BMC Geriatrics最新文献

{"title":"Development and validation of a dynamic nomogram for predicting cognitive impairment risk in older adults with dentures: analysis from CHARLS and CLHLS data.","authors":"Tongtong Guo, Xiaoqing Zhao, Xinyi Zhang, Yang Xing, Zhiwei Dong, Haiyan Li, Runguo Gao, Zhiping Huang, Xue Bai, Wengui Zheng, Qi Jing, Shanquan Chen","doi":"10.1186/s12877-025-05758-3","DOIUrl":"https://doi.org/10.1186/s12877-025-05758-3","url":null,"abstract":"<p><strong>Background and aims: </strong>Cognitive impairment is a common issue among older adults, with denture use identified as a potential, easily recognizable clinical risk factor. However, the link between denture wear and cognitive decline in older Chinese adults remains understudied. This study aimed to develop and validate a dynamic nomogram to predict the risk of cognitive impairment in community-dwelling older adults who wear dentures.</p><p><strong>Methods: </strong>We selected 2066 elderly people with dentures from CHARLS2018 data as the development and internal validation group and 3840 people from CLHLS2018 as the external validation group. Develop and treat the concentrated unbalanced data with the synthetic minority oversampling technique, select the best predictors with the LASSO regression ten-fold cross-validation method, analyze the influencing factors of cognitive impairment in the elderly with dentures using Logistic regression, and construct a nomogram. Subject operating characteristic curves, sensitivity, specificity, accuracy, precision, F1 score, calibration curve, and decision curve were used to evaluate the validity of the model in terms of identification, calibration, and clinical validity.</p><p><strong>Results: </strong>We identified five factors (age, residence, education, instrumental activities of daily living, and depression) to construct the nomogram. The area under the curve of the prediction model was 0.854 (95%CI 0.839-0.870) in the development set, 0.841 (95%CI 0.805-0.877) in the internal validation set, and 0.856 (95%CI 0.838-0.873) in the external validation set. Calibration curves indicated significant agreement between predicted and actual values, and decision curve analysis demonstrated valuable clinical application.</p><p><strong>Conclusions: </strong>Five risk factors, including age, place of residence, education, instrumental activities of daily living, and depression level, were selected as the final nomogram to predict the risk of cognitive impairment in elderly denture wearers. The nomogram has acceptable discrimination and can be used by healthcare professionals and community health workers to plan preventive interventions for cognitive impairment among older denture-wearing populations.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"127"},"PeriodicalIF":3.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARC-F: an effective screening tool for detecting sarcopenia and predicting health-related quality of life in older women in Sri Lanka.","authors":"Nirmala Rathnayake, Thilina Abeygunasekara, Gayani Liyanage, Sewwandi Subasinghe, Warsha De Zoysa, Dhammika Palangasinghe, Sarath Lekamwasam","doi":"10.1186/s12877-025-05786-z","DOIUrl":"https://doi.org/10.1186/s12877-025-05786-z","url":null,"abstract":"<p><strong>Objective: </strong>The \"Strength, Assistance with walking, Rise from a chair, Climb stairs, and Falls\" (SARC-F) is a simple, five-item tool used to identify individuals with suggestive signs of sarcopenia. This study assessed the validity of the Sinhala version of the SARC-F, evaluating its ability to detect sarcopenia in older women and its potential to predict health-related quality of life (HRQoL).</p><p><strong>Methods: </strong>The culturally adapted Sinhala version of the SARC-F, along with the Short Form-36 (SF-36) survey, was administered among 350 older women (aged ≥ 65) attending medical clinics at National Hospital Galle, Sri Lanka. Handgrip strength (HGS) was measured using a handheld dynamometer, and relative appendicular skeletal muscle mass index (RSMI) was estimated with a Sri Lankan-specific anthropometry-based equation. Gait speed (GS) was assessed using 4-m customary-paced walk test.