BMC Geriatrics最新文献

{"title":"Examining the matching of care preferences and care modalities for older dependents, and its association with satisfaction and wellbeing.","authors":"Albert Julià, Pedro Gallo, Marga Marí-Klose, Sandra Escapa","doi":"10.1186/s12877-025-05749-4","DOIUrl":"10.1186/s12877-025-05749-4","url":null,"abstract":"<p><strong>Background: </strong>As societies age, ensuring the quality of life of dependent individuals has become a pressing concern, affecting an increasing large segment of the population. Understanding whether dependent individuals receive the type of care they prefer is central to their well-being. However, there is limited evidence regarding the alignment between care preferences and the care arrangements received by dependent persons. This article aims to provide new insights into how individual and contextual factors are associated to the match -or mismatch- between care preferences and current care arrangements, as well as its implications for individuals' well-being and satisfaction with care.</p><p><strong>Methods: </strong>We use data from the 2023 Survey of Older People with Functional Dependency, which includes a representative sample (n = 1,600, with 992 self-respondents) of dependent individuals aged 65 and over in Barcelona, Spain. Logistic regression models are used to estimate the associations between dependent individuals' characteristics and their care preferences, as well as the matching between these preferences and their current care arrangements. We further examine how this alignment relates to satisfaction and well-being.</p><p><strong>Results: </strong>Care preferences differ based on sex, household size, level of dependency, and household income. Approximately 70 per cent of older dependents report that their current care arrangements do not match their care preferences. Older dependent women and those over 85 are less likely to have care arrangements aligned with their preferences. Living with others in the household increases the likelihood of alignment between preferences and care provision. While no significant association was found between alignment and well-being indicators, we observed that care match enhances individuals' satisfaction with care they receive.</p><p><strong>Conclusions: </strong>Older dependent individuals' preferences for care provision often do not match their current care arrangements. Both individual and contextual factors could explain this phenomenon. The widespread preference for receiving care at home highlights the need for social policies that promote home-based solutions. As family support for dependent individuals becomes less available, and given the significant burden this may place for family caregivers, there is a growing need to develop flexible, personalized, and sustainable care strategies.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"119"},"PeriodicalIF":3.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The factors determining early mobilization in elderly patients undergoing total knee replacement.","authors":"Li-Ling Hung, Yong-Chuan Chen, Yu-Ting Wang, Shun-Ping Wang","doi":"10.1186/s12877-025-05772-5","DOIUrl":"10.1186/s12877-025-05772-5","url":null,"abstract":"<p><strong>Background: </strong>Postoperative early mobilization after total knee replacement (TKR) is essential for preventing complications and offers numerous benefits. The purpose of this study was to evaluate the factors determining early mobilization (EM) after primary TKR and the effects on risk of falls and length of stay (LOS).</p><p><strong>Methods: </strong>This retrospective study recruited elder participants undergoing primary TKR. All patients were classified as EM(+), early mobilization (EM) within 24 h, or EM(-), delayed mobilization over 24 h. Demographic data, pain Visual Analog Scale (VAS), American Society of Anesthesiologists (ASA) score, perioperative blood pressure, postoperative pain control mode, medical catheters, dizziness or nausea/vomiting (PONV), falls during admission, and the LOS were collected.</p><p><strong>Result: </strong>A total of 1759 elder participants undergoing primary TKR were enrolled. Mean age was 73.00 ± 8.11 years. Among them, there were 1260 EM(-) and 499 EM(+) cases, with no significant differences in sex, BMI, PONV, postoperative Patient Controlled Analgesia (PCA) mode, or the use of medical catheters, but age, higher ASA score, VAS, muscle strength, postoperative nausea, and substantial changes of blood pressure were significantly different between the two groups. A greater reduction in systolic blood pressure, when compared to the preoperative baseline blood pressure, was found in EM(-) patients than EM(+) patients on the operative day (13 vs. 4 mmHg, P < 0.001) and first day post-TKR (20 vs. 17 mmHg, P = 0.005). LOS in EM(-) patients was significant longer than that in EM(+) patients, but risk of falls was not significantly different.