BMC Geriatrics最新文献

{"title":"Development and usability testing of an integrated geriatric care model (SMART system) to promote integrated home-based geriatric care.","authors":"Rongrong Guo, Huan Fan, Shuqin Xiao, Ziling Zheng, Fangyu Yang, Yanyan Xiao, Xue Yang, Ying Wu","doi":"10.1186/s12877-025-05829-5","DOIUrl":"https://doi.org/10.1186/s12877-025-05829-5","url":null,"abstract":"<p><strong>Background: </strong>Although integrated care has been proposed as a promising approach to the challenges of fragmented geriatric care, a universally accepted implementation framework for integrated care for older adults living at home remains elusive. This study aimed to address the gap by developing an integrated geriatric care model (SMART system) using a knowledge-based clinical decision support system (CDSS) architecture inspired by the principle of neural reflex and evaluate the usability of the SMART system.</p><p><strong>Methods: </strong>The development of our SMART system was guided by the knowledge-based Clinical Decision Support System architecture and the principle of neural reflexes, which included 5 phases: (1) functional design; (2) architecture and database design; (3) security measures design; (4) user interface and visualization design; (5) prototypes development and iteratively testing. Subsequently, a cross-sectional study was conducted from December 2020 to February 2021, collecting older Chinese adults aged 60 years old and above consecutively to evaluate their usability perception of the Care Receiver App within the SMART system via the Health Information Technology Usability Evaluation Scale (Health-ITUES) version designed for older adults.</p><p><strong>Results: </strong>The SMART system consisted of a Care Receiver App, a Professional Care Provider App, and a Cloud Platform. According to the assessment results and daily monitoring data, the SMART system can diagnose care problems and tailor interventions and implementation approaches to address the multifaceted care needs of older individuals. The personalized interventions and implementation approaches generated by the SMART system, after being reviewed and adjusted by professional geriatric nurses, will be sent to the corresponding care providers to facilitate coordinated care services. A total of 110 eligible older individuals were included in the usability testing. The Care Receiver App was perceived as useful and acceptable among older individuals with the mean scores for each item of the Health-ITUES version designed for older adults exceeding 3.00.</p><p><strong>Conclusions: </strong>This study successfully developed an integrated geriatric care model using a knowledge-based CDSS architecture inspired by the principle of neural reflex. Furthermore, the study indicated acceptable usability perception of the SMART system among older population.</p><p><strong>Trial registration: </strong>The study was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR-IOR-17010368) on 12/01/2017.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"208"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-producing an intervention to reduce sedentary behaviour in community-dwelling older adults aged ≥ 75 informed by behaviour change theory.","authors":"Ragy Tadrous, Anne Forster, Amanda Farrin, Peter A Coventry, Andrew Clegg","doi":"10.1186/s12877-025-05844-6","DOIUrl":"10.1186/s12877-025-05844-6","url":null,"abstract":"<p><strong>Background: </strong>Older adults are the fastest-growing and most sedentary group in society. With sedentary behaviour associated with negative health outcomes, reducing sedentary time may improve overall well-being. Adults aged ≥ 75 years are underrepresented in sedentary behaviour research, and tailored strategies to reduce sedentary time may be warranted. The development of an intervention to reduce sedentary behaviour in adults aged ≥ 75 years using co-production and behaviour change theory is reported.</p><p><strong>Methods: </strong>Four co-production workshops with community-dwelling older adults aged ≥ 75 years were held between October-December 2022. The intervention development process was informed by the Behaviour Change Wheel (BCW) and Theoretical Domains Framework (TDF). Audio recordings and workshop notes were iteratively analysed, with findings used to inform subsequent workshops.</p><p><strong>Results: </strong>The co-production group consisted of six community-dwelling older adults aged ≥ 75 years and two researchers. The developed intervention consists of four components (activity monitoring, educational material, group sessions and researcher follow-up), maps to 24 behaviour change techniques and targets barriers to reducing sedentary time. Participants were receptive of the co-production process.</p><p><strong>Conclusions: </strong>Integrating co-production with the BCW can provide several benefits, with the BCW providing structure to the intervention development process, and co-production increasing the likelihood of the developed intervention being viewed as feasible by older adults. Furthermore, coding intervention components to the BCW may further our understanding of what approaches are successful at influencing behavioural change. Transparent reporting of the intervention development process may benefit researchers developing interventions with older adults. Future research will pilot the co-produced intervention.