</p><p><strong>Results: </strong>The mean (± SD) age of the participants was 72 (± 5) years, with 56.3% (n = 197) having sarcopenia based on a SARC-F score of ≥ 4. The Sinhala version of SARC-F demonstrated a good internal consistency (Cronbach's alpha = 0.72). A significant positive correlation between SARC-F and HGS indicated concurrent validity (r = 0.23, p < 0.001). Women with sarcopenia had significantly lower HRQoL scores, HGS and GS compared to those without, confirming discriminant validity (p < 0.01). The sensitivity, specificity, and accuracy of the Sinhala SARC-F were 54.8%, 67.3%, and 60.3%, respectively, with an Area Under the Curve (AUC) of 0.61 (95% CI: 0.55-0.67) in detecting probable sarcopenia. The HRQoL domains of SF-36 (excluding emotional well-being), HGS and GS were inversely correlated with SARC-F (Spearman's rho range: -0.19 to -0.56, p < 0.001). SARC-F significantly associated with the physical function and pain domains of SF-36 explained 42% of the variance in the model (r = 0.65, R2 = 0.42).</p><p><strong>Conclusions: </strong>The Sinhala version of SARC-F is a reliable and valid tool for screening sarcopenia in Sinhala-speaking older women in Sri Lanka. It can be integrated into clinical practice to identify those with suggestive signs of sarcopenia and to predict HRQoL enabling timely interventions. Future studies with larger, more diverse populations, including men, are needed to enhance the tool's generalizability and diagnostic accuracy.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"129"},"PeriodicalIF":3.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internet use and life satisfaction among empty nesters in rural areas of Yangzhou: based on propensity score matching and mediating effect model.","authors":"Yitong Liu, Yaning Wang, Zhuoya Yang, Wenkun Xu, Guangyu Tian, Yuexiao Gao, Miaomiao Zhao, Rujian Lu, Yaqin Zhong","doi":"10.1186/s12877-025-05788-x","DOIUrl":"https://doi.org/10.1186/s12877-025-05788-x","url":null,"abstract":"<p><strong>Background: </strong>Empty nesters represent a unique group that deserves focused attention. Internet usage is becoming increasingly prevalent among older people. This study preliminarily discussed the differences in life satisfaction between empty nesters who used the Internet and those who did not. This study also provided insight into how Internet use interacted with social participation to improve their life satisfaction.</p><p><strong>Methods: </strong>A face-to-face survey was conducted in Yangzhou City, China, from July to August 2022. Covariates related to life satisfaction, such as sociodemographic characteristics and participants' health behaviors, were collected. Propensity Score Matching (PSM) was used to match Internet users with non-Internet users. Binomial logistic regression was employed to analyze the association between Internet use and life satisfaction, and the KHB method was used to examine the mediating effect.</p><p><strong>Results: </strong>1,177 respondents aged 60 and above were ultimately matched for analysis in this study. The results showed that Internet use was significantly correlated with higher levels of both social participation (β = 0.276, P < 0.05) and life satisfaction (β = 0.433, P < 0.05). Social participation partially mediated the relationship between Internet use and life satisfaction, with a mediating effect of 0.112 accounting for 21% of the total effect. Further analysis of group heterogeneity indicated that the positive association between Internet use and life satisfaction was more prominent among participants who were younger, male, unemployed, had an income, and were in relatively healthy conditions.</p><p><strong>Conclusions: </strong>Internet use was crucial in promoting social participation and enhancing life satisfaction among rural empty nesters. Interventions aimed at improving their life satisfaction should prioritize the creation of inclusive and supportive environments, encouraging social participation, and enhancing digital literacy.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"128"},"PeriodicalIF":3.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dying in residential care homes during the early COVID-19 pandemic: a qualitative interview study.","authors":"Nancy Preston, Zoë Cockshott, Siân Russell, Rachel Stocker, Jo Knight, Suzanne Mason, Barbara Hanratty","doi":"10.1186/s12877-025-05779-y","DOIUrl":"10.1186/s12877-025-05779-y","url":null,"abstract":"<p><strong>Background: </strong>Early in the COVID-19 pandemic, care homes (long-term care facilities) globally were severely impacted in many ways, including end-of-life care and death of residents. They experienced significantly elevated mortality rates amongst residents, compounded by restrictions on support from external healthcare and specialist palliative care providers. Family access to dying residents was often severely restricted. This paper explores experiences of deaths, dying and end-of-life care in care homes during the first year of the pandemic (Spring 2020-2021).