Elsa M Zúñiga-Lara, César M Zambrano-Virgen, José F Gaytán-Morales, Fredenet O Mendoza-Camargo, Yazmin A Gómez-Domínguez
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引用次数: 0
摘要
背景：临床病例：一名 11 岁女性患者接受了完全相合的非亲缘供体的造血祖细胞移植，随后出现了类似中毒性表皮坏死（TEN）的 IV 级皮肤移植物抗宿主病（GVHD）：临床病例：一名 11 岁女性在移植了来自 100%相合的非亲缘供体的造血祖细胞后，于第 +35 天在躯干和四肢出现皮疹样皮损。皮肤活检显示真皮萎缩、基底层空泡化、真皮表皮层有单核炎症细胞汇集的凋亡角质细胞，确诊为 TEN 样急性皮肤 GVHD：结论：在使用免疫抑制剂进行动态治疗后，患者的症状缓解了80%。
Graft-versus-host disease variety toxic epidermal necrolysis. Case report.
Background: We present the case of a patient who underwent hematopoietic progenitor cell transplantation from a fully compatible unrelated donor and subsequently developed Grade IV skin graft-versus-host disease (GVHD) resembling toxic epidermal necrolysis (TEN).
Clinical case: An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD.
Conclusion: The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.
期刊介绍：
The Boletín Médico del Hospital Infantil de México is a bimonthly publication edited by the Hospital Infantil de México Federico Gómez. It receives unpublished manuscripts, in English or Spanish, relating to paediatrics in the following areas: biomedicine, clinical, public health, clinical epidemology, health education and clinical ethics. Articles can be original research articles, in-depth or systematic reviews, clinical cases, clinical-pathological cases, articles about public health, letters to the editor or editorials (by invitation).
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