BMC Geriatrics最新文献

{"title":"The relationship between frailty, BMI, and mortality in older adults: results from the CLHLS.","authors":"Yang Gao, Hua Zhang, Kun Fang, Yao Yao, Jianshe Chen, Hui Lu, Xiangyang Gao, Yongsheng Liu","doi":"10.1186/s12877-025-06197-w","DOIUrl":"10.1186/s12877-025-06197-w","url":null,"abstract":"","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"539"},"PeriodicalIF":3.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle modifications and control of cardiovascular risk factors in older adults with hypertension: from NHANES 1999-2018.","authors":"Ying Tang, Zhi Zhang, Xiaowei Liu","doi":"10.1186/s12877-025-06204-0","DOIUrl":"10.1186/s12877-025-06204-0","url":null,"abstract":"<p><strong>Background: </strong>Self-management of hypertension is particularly emphasized for older patients. Specifically, it is critical that initiatives regarding lifestyle modifications be applied to reduce the cardiovascular burden of hypertension among the elderly population.</p><p><strong>Methods: </strong>We included participants aged 65 years or older with hypertension from the National Health and Nutrition Examination Survey (NHANES) years 1999-2018 to analyze the adherence to lifestyle recommendations and the control of cardiovascular risk factors. Recommended lifestyle behaviors and targets for cardiovascular risk factor controls were defined according to the clinical guidelines for the management of hypertension. Logistic regression analyses were utilized to identify factors associated with nonadherence.</p><p><strong>Results: </strong>Of 10,162 participants (mean age, 74.45 years) included, 4350 (42.81%) had controlled blood pressure. Adherence to healthy lifestyle behaviors varied among respondents. Smoking cessation (88.82%) and alcohol reduction (74.11%) were relatively high, whereas adherence to physical activity (14.57%), low salt diet (36.81%), and fiber intake (12.87%) were significantly lower. A significant proportion of respondents achieved target levels for LDL-C (76.00%) and HbA1c (72.49%), whereas fewer participants met BMI (25.02%) and waist circumference (31.26%) goals for cardiovascular risk factor control. After multivariable adjustment, male gender (OR: 1.53 [1.09-2.17]), non-Hispanic black race (OR: 1.85 [1.06-3.24]), metabolic syndrome status (no vs. yes, OR: 0.67 [0.47-0.94]), and chronic kidney disease status (no vs. yes, OR: 0.63 [0.41-0.97]) were associated with increased odds of unhealthy lifestyle, whereas male gender (OR: 1.37 [1.04-1.80]), high socioeconomic status (OR: 1.61 [1.05-2.49]), metabolic syndrome status (no vs. yes, OR: 0.03 [0.02-0.04]), and diabetes mellitus status (no vs. yes, OR: 0.68 [0.49-0.96]) were associated with increased odds of uncontrolled cardiovascular risk.</p><p><strong>Conclusions: </strong>Adherence to physical activity and healthy diet, and control of central obesity are suboptimal among older patients with hypertension. The etiology of nonadherence is multifactorial and includes causes associated with sociodemographic status, and comorbidities.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"537"},"PeriodicalIF":3.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of metabolic syndrome components with chronic kidney disease in patients with hypertension: a community-based cohort study.","authors":"Yan Yu, Jun Li, Xiao Ma, Linli Chen, Xin Yin, Xiaohua Liu, Guoyou Qin, Yongfu Yu, Huilin Xu","doi":"10.1186/s12877-025-06192-1","DOIUrl":"10.1186/s12877-025-06192-1","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MS) is a well-established risk factor for chronic kidney disease (CKD), especially in hypertensive patients. These patients are more likely to exhibit additional components of MS, further elevating their risk of developing CKD. This study aimed to investigate the association between the components of MS and the risk of CKD in hypertensive patients.</p><p><strong>Methods: </strong>This retrospective cohort study included 51,470 hypertensive patients who participated in the national basic public health services for hypertension management in Minhang District, Shanghai, China. Cases of CKD were identified through linkage with elderly physical examination statistics. Multivariable-adjusted Cox proportional hazard models were used to assess the relationship between the number of MS components and the risk of CKD. Additionally, the study explored the associations between different combinations of MS components and CKD.</p><p><strong>Results: </strong>During the 3-year follow-up period, the incidence of CKD was significantly higher in hypertensive patients with MS compared to those without MS (33.77 vs. 25.67 per 1000 person-years). Hypertensive patients with MS had a 15% increased risk of developing CKD compared to those without MS. Furthermore, the risk of CKD increased progressively with the number of MS components (P for trend < 0.01; HR 1.17, 1.27, and 1.37 for 3, 4, and 5 components, respectively, versus 1 component). Additionally, elevated waist circumference (WC) was significantly associated with CKD in hypertensive patients with only one additional MS component (P < 0.05).