Osteosarcoma in pre-adolescents: diagnostic interval, metastasis frequency, and treatment abandonment.

IF 0.5 Q4 PEDIATRICS

Boletín médico del Hospital Infantil de México Pub Date : 2025-01-01 DOI:10.24875/BMHIM.23000147

Ricardo Gómez-Martínez, Miguel Á Verdugo-Robles, Graciela López-Márquez, Aldo I Santiago-Aguilar, Hugo Romo-Rubio

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引用次数: 0

Abstract

Background: osteosarcoma is the most common malignant bone tumor, but it is rare before adolescence. The clinical behavior of the tumor that develops in pre-adolescents may differ from that seen during adolescence.

Method: This is a retrospective study of pre-adolescents with osteosarcoma diagnosed in a tertiary-level hospital. The patients were compared with adolescents diagnosed during the same period.

Results: we analyzed 149 patients (forty-four pre-adolescents). The diagnostic interval median was 7 weeks in pre-adolescents and 12 weeks in adolescents (p = 0.002). Forty-four patients had metastases at diagnosis (ten pre-adolescents) (p = 0.23). Limb-salvage surgery was performed on sixteen patients (two pre-adolescents). Fifty-six patients (thirteen pre-adolescents) abandoned the treatment (p = 0.18). Overall survival was 63 months in pre-adolescents and 52 months in adolescents (p = 0.301).

Conclusion: We only found differences in the diagnostic interval, which was shorter in pre-adolescent patients. Studies with a larger number of pre-adolescents are necessary to determine the differences in the characteristics of the disease in adolescent patients.

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青春期前骨肉瘤：诊断间隔、转移频率和放弃治疗。

背景：骨肉瘤是最常见的恶性骨肿瘤，但在青春期前很少见。在青春期前发展的肿瘤的临床表现可能与青春期所见的不同。方法：对在某三级医院诊断的青春期前骨肉瘤患者进行回顾性研究。将这些患者与同期确诊的青少年进行比较。结果：我们分析了149例患者（44例青春期前）。诊断间隔中位数在青春期前为7周，在青春期为12周（p = 0.002）。44例确诊时发生转移（10例为青春期前）（p = 0.23）。16例患者行保肢手术，其中2例为学龄前儿童。56例患者（13例青少年前）放弃治疗（p = 0.18）。青少年前期总生存期为63个月，青少年期为52个月（p = 0.301）。结论：我们只发现了诊断间隔的差异，青春期前患者的诊断间隔更短。有必要对大量的前青少年进行研究，以确定青少年患者的疾病特征的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletín médico del Hospital Infantil de México PEDIATRICS-

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Boletín Médico del Hospital Infantil de México is a bimonthly publication edited by the Hospital Infantil de México Federico Gómez. It receives unpublished manuscripts, in English or Spanish, relating to paediatrics in the following areas: biomedicine, clinical, public health, clinical epidemology, health education and clinical ethics. Articles can be original research articles, in-depth or systematic reviews, clinical cases, clinical-pathological cases, articles about public health, letters to the editor or editorials (by invitation).