</p><p><strong>Conclusions: </strong>Multiple factors influence patients' willingness to mobilize or ambulate earlier. However, more blood pressure reduction impeding early mobilization after TKR should be addressed. Maintaining post-TKR blood pressure without significant decreases is recommended for the successful mobilization after surgery. Early mobilization within 24 h after TKR may be beneficial in reducing the LOS and did not increase risk of falls.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"118"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive role of gait parameters and MRI markers in assessing cognitive decline in CSVD patients.","authors":"Yushuang Liu, Li Zhang, Shanshan Yang, Ruijia Liu, Lian Yi, Meng Liu, Sihan Liu, Zhongling Zhang","doi":"10.1186/s12877-025-05738-7","DOIUrl":"10.1186/s12877-025-05738-7","url":null,"abstract":"<p><strong>Background: </strong>Cerebral small vessel disease (CSVD) is a major contributor to cognitive decline and gait abnormalities in the elderly population. Understanding the relationship between these impairments can aid in early detection and intervention. This study investigated the association between gait performance and cognitive decline in patients with CSVD, focusing on specific gait parameters as potential clinical markers of cognitive impairment.</p><p><strong>Methods: </strong>This cross-sectional study included 95 elderly patients with confirmed atherosclerotic CSVD at Guangzhou Geriatric Hospital. Participants underwent comprehensive gait assessments using the Timed Up and Go (TUG) test, Berg Balance Scale (BBS), and Short Physical Performance Battery (SPPB). Cognitive function was evaluated using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Imaging markers, including total magnetic resonance imaging (MRI) CSVD burden and Fazekas scale score, were analyzed.</p><p><strong>Results: </strong>Participants with cognitive decline performed significantly worse on the TUG test, BBS, and SPPB, particularly on the SPPB sit-to-stand component. The total MRI CSVD burden and Fazekas scale scores were significantly higher in the cognitive decline group. Deep cerebral microbleeds and enlarged perivascular spaces in the basal ganglia were more prevalent in individuals with cognitive decline. The association between the SPPB sit-to-stand score and cognitive decline remained significant after adjusting for confounders (OR 0.44; 95% confidence interval (CI) 0.21 to 0.94; p = 0.034).</p><p><strong>Conclusion: </strong>This study highlighted the significant relationship between gait performance and cognitive decline in elderly patients with CSVD. In particular, the sit-to-stand component emerged as a robust predictor of cognitive impairment, suggesting its potential as a valuable clinical marker for early detection. The incorporation of gait assessments into routine clinical evaluations can enhance early intervention efforts, improve patient outcomes, and inform healthcare policies. Further longitudinal and multicenter studies are warranted to validate these findings and to explore the underlying mechanisms.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"116"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can a novel set of handgrips on a walking frame increase stability and support users when transferring to/from a chair?","authors":"Sibylle Brunhilde Thies, Susan Bevan, Matthew Wassall, Cynthia Poolay Mootien, Laurence Kenney, David Howard","doi":"10.1186/s12877-025-05754-7","DOIUrl":"10.1186/s12877-025-05754-7","url":null,"abstract":"<p><strong>Introduction: </strong>One important aspect of walking aid use is transferring safely to the aid from sitting and transferring back to the chair after walking, since these activities have been associated with falls in older adults. Standard frames require their user to push off the chair or ask for help from a carer, which may over time lead to back pain. This study's aim was to assess whether novel handgrips located above the rear feet of a walking frame would facilitate safe transfer as compared to utilizing only the seat cushion or armrests of the chair.</p><p><strong>Methods: </strong>In a gait lab-based trial 10 healthy older adults repeatedly transferred from sitting to standing, pushing off the chair's seat cushion, armrests, or using the new lower handles on the frame (alone or in combination with the seat cushion or armrest). The stability margin 'SM', defined as the distance between the centre of pressure and the nearest edge of the base of support for the user-device-chair system, was calculated as a mechanical measure of stability. Specifically, SM provides a measure of how close the system is to the point of tipping over. Additionally, 13 older frame users tried to use the new handgrips to transfer to/from the new frame and gave interviews which were thematically analysed.