</p><p><strong>Conclusion: </strong>In hypertensive patients, the risk of CKD significantly increases with the accumulation of MS components. Notably, elevated WC in hypertensive patients is particularly associated with a higher risk of CKD.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"536"},"PeriodicalIF":3.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calf circumference to body mass index ratio: a new anthropometric indicator for ultrasound based sarcopenic obesity.","authors":"Nermin Karakurt, Ayşe Fadıloğlu, Fatih Güngör, Eda Çeker, Esra Çataltepe, Zekeriya Ulger, Hacer Dogan Varan","doi":"10.1186/s12877-025-06038-w","DOIUrl":"10.1186/s12877-025-06038-w","url":null,"abstract":"<p><strong>Objectives: </strong>Traditional anthropometric measurements, such as calf and arm circumference, may not accurately reflect muscle mass in obese individuals. These limitations highlight the need for more sensitive and practical measures for the early detection of sarcopenic obesity. This study aimed to evaluate the predictive value of the calf circumference to body mass index ratio (CC/BMI) as an anthropometric indicator for ultrasound based sarcopenic obesity, and to compare its effectiveness with calf circumference adjusted for BMI (subtracting 3, 7, or 12 cm from calf circumference measurements corresponding to BMI categories of 25-29.9, 30-39.9, and ≥ 40 kg/m², respectively).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 573 patients aged 65 years and older from a geriatrics outpatient clinic. Exclusion criteria included having advanced dementia, knee or hip replacement, neurodegenerative diseases, decompensated heart failure or the use of muscle-impacting medications. Participants underwent geriatric assessments which included ultrasound measurements of anterior thigh muscle thickness and anthropometric evaluations. Sarcopenia was defined using the STAR index (anterior thigh muscle thickness/BMI ratio) and low handgrip strength. Patients who had both sarcopenia and a BMI ≥ 30 kg/m² were categorized as having sarcopenic obesity. CC/BMI, and calf circumference adjusted for BMI were calculated, and their predictive power for sarcopenic obesity was assessed.</p><p><strong>Results: </strong>Of the participants, 37.3% (n = 214) were sarcopenic, and 17.3% (n = 99) had sarcopenic obesity. Significant positive correlations were observed between the CC/BMI and age, as well as with handgrip strength, STAR index, and walking speed. The CC/BMI demonstrated a significantly higher predictive capability for sarcopenic obesity (AUC: 0.850, cutoff ≤ 1.20, sensitivity: 81.63%, specificity: 75.91%) compared to calf circumference adjusted for BMI (AUC: 0.672, cutoff ≤ 31 cm, sensitivity: 60.20%, specificity: 67.24%).</p><p><strong>Conclusion: </strong>The CC/BMI shows higher sensitivity and predictive value for diagnosing sarcopenic obesity compared to calf circumference adjusted for BMI. It could serve as a practical screening tool for sarcopenic obesity in older adults.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"534"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How socioeconomic status shapes health outcomes following severe falls: a cross-sectional analysis.","authors":"Elisa-Marie Speckmann, Lars Schwettmann, Laura Himmelmann, Tania Zieschang, Tim Stuckenschneider","doi":"10.1186/s12877-025-06198-9","DOIUrl":"10.1186/s12877-025-06198-9","url":null,"abstract":"<p><strong>Objective: </strong>Falls are a major health concern, leading to severe injuries, fatalities, and increased risk of future falls. Severe falls, requiring medical care, necessitate targeted interventions. Socioeconomic status (SES), measured by income and education, influences health outcomes, with lower SES linked to greater multimorbidity and reduced physical activity. While SES broadly impacts fall risk, limited research explores its effects following severe falls. Therefore, this study aims to evaluate the associations between socioeconomic status (SES) and health outcomes in older adults following a fall with presentation to the emergency department (ED).</p><p><strong>Methods: </strong>We analyzed data from the SeFallED study, comprising individuals over the age of 60, who presented to the ED following a recent fall, without requiring subsequent hospitalization. Income and education were used to characterize SES. Health outcomes include mental and functional performance, physical activity, mental well-being, and utilization of the health system. Linear and logistic regression models, adjusted for age and sex, were used to assess associations with health outcomes, incorporating multicollinearity checks, residual diagnostics, and bias-corrected bootstrapping to ensure robustness and reproducibility.