Bioresources and Bioprocessing最新文献

{"title":"Improving recombinant protein productivity in CHO cells via multi-omics data integration.","authors":"Yuan Shen, Lei Shi, Xi Zhang, Xiao Guo, Wei-Hua Dong, Tian-Yun Wang","doi":"10.1186/s40643-026-01123-3","DOIUrl":"10.1186/s40643-026-01123-3","url":null,"abstract":"<p><p>Chinese hamster ovary (CHO) cells represent the dominant host system for the production of recombinant therapeutic proteins. In recent decades, extensive research has focused on process/media optimization and cell line engineering to improve both the productivity and quality of biopharmaceutical proteins produced in CHO cells. Nevertheless, the inherent complexity of biological pathways and the heterogeneous cellular responses to different environmental conditions have posed substantial challenges to traditional methodologies. Recent advances in omics technologies have enabled comprehensive characterization of CHO cell physiology, providing multidimensional molecular and phenotypic insights that facilitate the enhancement of recombinant protein production. This review first summarizes the methodologies and advances in CHO omics research, including genomics, transcriptomics, proteomics, metabolomics, and epigenomics. It then examines contemporary approaches to integrate and analyze multi-omics data in CHO cells. The review further elucidates how these multi-omics datasets can be strategically applied across various developmental stages, including cell line selection, genetic engineering, expression vector design, and bioprocess optimization. Finally, we explore the transformative potential of integrating multi-omics with artificial intelligence and discuss promising future research directions in CHO cell studies. These emerging paradigms offer novel opportunities for data-driven cell engineering and bioprocess optimization in CHO-based biomanufacturing.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into volatile flavoromics and microbiomics for sensory quality improvement of flue-cured tobacco leaves fermented with Bacillus subtilis DB-15.","authors":"Yanxu Guo, Junxi Wang, Guiyuan Huang, Ningning Hou, Haiyang Pan, Wei Ding","doi":"10.1186/s40643-026-01124-2","DOIUrl":"10.1186/s40643-026-01124-2","url":null,"abstract":"<p><p>Low-quality tobacco leaves generally exhibit undesirable sensory characteristics due to excessive macromolecule accumulation and insufficient aroma release. Fermentation with functional microorganisms to improve tobacco quality is a green and efficient strategy. This study employed volatile flavoromics and microbiomics to investigate the flavor basis and underlying microbial regulatory mechanism for quality improvement by Bacillus subtilis DB-15. Results showed that B. subtilis DB-15 fermentation significantly degraded starch, protein, and cellulose, and comprehensively enhanced sensory quality by increasing aroma and sweetness while reducing irritation and off-flavors. Subsequently, a total of 94 volatile compounds were identified by HS-SPME-GC-MS. B. subtilis DB-15 promoted the enrichment of esters and heterocycles, and inhibited harmful substances such as short-chain fatty acids and nicotine. Microbiomics analysis indicated that inoculated B. subtilis DB-15 dominated the bacterial community and reshaped its structure, whereas fungal community succession was mainly driven by water addition rather than Bacillus inoculation. Functional prediction suggested a higher relative abundance of bacterial pathways related to carbohydrate and amino acid metabolism in the Bacillus inoculation group, whereas pathways related to terpenoid and polyketide metabolism showed lower predicted abundances. Correlation network analysis showed that Bacillus was positively correlated with sweet and fruity aroma compounds but negatively correlated with irritant acids, suggesting a potential contribution to improved sensory coordination. This study reveals the mechanism of sensory improvement by B. subtilis DB-15 fermentation from dual-omics perspective, providing a reliable technical strategy for upgrading low-quality tobacco resources.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-retention for lipid production in continuous Schizochytrium limacinum SR21 cultures fed with dark fermentation effluent.","authors":"Simon Täuber, Leonie Ackermann, Henry Schittkowski, Peter Neubauer, Stefan Junne","doi":"10.1186/s40643-026-01120-6","DOIUrl":"10.1186/s40643-026-01120-6","url":null,"abstract":"<p><p>The marine protist Schizochytrium limacinum SR21 is a promising producer of docosahexaenoic acid (DHA) from short-chain carboxylic acids (SCCAs). Dark fermentation effluent (DFE) is an SCCA- and nutrient-rich substrate derived from biogenic residues and has previously been evaluated for microbial lipid production. However, its low carbon concentration limits volumetric productivity and causes substantial culture dilution when larger feed volumes are required. Membrane-based cell