abstract":"","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 4","pages":"255"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Norma A Balderrábano-Saucedo, Ana C Cepeda-Nieto, Luis D Ramírez-Calvillo, Ana C Berni-Betancourt, Silvia S Gómez-Delgadillo, Lorena D Cruz-Villar, Victor de J Suárez-Valencia
{"title":"Unveiling the mystery of the female heart's rhythm: a look into gender inequalities in electrophysiology.","authors":"Norma A Balderrábano-Saucedo, Ana C Cepeda-Nieto, Luis D Ramírez-Calvillo, Ana C Berni-Betancourt, Silvia S Gómez-Delgadillo, Lorena D Cruz-Villar, Victor de J Suárez-Valencia","doi":"10.24875/BMHIM.24000030","DOIUrl":"https://doi.org/10.24875/BMHIM.24000030","url":null,"abstract":"<p><p>This review explores gender disparities in cardiac electrophysiology, highlighting differences in the electrical activity of the heart between men and women. It emphasizes the importance of understanding these variances for correct diagnosis and effective treatment of cardiac arrhythmias. Women show distinct cardiac characteristics influenced by sex hormones, affecting their susceptibility to various arrhythmias. The manuscript covers the classification, mechanisms, and management of arrhythmias in women, considering factors such as pregnancy and menopause. By addressing these gender-specific nuances, it aims to improve healthcare practices and outcomes for female patients with cardiac rhythm disorders.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 5","pages":"255-262"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura E Salinas-Nuñez, Daniel O Pacheco-Rosas, José H Pérez-Olais, Elizabeth Mendoza-Coronel, Roberto J Robles-Ramírez, Laura C Bonifaz, Ezequiel M Fuentes-Pananá
{"title":"Exploring atypical manifestations and multisystem involvement of Epstein-Barr virus infection in hospitalized pediatric patients from Mexico: insights from a tertiary hospital (2012-2022).","authors":"Laura E Salinas-Nuñez, Daniel O Pacheco-Rosas, José H Pérez-Olais, Elizabeth Mendoza-Coronel, Roberto J Robles-Ramírez, Laura C Bonifaz, Ezequiel M Fuentes-Pananá","doi":"10.24875/BMHIM.24000027","DOIUrl":"10.24875/BMHIM.24000027","url":null,"abstract":"<p><strong>Introduction: </strong>Epstein-Barr virus (EBV) infection, with a global prevalence exceeding 95%, typically manifests in children as infectious mononucleosis. However, clinical practice frequently encounters diverse atypical presentations characterized by multisystem involvement, often resulting in an unfavorable clinical course. Our objective is to describe the clinical manifestations and results of EBV infection in a tertiary pediatric hospital in Mexico.</p><p><strong>Method: </strong>An observational, transversal, retrospective, and descriptive study that included a systematic review of medical records (2012-2022) of patients under 18 years of age with detectable EBV particles in peripheral blood.</p><p><strong>Results: </strong>The study included 26 patients with a median age of 5 years and a male predominance of 53.8%. Predominant symptoms were fever (85%) and lymphadenopathy (35%). Sixty-five percent had severe and atypical manifestations, including pneumonia and hepatic, hematologic-oncologic, and autoimmune diseases. Anemia, thrombocytopenia and leukopenia were common, with lymphocytosis in 19% of cases. The median EBV viral load was 2816 copies/mL (range: 555-355,500 copies/mL). Four deaths related to EBV infection were reported. Viral load in these cases also varied widely from 594 to 121,000 copies/mL. Supportive care was administered to 85% of patients, while others received antiviral treatment, steroids, and rituximab.</p><p><strong>Conclusion: </strong>Atypical manifestations were common, especially in children with multisystem involvement. EBV should be considered as a potential contributor to a diverse spectrum of clinical presentations, emphasizing the need for comprehensive evaluation and awareness in clinical diagnosis.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 5","pages":"272-279"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indra A Andrade-Cabrera, Juan Garduño-Espinosa, Gina C Chapa-Koloffon, Mónica J Olguín-Quintero, Maria G Jean-Tron
{"title":"Exploring medical ethics: moral reasoning among new pediatric resident physicians in a tertiary hospital.","authors":"Indra A Andrade-Cabrera, Juan Garduño-Espinosa, Gina C Chapa-Koloffon, Mónica J Olguín-Quintero, Maria G Jean-Tron","doi":"10.24875/BMHIM.24000035","DOIUrl":"https://doi.org/10.24875/BMHIM.24000035","url":null,"abstract":"<p><strong>Background: </strong>Physicians are frequently faced with ethical dilemmas that require answers based in moral reasoning, which develops and evolves during their lives and their medical education. According to Kohlberg, there are three levels of moral reasoning development: pre-conventional (in which decisions are guided by oneself convenience), conventional (focused on obeying society's rules), and post-conventional (decisions are based in universal ethical principles). The aim of this study was to describe the level of moral reasoning among new pediatric resident physicians in a tertiary hospital.</p><p><strong>Method: </strong>This cross-sectional descriptive study was conducted from 2020 to 2023. The Defining Issues Test was used to assess the level of moral reasoning among 195 new pediatric resident physicians in a tertiary hospital.</p><p><strong>Results: </strong>Most resident physicians considered the fourth stage affirmations to be the most important. The median P-index (PI) was 40, and 49% of participants were on the post-conventional level of moral reasoning. The year with the lowest number of new resident physicians on the post-conventional level was 2021.</p><p><strong>Conclusion: </strong>The moral reasoning level among pediatric resident physicians was higher than the average found in general population. This suggests that the education received during the medical formation may influence the individuals' moral development.</p>","PeriodicalId":9103,"journal":{"name":"Boletín médico del Hospital Infantil de México","volume":"81 5","pages":"294-300"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}