Clinical research and trials最新文献_第6页

ED impact of a mass gathering pre-hospital support system: the Rouen 2013 Armada event 大规模聚集院前支持系统对ED的影响:2013年鲁昂无敌舰队事件

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000254

Dumouchel J, Roussel M, Taalba M, Lefevre A, Joly Lm, Lvovschi Ve

引用次数: 0

A new nano-fibre mat has a strong benefit for chronic low back pain patients – Results of a double-blind randomised trial 一种新型纳米纤维垫子对慢性腰痛患者有很强的益处——一项双盲随机试验的结果

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000275

Michael Ofner, Manuel Treven, H. Walach

{"title":"A new nano-fibre mat has a strong benefit for chronic low back pain patients – Results of a double-blind randomised trial","authors":"Michael Ofner, Manuel Treven, H. Walach","doi":"10.15761/crt.1000275","DOIUrl":"https://doi.org/10.15761/crt.1000275","url":null,"abstract":"Background: Chronic low back pain is one of the most debilitating medical problems worldwide and difficult to treat. New methods are wanted. A cotton mat with 30% silica fibres produced from traditional Korean clay by nano-technology, fibrilium, has shown very good informal results in practice. We tested this mat for clinical effectiveness. Methods and Findings: Randomized, placebo-controlled, blinded clinical trial in 50 chronic low back pain patients (median duration of illness 10 years; pain severity > 5 on a 10 point scale); 2 patients withdrew, 48 were analyzed. The study was fully blinded. Intervention was sleeping on a fibrilium mat on top of a normal matrace for 4 weeks or on a mat with only cotton fibres. Outcomes were functional scores (Oswestry Disability Score, Linton-Halldén Score, McGill Pain Questionnaire), sleep quality (Pittsburgh Sleep Quality Index), generic quality of life (SF 36), clinical ratings (pain, wellbeing), and physiological measures (skin conductance, heart rate, breathing frequency). All 5 multivariate linear models with baseline scores as covariates showed significant differences between groups in all measures (p < .038 to p < .0.0002), with large effect sizes for the functional scores between d = 0.8 and d = 1.4. We observed no negative effects. The trial’s main limitation is its short observation period. Conclusion: Sleeping on a fibrilium mat that contains 30% fibres made from silica containing clay using nano-technology has a strong therapeutic effect on chronic low back pain. *Correspondence to: Harald Walach, Change Health Science Institute, Schönwalder Str. 17D – 13347, Berlin, Germany, E-mail: hwalac@gmail.com","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treacher Collins syndrome and implications in the oral cavity Treacher Collins综合征及其对口腔的影响

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000278

C. Duque, I LopesCardoso

{"title":"Treacher Collins syndrome and implications in the oral cavity","authors":"C. Duque, I LopesCardoso","doi":"10.15761/crt.1000278","DOIUrl":"https://doi.org/10.15761/crt.1000278","url":null,"abstract":"Background and Objective: Treacher Collins syndrome, also called mandibula-facial dysostosis, is a congenital disorder. It is the aim of this work to clarify the etiology, diagnosis, phenotypic craniofacial and oral characteristics of the syndrome, as well as to discuss the treatments to be applied. Methods: A bibliographic search was performed using the keywords: \"Treacher Collins Syndrome\", \"treatment\", \"dental\", \"oral cavity\", \"TCOF1 gene\". Results: Most cases have an autosomal dominant transmission and variable expressivity. Mutations in the TCOF1 gene on chromosome 5 are usually known to cause Treacher Collins syndrome. The phenotypic craniofacial features are: micrognathia, maxillary hypoplasia with palate cleft, malar hypoplasia, antimongoloid inclination of palpebral fissures, coloboma of lower eyelid and microtia. Problems in the oral cavity are frequent in these patients because the deficiencies of the bone bases provoke crowding and can lead to incorrect bite. Other oral manifestations include reduced salivary flow, high levels of caries and plaque. Conclusions: Diagnosis and treatment should be performed in an early stage and are important for the reestablishment of masticatory, respiratory and auditory functions. *Correspondence to: Lopes Cardoso I, Faculdade de Ciências da Saúde, Universidade Fernando Pessoa Rua Carlos da Maia, 296, 4200-150 Porto, Portugal, Tel: +351 225071300; E-mail: mic@ufp.edu.pt","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67457018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

