BMC Geriatrics最新文献

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New indicators related to the osteosarcopenia in the elderly: assessment of intrinsic capacity. 与老年人骨骼肌减少症相关的新指标:内在能力评估。
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-29 DOI: 10.1186/s12877-025-06424-4
Xiuqi Qiao, Lina Zhang, Fuli Man, Weihao Wang, Lixin Guo, Qi Pan
{"title":"New indicators related to the osteosarcopenia in the elderly: assessment of intrinsic capacity.","authors":"Xiuqi Qiao, Lina Zhang, Fuli Man, Weihao Wang, Lixin Guo, Qi Pan","doi":"10.1186/s12877-025-06424-4","DOIUrl":"10.1186/s12877-025-06424-4","url":null,"abstract":"","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"737"},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring long-term recovery and community health management: a qualitative study of older adults and caregivers' experiences post COVID-19 in the Republic of Ireland. 探索长期康复和社区卫生管理:爱尔兰共和国老年人和护理人员在COVID-19后经历的定性研究
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-29 DOI: 10.1186/s12877-025-06368-9
Aoife McCarthy, Rose Galvin, Frances Dockery, Margaret O'Connor, Antonella Milos, Collette Devlin, Elaine Conway, Leonora Carey, Miriam Haaksma, Audrey Tierney, Katie Robinson
{"title":"Exploring long-term recovery and community health management: a qualitative study of older adults and caregivers' experiences post COVID-19 in the Republic of Ireland.","authors":"Aoife McCarthy, Rose Galvin, Frances Dockery, Margaret O'Connor, Antonella Milos, Collette Devlin, Elaine Conway, Leonora Carey, Miriam Haaksma, Audrey Tierney, Katie Robinson","doi":"10.1186/s12877-025-06368-9","DOIUrl":"10.1186/s12877-025-06368-9","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 remains a significant threat to older adults, who continue to be the primary drivers of COVID-19-related hospitalizations. Older adults face long-term risks of death and adverse health outcomes following hospitalisation for COVID-19. This study aimed to explore older adults' and their caregivers long-term experience of recovery from COVID-19 following inpatient geriatric rehabilitation.</p><p><strong>Methods: </strong>A qualitative descriptive study design was adopted. The COnsolidated criteria for REporting Qualitative research' were used to guide conduct and reporting of the study. A purposive and convenience sampling method was used to recruit participants.</p><p><strong>Results: </strong>Eight older adults (mean age = 83, SD = 8) and 6 caregivers were recruited (5 family caregivers and 1 formal caregiver). Mean time since hospitalisation for COVID-19 was 2.93 years (SD = 0.31 years). Data were analysed using a reflexive approach to thematic analysis. Three themes were identified. The first, \"Health and Function Changes: Unravelling the Impact of COVID-19 and Aging\", describes the challenges of distinguishing the long-term effects of COVID-19 from age related changes. The second theme, \"COVID-19: Left a Few Marks,\" highlights the enduring negative impacts of the virus on health and well-being. Finally, \"Enablers of Recovery\" describes how formal and informal caregivers, access to appropriate healthcare services, equipment and environmental adaptations, and primary care services support recovery and functional improvement.</p><p><strong>Conclusion: </strong>Older adults report their recovery from COVID-19 infection but note significant long-term effects on their health and well-being resulting in an increased need for formal and informal supports in the community.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"736"},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between preoperative geriatric nutritional risk index and major adverse cardiovascular and cerebrovascular events after non-cardiac surgery in older patients: a retrospective cohort study. 老年患者术前营养风险指数与非心脏手术后主要心脑血管不良事件的相关性:一项回顾性队列研究
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-29 DOI: 10.1186/s12877-025-06399-2
Zhisen Dai, Yanlin Wu, Huaqing Huang, Junheng Chen, Hui Jiang, Ying Wang, Huizhe Zheng
{"title":"Association between preoperative geriatric nutritional risk index and major adverse cardiovascular and cerebrovascular events after non-cardiac surgery in older patients: a retrospective cohort study.","authors":"Zhisen Dai, Yanlin Wu, Huaqing Huang, Junheng Chen, Hui Jiang, Ying Wang, Huizhe Zheng","doi":"10.1186/s12877-025-06399-2","DOIUrl":"10.1186/s12877-025-06399-2","url":null,"abstract":"","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"741"},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential dementia risks of motoric cognitive risk syndrome and mild cognitive impairment among older adults in China: a 7-year cohort study. 中国老年人运动认知风险综合征和轻度认知障碍的痴呆风险差异:一项为期7年的队列研究
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-29 DOI: 10.1186/s12877-025-06432-4
