BMC Geriatrics最新文献

{"title":"Utilizing machine learning to identify fall predictors in India's aging population: findings from the LASI.","authors":"Mrinmoy Pratim Bharadwaz, Jumi Kalita, Anandita Mitro, Aditi Aditi","doi":"10.1186/s12877-025-05813-z","DOIUrl":"10.1186/s12877-025-05813-z","url":null,"abstract":"<p><strong>Background: </strong>Depression has a detrimental effect on an individual's mental and musculoskeletal strength multiplying the risk of fall incidents. The current study aims to investigate the association between depression and falls in older adults using machine learning (ML) approach and identify its various predictors.</p><p><strong>Methods: </strong>Data for the study was derived from the Longitudinal Ageing Study in India, (LASI) conducted in 2017-18 for people aged 45-years and above. The study was carried out on 44,066 individuals. Depression was measured using the CIDI-SF scale. Bivariate cross-tabulations were used to study the prevalence of falls. And its association with depression and other independent factors were assessed using the novel ML, the Conditional inference trees (CIT) method.</p><p><strong>Results: </strong>Around 10.8 percent of older adults had fall incidents. CIT model predicted region to be a significant predisposing factor for an older adult to experience falls. Multimorbidity, depression, sleep problems, and gender were other prominent factors. The model predicted that, among depressed older adults, falls incidents were around 80 percent higher than non-depressed.</p><p><strong>Conclusions: </strong>An association between falls and depression was observed. Depressive symptoms were associated with an increased risk of falls, even after controlling for other co-factors. The CIT method leveraged us to select the most important variables to predict falls with great precision. To prevent and manage falls among the expanding and diverse older-aged population, a multilevel and cross-sectoral approach is required. Mental health, especially depression, should be dealt with greater precautions. Public health enthusiasts should focus on the physical as well as mental health of the country's older adult population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"181"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability-a cross-sectional study.","authors":"Niklas Löfgren, Lars Berglund, Vilmantas Giedraitis, Kjartan Halvorsen, Erik Rosendahl, Kevin J McKee, Anna Cristina Åberg","doi":"10.1186/s12877-025-05828-6","DOIUrl":"10.1186/s12877-025-05828-6","url":null,"abstract":"<p><strong>Background: </strong>Identifying cognitive impairment at an early stage is important to enable preventive treatment and lifestyle changes. As gait deviations precede cognitive impairment, the aim of this study was to investigate if step parameters during different Timed Up and Go (TUG) conditions could discriminate between people with different cognitive ability.</p><p><strong>Methods: </strong>Participants (N = 304) were divided into the following groups: (1) controls, n = 50, mean age:73, 44% women; (2) Subjective cognitive Impairment (SCI), n = 71, mean age:67, 45% women; (3) Mild Cognitive Impairment (MCI), n = 126, mean age: 73, 42% women; and (4) dementia disorders, n = 57, mean age: 78, 51% women. Participants conducted TUG and two motor-cognitive TUG-conditions: TUG while naming animals (TUGdt-NA) and reciting months in reverse order (TUGdt-MB). Tests were video recorded for data extraction of valid spatiotemporal parameters: step length, step width, step duration, single step duration and double step duration. Step length was investigated with the step length/body height ratio (step length divided by body height). Logistic regression models (adjusted for age, sex and education) investigated associations between step parameters and dichotomous variables of groups adjacent in cognitive ability: dementia disorders vs. MCI, MCI vs. SCI, and SCI vs. controls. Results were presented as standardized odds ratios (sORs), with 95% confidence intervals (CI⁹⁵) and p-values (significance level: p < 0.05). The areas under the Receiver Operating Characteristic curves were presented for the step parameters/conditions with the highest sORs and, where relevant, optimal cutoff values were calculated.</p><p><strong>Results: </strong>Step length showed greatest overall ability to significantly discriminate between adjacent groups (sOR ≤ . 67, CI⁹⁵: .45-.99, p = ≤ . 047) during all group comparisons/conditions except three. The highest sOR for step-length was obtained when discriminating between SCI vs controls during TUGdt-MB (sOR = .51, CI⁹⁵:.29- .87, p = .014), whereby the area under the curve was calculated (c-statistics = .700). The optimal cut-off indicated a step length of less than 32.9% (CI⁹⁵ = 22.1-43.0) of body height to identify SCI compared with controls.</p><p><strong>Conclusions: </strong>The results indicate that step length may be important to assess during TUG, for discrimination between groups with different cognitive ability; and that the presented cut-off has potential to aid early detection of cognitive impairment.