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"201"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, safety, and bleeding risk factor analysis of oral anticoagulants in AF patients ≥ 65 years of age: a multicenter retrospective cohort study.","authors":"Yanxian Lan, Jiana Chen, Peiguang Niu, Xinhai Huang, Xiaomin Dong, Cuifang You, Shuzheng Jiang, Jinhua Zhang","doi":"10.1186/s12877-025-05838-4","DOIUrl":"10.1186/s12877-025-05838-4","url":null,"abstract":"<p><strong>Background: </strong>Stroke prevention in elderly patients with atrial fibrillation (AF) is challenging and requires a balance between thromboembolic prevention and bleeding. The comparison of novel oral anticoagulants (NOACs) and warfarin in clinical practice in elderly Asian patients has not been well studied. The purpose of this study was to evaluate the efficacy and safety of NOACs versus warfarin in elderly patients with AF in conjunction with data from real-world observational studies.</p><p><strong>Methods: </strong>This was a retrospective multicenter cohort study conducted in 4 centers in China, where patient information and clinical events were collected through an average of 15 months of follow-up and case queries. Clinical outcomes included major bleeding, minor bleeding, total bleeding, thrombosis, and all-cause mortality.</p><p><strong>Results: </strong>A total of 3450 elderly patients with AF were enrolled. 2656 patients were treated with at least 1 NOAC (dabigatran, rivaroxaban, apixaban, or edoxaban), and 794 patients were treated with warfarin. After correcting for confounders, NOACs significantly reduced the risk of minor bleeding [OR 0.70 (95% CL, 0.49-1.01),P = 0.049] and all-cause mortality [OR 0.57( 95% CI, 0.44-0.75),P < 0.001] compared with warfarin, however, major bleeding events [OR 1.51 (95% CL, 0.98-2.42),P = 0.075] and thrombotic events [OR 0.79 (95% CL, 0.57-1.13),P = 0.187] were not significantly different. There was no heterogeneity between clinical outcomes of NOACs and warfarin in subgroup analyses of age (65-74, 75-84, ≥ 85 years), sex (male, female), BMI (≥ 25, < 25), comorbidities (including hypertension, diabetes and no hypertension, no diabetes), except in female subgroup, where NOACs significantly reduced the risk of minor bleeding [OR 0.56 (95% CL, 0.34-0.91),P = 0.018] and increased the risk of major bleeding [OR 2.28 (95% CL, 1.12-5.14),P = 0.032] compared with warfarin.</p><p><strong>Conclusion: </strong>Compared with warfarin, NOACs significantly reduced the risk of minor bleeding, all-cause mortality, and there were no statistically significant differences in major bleeding or thrombotic events. NOACs were not more effective than warfarin in thrombotic and bleeding events, regardless of the subgroup analyses on age, male, BMI and comorbid hypertension and diabetes.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"203"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of proprioceptive neuromuscular facilitation techniques compared to general aerobic exercise on balance, fear of falling, and quality of life in older adults living in nursing homes: a randomized controlled trial.","authors":"Mehrnaz Kajbafvala, Mina Ansari Eshlaghi, Shabnam ShahAli, Fateme Pourkazem, Anahita Hejazi","doi":"10.1186/s12877-025-05822-y","DOIUrl":"10.1186/s12877-025-05822-y","url":null,"abstract":"<p><strong>Background: </strong>With aging, changes occur in various body systems, such as cardiovascular, respiratory, neuromusculoskeletal, and vestibular, leading to a decreased quality of life (QOL) and an increased fear of falling (FOF). Exercise and physical activity reduce the progression of aging complications. Therefore, we examined the effect of proprioceptive neuromuscular facilitation techniques compared to aerobic exercise on balance, fear of falling, and quality of life in older adults living in nursing homes.</p><p><strong>Methods: </strong>Fifty-two older adults aged over 60 (31 males, 21 females) living in nursing homes were included. After initial evaluation, individuals were randomly assigned to two treatment groups (PNF techniques and aerobic exercise). Both treatment groups received 12 treatment sessions over 4 weeks. Balance, fear of falling, and quality of life were assessed at baseline and after a 4-week intervention. Analysis of covariance (ANCOVA) and paired samples t-test were utilized to between and within-group changes of variables.</p><p><strong>Results: </strong>The results showed no significant differences in balance, fear of falling, and quality of life between groups after the intervention (P > 0.05). In the within-group comparison, only the PNF techniques group showed significant improvement in the Berg Balance Scale (BBS) after the intervention (P < 0.05).</p><p><strong>Conclusion: </strong>The findings suggest that PNF techniques compared with aerobic exercise could not contribute to improved balance, fear of falling, and quality of life. Therefore, more clinical trial studies with a control group are needed to determine the exact effects of these techniques.