</p><p><strong>Methods: </strong>As part of a wider study of experiences in care homes in Northern England during the early pandemic, we conducted semi-structured interviews with care home staff (16), residents (3), family members (5) and health service staff (10). Interviews were analysed using reflexive thematic analysis, this secondary analysis focusing on experiences of death and dying over the period.</p><p><strong>Results: </strong>Thematic analysis generated three key themes: (1) Preparing for large scale deaths: Care home staff reported a sense of foreboding at requirements to prepare for large scale resident deaths, sometimes feeling left with minimal external support to manage this, and uneasy about the rapid roll-out of emergency care planning to residents; (2) Balancing support and policing visiting during the terminal phase: The requirement to restrict access for family members when their relatives were dying was experienced as distressing for both family members and care home staff; and, (3) Distress surrounding deaths for staff and families: Care home staff were distressed by the frequency and speed of deaths that they witnessed when their care home had a COVID-19 outbreak. Family separation near time of death was a source of distress for everyone involved, with suggestions that this led to regrets in bereavement for family members, and moral distress in staff.</p><p><strong>Conclusions: </strong>The experience of death and dying in care homes in the early waves of the COVID-19 pandemic was extremely challenging for care home staff and family members. Our analysis suggests that the ramifications of stringent visitation policies and the consequent distress may shape experiences in bereavement. Monitoring for longer term consequences, such as prolonged grief and moral injury, should be a priority.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"126"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative clinical frailty scale and hospital frailty risk score in identifying frailty and predicting mid-term outcomes in older patients with acute coronary syndrome: a multicenter cohort study in Vietnam.","authors":"Tan Van Nguyen, Huy Minh Tran, Trinh Kim Thi Ngo","doi":"10.1186/s12877-025-05690-6","DOIUrl":"https://doi.org/10.1186/s12877-025-05690-6","url":null,"abstract":"<p><strong>Background: </strong>We aimed to compare the agreement between two common frailty assessment tools, Clinical Frailty Scale (CFS) and Hospital Frailty Risk Score (HFRS), and their ability to predict mid-term adverse outcomes in older patients admitted with acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>We conducted a prospective analysis of patients aged ≥ 60 admitted with ACS at multiple centers in Vietnam between July 2022 and June 2023. A cross-tabulation method was used to describe the correlation between CFS and HFRS. To test the predictive accuracy of HFRS for identifying patients with frailty according to CFS, we evaluated the area under the curves of receiver operating characteristic (ROC) analysis. Youden J index was used to identify a new optimal probability threshold for HFRS. We employed Cox regression models to investigate the association between frailty assessed by CFS, HFRS (using both old and new cut-offs), and 9-month mortality.</p><p><strong>Results: </strong>We included 504 older patients admitted with ACS (median age 72.7 years; male: 59.9%). The correlation between CFS and HFRS was fair (AUC = 0.787, p < 0.010). HFRS had a sensitivity of 39.7% and a specificity of 79.2% to detect frailty based on CFS classification. The new optimal probability threshold of HFRS (≥ 1.15 points) improved the instrument's performance with a significantly higher sensitivity of 90.2%. While frailty categorized by HFRS with the original cut-off did not impact mid-term all-cause and cardiovascular mortality, frailty according to CFS and HFRS with the new threshold was shown to be a predictor of mid-term all-cause and cardiovascular mortality (HR = 4.48, p < 0.001 vs. HR = 2.29, p = 0.001; HR = 5.19, p < 0.001 vs. HR = 1.99, p = 0.020).