retention is an established process intensification strategy for low-concentration feed solutions, as it decouples hydraulic residence time from biomass residence time. However, the combination of DFE utilisation and cell retention for DHA production by S. limacinum has received little attention. In this study, repeated fed-batch and cell retention strategies were evaluated to overcome dilution limitations and enable intensified biomass and lipid production from DFE. Additional cultivations with defined SCCA mixtures showed preferential uptake of acetate and butyrate over propionate and lactate, which was also observed during DFE conversion. In repeated fed-batch operation, biomass output reached 7.5 g after 95 h. In contrast, a final biomass output of 33 g was achieved in cell retention mode, representing a 4.4-fold increase. This improvement was not associated with enhanced substrate conversion efficiency but resulted from retaining biomass while increasing DFE throughput. While applying cell retention, the specific palmitic acid concentration increased to 116 mg g⁻¹, while DHA remained comparatively stable at 57 mg g⁻¹. This resulted in a DHA titre of 1.9 g L⁻¹ compared with 0.24 g L⁻¹ in repeated fed-batch. Nitrogen and phosphate removal reached 58% and 87%, respectively. However, the relatively high nutrient content of DFE limited the establishment of strong nitrogen limitation. Overall, cell retention enabled process intensification with a total lipid space-time yield of 0.07 g_lipids L⁻¹ h⁻¹ and a DHA space-time yield of 19.7 mg L⁻¹ h⁻¹. The results demonstrate that cell retention is an effective strategy for valorising low-concentration DFE while operational boundaries for DFE-based DHA production are identified.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variable-specific preprocessing enables cross-scale transferable Raman models from high-throughput bioreactor data.","authors":"Sung-Hyuk Han, Jiyun Park, Kwang-Bae Lee, Cheol-Hwan Park, Dong-Yup Lee","doi":"10.1186/s40643-026-01105-5","DOIUrl":"10.1186/s40643-026-01105-5","url":null,"abstract":"<p><p>Raman spectroscopy is increasingly used as a process analytical technology (PAT) for real-time monitoring of bioprocesses. However, chemometric models developed using high-throughput (HT) mini-bioreactor systems often show limited predictive performance when applied to larger-scale processes, reflecting an out-of-distribution (OOD) challenge in cross-scale model transfer. In this study, we investigated whether variable-specific data preprocessing strategies can improve the cross-scale prediction performance of Raman chemometric models calibrated using HT cell culture data. Multiple preprocessing approaches were systematically evaluated for key cell culture target outputs, and the optimal preprocessing pipeline for each output was selected based on its ability to minimize cross-scale prediction error. The optimized variable-specific preprocessing pipelines reduced cross-scale prediction errors by 14.0-56.1% in RMSEP across the five initially poorly transferable target outputs compared with the standard single-scale preprocessing pipeline. Consequently, these optimized single-scale models achieved predictive accuracy approaching that of resource-intensive combined-scale models. Importantly, the improvement was not dependent on a specific preprocessing technique but rather on selecting preprocessing strategies suited to the spectral characteristics of each target output. These findings suggest that intelligent preprocessing selection can mitigate out-of-distribution effects in Raman chemometric models and enable more reliable prediction across scales using HT datasets for model calibration. This approach highlights the potential of Raman spectroscopy as a practical and scalable PAT tool for industrial bioprocess development.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico study of active phytochemicals and molecular mechanism of Hydrocotyle javanica Thunb.in treating MDR enterobacterial infection.","authors":"Debasmita Paul, Megha Ghosh, Manab Mandal","doi":"10.1186/s40643-026-01078-5","DOIUrl":"https://doi.org/10.1186/s40643-026-01078-5","url":null,"abstract":"<p><p>Enterobacterial infections being severe, with a high mortality rate, particularly affecting ICU patients, and 80% newborns. These infections have multifactorial multi-drug resistance (MDR) mechanisms, which frequently causes current antibiotic therapies to fail, mortality rate remains high, and creating an urgent need for alternative multi-targeted therapies, such as plant-derived compounds to restore clinical effectiveness. This study aims to discover novel anti enteric compounds in Hydrocotyle javanica Thunb. (H. javanica) belongs to Apiaceae family and understanding their interaction mechanism with enterobacterial infection targeted genes, using network pharmacology with in-silico docking and molecular dynamics simulation approaches. Four bioactive compounds