</p><p><strong>Results: </strong>Stability for the 10 healthy older adults was statistically either equivalent or better when using one or both handles on the novel frame as compared to pushing off the chair's seat cushion or armrests. Amongst the 13 older frame users the frame's new handgrips were useful to those living in the community and one person living in care, and they perceived them to facilitate independence and control.</p><p><strong>Discussion & conclusions: </strong>The novel handgrips offer continuous support when getting up/sitting down and are well-received by those able to use them. The significance of the research lies in the reported number of falls during transfer from sitting to standing and vice versus, with underlying causes reported including loss of support. The proposed design is timely considering the documented increases in frailty and walking aid use in our ageing population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"117"},"PeriodicalIF":3.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini nutritional assessment short-form as a risk factor for mortality in patients with respiratory disease undergoing urgent hospitalization.","authors":"Mayuko Ishiwari, Yuta Kono, Yuki Togashi, Kenichi Kobayashi, Ryota Kikuchi, Mariko Kogami, Ami Suekawa, Yasushi Miyazawa, Shinji Abe","doi":"10.1186/s12877-025-05767-2","DOIUrl":"10.1186/s12877-025-05767-2","url":null,"abstract":"<p><strong>Background: </strong>Studies of nutritional status in geriatric patients with respiratory diseases are limited. The aim of this study was to investigate the mortality risk of older patients undergoing urgent hospitalization for various respiratory diseases.</p><p><strong>Methods: </strong>This was a retrospective study of patients aged ≥ 65 years with respiratory diseases who were urgently hospitalized between April 2022 and November 2024. The Mini Nutritional Assessment Short-Form (MNA-SF) was evaluated at the time of urgent admission, and the malnutrition risk was defined by the MNA-SF score < 11. Comorbidities and frailty were assessed using the Charlson comorbidity index (CCI) and Clinical frailty scale (CFS), respectively. Biomarkers of inflammation and acute respiratory failure such as neutrophil-to-lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), Respiratory rate-oxygenation (ROX) index, and the pulse oximetric saturation (SpO₂)/fraction of inspired oxygen (FiO₂) [S/F] ratio were calculated and analyzed as risk factors of in-hospital mortality.</p><p><strong>Results: </strong>A total of 168 consecutive patients were enrolled in the study with median age of 77 years (interquartile range [IQR]: 72-84). Thirty-nine patients (23.2%) died during hospitalization, and the median time to death was 17 days (IQR: 10-25). Univariate analysis demonstrated that older age (> 77 years), low S/F ratio (< 315), low ROX (< 8.3), high NLR (> 6), high CFS (> 5), and low MNA-SF (< 11) were associated with in-hospital mortality, multivariate analysis revealed that low MNA-SF was an independent predictor.</p><p><strong>Conclusions: </strong>The MNA-SF is a risk factor for mortality in older patients undergoing urgent hospitalization due to various respiratory diseases.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"113"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between neutrophil-lymphocyte ratio and risk of cognitive impairment among Chinese older adults.","authors":"Xin Wang, Binbin Wang, Xueqing Du, Peng Liu, Fuwen Yang, Jiao Su, Yue Zhang","doi":"10.1186/s12877-025-05763-6","DOIUrl":"10.1186/s12877-025-05763-6","url":null,"abstract":"<p><strong>Background: </strong>Associations between the neutrophil-lymphocyte ratio (NLR) and cognitive performance in older population are rarely reported. We investigated the associations between NLR and risk of cognitive impairment in Chinese community-dwelling older adults.</p><p><strong>Methods: </strong>Individuals aged ≥ 65 years from the 2011 and 2014 waves of the Chinese Longitudinal Healthy Longevity Survey were enrolled. We used the Chinese version of the Mini-Mental State Examination to evaluate cognitive function, with a score <18 indicating cognitive impairment. NLR was expressed as derived NLR (white blood cell count - lymphocyte count]/lymphocyte count). Logistic regression was used to evaluate the association between NLR levels and risk of cognitive impairment.</p><p><strong>Results: </strong>The study enrolled 2375 cognitively healthy participants and 838 with cognitive impairment. Significantly higher NLR values were noted in the latter than in the former group. In the cross-sectional analysis, NLR values in the highest than in the lowest quartile indicated significantly increased risk of cognitive impairment, after controlling for all confounding factors. During follow-up, 134 of the 1173 healthy participants at baseline developed cognitive impairment. NLR values in the highest two quartiles indicated higher risk of cognitive impairment than those in the lowest quartile. When NLR was classified into dichotomous groups, the risk of cognitive impairment was significantly higher in the high-inflammation than in the noninflammatory status group, regardless of the analysis used (cross-sectional or prospective).