CAR-T cells with co-expressed cytokines and chemokines better overcome inhibitory microenvironment of solid tumors 共表达细胞因子和趋化因子的CAR-T细胞能更好地克服实体肿瘤的抑制微环境

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000253

V. Golubovskaya

引用次数: 0

Heller syndrome in two Iraqi children 两名伊拉克儿童的海勒综合症

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000271

Aamir Jalal Al-Mosawi

引用次数: 1

Upper and lower gastrointestinal symptoms in HIV-infected adults in a clinical cohort in Midwestern Brazil: incidence and associated factors 巴西中西部一个临床队列中hiv感染成人的上消化道和下消化道症状:发病率和相关因素

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000281

A. Santos, É. A. Silveira

{"title":"Upper and lower gastrointestinal symptoms in HIV-infected adults in a clinical cohort in Midwestern Brazil: incidence and associated factors","authors":"A. Santos, É. A. Silveira","doi":"10.15761/crt.1000281","DOIUrl":"https://doi.org/10.15761/crt.1000281","url":null,"abstract":"Aim : The present study aimed to investigate the incidence of both upper and lower gastrointestinal symptoms and associated factors in HIV-infected adults with or without antiretroviral therapy (ART). Methodology : This study is part of a clinical cohort conducted with adult HIV-infected adults in Midwestern Brazil on outpatient care. Outcome variables were the presence of upper (nausea/vomiting, dyspepsia, and heartburn) and lower (diarrhea, constipation, and flatulence) gastrointestinal symptoms incident on the week before data collection. Explanatory variables were sex, tobacco use, nutritional status, waist circumference (WC), duration of ART, protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) use, and CD4+ T lymphocyte count. The estimate of the effect was analyzed by the incidence ratio (IR) and 95% confidence interval (CI). Statistical significance level was set at p<0.05. Results : Of 290 study participants, 69.0% were on ART. The most incident gastrointestinal symptom was heartburn (49.3%), followed by flatulence (43.4%), dyspepsia (24.5%), nausea/vomiting (22.8), diarrhea (18.3%), and constipation (16.2%). No difference was observed in the incidence of gastrointestinal symptoms in participants with or without ART. The associated factors with upper and/or lower gastrointestinal symptoms were female sex, excess of body weight, abdominal obesity, less than one year of ART use, tobacco exposure, and CD4+ T lymphocyte count. Conclusion : A high incidence of several gastrointestinal symptoms was found in HIV-infected adults, associated with both modifiable and non-modifiable risk factors. These findings contribute to gastrointestinal symptoms management in clinical practice for people living with HIV/AIDS, mainly those in risk categories, as gastrointestinal symptoms could result in adverse outcomes for this population.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of ischemia-reperfusion in oxidative stress-mediated injury during kidney transplantation 缺血-再灌注在肾移植中氧化应激介导的损伤中的作用

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000260

C. Ávila, L. Líbano, Ignacio Rojas, R. Rodrigo

{"title":"Role of ischemia-reperfusion in oxidative stress-mediated injury during kidney transplantation","authors":"C. Ávila, L. Líbano, Ignacio Rojas, R. Rodrigo","doi":"10.15761/crt.1000260","DOIUrl":"https://doi.org/10.15761/crt.1000260","url":null,"abstract":"Renal transplant (RT) is the definitive treatment for end-stage renal disease, which is known as a high prevalence pathology with strong economic repercussion both for patients and health systems. Solid organ transplantation is a classically described clinical setting in which massive amounts of reactive oxygen species (ROS) are produced due to ischaemia-reperfusion, thus becoming an essential pathophysiological element involved in delayed graft function in the context of RT. Nevertheless, no clinical protocol yet exists to counteract the damage mediated by ROS intensively produced throughout the transplant process. The available evidence shows a number of successful experiences in the use of antioxidant supplementation and reinforcement over other oxidative stress-related pathologies. This article addresses the pathophysiological role of oxidative stress in RT and its known consequences in function and structure of the allograft, with the objective of gathering consistent information that demonstrates the central role of oxidative stress in this pathology, and to consider it as a possible therapeutic approach in the future. *Correspondence to: Ramón Rodrigo, Laboratory of Oxidative Stress and Nephrotoxicity, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, P.O.B. 70058, Chile, E-mail: rrodrigo@med.uchile.cl","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67456230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cardiac arrest following HPV Vaccination HPV疫苗接种后心脏骤停