Bochao Niu, Dan Chen, Zhezhe Niu, Jian Wang
{"title":"Differential dementia risks of motoric cognitive risk syndrome and mild cognitive impairment among older adults in China: a 7-year cohort study.","authors":"Bochao Niu, Dan Chen, Zhezhe Niu, Jian Wang","doi":"10.1186/s12877-025-06432-4","DOIUrl":"10.1186/s12877-025-06432-4","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) and motoric cognitive risk syndrome (MCR) are two pre-dementia stages, which may exist independently or concurrently, and both increase the risk of dementia. The association between MCI, MCR, and their co-occurrence with dementia risk in the elderly Chinese population remains unclear.</p><p><strong>Objective: </strong>This study aims to explore the relationship of MCI, MCR, and their co-occurrence with the incidence of dementia among the elderly population in China, based on a nationwide large-scale survey.</p><p><strong>Methods: </strong>A total of 2,411 elderly individuals from the China Health and Retirement Longitudinal Study (CHARLS) were included in this study. At baseline in 2011, all eligible participants were categorized into four groups: CHI (cognitively healthy individuals) group, MCI (individuals with MCI alone) group, MCR (individuals with MCR alone) group, and MCI + MCR (individuals with both MCI and MCR) group. After a 7-year follow-up, logistic regression models were used to analyze the longitudinal association between pre-dementia stages and the onset of dementia.</p><p><strong>Results: </strong>At baseline, the prevalence rates were 14.5% for MCI group, 9.8% for MCR group, and 2.2% for MCI + MCR group. The median total cognitive scores at baseline were 16 points for both CHI group and MCR group, 9 points for MCI group, and 8.7 points for MCI + MCR group (P < 0.001). After 7 years of follow-up, the cognitive scores remained unchanged in MCI group, decreased by 1 point in both the CHI group and MCI + MCR group, and decreased by 2 points in MCR group (P < 0.001). The 7-year dementia incidence was 4.8%. Multivariate logistic regression model showed that the risk of dementia was significantly associated with MCI (OR = 2.319, 95%CI:1.420-3.785, P < 0.001), MCR (OR = 2.488, 95%CI:1.441-4.294, P = 0.001), and MCI + MCR (OR = 3.226, 95% CI:1.340-7.762, P = 0.009).</p><p><strong>Conclusion: </strong>Both MCI and MCR were associated with an increased risk of dementia, and the co-occurrence of MCI and MCR conferred a higher risk of dementia. Although the MCR group showed no significant baseline cognitive impairment, their subsequent cognitive decline and dementia risk were higher than those of the MCI group. Therefore, promoting MCR screening in China's primary healthcare system may be more feasible than MCI screening, which could help in early identification of high-risk populations and the implementation of targeted interventions to delay or prevent the onset of dementia.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"746"},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Community dwelling older adults' decision to, and experience of attending the Emergency Department during COVID-19: a qualitative study. 社区居住老年人在COVID-19期间就诊急诊的决定和经历:一项定性研究
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-26 DOI: 10.1186/s12877-025-06401-x
Siobhán Ryan, Louise Barry, Christine Fitzgerald, Rose Galvin, Owen Doody
{"title":"Community dwelling older adults' decision to, and experience of attending the Emergency Department during COVID-19: a qualitative study.","authors":"Siobhán Ryan, Louise Barry, Christine Fitzgerald, Rose Galvin, Owen Doody","doi":"10.1186/s12877-025-06401-x","DOIUrl":"10.1186/s12877-025-06401-x","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic resulted in a decrease in emergency department (ED) visits, particularly among older adults. The objective of this study is to explore the experiences of older adults attending the ED during COVID-19.</p><p><strong>Methods: </strong>The study utilised a qualitative descriptive approach as part of a larger mixed-methods study. Data were collected at five different ED's in Ireland, which represented both urban and rural populations. The participants were all aged over 65 years. Semi-structured phone interviews were conducted up to 10 days after attending the ED and the interviews were audio-recorded. The interviews were transcribed and imported to NVivo software, and the data was analysed using reflexive thematic analysis.