</p><p><strong>Conclusions: </strong>Elevated NLR status is associated with increased risk of cognitive impairment in Chinese community-dwelling older adults.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"114"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonising artistic designs with private and collective notions of home: a focus group study of older persons' experiences of art in residential care specialised in dementia care.","authors":"Synneve Dahlin-Ivanoff, Ewa Wikström, Maja Gunn, Qarin Lood","doi":"10.1186/s12877-025-05775-2","DOIUrl":"10.1186/s12877-025-05775-2","url":null,"abstract":"<p><strong>Background: </strong>Integrating art in residential care settings aims to create meaningful experiences and enhance the facility's aesthetic as a home. However, the literature shows a gap, as the voices of older persons are largely absent. This study aimed to explore the views of older persons in residential care facilities specialised in dementia care regarding art and expressions of home. Older persons with cognitive impairments are frequently depicted as lacking meaningful contributions, limiting their opportunities to voice their opinions and influence their environment.</p><p><strong>Methods: </strong>This study used a qualitative explorative design with focus group method, allowing older persons with dementia to discuss their views of art in relation to expressions of home. Eleven older persons participated in four focus groups. This method encourages interaction between participants, shedding light on a collective understanding.</p><p><strong>Results: </strong>The study found that the residential care facility was perceived as a home by the participants, based on their descriptions of how both private and shared collective spaces in the facility fostered a dynamic sense of belonging. Art owned by the older persons often held personal value and they valued art for its intrinsic qualities, such as beauty, meaning, and expression. The perception of art differed between the private and collective spaces, and the discussions centered on aligning the artistic design with the participants' notions of home to foster a socially engaging environment.</p><p><strong>Conclusion: </strong>Clearly defined private and collective spaces seem to be crucial for fostering self-determination and a sense of belonging for older persons living in residential care facilities specialised in dementia care. A balance between private and collective spaces boosted social engagement, with art playing a key role in reflecting older persons' previous lives, shared interests and experiences, with co-creation of artistic design ensuring a dynamic environment.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"115"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational attainment and male-female health-survival paradox among older adults in China: a nationally representative longitudinal study.","authors":"He Chen, Man Li, Ye Zhang","doi":"10.1186/s12877-024-05598-7","DOIUrl":"10.1186/s12877-024-05598-7","url":null,"abstract":"<p><strong>Background: </strong>The male-female health-survival paradox is characterized by the phenomenon where \"women get sicker, but men die quicker.\" Health expectancy, as a composite metric that encompasses both the quantity and quality of life, serves as a unique tool for analyzing this gender paradox. In this study, we investigate the relationship between educational attainment and the gender paradox among older adults in China.</p><p><strong>Methods: </strong>Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS), we focused on community-dwelling individuals aged 60 and above. Health was assessed using the Activities of Daily Living (ADLs). Educational attainment was dichotomized into low (primary education and below) and high (secondary education and above). We controlled for demographic, socioeconomic, and health behaviors confounders. Microsimulation techniques were employed to estimate total life expectancy (TLE), disability-free life expectancy (DFLE), and health ratio.</p><p><strong>Results: </strong>In China, educational attainment was positively associated with TLE and DFLE, with these benefits being more pronounced in females. Among individuals with lower educational attainment, females had significantly greater TLE (female-male difference: 3.82 years, 95% CI: 3.68 to 3.96) and DFLE (2.91 years, 95% CI: 2.78 to 3.04), but a lower health ratio (-2.14%, 95% CI: -2.41% to -1.87%) compared to males. In contrast, females with higher educational attainment not only lived longer but also healthier. Among these individuals, females had significantly greater TLE (5.89 years, 95% CI: 5.71 to 6.08), DFLE (6.02 years, 95% CI: 5.84 to 6.19), and a more favorable health ratio (95% CI: 2.60% to 3.19%) compared to males.</p><p><strong>Conclusions: </strong>Education plays a crucial role in enabling females to overcome disadvantages associated with the gender paradox in China. Enhancing gender equality in educational opportunities is expected to promote healthy longevity among females in the country.