Clinical research and trials最新文献

{"title":"Validation of myocardial damage biomarkers as reliable predictors of infarct size and ejection fraction impairment assessed by cardiac magnetic resonance","authors":"Lucía Del Valle-Batalla, Raúl Castillo-Astorga, Rodolfo Prieto-Riveros, Jaime Gonzalez, R. Aguayo, Kjersti Nes, C. Ramos, Juan Carlos Prieto, R. Rodrigo","doi":"10.15761/crt.1000257","DOIUrl":"https://doi.org/10.15761/crt.1000257","url":null,"abstract":"Background: Acute myocardial infarction (AMI) is the leading cause of morbidity and mortality worldwide. The final infarct size (FIS) and left ventricular ejection fraction (LVEF) are the greatest predictors of post-AMI mortality, with cardiac magnetic resonance (CMR) being the gold standard method for their measurement. Myocardial damage biomarkers, such as creatine kinase (CK) and myocardial creatine kinase (CKMB) are currently used to diagnose AMI and estimate the myocardial damage extent. It would be plausible to use them as predictors of FIS and LVEF; however, current evidence is not available up to date. Objective: To determine the potential power of plasma CK and CKMB levels as predictors of FIS and LVEF impairment, respectively, on the basis of their correlation in patients undergoing primary coronary angioplasty (PCA) following ST-elevation acute myocardial infarction (STEMI). Methodology: A retrospective analysis of PREVEC Trial (ISRCTN registry: 56034553), a multicentric, randomized, double-blind clinical study was performed. Sixty-seven patients with STEMI scheduled for PCA were enrolled. The CMR was performed 7-15 days after the event. Three radiologists blinded to clinical information measured FIS and LVEF. Total CK and CKMB were measured in peripheral venous blood at 6-8 hours after PCA. Correlation coefficient were obtained, and the tests were considered significant with a p value <0.05. The software GraphPrism 6.0 was used for the statistical analysis. Results: A significant positive correlation was obtained between levels of cardiac biomarkers and FIS [total CK (r-square 0.3, p<0.0001) and CK MB (r-square 0.15, p<0.0027)]. In addition, the levels of these biomarkers showed a significant negative correlation with LVEF [total CK (r-square 0.3, p<0.0001) and CK MB (r-square 0.18, p<0.0012)]. Conclusion: These results are consistent with the view that the myocardial damage biomarkers CK and CKMB are reliable as predictors of FIS and LVEF measured by CMR in post-AMI patients. These data suggest that these biomarkers could be included in future Risk Scores. *Correspondence to: Ramón Rodrigo, Medical students, Faculty of Medicine, University of Chile, Chile, E-mail: rrodrigo@med.uchile.cl","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67455844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences, similarities and controversies between bronchial asthma and chronic obstructive pulmonary disease","authors":"A. Alvarado","doi":"10.15761/crt.1000261","DOIUrl":"https://doi.org/10.15761/crt.1000261","url":null,"abstract":"Bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are two major health problems whose incidence is increasing. Both are recognized as major causes of morbidity and mortality worldwide. Never as now is better known the pathophysiology of both, as well as their inflammatory, cellular and immunological profiles. It has powerful diagnostic, image, gasometric, functional, cellular, and immunological tools, as well as abundant basic, clinical, genetic and therapeutic research. However, despite having international guidelines based on evidence, the responses to the treatments are sub-optimal in both. In BA the incidence of uncontrolled patients is high and in COPD, treatment with inhaled bronchodilators and glucocorticoids (IGCs) improves symptoms and quality of life but does not impact the deterioration in lung function or improve life expectancy. The problem is amplified by patients in which the two entities overlap and this creates problems of diagnosis and treatment. Therefore the research of new therapeutic tools (such as antioxidants, biological and those that impact the function of mitochondria) is vigorous. This monograph therefore aims to establish, as clearly as possible, the differences and similarities between BA and COPD to give the clinician a tool that brings him closer to a more precise diagnosis and a more rational treatment. *Correspondence to: Alcibey Alvarado. Clínica de Diagnóstico Médico. Torre Médica. 3 piso. Paseo Colón, San José, Costa Rica, Tel: 50622237134; 50622566439; 50687351858; Fax: 50622216754; E-mail: alcialvagonza@yahoo. com.mx","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-derived vesicles in acute myocardial infarction","authors":"A. Berezin, A. Berezin","doi":"10.15761/crt.1000262","DOIUrl":"https://doi.org/10.15761/crt.1000262","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albumin and adequacy of its application","authors":"A. Belousov","doi":"10.15761/crt.1000263","DOIUrl":"https://doi.org/10.15761/crt.1000263","url":null,"abstract":"The advantages of albumin over less costly alternative fluids continue to be debated. Many scientific articles were devoted to the clinical analysis of the use of albumin in acute illness as well as its comparison with other fluid regimens. However, the lack of fundamental knowledge about the physical and chemical properties of commercial albumin generates many unpromising discussions about the effectiveness of the use of albumin among practitioners and medical scientists. The manuscript provides information about the different variants of commercial albumin, the mechanisms of their action, indications and contraindications to use. The presented information is based on fundamental knowledge of physical and chemical properties of commercial albumin. This manuscript is not only educational information, but also is guide to action for clinicians.