</p><p><strong>Trial registration number (trn) and date of registration: </strong>The trial was registered at the ( https://www.irct.ir ), (IRCT20210505051181N4) on 9/2/2023.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"200"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social interactions in dementia: perceptions of current situation and opportunities.","authors":"Hanna L Knecht, Francisca S Rodriguez","doi":"10.1186/s12877-025-05850-8","DOIUrl":"10.1186/s12877-025-05850-8","url":null,"abstract":"<p><strong>Background: </strong>Social interactions can have a beneficial effect on people with dementia (PWD). However, little is known about the details of social interactions in dementia, information that is useful for planning social interventions. The aim of our study was to gain a deeper insight, provided by people in dementia care, into (i) the characteristics of social interactions of PWD, (ii) which social interactions are considered as particularly important, (iii) how important social interactions are perceived, and (iv) what is perceived to increase social interactions among PWD.</p><p><strong>Methods: </strong>Responses of 501 people in dementia care (mostly family and professional caregivers; more than three-quarters female; average age 53.5 years) provided in a structured, quantitative survey were included in this analysis. Descriptive analyses were conducted.</p><p><strong>Results: </strong>The majority of PWDs' social interactions take place in their home or day care and arise from support services as well as organized activities. More than half of the participants perceived singing, telling life stories, or moving together (e.g., walking, dancing) as valuable social interactions that PWD benefit from in many ways. Positive effects (e.g., aggression, depression, positive emotions, activation) are mainly perceived for social interactions such as laughing together, touch, hugging, simply being together, or being involved in daily activities. Overall, participants rated social interactions as rather important for the course of the symptoms. A fixed social contact besides the primary caregiver and offers from the community, associations, and religious institutions are considered rather important in increasing the social interactions of PWD.</p><p><strong>Conclusions: </strong>Simple social interactions of PWD such as laughing, eating or singing together that can be realized in the home environment and in the context of organized caregiving activities are perceived most valuable. Enhancing social interactions, especially beyond the primary caregiving context, may be valuable for those living with dementia.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"202"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis risk and its association with all-cause and cause-specific mortality among the elderly: a 16-year nationwide cohort study.","authors":"Xing-Bing Pan, Qing-Ya Ma, Teng Gao, Tai Zhang, Jian Xun, Xiang-Tao Ma, Yan-Yu Liu","doi":"10.1186/s12877-025-05843-7","DOIUrl":"10.1186/s12877-025-05843-7","url":null,"abstract":"<p><strong>Background: </strong>Aged osteoporosis poses a significant threat to the well-being and longevity of older individuals, yet evidence regarding the relationship between osteoporosis risk and mortality among the elderly population in Asia remains unknown.</p><p><strong>Aims: </strong>Our study aimed to investigate associations between osteoporosis risk and all-cause mortality, as well as cause-specific mortality, among the Chinese elderly population.</p><p><strong>Methods: </strong>Pooled data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted between 2002 and 2018 were utilized to analyze the associations between osteoporosis risk and all-cause, heart disease, cardiovascular disease (CVD), respiratory disease, and cancer mortality. Cox proportional hazards models were employed for this analysis. Osteoporosis risk was assessed using the Osteoporosis Self-Assessment Tool for Asians (OSTA). Restricted cubic spline (RCS) functions were applied to explore the nonlinear relationship between OSTA and mortality. The robustness of the Cox models was evaluated through internal verification, subgroup analyses, and sensitivity analyses.</p><p><strong>Results: </strong>A total of 12,711 elderly individuals aged ≥ 65 years were included for analysis at baseline. During a 16-year follow-up, 7,963 individuals in the cohort were identified as deceased. Compared to those with low osteoporosis risk, elderly individuals with high osteoporosis risk demonstrated a significantly elevated risk of all-cause, heart disease, CVD, respiratory disease and cancer mortality. The relationship between OSTA level and all-cause and cause-specific mortality exhibited a significant L-shaped pattern.