{"title":"The case number 130 of Townes Brocks syndrome","authors":"Aamir Jalal Al-Mosawi","doi":"10.15761/crt.1000286","DOIUrl":"https://doi.org/10.15761/crt.1000286","url":null,"abstract":"Townes Brocks syndrome is a very rare genetic syndrome with 129 well-documented patients reported in the medical literature. Townes Brocks syndrome has not been reported before in Iraq. The main aim of this paper is to describe the first case of this syndrome in Iraq which seems to be the case number 130.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67458406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bayesian methods for mixed method synthesis","authors":"L. Roever","doi":"10.15761/crt.1000269","DOIUrl":"https://doi.org/10.15761/crt.1000269","url":null,"abstract":"Received: July 09, 2019; Accepted: August 02, 2019; Published: August 06, 2019 Bayesian methods generate summative statements of the evidence through the meta-aggregation of data, and this can involve attributing a numerical value to all qualitative data, facilitating a final statistical analysis of individual syntheses (i.e. translating qualitative data into quantitative), or attributing a qualitative thematic description to all quantitative data, thereby permitting a final meta-aggregation of individual syntheses (i.e. translating quantitative data into qualitative) (Table 1) [1-4].","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The sixty fourth case of pediatric Churg Strauss syndrome","authors":"Aamir Jalal Al-Mosawi","doi":"10.15761/crt.1000272","DOIUrl":"https://doi.org/10.15761/crt.1000272","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina B Pateva, Elizabeth H Kerling, Manju Reddy, Dan Chen, Susan E Carlson, Jakica Tancabelic
{"title":"Effect of Maternal Cigarette Smoking on Newborn Iron Stores.","authors":"Irina B Pateva, Elizabeth H Kerling, Manju Reddy, Dan Chen, Susan E Carlson, Jakica Tancabelic","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Maternal smoking has been known to have a negative impact on the well being of the developing fetus. Prenatal smoking has been associated with premature births, low birth weight and with certain birth defects. Small research studies have also found a negative correlation between maternal smoking and neonatal body iron.</p><p><strong>Objectives: </strong>To study and compare the relationship between maternal and infants' body iron in smokers and non-smokers in a large matched-pair cohort.</p><p><strong>Methods: </strong>This was a prospective cohort study involving 144 mothers - 72 smokers and 72 non-smokers and their respective infants. Samples were obtained from maternal and infants' cord blood at delivery for Serum transferrin receptor (sTfR) and ferritin levels. Serum TfR and ferritin were measured by RAMCO ELISA and RIA assays. Total Body Iron (TBI) was calculated using the sTfR/ferritin ratio in a previously described formula by Cook et al.</p><p><strong>Results: </strong>Women who smoked had lower sTfR, higher ferritin and higher body iron compared to nonsmoking women. In contrast to their respective mothers, we found a small, but statistically significant negative correlation between smoking and infants' total body iron. The number of packs per day smoked was also negatively correlated with infants' ferritin and total body iron. Lower birth weight was noted in babies of smokers compared to nonsmokers (mean /- SD =3270 +/-475 vs. 3393 g +/- 475 g, p=0.03).</p><p><strong>Conclusion: </strong>Women who smoked during pregnancy had higher iron stores but their newborn infants had lower iron stores than those of non-smoking mothers. The more packs per day (PPD) and more days smoked during pregnancy led to lower total body iron of the babies. There may be a negative dose-dependent response between fetal smoke exposure and infant iron stores.</p>","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469279/pdf/nihms696394.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33401382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina B. Pateva, E. Kerling, M. Reddy, Dan Chen, S. Carlson, Jakica Tancabelic
{"title":"Effect of Maternal Cigarette Smoking on Newborn Iron Stores.","authors":"Irina B. Pateva, E. Kerling, M. Reddy, Dan Chen, S. Carlson, Jakica Tancabelic","doi":"10.15761/CRT.1000102","DOIUrl":"https://doi.org/10.15761/CRT.1000102","url":null,"abstract":"BACKGROUND Maternal smoking has been known to have a negative impact on the well being of the developing fetus. Prenatal smoking has been associated with premature births, low birth weight and with certain birth defects. Small research studies have also found a negative correlation between maternal smoking and neonatal body iron. OBJECTIVES To study and compare the relationship between maternal and infants' body iron in smokers and non-smokers in a large matched-pair cohort. METHODS This was a prospective cohort study involving 144 mothers - 72 smokers and 72 non-smokers and their respective infants. Samples were obtained from maternal and infants' cord blood at delivery for Serum transferrin receptor (sTfR) and ferritin levels. Serum TfR and ferritin were measured by RAMCO ELISA and RIA assays. Total Body Iron (TBI) was calculated using the sTfR/ferritin ratio in a previously described formula by Cook et al. RESULTS Women who smoked had lower sTfR, higher ferritin and higher body iron compared to nonsmoking women. In contrast to their respective mothers, we found a small, but statistically significant negative correlation between smoking and infants' total body iron. The number of packs per day smoked was also negatively correlated with infants' ferritin and total body iron. Lower birth weight was noted in babies of smokers compared to nonsmokers (mean /- SD =3270 +/-475 vs. 3393 g +/- 475 g, p=0.03). CONCLUSION Women who smoked during pregnancy had higher iron stores but their newborn infants had lower iron stores than those of non-smoking mothers. The more packs per day (PPD) and more days smoked during pregnancy led to lower total body iron of the babies. There may be a negative dose-dependent response between fetal smoke exposure and infant iron stores.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67455083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immune Checkpoint Inhibitors: A Review","authors":"Alcibey Alvarado González","doi":"10.15761/crt.1000370","DOIUrl":"https://doi.org/10.15761/crt.1000370","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67462533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Freitas, L. Gonçalves, M. J. Coelho, M. Ferraz, R. Magalhaes, C. Piña, I. Cardoso
{"title":"Prevalence of antibiotic (β-lactams, tetracycline, metronidazole, erythromycin) resistance genes in periodontic infections","authors":"D. Freitas, L. Gonçalves, M. J. Coelho, M. Ferraz, R. Magalhaes, C. Piña, I. Cardoso","doi":"10.15761/crt.1000280","DOIUrl":"https://doi.org/10.15761/crt.1000280","url":null,"abstract":"Objective: Porphyromonas gingivalis and Prevotella intermedia are thought to be pathogens in adult periodontitis. Antibiotherapy is usually needed in the treatment of periodontitis being often prescribed empirically. To allow prescription of a specific antibiotic treatment, identification of resistance genes should be performed. The aim of this study was the identification of the presence of TetM, TetQ, TEM, cfxA, MefA, ErmB and Nim resistance genes in previously identified P. intermedia and P. gingivalis isolated from samples collected from periodontal infections. Method: PCR was used for the identification of TetM, TetQ, TEM, cfxA, MefA, ErmB and Nim resistance genes in strains isolated from samples collected from periodontal infections. Results: It was seen that 8% of isolates had one of the tested tetracycline resistance genes. A total of 32% of β-lactamases resistance genes was observed in isolated strains. It was also observed that 2% of isolates had one of the analysed erythromycin resistance genes. None of the isolates showed the presence of the metronidazole resistance gene. Conclusions: Most strains harboring β-lactamase resistance genes had been previously identified as P. intermedia. No tetracycline resistance gene and a very low percentage of β-lactamase resistance genes were observed in P. gingivalis strains. *Correspondence to: Inês Lopes Cardoso, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa Rua Carlos da Maia, 296, 4200-150 Porto, Tel: 351 225071300; E-mail: mic@ufp.edu.pt","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67457124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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