</p><p><strong>Results: </strong>16 interviews were conducted with older adults over 65 years. Three themes were generated following thematic analysis: Complexity of decision making regarding the ED attendance (theme 1), Quality and timeliness of care in the ED (theme 2), Communication with and empathy towards healthcare staff in the ED (theme 3). The COVID-19 pandemic had a significant impact on the decision-making process and pathway for older adults seeking emergency medical care. Despite the challenges, older adults reported a positive experience in the ED. This was attributed to improved conditions, including shorter triage waiting times and the implementation of COVID-19 protocols. Participants demonstrated resilience and expressed gratitude for the care they received. However, for some participants it was noted there was a reluctance to express any dissatisfaction or complain about the care they received while in the ED. The study also highlighted concerns regarding discharge information and follow-up care for the older adult.</p><p><strong>Conclusion: </strong>The findings demonstrate that ED healthcare providers provided quality and timely care to older adults in the ED during COVID-19. However, the need for clear communication and information sharing from healthcare providers on ED discharge and across transitions of care was highlighted as an area needing improvement.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"714"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal association between body mass index and handgrip strength in community-dwelling older adults: a population-based nationwide cohort study. 社区居住老年人体重指数和握力的纵向关联:一项基于人群的全国队列研究。
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-26 DOI: 10.1186/s12877-025-06366-x
Haixia Xiao, Shan Huang, Huanshun Xiao, Wenni Zhang, Shuangming Cai
{"title":"Longitudinal association between body mass index and handgrip strength in community-dwelling older adults: a population-based nationwide cohort study.","authors":"Haixia Xiao, Shan Huang, Huanshun Xiao, Wenni Zhang, Shuangming Cai","doi":"10.1186/s12877-025-06366-x","DOIUrl":"10.1186/s12877-025-06366-x","url":null,"abstract":"","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"711"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A machine learning-based fall-risk score for severity of fall-related adverse outcomes in community older adults. 基于机器学习的社区老年人跌倒相关不良后果严重程度的跌倒风险评分。
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-26 DOI: 10.1186/s12877-025-06371-0
Huihe Chen, Tongsheng Ling, Lanhui Huang, Ling Wang, Xuehai Guan, Ming Gao, Zhao Wang, Wei Lan, Jian-Wen Xu, Zhuxin Wei
{"title":"A machine learning-based fall-risk score for severity of fall-related adverse outcomes in community older adults.","authors":"Huihe Chen, Tongsheng Ling, Lanhui Huang, Ling Wang, Xuehai Guan, Ming Gao, Zhao Wang, Wei Lan, Jian-Wen Xu, Zhuxin Wei","doi":"10.1186/s12877-025-06371-0","DOIUrl":"10.1186/s12877-025-06371-0","url":null,"abstract":"<p><strong>Background: </strong>Models that detect fall risk have been proposed. However, the value of an indicator derived from such models in fall-severity stratification is understudied. This study developed a machine learning (ML)-based fall classification model, constructed a fall-risk score, and explored its association with fall-related adverse outcomes.</p><p><strong>Methods: </strong>We used the eXtreme Gradient Boosting algorithm to build a fall classification model using data from 15,457 community-dwelling adults aged 60 Years and older. Of the 216 fall-associated variables, the 15 most important variables were selected for modelling, and their directional relationships with falls were evaluated using the SHapley Additive exPlanation (SHAP) value. An ML-based fall-risk score (ML-FRS) was generated. Multilevel regression analysis was used to measure the associations between the ML-FRS and fall-related adverse outcomes, defined as recurrent falls or falls requiring treatment, in a subset of 3,514 participants.</p><p><strong>Results: </strong>Participants had a mean age of 85.4 Years, with 56.3% being women, and a 22.5% prevalence of a fall history. Women and older participants were more Likely to fall and experience fall-related adverse outcomes. Inability to stand up from sitting in a chair was the most important predictor of increased fall risk. A small calf circumference and a low plant-based diet score were associated with increased fall risk. The ML-based model had an area under the curve of 0.797. Compared with non-fallers, participants in the highest ML-FRS quartile had a significantly higher risk of one fall without treatment, recurrent falls without treatment, one fall with treatment, and recurrent falls with treatment.</p><p><strong>Conclusions: </strong>The ML-FRS could be used to screen for fall risk and fall-related adverse outcomes in community-dwelling older adults.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"724"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-friendly hospitals: a concept analysis. 老年人友好型医院:概念分析。