</p><p><strong>Conclusions: </strong>The risk of osteoporosis is independently associated with the prediction of mortality. The OSTA may serve as a suitable predictor for mortality related to osteoporosis among the Asian population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"199"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physical activity on the depression and self-care ability among Chinese older adults during the COVID-19 pandemic: propensity score matching analysis.","authors":"Xiaotian Li, Zhuang Gu, Bing Zhan, Qingzhu Yang, Qiurui Wang, WenJie Li, Zhixiong Zhou","doi":"10.1186/s12877-025-05705-2","DOIUrl":"10.1186/s12877-025-05705-2","url":null,"abstract":"<p><strong>Introduction: </strong>The present study aimed to explore the effect of different levels of physical activity on depression, instrumental activities of daily living (IADLs), and activities of daily living (ADLs) among older adults over the age of 60.</p><p><strong>Methods: </strong>Data on older adults' health were obtained from the China Longitudinal Aging Social Survey (CLASS) conducted in 2021. A questionnaire was used to survey older adults aged 60 years and older in 28 regions of China. The International Physical Activity Questionnaire (IPAQ) was used to evaluate physical activity, and participants were categorized into groups based on their physical activity levels: vigorous (5.38%), moderate (16.33%), light (74.58%), and no physical activity (control group). The CES-D9 scale was used to assess the level of depression, and both the activities of daily living (ADLs) scale and the instrumental activities of daily living (IADLs) scale were used to evaluate self-care ability. Propensity score matching was used to determine the intensity of physical activity that affected depression, instrumental daily activity ability (IADLs), and activities of daily living (ADLs) among the participants.</p><p><strong>Results: </strong>The participation rates of vigorous, moderate, and light physical activities among the older adult Chinese participants were 5.38%, 16.33%, and 74.58%, respectively. Propensity score matching (PSM) showed moderate and light physical activity decreased depression by -0.367 and - 0.409 units, respectively. Moderate and light physical activity increased instrumental activities of daily living (IADLs) by 0.165 and 0.607 units, respectively. Light physical activity increased the level of activities of daily living (ADLs) by 0.265 units.</p><p><strong>Conclusion: </strong>Moderate and light physical activity in older adults alleviates depression and improves instrumental activities of daily living (IADLs), and light physical activity improves the level of activities of daily living (ADLs).</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"198"},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of population aging trend and analysis of influencing factors based on grey fractional-order and grey relational models: a case study of Jiangsu Province, China.","authors":"Xiaojun Guo, Ying Wu, Yueyue Wang, Houxue Shen, Yingjie Yang, Yun Fan","doi":"10.1186/s12877-025-05848-2","DOIUrl":"10.1186/s12877-025-05848-2","url":null,"abstract":"<p><strong>Background: </strong>With the rapid development of society, China is facing an increasingly serious problem of population aging. This trend poses new challenges to the labor force structure, public medical care construction and elderly care services, forcing the government to make a series of policy adjustments. Jiangsu Province, as a region with prominent aging problems in China, has a particularly significant aging phenomenon. Against the backdrop of the Chinese government's active response to the challenges of aging, this study conducts an in-depth analysis of the aging trend and its influencing factors in Jiangsu Province.</p><p><strong>Methods: </strong>Based on the statistical data of the total population and the aging population in Jiangsu Province from 2011 to 2023, this study employs the grey fractional-order prediction model (FGM(1,1)) to forecast the trend of the aging population and the aging coefficient in Jiangsu Province over the next decade. Additionally, grey relational analysis (GRA) based on panel data was conducted to thoroughly examine the relevant influencing factors of population aging in Jiangsu Province. The analysis identified key factors such as general public budget expenditure, health technicians, urbanization rate, and education level as being highly correlated with population aging.</p><p><strong>Results: </strong>The results of trend prediction indicate that the elderly population in Jiangsu Province is projected to continue increasing over the next decade, with the degree of aging becoming more pronounced. Additionally, GRA based on panel data reveals that factors such as general public budget expenditures and the number of health technicians significantly influence the aging process. This suggests that public financial investment and the quantity and quality of health technicians play crucial roles in shaping the aging trend.