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000279

S. Dahan, Yahel Segal, A. Dagan, Y. Shoenfeld, M. Eldar, D. Kanduc

引用次数: 2

An innovative patient-mentoring program for kidney transplant patients to reduce anxiety and readmission rates: a randomized controlled trial leveraging patients 一项创新的肾移植患者指导计划，以减少患者的焦虑和再入院率:一项利用患者的随机对照试验

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000252

Chelsea R Horwood, S. Moffatt-Bruce, Shannon Harris, Yeojun Chun, Kristen Hill, Mary Lou Hauenstein, Patrick Howe, Aravind Chandrasekaran

{"title":"An innovative patient-mentoring program for kidney transplant patients to reduce anxiety and readmission rates: a randomized controlled trial leveraging patients","authors":"Chelsea R Horwood, S. Moffatt-Bruce, Shannon Harris, Yeojun Chun, Kristen Hill, Mary Lou Hauenstein, Patrick Howe, Aravind Chandrasekaran","doi":"10.15761/crt.1000252","DOIUrl":"https://doi.org/10.15761/crt.1000252","url":null,"abstract":"Background: There is an increasing number of patient’s undergoing kidney transplantation in the United States. Kidney recipients have high occurrence of 30-day readmissions that leads to high hospital costs and decreased quality of life. Previous research found that a high level of post-transplant anxiety is correlated with increased likelihood of 30-day readmissions. The goal of this paper is to describe the study design and implementation process of a randomized control trial (RCT) using a standardized post-transplant mentoring program in order to reduce 30-day readmission and post-transplant anxiety among kidney transplant recipients. Methods/Design: A single institution RCT evaluating post-kidney transplant patient’s anxiety level and readmission rates (both 30- and 90-day). The intervention group will consist of a standardized mentoring process during a four-week period following transplantation and the control group will undergo routine post-operative (PO) care. The mentors will be prior kidney-transplant recipients who will undergo a standardized training process. They will contact the intervention group at week intervals to help counsel on proper PO care and give routine advice. Objective and subjective data will be collected at week intervals for all participants over a one-year study period. Discussion: Standardizing a post-transplant mentoring process has the possibility of improving transplant recipient quality of life, reducing post-transplant anxiety and result in fewer readmission rates.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67454781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe hepatopathy and celiac disease (CD) 严重肝病和乳糜泻(CD)

Clinical research and trials Pub Date : 2019-01-01 DOI: 10.15761/crt.1000256

Firwana M, B. I, Aomari A, Ajana Fz

{"title":"Severe hepatopathy and celiac disease (CD)","authors":"Firwana M, B. I, Aomari A, Ajana Fz","doi":"10.15761/crt.1000256","DOIUrl":"https://doi.org/10.15761/crt.1000256","url":null,"abstract":"Of a total of 248 cases of celiac disease observed in our department, 78 cases (31.5%) had chronic associated liver disease, including 05 cases of severe liver disease. There are 3 women and 2 men with a sex ratio F / H of 1.5, the average age was 35 years [25-57]. The diagnosis of celiac disease was made before the appearance of chronic liver disease in 04 patients with an average delay of 9.5 years, whereas only one patient had a chronic liver disease diagnosed 05 years before the discovery of celiac disease. The reason for consultation was mainly malabsorption diarrhea (5 cases). The physical examination found a syndrome of portal hypertension in 3 cases and is normal in 2 cases. In the biology, there was anemia in 4 cases including one case of pan cytopenia, one hepatic cytolysis in 4 cases. The abdominal ultrasound showed a chronic hepatic appearance ± sign of HTP in 4 cases and normal in one case. The etiological balance of cytolysis was negative (B, C, autoimm, overload). Upper digestive endoscopy showed a rarefaction of duodenal folds in 3 cases, with signs of HTP in all patients. The histopathological study of the biopsies showed intraepithelial lymphocytosis> 30% with villous atrophy in all patients. Anti transglutaminase antibodies were positive in 04 patients and negative in 01 cases. The liver biopsy puncture, showed severe fibrosis (F3) in 03 cases and cirrhosis (F4) in 2 cases. All our patients are on gluten-free diet, with symptomatic treatment of portal hypertension. The evolution was marked by a stabilization of chronic liver disease and its complications. One case presented ascitic decompensation for poor compliance with the gluten-free diet. No case of CHC has been noted in our series.","PeriodicalId":90808,"journal":{"name":"Clinical research and trials","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67455820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0