Clinical research and trials最新文献

{"title":"Neurosurgery - A Medical student’s perspective on its emotional toll","authors":"Vishnu Vardhan Byroju, S. Patra","doi":"10.15761/crt.1000283","DOIUrl":"https://doi.org/10.15761/crt.1000283","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67457837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drugs–β-Cyclodextrin inclusion complex: Would be a new strategy to improve Antihypertensive Therapy?","authors":"Quiara Lovatti Alves, Samuel Barbosa Camargo, Rafael Leonne Cruz de Jesus, Darízy Flávia Silva","doi":"10.15761/crt.1000268","DOIUrl":"https://doi.org/10.15761/crt.1000268","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"propofol-target-controlled-infusion-performance-of-the-schnider-model-in-the-clinical-setting-for-major-surgical-procedures","authors":"Luis Neumann, T. Mohler, M. Steurer, M. Zueger, T. Kraemer, A. Dullenkopf","doi":"10.15761/crt.1000259","DOIUrl":"https://doi.org/10.15761/crt.1000259","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of oxidative stress in hepatic ischemia-reperfusion injury: potential target for interventions in liver transplantation","authors":"Consuelo Orellana, R. Villagrán, Jonathan Zang, R. Rodrigo","doi":"10.15761/crt.1000258","DOIUrl":"https://doi.org/10.15761/crt.1000258","url":null,"abstract":"Liver transplantation is the definitive therapy for most patients with end-stage liver failure. During this surgical procedure, hepatic ischemia-reperfusion is an unavoidable phenomenon known to be involved in graft injury, often resulting in postoperative complications and liver dysfunction. Although the pathophysiology behind ischemia reperfusion injury (IRI) comprises various mechanisms, oxidative stress (OS) has been recognized as a key factor. The aims of this review are to provide an updated overview of the role of OS in liver IRI, providing some bases for therapeutic interventions based on counteracting the OS-related mechanism of injury and thus suggesting novel possible strategies in the prevention of IRI in liver transplants. *Correspondence to: Ramón Rodrigo, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, Chile, E-mail: rrodrigo@med.uchile.cl","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to improve disease management of chronically ill patients? Perception of telemetric ECG recording and a novel software application","authors":"Michael Lang, Stefan Ringbauer, M. Mayr, L. Cepek","doi":"10.15761/crt.1000266","DOIUrl":"https://doi.org/10.15761/crt.1000266","url":null,"abstract":"Background and Objective: During the last years, mobile applications and telemetry have been discussed to become an attractive tool to support and monitor patients with chronic diseases. This study aimed to evaluate the usability and perception of both telemetry and a novel app in MS patients scheduled for an ECG due to medication adjustment or follow-up. Methods: In 211 neurological centers throughout Germany, telemetric 2-channel ECG was applied in 1082 patients with fingolimod prescriptions, who have to be subjected to ECG recording as a mandatory monitoring step. In a second approach, patients were offered to use the PatientConcept app, an application designed to ease patient-physician contact and to support patients in their daily life. Patients as well as physicians from the participating centers were surveyed to evaluate handling, acceptance and utility of both devices. Results: The majority of patients perceived telemetric ECG recording as an interesting tool and appreciated shorter waiting times. 95%, 95% and 98% of the centers believed that using telemetric ECG recording eliminates waiting times, accelerates medical reporting and provides a relief for test persons, respectively. Both, patients and physicians perceived the use of PatientConcept app as useful. Conclusion: Being both well accepted, telemetric ECG recording and the use of a mobile app might provide new concepts to improve patient care. The positive results gained in this study may help to develop new perspectives for using these tools in the future, which may constitute a relief for the complex management of chronic diseases. *Correspondence to: Michael Lang, Nervenfachärztliche Gemeinschaftspraxis Ulm Pfauengasse 8, 89073 Ulm, Germany, Tel: 0049 731 65 66 5; Fax 0049 731 65 42 0; E-mail: lang@neurologie-ulm.de","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-Aided transoral partial mandibulectomy and reconstruction: Case Report","authors":"Christopher Liangcheng Chen, Yanzhao Chen, Michael Y. Chen","doi":"10.15761/crt.1000267","DOIUrl":"https://doi.org/10.15761/crt.1000267","url":null,"abstract":"Virtual planning software and three-dimensional printing technology have improved the operation time and surgical accuracy. We performed partial mandibulectomy and reconstruction via the intraoral approach with relatively acceptable clinical results in two patients with ameloblastoma. Preoperative preparations were full skull computed tomography, virtual surgical cuttings, pre-bent load-sharing titanium plates that conformed to the additive stereolithographic models, and complex computer-aided design/computer-assisted manufacturing surgical guide for intraoperative screw placement and plate fixation. Procedures were performed transorally, but two tiny stab skin incisions were made on the unilateral posterior cheek for transbuccal screw fixation on proximal segments. Bony defects due to ameloblastoma were created by load-sharing plates and autogenous iliac bone grafts plus platelet rich plasma/fibrin followed by 6-week intermaxillary fixation. Transplanted autogenous bone grafts consolidated uneventfully, occlusion remained well and stable with intact facial