</p><p><strong>Trial registration number: </strong>NCT05893524 (retrospectively registered 08/06/23).</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"182"},"PeriodicalIF":3.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adult's acceptance and uptake of referral after screening for cognitive impairment: a cross-sectional study in China.","authors":"Caiyun Tang, Lily Dongxia Xiao, Rong Huang, Ying Hu, Yao Wang","doi":"10.1186/s12877-025-05824-w","DOIUrl":"10.1186/s12877-025-05824-w","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown that the referral situation after cognitive screening is not optimistic. However, little is known about the situation in China. The current study assessed the cognitive function of older adults with an Eight-item Ascertain Dementia (AD8) score of ≥ 2 in a community health center and investigated their willingness to accept referrals.</p><p><strong>Methods: </strong>In our cross-sectional study, a total of 970 participants completed a cognitive screen using AD8. Those with a score of ≥ 2 were further assessed using the Mini-Mental State Examination. Sociodemographic information was collected. The participants were asked to respond to a questionnaire about their acceptance and uptake of referral after screening and their knowledge of cognitive impairment. The data were analyzed using descriptive statistics, the chi-square test, the Mann-Whitney U rank sum test, and binary logistic regression.</p><p><strong>Results: </strong>We screened 140 older adults with cognitive impairment from 970 participants. Among the 140 subjects, 37 (26.43%) indicated a willingness to be referred, and 103 (73.57%) declined to be referred. We investigated the reasons for declining referrals, and 69 (66.99%) indicated that they thought referrals were unnecessary. The knowledge of referrals, attitude toward referrals, and knowledge of cognitive impairment showed significant differences concerning participants' willingness to be referred(all p < 0.01). The participants with high knowledge of cognitive impairment were willing to accept referrals (p = 0.009; OR = 1.305; 95% CI: 1.070-1.591).</p><p><strong>Conclusions: </strong>Chinese older adults with cognitive impairment exhibit a low willingness to be referred. Health education in older adults is needed to raise awareness of cognitive impairment, dementia prevention, treatment, and care.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"178"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falls among geriatric cancer patients: a systematic review and meta-analysis of prevalence and risk across cancer types.","authors":"Doddolla Lingamaiah, Ganesh Bushi, Shilpa Gaidhane, Ashok Kumar Balaraman, G Padmapriya, Irwanjot Kaur, Madan Lal, Suhaib Iqbal, G V Siva Prasad, Atreyi Pramanik, Teena Vishwakarma, Praveen Malik, Promila Sharma, Mahendra Pratap Singh, Ankit Punia, Megha Jagga, Muhammed Shabil, Rachana Mehta, Sanjit Sah, Quazi Syed Zahiruddin","doi":"10.1186/s12877-025-05722-1","DOIUrl":"10.1186/s12877-025-05722-1","url":null,"abstract":"<p><strong>Background: </strong>Falls represent a significant health concern among the older adults, particularly geriatric cancer patients, due to their increased susceptibility from both age-related and cancer treatment-related factors. This systematic review and meta-analysis aimed to synthesize global data on the prevalence and risk of falls in this population to inform targeted fall prevention strategies.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines, we conducted a comprehensive search of PubMed, Embase, and Web of Science up to October 2024. Articles were screened using Nested Knowledge software by two independent reviewers. Eligible studies included those involving geriatric cancer patients aged 60 years or older reporting on fall prevalence. Quality assessment was performed using a modified Newcastle-Ottawa Scale, and meta-analysis was conducted using random-effects models with R software.</p><p><strong>Results: </strong>From 1,365 identified studies, 86 met the inclusion criteria, encompassing 180,974 participants. The pooled prevalence of falls was 24% (95% CI, 20%-28%), with substantial heterogeneity (I² = 100%). Country- and cancer-type-specific analyses revealed variability in fall prevalence, with breast cancer patients showing the highest prevalence. The comparative risk analysis did not show a statistically significant difference in fall risk between cancer patients and non-cancer controls.</p><p><strong>Conclusion: </strong>Falls are a prevalent and concerning issue among geriatric cancer patients, with substantial variability influenced by cancer type and study design. Personalized fall prevention strategies tailored to cancer-specific risk factors are essential. Further research is warranted to explore the complex interplay of cancer treatments, frailty, and fall risk in this vulnerable population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"179"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term mortality impact of postoperative hyperactive delirium in older hip fracture surgery patients.","authors":"Mingyang Sun, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang","doi":"10.1186/s12877-025-05817-9","DOIUrl":"10.1186/s12877-025-05817-9","url":null,"abstract":"<p><strong>Background: </strong>Postoperative hyperactive delirium is a common and serious complication in older patients undergoing surgery, but the association between delirium and mortality remains controversial. Compared to other delirium subtypes, hyperactive delirium is characterized by more overt clinical manifestations, facilitating accurate detection and evaluation. This study aimed to clarify this association by comparing long-term mortality between patients with and without postoperative hyperactive delirium, using propensity score matching for robust analysis.