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-26 DOI: 10.1186/s12877-025-06400-y
Bingjie Fan, Meng Wang, MengJiao Chen, Huiyun Luo, Xiaoyi Wang, Yeqin Yang
{"title":"Age-friendly hospitals: a concept analysis.","authors":"Bingjie Fan, Meng Wang, MengJiao Chen, Huiyun Luo, Xiaoyi Wang, Yeqin Yang","doi":"10.1186/s12877-025-06400-y","DOIUrl":"10.1186/s12877-025-06400-y","url":null,"abstract":"<p><strong>Background: </strong>In light of the growing ageing population, the World Health Organization called for special attention to the age-friendliness of hospitals. Despite the concept of 'age-friendly hospitals' promising to enhance health care, there is no consensus within the field regarding its definition. The aim of this concept analysis was to clarify the attributes, antecedents, and consequences of age-friendly hospitals, thereby fostering a deeper understanding of the concept.</p><p><strong>Methods: </strong>Walker and Avant's eight-step concept analysis method was employed. A systematic review of the Literature on age-friendly hospital settings was conducted across 11 electronic databases, including PubMed, Scopus, Web of Science, CINAHL (EBSCO), Cochrane Library, Embase, CNKI, Wanfang Data, VIP Database, Airiti Library, and SinoMed. The original search covered publications from each database's inception to November 2022. An updated search (December 2023) captured studies published after the initial search and up to December 2023, with duplicates excluded. Two researchers independently screened the literature and cross-checked it against the inclusion and exclusion criteria. A qualitative content analysis was conducted for data synthesis.</p><p><strong>Results: </strong>A total of 5,489 records were identified through the initial and updated searches. After removing duplicates and screening titles and abstracts, 56 articles were included in the final analysis. The defining attributes of age-friendly hospitals were identified as adapting to the developmental needs, promoting the autonomy and engagement, and a sense of ease and burden-free for older adults. Antecedents included recognizing the unique needs of older adults, a discrepancy between needs and hospital services, and a transformation of health care. The consequences of implementing age-friendly hospitals can be categorized into three themes: promoting the health, function, and well-being of older adults, improving satisfaction with the hospital experience, and advancing levels of hospital services.</p><p><strong>Conclusions: </strong>By providing a clear understanding of what an age-friendly hospital entails, our theoretical definition allows for a more systematic approach to evaluating and improving hospital facilities for older adults. The theoretical definition proposed in this paper can be used as a starting point for operationalizing the concept, which will facilitate the optimization of future age-friendly hospital standards and the development of empirical studies.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"726"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mediating effect of activities of daily living (ADL) disability on the association between depressive symptoms and cognitive impairment in older adults: a National study. 日常生活活动障碍在老年人抑郁症状与认知障碍之间的中介作用:一项全国性研究。
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-26 DOI: 10.1186/s12877-025-06380-z
Xuemei Yao, Dognfang Han, Qinrui Lu
{"title":"The mediating effect of activities of daily living (ADL) disability on the association between depressive symptoms and cognitive impairment in older adults: a National study.","authors":"Xuemei Yao, Dognfang Han, Qinrui Lu","doi":"10.1186/s12877-025-06380-z","DOIUrl":"10.1186/s12877-025-06380-z","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have demonstrated a correlation between depressive symptoms and a higher likelihood of cognitive impairment among older adults. Little is known about the underlying pathway connecting these two conditions.</p><p><strong>Objective: </strong>This study aimed to investigate whether activities of daily living (ADL) disability potentially mediate the relationship between depressive symptoms and cognitive function.</p><p><strong>Methods: </strong>This study is a cross-sectional design. A total of 6623 Chinese older adults aged 65 years and above from the 2018 China Longitudinal Healthy Longevity Survey (CLHLS) were included in this study. Multiple linear regression was conducted to examine the relationships among depressive symptoms, ADL disability and cognitive function, while accounting for all confounding factors. Mediation analyses were performed to examine whether ADL disability mediated the relationship between depressive symptoms and cognitive function via PROCESS macro version 4.0.