profile, frontal symmetry, and inconspicuous incision marks on posterior cheeks. In selected cases, we resected huge pathologic lesions of the mandible and immediate reconstruction through a relatively conservative approach, attaining less donor site morbidities, reasonable functional and esthetic outcomes, and maintenance of adequate life quality. The perfusion status of the soft tissue matrix around the affected bone segment helps determine whether to adopt this protocol. *Correspondence to: Michael Yuanchien Chen, Division of Oral & Maxillofacial Surgery, Dental Department, China Medical University Hospital, Taichung, Taiwan, Dental College, China Medical University, Taichung, Taiwan, Tel: +886928182949; Fax: +886-0422037746; E-mail: mychen@mail.cmuh.org.tw","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulicatella adiacens endocarditis of a complex congenital heart disease on an adult","authors":"N. Espinola-Zavaleta, Luis Javier Castellanos-Vizcaíno, Andrea Salazar-Vitale, Rodrigo Escalante-Armenta, E. Alexanderson-Rosas","doi":"10.15761/crt.1000285","DOIUrl":"https://doi.org/10.15761/crt.1000285","url":null,"abstract":"We present a 23-year-old man with complex CHD, who came to our institution due to moderate exertion dyspnea and fever. He was diagnosed with mitral valve endocarditis and Granulicatella adiacens was isolated. He was treated with antibiotics and discharged as he refused surgery. He came back on August 2019 with progressive increase of abdominal perimeter, lower limbs edema and chest pain. On cardiac examination pericardial rub and III/VI apical holosystolic murmur were found. The transthoracic echocardiogram showed situs solitus, atrioventricular discordance, double-outlet right ventricle with transposition of great arteries, interventricular septal defect, moderate tricuspid regurgitation, vegetations in both leaflets of mitral valve and severe mitral regurgitation, subvalvular pulmonary stenosis and huge pericardial effusion. The patient underwent successful mitral valve replacement and he was discharged in good condition. *Correspondence to: Nilda Espinola-Zavaleta, MD, National Institute of Cardiology Ignacio Chavez, Juan Badiano No 1, Colonia Sección XVI, Tlalpan, P.C. 14080, Mexico City, Mexico, E-mail: niesza2001@hotmail.com","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67458312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic cardiac autonomic neuropathy: Effects of statins and omega-3 polyunsaturated fatty acids on lipid profile and insulin resistance parameters","authors":"V. Serhiyenko, Ludmila Serhiyenko, S. Ajmi, A. Serhiyenko","doi":"10.15761/crt.1000274","DOIUrl":"https://doi.org/10.15761/crt.1000274","url":null,"abstract":"Background: Currently, there is no unified treatment algorithm of cardiac autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effects of simvastatin (SIM) and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) on blood lipid profile and insulin resistance (IR) in patients with T2DM and definite CAN. Methods: The study involved 72 patients with T2DM and definite CAN. Patients were divided into four groups: 1st received standard hypoglycemic therapy control (n = 15); 2nd (n = 22) – in addition SIM 20 mg/q.d.; 3rd (n = 18) in addition 1 capsule/q.d. of the ω-3 PUFAs; 4th (n = 17) in addition SIM 10 mg/ q.d and 1 capsule/q.d of the ω-3 PUFAs for three months. The concentration of glucose, glycated hemoglobin A1c, immunoreactive insulin (IRI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) in the blood were determined. Homeostasis model assessment IR (HOMA-IR), atherogenic coefficient (AC), TG/LDL-C, TG/TC, TG/LDL-C and TG glucose (TyG) were calculated. Results: Prescription of SIM was accompanied by a statistically significant decrease in TC, LDL-C, TG concentrations. In parallel, SIM induced a decrease of AC, TG/HDL-C, increase in HDL-C, and does not affect the IRI, HOMA-IR, TG/LDL-C, TG/TC, TC/LDL-C/HDL-C, TyG. The use of ω-3 PUFAs has contributed to a significant reduction in TG, AC, TG/LDL-C, TG/TC, TG/HDL-C, TyG index, increase in HDL-C, and was not accompanied by changes in IRI content, HOMA-IR, TC, LDL-C, and TC/LDL-C/HDL-C. The combined prescription of SIM and ω-3 PUFAs was accompanied by more pronounced, statistically significant changes in the blood lipid spectrum, as well as a decrease in the IRI and HOMA-IR. Conclusion: Obtained results justify the appropriateness of combined SIM and ω-3 PUFAs prescription to patients with T2DM and definite CAN. *Correspondence to: Victoria A Serhiyenko, Assistant Professor, Department of Endocrinology, Danylo Halytsky Lviv National Medical University, 69, Pekarska Str., 79010, Lviv, Ukraine, Tel: 00380987463315; E-mail: serhiyenkoa@gmail. com; serhiyenkov@gmail.com","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The syndrome of congenital facial palsy and unilateral anotia","authors":"Aamir Jalal Al-Mosawi","doi":"10.15761/crt.1000284","DOIUrl":"https://doi.org/10.15761/crt.1000284","url":null,"abstract":"","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67458478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case number 130 of Townes Brocks syndrome","authors":"Aamir Jalal Al-Mosawi","doi":"10.15761/crt.1000286","DOIUrl":"https://doi.org/10.15761/crt.1000286","url":null,"abstract":"Townes Brocks syndrome is a very rare genetic syndrome with 129 well-documented patients reported in the medical literature. Townes Brocks syndrome has not been reported before in Iraq. The main aim of this paper is to describe the first case of this syndrome in Iraq which seems to be the case number 130.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67458406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}