</p><p><strong>Methods: </strong>We conducted a cohort study to evaluate the association between postoperative hyperactive delirium and long-term mortality in older patients undergoing emergency hip fracture surgery. We used the Taiwan National Health Insurance Service database to identify patients aged 65 years or older who underwent emergency hip fracture surgery between 2008 and 2018. The primary outcome was all-cause mortality.</p><p><strong>Results: </strong>A total of 270,437 patients were included in the analysis, with 6,795 patients in the postoperative hyperactive delirium group and 263,642 patients in the no postoperative hyperactive delirium group. After PSM, both groups contained 6,795 patients, ensuring balanced baseline characteristics for comparison. Postoperative hyperactive delirium was an independent risk factor for all-cause death, with an adjusted hazard ratio of 1.62 (95% confidence interval, 1.51-1.74; P < 0.0001) after PSM. Subgroup analysis revealed that older patients with postoperative hyperactive delirium consistently exhibited significantly higher adjusted hazard ratios of all-cause death compared with those without postoperative hyperactive delirium, regardless of age, sex, income levels, or ASA scores. Although the difference in 5-year overall survival between groups (81.7% vs. 89.8%, P < 0.0001) was statistically significant, the high survival rates in both groups suggest a modest absolute clinical impact.</p><p><strong>Conclusion: </strong>Postoperative hyperactive delirium is an independent risk factor for long-term mortality in older patients undergoing emergency hip fracture surgery. While the statistical association is evident, it is important to carefully consider the modest absolute difference in survival rates and its implications for clinical application.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"180"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the cost burden of dietary supplements in older adults: an analysis from the AAA longroad study.","authors":"Sara Baird, Ryan Moran, Sarah Hacker, Dylan Lawton, Linda Hill","doi":"10.1186/s12877-025-05823-x","DOIUrl":"10.1186/s12877-025-05823-x","url":null,"abstract":"<p><strong>Background: </strong>The use of dietary supplements (DS) has steadily increased over the last several decades, particularly among older adults, contributing to the growth of the multibillion-dollar DS industry. The cost of prescription medication is a known contributor to medication nonadherence, yet the cost burden of DS among older adults is not well understood.</p><p><strong>Methods: </strong>Using medication data from the 5-year multicenter longitudinal cohort AAA LongROAD study of older adults who drive, DS were identified and categorized. Cost estimates were based on prices obtained from a popular online marketplace, using dosing and frequency recommendations from the National Institutes of Health Office of Dietary Supplements database. ANOVA was used to explore associations between demographics and DS cost burden.</p><p><strong>Results: </strong>Of the 2,990 participants at baseline, 2068 (69%) followed up through year 5. The number of DS users ranged from 70.4 to 82.7% of the participants from baseline to year 5. Among the 160 supplement formulations identified, 142 (88%) had price data and were included in the analysis. The mean estimated cost of individual supplements ranged from $0.73 to $49.59 per month. The mean monthly cost burden for all older adult participants ranged from $10.23 (SD 14.74) at baseline to $13.14 (SD 16.93) in year 3, with a mean annual cost burden of $142 per participant across all years. The mean monthly cost burden for DS users only ranged from $14.56 (SD 15.59) at baseline, to $16.45 (SD 17.45) in year 3, with a mean annual cost burden of $186 per DS user across all years. Increased spending was associated with female gender, older age, higher income, not working, and being White non-Hispanic.</p><p><strong>Conclusion: </strong>The use of DS is common among older adults. Using conservative estimates of monthly cost, the spending of older adults on DS is high. The real-world impact of DS costs on older adults, such as the impact on the affordability of prescription medication, is a key point for future research.</p><p><strong>Clinical trial number: </strong>Not applicable.