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"112"},"PeriodicalIF":3.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral healthcare for older adults in Swedish municipal healthcare-a qualitative study of healthcare professionals' experiences.","authors":"Maria Snogren, Kristina Ek, Ulrika Lindmark, Maria Browall, Irene Eriksson","doi":"10.1186/s12877-025-05764-5","DOIUrl":"10.1186/s12877-025-05764-5","url":null,"abstract":"<p><strong>Introduction: </strong>Oral health is multi-faceted and influences a person's daily life, and numerous potential barriers and factors can challenge and pose barriers to good oral health. Shortages of healthcare professionals or incorrect care practices can be barriers to performing good oral healthcare. A knowledge gap has been identified in qualitative research on description of healthcare professionals' experiences of oral healthcare among older adults in municipal healthcare.</p><p><strong>Aim: </strong>To describe healthcare professionals' experiences of oral healthcare among older adults in Swedish municipal healthcare.</p><p><strong>Design and methods: </strong>The study employed a qualitative design guided by a secondary qualitative analysis method comprising inductive qualitative content analysis. Data were collected through semi-structured individual interviews with healthcare professionals.</p><p><strong>Results: </strong>Good relationships and mutual trust create the conditions for delivering good oral healthcare. Knowledge provides confidence and trust in performing oral healthcare, experiences and strategies influence the individual adaptation of oral healthcare, and priorities and collaboration influence oral healthcare provision.</p><p><strong>Conclusion and implications: </strong>The performance of oral healthcare is complex and cannot be achieved without establishing a relationship with the older adult who needs care. Oral healthcare includes prerequisites such as routines, sufficient time, work-time planning, and collaboration between healthcare professionals. Registered nurses positively experience opportunities to collaborate with other healthcare professionals regarding oral healthcare and are seen as leaders in the Fundamentals of Care and are sharing good examples of oral healthcare in palliative care.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"110"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of remimazolam tosilate for injection (HR7056) versus sevoflurane on the incidence of postoperative delirium in older patients undergoing total hip arthroplasty: study protocol for a prospective, multicentre, two-arm, parallel-group, randomised controlled trial.","authors":"Lin-Yu Wang, Meng-Qing Zhang, Rui Sun, Liang Li, Dong-Liang Li","doi":"10.1186/s12877-025-05766-3","DOIUrl":"10.1186/s12877-025-05766-3","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative delirium (POD) is a common postoperative complication and is associated with numerous adverse outcomes. Advanced age and hip surgery are high risk factors for POD. Both remimazolam tosilate for injection and sevoflurane can be used as sedatives for the maintenance of general anesthesia, but the comparison of their impacts on the incidence of POD has not been reported. This study aims to compare the effect of remimazolam tosilate vernus sevoflurane on the incidence of POD in older patients undergoing total hip arthroplasty.</p><p><strong>Methods and analysis: </strong>This is a two-arm, parallel, prospective, multicenter, randomized controlled trial. A total of 456 older patients at six clinical trial centers in China will be randomly assigned in a 1:1 ratio to receive general anesthesia with remimazolam tosilate or sevoflurane as sedative. The primary outcome measure is the prevalence of POD during the first 4 postoperative days. Secondary outcomes include cognitive function [Mini-Mental State Examination (MMSE)], perioperative pain degree [Visual Analogue Scale (VAS)], postoperative nausea and vomiting (PONV) within 4 days after surgery, recovery time after drug withdrawal, the amount of vasoactive drugs used during operation, length of hospital stay, and in-hospital complications.</p><p><strong>Ethics and dissemination: </strong>The Research Ethics Committee of Qilu Hospital of Shandong University has approved the study protocol (REF: KYLL-202206-25), which is applicable to all research centers. Participant recruitment begins in August 2022. Written informed consent will be obtained from each patient before randomization. The findings will be published in an international peer-reviewed medical journal.</p><p><strong>Trial registration: </strong>The trial has been registered at the Chinese Clinical Trial Registry: ChiCTR2200062455; date of registration: 2022-08-08.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"109"},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}