</p><p><strong>Results: </strong>The results indicated that the relationship between depressive symptoms and cognitive function was significantly mediated by ADL disability (estimated indirect effect = -0.040, bootstrapped SE = 0.020, bootstrapped standard 95% CI= -0.083 - -0.007), with ADL disability accounting for 7.5% of the total effect. Moreover, the mediating role of ADL disability was moderated by gender, as the interaction between depressive symptoms and gender on ADL disability was found to be significant (β=-0.102, p = 0.033, IMM: 0.005, 95%CI: 0.001-0.011). When stratified by gender, the mediating effect of ADL disability was observed exclusively in males (estimated indirect effect= -0.055, bootstrapped SE = 0.031, bootstrapped standard 95% CI= -0.123 - -0.004), with a relative proportion of 9.7%.</p><p><strong>Limitations: </strong>The causal relationship was not able to certain because of the cross-sectional design.</p><p><strong>Conclusion: </strong>This study revealed that ADL disability may partially mediate the relationship between depressive symptoms and cognitive function in older adults. Furthermore, the mediating effect of ADL disability was moderated by gender, and the effect was observed exclusively in males when analyzed hierarchically.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"713"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mediating role of possible sarcopenia in the association between diabetes and stroke: finding from the China health and retirement longitudinal study. 肌肉减少症在糖尿病和脑卒中之间的中介作用:来自中国健康和退休纵向研究的发现。
IF 3.8 2区 医学
BMC Geriatrics Pub Date : 2025-09-26 DOI: 10.1186/s12877-025-06378-7
Jing Cai, JingMin Qiao, YiRan Liu, HongYan Li, CaiPing Lu, Ying Gao
{"title":"Mediating role of possible sarcopenia in the association between diabetes and stroke: finding from the China health and retirement longitudinal study.","authors":"Jing Cai, JingMin Qiao, YiRan Liu, HongYan Li, CaiPing Lu, Ying Gao","doi":"10.1186/s12877-025-06378-7","DOIUrl":"10.1186/s12877-025-06378-7","url":null,"abstract":"<p><strong>Background: </strong>Diabetes and sarcopenia were risk factors for the development of stroke. The presence of diabetes increased the likelihood of developing sarcopenia. No prior study has investigated the potential mediating role of sarcopenia in the association between diabetes and stroke risk. In this study, we aimed to explore the mediating effect of possible sarcopenia between diabetes and stroke, utilizing data from China Health and Retirement Longitudinal Study (CHARLS).</p><p><strong>Methods: </strong>In this retrospective cohort study, we included 3,997 individuals aged ≥ 65 years old from CHARLS database of 2015, followed up until 2018. The study outcome was the stroke incident. Possible sarcopenia was defined based on the Asian Working Group on Sarcopenia 2019 criteria: low muscle strength with or without reduced physical performance. The observation period for the outcome event was in 2018, while other baseline data were collected in 2015. The relationship between diabetes, possible sarcopenia and stroke were examined by univariate and multivariate logistic regression models. Distribution-of-product method was used to test the mediating effect. P < 0.05 was considered statistically significant for this study.</p><p><strong>Results: </strong>The incidence of stroke in the studied populations was approximately 7.11%. The result of multivariate logistic regression analysis indicated that diabetes was related to an increased stroke risk [total effect: adjusted odds ratio (OR) = 1.37, 95% confidence interval (CI): 1.04-1.82)], and a higher risk of possible sarcopenia (adjusted OR = 1.21, 95% CI: 1.02-1.43). Additionally, possible sarcopenia was identified as being linked to an associated with stroke risk (adjusted OR = 1.31, 95% CI: 1.01-1.70). Using the distribution-of-product test, a potential mediating effect of possible sarcopenia on the relationship between diabetes and stroke was observed (indirect effect: adjusted OR = 1.062, 95%CI: 1.003-1.156), with a 95% CI for distribution-of-product of 0.060 (95% CI: 0.003-0.145). The percentage of the mediating effect of 5.41%.</p><p><strong>Conclusion: </strong>Possible sarcopenia partially mediates the association between diabetes and stroke. This finding provides evidence underscoring the significance of maintaining and improving stroke by somewhat reducing the risk of possible sarcopenia, particularly in populations with diabetes. Future studies should focus on understanding the mechanisms underlying these associations.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"718"},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12466046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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