</p><p><strong>Conclusions: </strong>In conjunction with the analysis results from FGM(1,1) model and GRA of panel data, this study enhances the comprehensive understanding of the aging issue in Jiangsu Province. The insights derived herein offer crucial data support and a scientific foundation for both Jiangsu Province and the Chinese government to develop policies addressing population aging. Considering the anticipated future trends in aging, it is recommended that the government revise fertility policies to optimize population structure, increase investment in public finance and medical security, and promote the development of elderly care systems. These measures aim to mitigate the challenges posed by aging and achieve sustainable economic and social development.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"197"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary overactive bladder syndrome with restless legs syndrome following cerebral infarction: report of 2 cases.","authors":"Ying Cui, Qiang Huang, Yitong Du, Lin Wang, Shiya Wang, Wenlu Zhao, Houzhen Tuo","doi":"10.1186/s12877-025-05724-z","DOIUrl":"10.1186/s12877-025-05724-z","url":null,"abstract":"<p><strong>Background: </strong>Previous research has commonly regarded overactive bladder syndrome (OAB) and restless legs syndrome (RLS) as distinct disorders in terms of their underlying causes, clinical diagnosis, and treatment approaches. However, there is evidence of an overlap in the occurrence of these two conditions following cerebral infarction(CI). Specifically, restless bladder syndrome (RBS), a subtype of RLS, exhibits symptoms similar to those of OAB. Consequently, further investigation is warranted to better understand the relationship between these two disorders.</p><p><strong>Case presentation: </strong>In this report, we present the cases of two patients who presented with both OAB following CI, along with RLS. Following administration of oral pramipexole, both nocturia and RLS exhibited prompt and efficient alleviation.</p><p><strong>Conclusions: </strong>There may exist a shared pathological foundation between certain RLS cases and OAB. In instances where patients exhibit evident OAB symptoms following CI and concurrently experience RLS, it is advisable to prioritize the administration of dopaminergic agonists over M receptor inhibitors and β₃ agonists. Furthermore, it is plausible that the RBS or a subset of RLS cases could potentially be classified as a form of OAB, although this correlation has yet to be definitively established.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"196"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meaning in life: bidirectional relationship with depression, anxiety, and loneliness in a longitudinal cohort of older primary care patients with multimorbidity.","authors":"King Wa Tam, Dexing Zhang, Yiqi Li, Zijun Xu, Qiao Li, Yang Zhao, Lu Niu, Samuel Ys Wong","doi":"10.1186/s12877-025-05762-7","DOIUrl":"10.1186/s12877-025-05762-7","url":null,"abstract":"<p><strong>Background: </strong>Depression, anxiety and loneliness are common among older patients. As a potential psychological buffer against these challenges, meaning in life (MIL) remains underexplored in longitudinal studies within this population. This study aims to examine the longitudinal relationship of MIL with depression, anxiety, and loneliness among older adults with multimorbidity in Hong Kong.</p><p><strong>Methods: </strong>In a prospective cohort of 1077 primary care patients aged 60 or above with multimorbidity in Hong Kong, MIL was assessed using an item from the Chinese Purpose in Life test at baseline, the 1st follow-up (median: 1.3 years), and the 2nd follow-up (median: 3.1 years). Depression, anxiety, and loneliness were assessed using the Patient Health Questionnaire, Generalized Anxiety Disorder, and De Jong Gierveld Loneliness scales, respectively, at each time point. Cross-lagged relationships between MIL and these measures were examined using cross-lagged panel models.</p><p><strong>Results: </strong>Participants had an average age of 70.0 years, with 70.1% being female. Higher MIL predicted lower depression (β = -0.15), anxiety (β = -0.13), overall loneliness (β = -0.18), emotional loneliness (β = -0.15), and social loneliness (β = -0.16) at the 1st follow-up. Additionally, higher MIL predicted lower overall loneliness (β = -0.12), emotional loneliness (β = -0.11), and social loneliness (β = -0.10) at the 2nd follow-up. At baseline, higher depression (β = -0.21), overall loneliness (β = -0.15), emotional loneliness (β = -0.11), and social loneliness (β = -0.11), but not anxiety, predicted lower MIL at the 1st follow-up. At the 1st follow-up, depression (β = -0.23), anxiety (β = -0.16), overall loneliness (β = -0.10), and emotional loneliness (β = -0.11), but not social loneliness, predicted lower MIL at the 2nd follow-up.</p><p><strong>Conclusions: </strong>The findings suggest a bidirectional relationship between MIL and mental health outcomes in older patients with multimorbidity in Hong Kong. Emotional loneliness demonstrated a more consistent bidirectional association with MIL than social loneliness. Further research is needed to understand the underlying mechanisms and develop targeted interventions addressing both MIL and mental health problems.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"195"},"PeriodicalIF":3.4,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}