</p><p><strong>Conclusions: </strong>Although a fair correlation existed between the CFS and the HFRS in older patients with ACS, HFRS demonstrated limited predictive validity for mid-term mortality. We advocate for a revised cutoff (HFRS ≥ 1.15 points) to enhance its sensitivity and predictive accuracy. Future research should prioritize the integration of additional clinical biomarkers and conducting longitudinal studies to assess the efficacy of targeted interventions informed by frailty scores, ultimately striving to improve outcomes in this vulnerable population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"125"},"PeriodicalIF":3.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011-2014.","authors":"An-Bang Liu, Yan-Xia Lin, Guan-Ying Li, Ting-Ting Meng, Peng Tian, Jian-Lin Chen, Xin-He Zhang, Wei-Hong Xu, Yu Zhang, Dan Zhang, Yan Zheng","doi":"10.1186/s12877-025-05752-9","DOIUrl":"10.1186/s12877-025-05752-9","url":null,"abstract":"<p><strong>Background: </strong>The global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect all-cause and cardiovascular disease (CVD) mortality.</p><p><strong>Methods: </strong>The cohort study we examined 2,442 participants aged ≥ 60, is the secondary analysis from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Frailty was quantified using a 49-item frailty index, while pMCI was determined by three composite cognition scores one standard deviation (SD) below the mean. The associations between frailty, pMCI, comorbidity, and mortality were assessed using weighted Cox proportional hazards models.</p><p><strong>Results: </strong>Of the participants, 31.37% were frail, 17.2% had pMCI, and 8.64% exhibited both conditions. The cohort was stratified into four groups based on frailty and pMCI status. After a median follow-up period of 6.5 years, frail individuals with pMCI had the highest all-cause (75.23 per 1,000 person-years) and CVD (32.97 per 1,000 person-years) mortality rates. Adjusted hazard ratios (HRs) for all-cause (3.06; 95% CI, 2.05-4.56) and CVD (3.8; 95% CI, 2.07-6.96) mortality were highest in frail older adults with pMCI compared to those who were non-frail without pMCI.</p><p><strong>Conclusion: </strong>Our study highlights the ubiquity of frailty and cognitive impairment in older adults and underscores the heightened risk of mortality associated with their coexistence. These findings suggest the critical need for proactive screening and management of frailty and cognitive function in clinical practice to improve outcomes for the older adults.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"124"},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freedom of movement and health of nursing home residents with dementia: an exploratory cross-sectional study.","authors":"Suzan P van Liempd, Sascha R Bolt, Katrien G Luijkx","doi":"10.1186/s12877-025-05774-3","DOIUrl":"10.1186/s12877-025-05774-3","url":null,"abstract":"<p><strong>Background: </strong>Having more freedom of movement may relate to better health in nursing home (NH) residents with dementia. Research that tests whether residents in NHs with more freedom of movement are healthier compared to residents in closed NHs is scarce. Also, existing research on freedom of movement does not consider the diverse dimensions of health. This study explored health differences between two groups of nursing home residents with dementia with different levels of freedom of movement.</p><p><strong>Methods: </strong>We used a quantitative cross-sectional design to investigate differences in health between two groups of NH residents with dementia. One group lived in closed NHs (i.e., with closed unit doors) and the other group in semi-open NHs (i.e., with closed NH entrance doors). A total of 124 residents with dementia were recruited from five NHs in the Netherlands, of whom 61 residents lived in semi-open NHs and 63 residents lived in closed NHs. Data were collected using questionnaires to cover health dimensions according to the concept of Positive Health, including quality of life and participation, mental functioning and perception, daily functioning and bodily functions. An analysis of covariance, adjusted for age, gender and type of dementia, was used to examine differences in residents' health.</p><p><strong>Results: </strong>Most included residents had Alzheimer's or vascular dementia and 68% were female. No significant demographic differences were observed between the two groups in age, gender, type of dementia, length of stay, length of diagnoses and type of care package (p-values ranged from 0.097 to 0.606). After adjusting for multiple comparisons, there were no significant differences in any of the assessed health dimensions between residents of semi-open nursing homes and those of closed nursing homes, with a significance threshold of p <.004 accounting for the correction for multiple testing (p-values ranged from 0.020 to 0.870).