</p><p><strong>Results: </strong>In this cross-sectional study of 172 older adults (median age 74 years) following a severe fall, education was positively associated with functional and mental outcomes, including Activities of Daily Living (ADLs), cognitive status, hand grip strength, and physical performance (p < .001). Regression analysis, adjusting for age and sex, revealed that higher education was significantly associated with better ADLs, cognitive status, hand grip strength, and physical performance, while income showed no significant associations with these outcomes.</p><p><strong>Conclusion: </strong>This study revealed that the associations with mental and functional health outcomes in older adults following a severe fall were the strongest for education, rather than income. Higher education was associated with better performance. Income showed limited associations but was negatively correlated with concerns about falling. Age and sex were critical covariates, influencing key health outcomes. These findings provide insights that may be relevant for future research and considerations in studies involving older adults presenting to EDs.</p><p><strong>Trial registration: </strong>DRKS00025949 https://drks.de/search/en/trial/DRKS00025949 , Registered on 4th November, 2021.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"533"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NT-proBNP changes predict outcomes in elderly type 2 myocardial infarction patients.","authors":"Jinling Ma, Ang Li, Suyan Bian","doi":"10.1186/s12877-025-06169-0","DOIUrl":"10.1186/s12877-025-06169-0","url":null,"abstract":"<p><strong>Background: </strong>N-terminal pro-B-type natriuretic peptide (NT-proBNP) is useful to predict adverse outcomes. Change in NT-proBNP level may provide additional actionable risk assessment information. This study aimed to determine the association of change in NT-proBNP level with adverse outcomes among elderly individuals with type 2 myocardial infarction (MI).</p><p><strong>Methods: </strong>A retrospective analysis was conducted among elderly individuals with type 2 MI between December 2010 and December 2022. Change of NT-proBNP level was determined as the difference between the baseline and last measurement obtained during the period of 30 days.</p><p><strong>Results: </strong>A total of 3007 participants aged 80 years and older were included. The patients were divided in accordance with the change in NT-proBNP level into those with NT-proBNP change ≥ 30% decrease, NT-proBNP change < 30% decrease and ≤ 10% increase, and NT-proBNP change > 10% increase. The patients with NT-proBNP change > 10% increase were older, had higher systolic blood pressure, loop diuretics use, and higher incidence of atrial fibrillation and chronic kidney disease. The quartile of change in NT-proBNP > 10% increase was markedly associated with increased risk of incident HF, as well as all-cause and cardiovascular mortality. The incidence rate of mortality increased in a graded fashion with change in NT-proBNP level. The Kaplan-Meier event-free curves showed that patients with NT-proBNP change > 10% increase had the highest risk, followed by those with NT-proBNP change < 30% decrease and ≤ 10% increase, and NT-proBNP change ≥ 30% decrease.</p><p><strong>Conclusions: </strong>The change in NT-proBNP level can be used for identifying patients at a high risk of incident HF, as well as cardiovascular and all-cause mortality in elderly individuals with type 2 MI. It may be a promising biomarker to guide personalized therapy optimization.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"535"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fall risk perception toolkit based on \"digital human\" for community-dwelling older patients with stroke: development and validation.","authors":"Jiang Nan, Yi Hou, Manyao Sun, Xueying Huang, Jing Gao, Xueqiong Zou, Zhongyi Chen, Yuyu Jiang","doi":"10.1186/s12877-025-06186-z","DOIUrl":"10.1186/s12877-025-06186-z","url":null,"abstract":"<p><strong>Background: </strong>This study aims to develop a fall risk perception toolkit based on \"digital human\" (FRP-digital human), test its usability among community-dwelling older patients with stroke, and verify its implementation effect.</p><p><strong>Methods: </strong>The toolkit underwent three phases: development, usability test, and effectiveness verification. A mixed method usability test was conducted with 20 participants who met the criteria. The toolkit was validated in a 12-week two-arm pilot study involving 80 community-dwelling older patients with stroke. Two groups of participants were randomly assigned to either the intervention or the control group to receive the same content of health education. Intervention group received health education based on \"digital human\", while control group received traditional online PDF text health education. The usability test contained Post-Study System Usability Questionnaire (PSSUQ), Customer Effort Score (CES), Net Promoter Score (NPS), and user interviews. Rate of Participant (RP), Rate of Adherence (RA), fall risk perception, object fall risk and quality of life were selected as outcome indicators. The corresponding measurement tools were calculation of RP and RA, Fall Risk Perception Scale for community-dwelling older adults (FRPS), Timed Up and Go test (TUG), and the Short Version of the Stroke Specific Quality of Life scale (SV-SS-QoL).