as tetracosanoic acid, alpha-Amyrenyl acetate, stigmasterol glucoside, stigmasterol were identified as potential therapeutic agents. Most of the compounds exhibited favourable pharmacokinetic properties, complying with Lipinski's rule, with high bioavailability score 0.85 and non-toxic profiles. In-silico antibacterial prediction indicated both bacterial and bacteriostatic activities. A total of 53 common targets were identified with network analysis revealing key hub genes including HSD11B1, PTGS2,FDFT1,CYPHA1, and AKR1C2. Functional enrichment analysis showed significant involvement in immune and inflammatory pathways, particularly calcium signaling, MAPK signaling and reactive oxygen species related pathways. The docking result showed highest binding affinity, with stigmasterol showing highest score (-10.7 kcal/mol). A 100 ns molecular dynamics simulation further confirmed the stability of the stigmasterol-protein complex, with stable RMSD values 1-2 Å, low RMSF fluctuations and consistent hydrogen bonding, indicating sustained structural integrity. The present study highlights that phytocompounds from Hydrocotyle javanica exhibit significant binding affinity toward key enterobacterial targets, along with favorable ADME and toxicity profiles. These findings suggest their potential as promising lead molecules for anti-enterobacterial drug development, warranting further experimental validation.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of microbial inoculants, cellulase, and sodium diacetate on fermentation profiles, bacterial succession, and predicted functional profiles of alfalfa silage.","authors":"Yanfen Li, Lizhuang Wu, Xaysana Panyavong, Jonggeun Kim","doi":"10.1186/s40643-026-01104-6","DOIUrl":"10.1186/s40643-026-01104-6","url":null,"abstract":"<p><p>Alfalfa is a high-protein forage crop widely used in ruminant production, yet its ensiling is generally challenged by low water-soluble carbohydrate content and high buffering capacity. This study systematically evaluated the effects of microbial inoculants, cellulase, and sodium diacetate on fermentation quality, microbial succession, and predicted metabolic functions of alfalfa silage using fermentation analyses and 16S rRNA sequencing. Lactic acid was detected only in the microbial inoculant-treated silages on day 1, accompanied by a rapid decline in pH below 5.8 (p < 0.05). After 60 days, all microbial inoculants except BSM lowered pH below 4.5 and reduced ammonia nitrogen (NH₃-N) (p < 0.05), while promoting Lactiplantibacillus- or Pediococcus-dominated communities and suppressing Enterobacter and Serratia (p < 0.05). Predicted functional profiles suggested lower lysine degradation and enhanced lysine biosynthesis. Among inoculants, KL yielded the most favorable profile, with the highest Lactiplantibacillus abundance (78.23%), lower gas loss, Chao1, Shannon, and NH₃-N (4.35% total nitrogen (TN)). Cellulase improved fermentation quality compared with the control and displayed the lowest fiber content, but showed slower early acidification, resulting in higher NH₃-N (6.46% TN), gas loss, and Enterobacter abundance (2.94%) after 60 days (p < 0.05). Sodium diacetate followed a distinct pathway, producing acetic acid (1.32% dry matter (DM)) rather than lactic acid on day 1 and reducing pH to 5.58. After 60 days, sodium diacetate produced well-preserved silage with a lower pH (4.28), NH₃-N (3.72% TN), and gas loss, higher lactic acid concentration (6.93% DM) (p < 0.05), and Lactiplantibacillus-dominated bacterial community. These findings highlight that silage additives govern fermentation outcomes through distinct mechanisms, with the KL inoculant and sodium diacetate providing the most effective preservation strategies in this study.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-scale characterization and mechanistic comparison of acid-alkali pretreatment during cell wall deconstruction of Achnatherum splendens.","authors":"Zhennan He, Guolin Yang, Siyi Wang, Yuanyuan Jing, Fengqin Gao","doi":"10.1186/s40643-026-01097-2","DOIUrl":"https://doi.org/10.1186/s40643-026-01097-2","url":null,"abstract":"<p><p>Achnatherum splendens was used as a high-lignin herbaceous feedstock to compare the effects of dilute sulfuric acid and sodium hydroxide pretreatments on component degradation and cell wall structure. Chemical composition analysis, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) were used for multi-scale characterization. The results showed that dilute sulfuric acid pretreatment mainly promoted hemicellulose degradation, with a hemicellulose degradation rate of 79.2% under 1.5% H₂SO₄, while lignin dissolution remained limited at 20.5%. In contrast, NaOH pretreatment showed stronger lignin removal and fiber separation, with lignin dissolution increasing to 44.8% at 4% NaOH. Both pretreatments increased cellulose crystallinity from 47.0% to between 53.4 and 60.8%, whereas crystallite size showed no significant change, indicating that the crystalline cellulose domains were largely preserved. FTIR results showed spectral inconsistencies after acid treatment, including increased absorbance at 1510 cm^-1 and limited reduction at 1730 cm^-1, which may be associated with pseudo-lignin-related interference. SEM observations showed that acid treatment generated pores and cracks, whereas alkali treatment resulted in more obvious fiber bundle separation and surface cleaning. These results indicate that acid and alkali pretreatments have complementary effects on the deconstruction of Achnatherum splendens. The findings provide structural-level evidence for pretreatment selection and optimization of high-lignin energy grasses.