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"177"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice of frailty management among clinical nurses: a cross-sectional study.","authors":"Xueyan Huang, Haifang Zhou, Ying Feng, Mengchi Li, Rui Wang, Ge Fang, Lumeng Lu, Jian'ao Chen, Wenhui Jiang","doi":"10.1186/s12877-025-05776-1","DOIUrl":"10.1186/s12877-025-05776-1","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a leading risk factor of falls, incapacitation, functional decline, and even death in aging populations globally. Clinical nurses play pivotal roles in screening, prevention, and intervention to reverse or slow the progression of frailty. The present study aimed to (1) understand the extent and influencing factors of knowledge, attitudes, and practices of clinical nurses for managing frailty, (2) elucidate the relationships of the knowledge, attitudes, and practices of clinical nurses for frailty management.</p><p><strong>Methods: </strong>This cross-sectional study was conducted from March to April 2024 on 524 clinical nurses in a tertiary hospital in Zhejiang Province, China. The survey instruments included a questionnaire inquiring about the knowledge, attitudes, and practices of nurses in terms of frailty management, a demographic data form, and a self-designed frailty educational information questionnaire. Data were analyzed by descriptive statistics, univariate analysis, multiple linear regression, and structural equation modeling.</p><p><strong>Results: </strong>Of 524 nurses, Only 37.2% were rated as good in terms of knowledge, attitude, and practice of frailty management, while 55.7% were rated as moderate. Among them, the proportion of nurses with good knowledge (10.3%) and practical skills (13.4%) is much lower than their attitude (65.3%). Structural equation modeling found that knowledge and attitudes were related to frailty management practices, with significant associations between knowledge and practices(β = 0.499, p < 0.001). Of the total effect size of knowledge influencing practice (total effect = 0.624, 95% CI: 0.455,0.791), approximately 20.0% was mediated by attitudes (indirect effect = 0.125, 95% CI: 0.076,0.187). Multiple linear regression analysis showed that age, organizational support, familiarity with relevant guidelines, familiar with the term frailty, and department all had a significant effect on the total score(adjusted R² = 0.264, p < 0.001).</p><p><strong>Conclusions: </strong>Despite inadequate knowledge and limited experience in frailty management, clinical nurses' attitudes towards frailty management were positive, indicating potential for improvement. The model was useful to explain practices in frailty management, thereby providing a theoretical basis for development of targeted training programs.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"174"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between driving and depression in older adults: findings from an ancillary study of a prospective cohort.","authors":"Edouard Baudouin, R Colle, L Becquemont, E Corruble, E Duron","doi":"10.1186/s12877-025-05826-8","DOIUrl":"10.1186/s12877-025-05826-8","url":null,"abstract":"<p><strong>Background: </strong>Depression is prevalent among older adults, particularly those with somatic comorbidities, and is linked to cognitive decline and reduced quality of life. Driving may act as a protective factor by enhancing cognitive function and social engagement. However, few prospective studies have investigated this association. This study aimed to assess whether driving was associated with a lower risk of new-onset depression and lower antidepressant medication.</p><p><strong>Methods: </strong>This ancillary study of the prospective S.AGES cohort (Sujets AGÉS-Aged Subjects) which included 3,434 participants (mean age 77.6 ± 6.2 years) with somatic comorbidities (chronic pain, type 2 diabetes, or atrial fibrillation) enrolled between 2009 and 2014. Driving status was recorded at baseline, and participants were monitored for 36 months. Depression was measured by the Geriatric Depression Scale (GDS), and antidepressant prescription was recorded at follow-up. Time-to-event analyses were performed on propensity-matched cohorts comparing drivers and non-drivers for new-onset depression (GDS ≥ 5/15) and antidepressant use.</p><p><strong>Results: </strong>In the first cohort (126 drivers and 126 matched non-drivers), drivers had a significantly lower risk of new-onset depression (hazard ratio [HR] = 0.58 [0.40-0.86]). In the second cohort (368 drivers and 368 non-drivers), drivers had a lower risk of antidepressant use (HR = 0.49 [0.29-0.84]).</p><p><strong>Discussion: </strong>Driving at baseline was associated with a reduced risk of depression and antidepressant prescription in older adults with somatic comorbidities, highlighting the potential importance of maintaining mobility and driving to support mental health in this population.</p><p><strong>Trial registration: </strong>The study was registered at ClinicalTrials.gov NCT01065909 with a first registration date of February 8, 2010.