</p><p><strong>Conclusions: </strong>This exploratory study found no significant differences in health between residents with dementia in semi-open and closed NHs. These findings contradict earlier research suggesting that more freedom of movement may enhance overall health in this population. Further research, preferably employing longitudinal designs, is necessary to establish causal pathways and identify the underlying mechanisms.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"123"},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Arabic Version of the Pittsburgh Fatigability Scale for Older Adults: Translation and Validation.","authors":"Mutasim D Alharbi, Fayaz Khan, Aya Saeb, Nancy W Glynn, Baian A Baattaiah","doi":"10.1186/s12877-025-05759-2","DOIUrl":"10.1186/s12877-025-05759-2","url":null,"abstract":"<p><strong>Background: </strong>The Pittsburgh Fatigability Scale (PFS) was developed to assess perceived physical and mental fatigability in older adults (≥ 60 years). No perceived fatigability questionnaire has been validated to date for use among the Arabic older adult population. The aim of this study was to translate the PFS into Arabic language, and to assess the reliability and validity of the translated version among an Arabic older adult population.</p><p><strong>Methods: </strong>The primary design of this methodological study was cross-sectional. The PFS was translated into Arabic using the forward-backward translation method according to established guidelines. Internal consistency was evaluated by Cronbach's alpha coefficient. The test-retest reliability was evaluated using intraclass correlation coefficients over a two-week interval. Construct validity was evaluated by exploratory and confirmatory factor analyses. The convergent and discriminant validity were measured by calculating Spearman's correlation coefficients between the PFS- Arabic version and the Arabic versions of the Fatigue Severity Scale (FSS), Perceived Stress Scale (PSS), and WHO-5 Well-Being Index.</p><p><strong>Results: </strong>The validity and reliability sample included 277 older adults with a mean age of 66.0 ± 5.3. For the PFS- Arabic version, the intraclass correlation coefficient for test-retest reliability for both the physical and mental subscale was high (0.97). Cronbach's alpha for the PFS- Arabic version was 0.75 for the physical fatigability subscale and 0.71 for the mental fatigability subscale. The results of the factor analyses revealed that a four-factor model of PFS- Arabic version physical and mental subscales was a good model fit in our sample. Both subscales of PFS- Arabic version showed moderate correlation with FSS (r = 0.3, p < 0.0001) and weak correlation with PSS (r = 0.2). The WHO-5 showed a moderate correlation with PFS- Arabic Physical subscale (r = -0.3) and weak correlation with PFS- Arabic Mental subscale (r = -0.2).</p><p><strong>Conclusion: </strong>The PFS- Arabic version showed good psychometric properties and is recommended for use among Arabic-speaking populations to assess perceived fatigability in older adults.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"122"},"PeriodicalIF":3.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating effect of instrumental activities of daily living on the relationship between loneliness and depression in people with cognitive frailty.","authors":"Yafang Zhao, Xiaopeng Huo, Hongdi Du, Xiaoxing Lai, Zhen Li, Zhiyuan Zhang, Longfei Yang","doi":"10.1186/s12877-025-05700-7","DOIUrl":"10.1186/s12877-025-05700-7","url":null,"abstract":"<p><strong>Background: </strong>The identification of depression and loneliness among people with cognitive frailty (CF) could prevent negative psychological and physical health outcomes. Few studies have focused on physical and mental health together, and little is known about the role of daily activity in the association between depression and loneliness among elderly individuals with CF.</p><p><strong>Objectives: </strong>To determine the positive effect of loneliness on depression among community-dwelling older adults with CF as well as the moderating effect of instrumental activities of daily living (IADL) on this association.