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13486453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous removal of methylene blue and Cd(II) by pecan shell-based activated carbon: adsorption kinetics, isotherms, and physicochemical characterization.","authors":"Jae-Hyeok Lee, Jae-Wook Lee, Sung-Hee Roh","doi":"10.1186/s40643-026-01117-1","DOIUrl":"https://doi.org/10.1186/s40643-026-01117-1","url":null,"abstract":"<p><p>The coexistence of organic dyes and heavy metals in wastewater requires efficient and sustainable adsorbents capable of simultaneous contaminant removal. In this study, pecan shell-based activated carbons (PSC-0-PSC-3) were prepared by KOH activation using different impregnation ratios; their physicochemical properties and adsorption performance toward methylene blue (MB) and Cd(II) were systematically investigated under single- and binary-component systems. Among the prepared adsorbents, PSC-3 exhibited the highest BET specific surface area (2857 m² g^-1) and total pore volume (1.61 cm³ g^-1). MB adsorption was best described by the Freundlich isotherm model (R² = 0.998), indicating heterogeneous adsorption behavior. The Langmuir model estimated a maximum adsorption capacity of 529.5 mg g^-1. Under binary-component conditions, PSC-3 achieved nearly complete MB removal (≈ 100%), whereas Cd(II) removal was strongly dependent on solution pH and adsorbent dosage. The adsorption of Cd(II) was primarily governed by electrostatic attraction and surface complexation with oxygen-containing functional groups. Adsorption-desorption experiments demonstrated that PSC-3 retained approximately 85% and 80% of its initial adsorption efficiency for MB and Cd(II), respectively, after five regeneration cycles, indicating good reusability. These findings demonstrate that PSC-3 is a low-cost, sustainable, and highly efficient adsorbent with strong potential for the simultaneous removal of organic dyes and heavy metal ions from mixed wastewater.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced heparosan biosynthesis in Corynebacterium glutamicum by systematic metabolic engineering and translation-level fine-tuning.","authors":"Jie Zhang, Yanan Cui, Peiyi Zhang, Mengqi Zhao, Liqiang Fan, Xu Li, Chen Deng, Liming Zhao","doi":"10.1186/s40643-026-01113-5","DOIUrl":"10.1186/s40643-026-01113-5","url":null,"abstract":"<p><p>As a widely used anticoagulant, heparin is industrially produced chiefly via animal tissue extraction, which suffers from unstable supply and potential safety hazards. Heparosan shares a similar polysaccharide backbone with heparin and can be converted into heparin under mild enzymatic catalysis. In addition, heparosan exhibits favorable biocompatibility and non-immunogenicity, rendering its efficient, eco-friendly biosynthesis essential. In this study, we systematically engineered Corynebacterium glutamicum, a Generally Recognized as Safe (GRAS) microorganism, to synthesize heparosan via two complementary strategies. First, genome-scale modification was implemented to stably upregulate genes ugd, glmS, and ndk. The heparosan titer of recombinant strain Cg24 increased from 226.37 to 595.39 mg/L. Second, translation-level fine-tuning was implemented to modulate expression of individual genes within the kfiB-kfiC-kfiA cassette by constructing a high-coverage random ribosome binding site (RBS) library, which further lifted heparosan titer to 1161.37 mg/L. In fed-batch fermentation using a 5 L bioreactor with a two-stage growth-production regulation strategy, the recombinant strain Cg24-11 produced 5.36 g/L of heparosan, demonstrating its great potential for efficient heparosan biosynthesis. This combined modification strategy also provides valuable references for constructing high-efficiency cell factories for other complex compounds.</p>","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Grey-box modeling framework for consolidated bioprocessing systems: an endpoint-guided approach.","authors":"Mark Korang Yeboah, Dirk Söffker","doi":"10.1186/s40643-026-01108-2","DOIUrl":"10.1186/s40643-026-01108-2","url":null,"abstract":"","PeriodicalId":9067,"journal":{"name":"Bioresources and Bioprocessing","volume":"13 1","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}