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"173"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated factors of frailty among community-dwelling older adults with multimorbidity from a health ecological perspective: a cross-sectional study.","authors":"Yunqiu Che, Hanjia Xin, Yingying Gu, Xiuxiu Ma, Ziying Xiang, Chaozhu He","doi":"10.1186/s12877-025-05777-0","DOIUrl":"10.1186/s12877-025-05777-0","url":null,"abstract":"<p><strong>Background: </strong>As the global aging process accelerates, the older population is increasing annually, with the majority suffering from one or more chronic diseases. Due to the influence of chronic disease comorbidity, frailty among the older is widespread. Therefore, early identification of frailty in older adults with comorbidities from a comprehensive perspective, along with proactive measures for prevention and timely intervention, becomes an inevitable requirement for healthy aging. This study aimed to identify the entry point of frailty management in the older with multimorbidity in the community and clarify the focus of frailty management.</p><p><strong>Methods: </strong>A national cross-sectional survey of 1056 older adults with comorbidities in 148 cities across China was conducted. Frailty was assessed using the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale. Based on the health ecological model, the factors which may influence frailty were collected from five levels. Univariate and multivariate analysis were utilized to determine the factors influencing frailty. The STROBE checklist was used preparing the manuscript.</p><p><strong>Results: </strong>A total of 417 patients (39.5%) reported having frailty, while 613 patients (58.0%) were in the pre-frail state. Multivariate logistic regression analysis indicate that compared with robust patients, number of comorbidities, self-efficacy, sleep quality and perceived social support are associated with frailty in older patients with comorbidities (P < 0.05). Compared to pre-frail group, factors such as number of comorbidities, gender (female), cognitive status of diseases, anxiety, having four or more comorbidities, smoking, eating habits, taking three or more different types of medication and perceived social support are associated with frailty (P < 0.05).</p><p><strong>Conclusions: </strong>The prevalence of frailty among older adults with comorbidities is exceptionally high, influenced by various dimensions from health ecology perspective. Psychological care and daily behavior management should be strengthened for the frail older with multimorbidity. Precise and individualized care interventions need to be developed to help promote healthy aging.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"172"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is caregiver burden associated with sex and gender-related characteristics? A large-scale survey study among family caregivers of people with dementia.","authors":"M L A de Graaff, I van der Heide, J J D J M Rademakers, I G M van Valkengoed, A L Francke, A Woonink, F M Bijnsdorp","doi":"10.1186/s12877-025-05795-y","DOIUrl":"10.1186/s12877-025-05795-y","url":null,"abstract":"<p><strong>Background: </strong>The association between the sex of family caregivers and their perceived care burden has been examined thoroughly. The role of sex- and gender-related characteristics of these caregivers in this association remains unknown. We therefore explored the extent to which various gender-related characteristics of caregivers and the sex of people with dementia explain or affect the association between sex of caregivers and their perceived care burden.</p><p><strong>Methods: </strong>Data were derived from a large-scale survey among Dutch family caregivers of people with dementia in 2022 (N = 3067). Both linear and logistic regression analyses were performed to assess mediation of gender-related caregiver characteristics in the association between the sex of the caregiver and the perceived care burden. These characteristics included: hours per week spent on caregiving, being the primary caregiver, relationship with the person with dementia and perceived difficulty in combining daily activities with caregiving. Linear regression analyses were used to assess moderation of the sex of the person with dementia in the association between the sex of the caregiver and the perceived care burden.</p><p><strong>Results: </strong>Female caregivers perceived a greater care burden than male caregivers. This association was partly explained by female caregivers more often perceiving difficulty of combining daily activities with caregiving than male caregivers. Male caregivers perceived a slightly greater care burden when caring for a female than when caring for a male. The perceived care burden of female caregivers was not related to the sex of the person with dementia.</p><p><strong>Discussion: </strong>This study highlights how gender-related aspects of family caregiving can contribute to sex differences in perceived care burden. The findings imply that it is important to take gender-related aspects of caregiving into account when developing or offering caregiver support, as support needs differ between male and female caregivers.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"171"},"PeriodicalIF":3.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}