</p><p><strong>Design, setting, participants, and measurements: </strong>This cross-sectional study included 529 adults aged 65 years and older from a community-dwelling population who were screened for CF and was conducted from July 2023 to December 2023. The participants were assessed via validation instruments for the following main variables: Short-form Geriatric Depression Scale, Loneliness Questionnaire, Athens Insomnia Scale, Instrumental Activities of Daily Living (IADL), Social Support Scale, and sociodemographic characteristics. The participants were classified as having reversable CF (RCF) or potentially reversable CF (PRCF).</p><p><strong>Results: </strong>The IADL, depression, insomnia, and loneliness scores were lower among individuals with RCF than among individuals PRCF. The moderating effect of IADL scores shows that the relationship between loneliness and depression has a steeper and positive slope when lower levels of IADL exist, compared with a straight line when there are higher levels of IADL, for this case, the line is less steep and showed negative association.</p><p><strong>Conclusions: </strong>The integrity of physical and social connections has a protective effect on the mental health of elderly people with CF. It is necessary to pay attention to disability and loneliness among elderly individuals. Targeted interventions for improving physical activity and social participation seem to be practical and feasible solutions to alleviate depressive symptoms.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"121"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No long-term benefits from resistance training on brain grey matter volumes in active older adults at retirement age.","authors":"Mads Bloch-Ibenfeldt, Naiara Demnitz, Anne Theil Gates, Ellen Garde, Hartwig R Siebner, Michael Kjaer, Carl-Johan Boraxbekk","doi":"10.1186/s12877-025-05778-z","DOIUrl":"10.1186/s12877-025-05778-z","url":null,"abstract":"<p><strong>Background: </strong>Resistance training and other forms of physical exercise are commonly suggested to promote brain health, yet the relationship between resistance training and brain structure in aging is poorly understood. We examined the short- and long-term influence of one year of supervised resistance training at two different loadings on brain structure in aging.</p><p><strong>Methods: </strong>In the LISA (LIve active Successful Ageing) study, well-functioning older adults at retirement age (mean age: 66 ± 2 years) were randomized to one year of heavy resistance training (HRT), moderate intensity training (MIT), or a non-exercising control group (CON). Magnetic resonance imaging (MRI) of the brain was performed at baseline, 1-, 2-, and 4-years follow ups. Trajectories of total grey matter, hippocampus, dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), and white matter hyperintensities were analyzed in relation to changes in muscle strength.</p><p><strong>Results: </strong>Individuals (n = 276) with MRI scans at all 4 timepoints were included (HRT, n = 96; MIT, n = 95; CON, n = 85). Total grey matter volume decreased with time across all groups (F_3,819 = 231.549, p < 0.001, <math> <msup><mrow><mi>η</mi></mrow> <mn>2</mn></msup> </math> = 0.46), as did hippocampal (F_3,819 = 310.07, p < 0.001, <math> <msup><mrow><mi>η</mi></mrow> <mn>2</mn></msup> </math> = 0.53), vlPFC (F_3,818 = 74.380, p < 0.001, <math> <msup><mrow><mi>η</mi></mrow> <mn>2</mn></msup> </math> = 0.21), and dlPFC (F_3,818 = 3.640, p = 0.013, <math> <msup><mrow><mi>η</mi></mrow> <mn>2</mn></msup> </math> = 0.01) volumes. White matter hyperintensity volumes increased (F_3,819 = 101.876, p < 0.001, <math> <msup><mrow><mi>η</mi></mrow> <mn>2</mn></msup> </math> = 0.27). There were no significant group x time interactions for any of the brain structures. Additional cortical and subcortical vertex-wise analyses showed no group differences. Change in isometric leg strength was weakly associated with change in white matter hyperintensity volume across all individuals (r² = 0.01, p = 0.048).</p><p><strong>Conclusions: </strong>One year of resistance training in well-functioning older adults at retirement age did not influence volume changes in selected brain regions over a 4-year period.</p><p><strong>Trial registration: </strong>The study was approved by the regional ethics committee and registered on clinicaltrials.gov 2014-04-24 (NCT02123641).</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"120"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}