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurogenic hyperpyrexia following acute traumatic spinal cord injury. A Systematic Review","authors":"P. Korovessis","doi":"10.15761/crt.1000264","DOIUrl":"https://doi.org/10.15761/crt.1000264","url":null,"abstract":"Study Design : Systematic review. Objective : To report the incidence, pathogenesis, treatment options and outcomes related to neurogenic hyperpyrexia following acute traumatic spinal cord injury (SCI). Methods : A systematic review was performed on hyperpyrexia secondary to acute traumatic SCI in adult patients. A literature search was performed using PubMed and available literature. Results : Using the headings terms “Spinal Cord Injury” and “Fever” and after removing duplicates, 292 articles were collected independently of the number of cases included. Papers with fever of other etiology than neurogenic hyperpyrexia were subsequently excluded. In this last search 9 original articles were selected, from which only 4 fulfilled the criteria for this systematic review. Cervical was much more often than thoracic SCI associated with hyperpyrexia. Although the incidence of fever of all origins after SCI averaged 50.5%, (range 22.5 to 71.7%) the incidence of neurogenic hyperpyrexia in patients sustained acute SCI averaged 8.0%, (range 2.6 to 27.8%). ASIA A SCI had a higher incidence of hyperpyrexia than ASIA B to D incomplete SCI injuries. The pathogenesis of so-called “neurogenic hyperpyrexia” following reported acute SCI is not thoroughly understood, and mostly cases have been. Few methods for treatment of hyperpyrexia have been suggested including steroids, cooling, combined steroids and hypothermia and endovascular cooling Conclusion : Neurogenic hyperpyrexia is a relatively common clinical entity following acute SCI. However, there is little literature to help physicians prevent or treat this potential fatal condition. Further studies with larger sample sizes, focusing on incidence rate, clinical outcomes, and pathogenesis of neurogenic hyperpyrexia following acute traumatic SCI are needed. The results of this systematic review that are based on very few clinical studies suggest further research with controlled clinical trials.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter aortic valve replacement and Candida parapsilosis endocarditis: a deadly combination","authors":"Susana Ortega-Silva, Willian A. Ortiz-Solis, Diego Neach de la Vega, N. Espinola-Zavaleta, America G. Urbina-Vazquez, Antonio R. Bailon-Sotelo, Abraham Villalobos-Flores","doi":"10.15761/crt.1000276","DOIUrl":"https://doi.org/10.15761/crt.1000276","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of immune thrombocytopenic purpura and polycythemia vera","authors":"Didar Yanardağ Açık","doi":"10.15761/crt.1000255","DOIUrl":"https://doi.org/10.15761/crt.1000255","url":null,"abstract":"Polycythemia vera and immune thrombocytopenic purpura clinics are two different hematologic diseases in aspect of etiology and treatment. Coexistence of both diseases may cause difficulties in treatment method. There is very few source relating to treatment method and coexistence of polycythemia vera and immune thrombocytopenic purpura in literature. We have presented two cases with polycythemia vera and immune thrombocytopenic purpura and our treatment method. *Correspondence to: Didar Yanardag Acik, Ministry of Health, Adana State Training and Research Hospital, Hematology and Internal Diseases Clinic, Adana, Turkey, E-mail: didaryanardag@gmail.com","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67455606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"50 of the Best Online Resources for Senior Citizens","authors":"Jesse Davidson","doi":"10.15761/crt.1000282","DOIUrl":"https://doi.org/10.15761/crt.1000282","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the controversies surrounding host immune response to helminth and malaria parasites","authors":"D. Adu-Gyasi, Margaret T. Frempong, Harry Danwonno, Alberta Bedford Moses, B. Gyan","doi":"10.15761/crt.1000270","DOIUrl":"https://doi.org/10.15761/crt.1000270","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bisphenol A in Odontology: Recent data","authors":"Vautherin T, Lopes Cardoso I","doi":"10.15761/crt.1000277","DOIUrl":"https://doi.org/10.15761/crt.1000277","url":null,"abstract":"Background and Objective: Bisphenol A (BPA) is an organic compound of the aromatic family used mainly as a monomer, for more than 50 years in the production of polycarbonate plastics and epoxy resins. Nowadays, bisphenol A is a worrying substance that deserves special attention. The goal of this work is to focus on bisphenol A and its biological effects on the human body. Methods: A bibliographic search was performed in databases such as PubMed, b-On and Elsevier. The keywords used were: \"Bisphenol A\", \"BPA\", \"Endocrin Disruptor Chemicals\". Results: There are several known effects on the human body resulting from the exposure to BPA such as in the reproductive system, dentition, brain, behavior, cardiovascular and in immune systems. In the oral cavity, dental composites release bis-GMA and BPA immediately after placement but released doses are usually too low to lead to biological effects. Conclusion: There are other materials such as silorans, Ormocer® and ionomer glass cements that can be good alternatives. Clinical studies are still neaded to prove that these materials are better than the composites, being these ones still the most used materials in conservative dental medicine.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}