</p><p><strong>Results: </strong>Four functional modules of FRP-digital human were determined. 20 participants completed the usability test. The CES was 3.1, NPS was 4.5 and the overall satisfaction of PSSUQ was 72.14%. Six themes were obtained from user interviews. A total of 80 participants completed the pilot study. The RP was 100% in both intervention group and control group, and significant differences was observed in RA between two groups (P < 0.05). There were statistically significant differences in FRPS and the SV-SS-QoL between two groups (P < 0.001). No statistically significant was observed in TUG between two groups (P = 0.996).</p><p><strong>Conclusion: </strong>FRP-digital human can be accepted by community-dwelling older patients with stroke and help improve their fall risk perception and quality of life. Moreover, the design of the WeChat mini program increased its generalizability to promote more successful health care delivery.</p><p><strong>Trial registration: </strong>This study has been registered at the Chinese Clinical Trial Registry: ChiCTR2300068365 (2023-02-16).</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"532"},"PeriodicalIF":3.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Diurnal Temperature Range, Daily Mean Temperature and Sarcopenia States in Older Adults: Evidence from the CHARLS.","authors":"Yang Zhong, Suyuan Wang, Doudou Hao, Suyin Zhu, Yanli Chen, Zhiyou Shi, Qing Yang, Yunhong Wu","doi":"10.1186/s12877-025-06179-y","DOIUrl":"10.1186/s12877-025-06179-y","url":null,"abstract":"<p><strong>Background: </strong>With growing concern about global climate change and its potential consequences, its health impacts have been widely studied. However, the association between temperature and sarcopenia states in Chinese older adults remains unclear. The study aimed to examine the association based on a nationally representative large-scale survey.</p><p><strong>Methods: </strong>The study used data from three waves (2011, 2013, 2015) of the China Health and Retirement Longitudinal Study (CHARLS) for adults aged ≥ 60 years, combined with meteorological and PM_2.5 data from the China Research Data Services (CNRDS) Platform (2011-2015). Sarcopenia states were assessed using the Asian Working Group for Sarcopenia criteria 2019 (AWGS2019). Cross-sectional analysis used generalized additive models with cubic splines to identify non-linear relationships between temperature and sarcopenia states prevalence. For longitudinal analysis, four multivariable logistic regression models were developed to assess the association, adjusting for confounders. Subgroup analyses evaluated population sensitivity to temperature exposure.</p><p><strong>Results: </strong>The prevalence of possible sarcopenia was 29.4%, 28.5%, and 24.8% in 2011, 2013, and 2015, respectively, while sarcopenia rates were 9.6%, 10.7%, and 9.8%. Cross-sectional analysis showed that possible sarcopenia was associated with a higher risk of falls (OR: 1.31, P < 0.001) and hip fractures (OR: 1.63, P < 0.001). Longitudinal analysis revealed that a 1℃ increase in the three-year average diurnal temperature range (mDTR) raised the risk of possible sarcopenia by 8% (OR: 1.08, 95% CI: 1.01-1.15) and sarcopenia by 13% (OR: 1.13, 95% CI: 1.01-1.26). Conversely, a 1℃ increase in the three-year average daily mean temperature (mDMT) within 0-25℃ reduced the risk of possible sarcopenia by 4% (OR: 0.96, 95% CI: 0.94-0.99). Individuals living at altitudes ≥ 500 m were more vulnerable to the adverse effects of temperature fluctuations on possible sarcopenia.</p><p><strong>Conclusions: </strong>Our study found that temperature is associated with sarcopenia states in Chinese older adults. Increased mDTR raised the risk of possible sarcopenia and sarcopenia, while mDMT (0-25℃) lowered possible sarcopenia risk. Individuals living at altitudes ≥ 500 m were more vulnerable to the adverse effects of temperature fluctuations on sarcopenia.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"531"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12265143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An individualized physical function improvement program for frailty elderly using goal attainment scaling (GAS) as evaluation method: protocol for a randomized controlled trial.","authors":"Yu Kang, Zi-Cheng Qi, Meng-Tian Guo, Xiao-Juan Wang","doi":"10.1186/s12877-025-06203-1","DOIUrl":"10.1186/s12877-025-06203-1","url":null,"abstract":"<p><strong>Background: </strong>Frailty is the deterioration of physiological functions due to aging, linked to negative outcomes. Frailty, being a reversible and dynamic state, calls for individualized and comprehensive management. Goal Attainment Scaling (GAS) is a personalized method for establishing and assessing progress towards individual goals, suitable for older adults with complex requirements. We focus on attaining personalized intervention goals for elderly patients with frailty, correcting frailty manifestations, maintaining enhanced functional capacity, and cultivating sustainable health awareness, with the goal of improving overall quality of life.</p><p><strong>Methods: </strong>We conducted a randomized clinical trial of an individualized intervention program using GAS as goal setting and evaluation method designed to improve physical functional in frailty elderly. A total of 160 individuals aged ≥ 60 years, who fulfill the Fried scale of frailty will be recruited from Beijing Chaoyang Hospital, Capital Medical University. All participants set personalized goals through GAS. Patients in the intervention group receive individualized interventions, implement tailored measures based on personalized goals, attain personalized intervention goals to improve or reverse the frailty state. The participants will be followed up for 3 months and 12 months.</p><p><strong>Discussion: </strong>The advantage of the present study is the method of intervention. Personalized interventions will implement based on patient-specific needs through individualized goal-setting formulated according to the GAS. If a positive consequence could be obtained, this study's findings will offer essential information for managing frailty in older adults, applicable in regular clinical settings.</p><p><strong>Ethics and trial registration: </strong>The trials have received ethics approval from the Institutional Review Board for Human Studies of Beijing Chaoyang Hospital, Beijing, China. The clinical study is supported by the National Health Commission of the People's Republic of China (2024YB53). We declare that the funding agency has independently reviewed the protocol as part of the process of awarding funding. The trial is registered as ClinicalTrials.gov Identifier: NCT06919575 (Registration Date: 2025-04-02).</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"528"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biopsychosocial approach to improving multidimensional frailty status in community-dwelling older adults: a protocol for a cluster randomized controlled trial.","authors":"Jiao Jiao, David Wai-Kwong Man, Sonia Lippke, Holger Hassel, Bjorn Tsz-King Tam, Connie Hoi-Man Chan, Yuen-Ling Ng, Kenneth Ka-Hei Lo","doi":"10.1186/s12877-025-06053-x","DOIUrl":"10.1186/s12877-025-06053-x","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a significant clinical syndrome affecting aging populations, leading to increased risks of negative outcomes such as falls, disability, hospitalization, and premature mortality. The concept has evolved from a simplistic view to a complex view that incorporates physical, psychological, cognitive, and social domains. Early intervention is crucial, yet research on the interactions among these domains is limited. This study protocol aims to outline various combinations of biological, psychosocial and nutritional interventions in prefrail older adults to address their effects on frailty status, including physical, psychological, and social functioning, nutritional status, and lifestyle changes over a 9-month intervention and follow-up period.</p><p><strong>Methods: </strong>This study is a cluster-randomized controlled trial involving N = 308 prefrail older adults aged 60-80 from 32 community elderly centres in Hong Kong. Participants will be randomly selected and classified into four frailty deficit patterns. They will be assigned to one of four intervention strategies: biological/psychosocial/nutritional, biological/nutritional, psychosocial/nutritional, and inactive control. The intervention will focus on improving physical, psychological, and social functioning, nutritional status, and lifestyle changes over the 9-month period.</p><p><strong>Discussion: </strong>This study is expected to provide substantial evidence on the effectiveness of these strategies in enhancing frailty status across bio-psycho-social domains in diverse elderly groups. The findings will have practical implications for healthcare professionals, caregivers, and policymakers, potentially leading to improved care and support for community-dwelling older adults in Hong Kong.</p><p><strong>Trial registration: </strong>The trial has been registered in ClinicalTrials.gov under U.S. NIH (ID: NCT06741878, date: December 19, 2024).</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"530"},"PeriodicalIF":3.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12261824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}