BMC Geriatrics最新文献

{"title":"Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial.","authors":"Nene Sato, Yuji Terashima, Makoto Sugawara, Ryoichi Unno, Hiroaki Asao, Mitsuhiro Iwasaki, Tomoyuki Watanabe, Tomoko Uno, Mitsuo Maruyama","doi":"10.1186/s12877-024-05539-4","DOIUrl":"https://doi.org/10.1186/s12877-024-05539-4","url":null,"abstract":"<p><strong>Background: </strong>To investigate whether continuous intervention using soymilk containing high soy protein improves physical frailty, a randomized controlled trial was conducted among the Japanese pre-frail and frail elderly.</p><p><strong>Methods: </strong>Japanese pre-frail and frail elderly participants (n = 73) were randomly assigned to the high-soy protein and control groups, who then ingested soymilk containing 14.5 g/200 ml and 3.2 g/200 ml of soy protein, respectively. Before and after the 12-week intervention, walking speed, skeletal muscle mass, grip strength, and the revised Japanese CHS questionnaire regarding fatigue and physical activity were examined to evaluate the impact of each soymilk on physical frailty and compare the variation between the two groups. Physical activity (monitored using a pedometer), dietary intake (determined by questionnaire), and estimated protein intake (determined by casual urine testing) were also recorded before and after the intervention.</p><p><strong>Results: </strong>For the final analysis of the entire cohort (n = 70), there were no significant differences in the endpoints between the two groups. In the subgroup analysis, among participants with a walking speed of at least 1 m/s (n = 35, P = 0.012) and at least 5,000 steps/day before intervention (n = 27, P = 0.0083), the variation in walking speed after the 12-week intervention was significantly higher in the high-soy protein group than in the control group. Estimated protein intake was also significantly higher in the high-soy protein group than in the control group after the intervention. Regarding physical activity and dietary intake, no significant differences were observed between the groups before or after the intervention.</p><p><strong>Conclusion: </strong>The continuous 12-week intervention of high soy protein increased the walking speed among the Japanese pre-frail and frail elderly participants who had an ordinarily high walking speed and high step counts.</p><p><strong>Trial registration: </strong>UMIN Clinical Trials Registry, UMIN000044999. Registered July 29, 2021; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051409 .</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"35"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between edaravone use and activities of daily living in older patients with atherothrombotic stroke: an observational study using Japanese real-world data.","authors":"Yukari Ogawa, Hiroko Akiyama, Takeshi Horii, Kiyoshi Mihara","doi":"10.1186/s12877-024-05666-y","DOIUrl":"https://doi.org/10.1186/s12877-024-05666-y","url":null,"abstract":"<p><strong>Background: </strong>Edaravone is marketed in nine countries, although only Japan has approved edaravone for improvement of neurological symptom, disability of activities of daily living (ADL), and functional disability associated with acute stroke. This study aimed to elucidate the association of edaravone use with ADL using real-world data of older patients with atherothrombotic stroke.</p><p><strong>Methods: </strong>This retrospective observational research using the Medical Data Vision database in Japan included patients aged 65 years and older who had acute ischemic stroke of the atherothrombotic subtype. Primary outcome was ADL improvement defined as change in Barthel Index from admission to discharge of greater than zero points. The major secondary outcome was good functional outcome (Barthel Index ≥ 90 or modified Rankin Scale 0-2 at discharge). Multivariate logistic regression analyses were conducted to calculate odds ratios with 95% confidence intervals for the outcomes. We further compared the change in Barthel Index from admission to discharge and in-hospital death rate between the edaravone- and non-edaravone- treated patients.</p><p><strong>Results: </strong>A total of 5,576 patients were included in this study, and were divided into edaravone group (n = 3,825) and non-edaravone group (n = 1,751). The median age of this cohort was 79 years, and median Barthel Index at admission was 30 points. Edaravone use was associated with improved ADL with an adjusted odds ratio of 1.18 (95% confidence interval: 1.01‒1.37). However, no significant association was observed between edaravone use and good functional outcome. The edaravone group had significantly greater change in Barthel Index from admission to discharge than the non-edaravone group, with a difference of 5 points. The in-hospital death rate was comparable between the two groups.</p><p><strong>Conclusions: </strong>Edaravone use may contribute to improve ADL at discharge in patients aged 65 years and older with atherothrombotic stroke.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"31"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of suicidal ideation and its associated factors among the geriatric population in Vyas Municipality, Tanahun District, Nepal: a cross-sectional study.","authors":"Durga Shrestha, Hari Prasad Kaphle","doi":"10.1186/s12877-025-05677-3","DOIUrl":"https://doi.org/10.1186/s12877-025-05677-3","url":null,"abstract":"<p><strong>Background: </strong>Suicidal ideation among the geriatric population is a pressing concern, particularly in regions such as Nepal where mental health resources are limited. This study aimed to determine the prevalence of suicidal ideation and its associated factors among the geriatric population in Vyas Municipality, Nepal.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among individuals aged 60 years and above in Vyas Municipality, Nepal. A total of 311 participants were selected using multistage sampling. The data were collected through face-to-face interviews using a structured interview schedule. Multivariate logistic regression analysis was performed to identify independent variables associated with suicidal ideation.</p><p><strong>Results: </strong>The overall prevalence of suicidal ideation within the last twelve months among the geriatric population was 6.4% (n = 20). After adjustment for covariates in multivariate logistic regression analysis, living in a nuclear family (OR: 3.033, C.I. 95%:1.007-9.136), and experiencing depressive symptoms [(Mild depression:- OR: 5.358, C.I. 95%:1.548-18.539), (Moderate depression:- OR: 15.739, C.I. 95%:2.536-97.687), and (Severe depression:- OR: 17.423, C.I. 95%:2.218-136.878)] were found to be significant influencing factors for suicidal ideation.</p><p><strong>Conclusion: </strong>This study emphasizes the need to enhance mental health services and strengthen family and community support systems to address suicidal ideation among older adults in Nepal. Further research is required to identify additional determinants and evaluate interventions to mitigate this risk.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"34"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of caregivers of older people in Sri Lanka: an overlooked concern in the health care system.","authors":"Nirmala Rathnayake, Wedura Kannangara, Thilina Abeygunasekara, Warsha De Zoysa, Dhammika Palangasinghe, Sarath Lekamwasam","doi":"10.1186/s12877-025-05681-7","DOIUrl":"https://doi.org/10.1186/s12877-025-05681-7","url":null,"abstract":"<p><strong>Background: </strong>Caring for older people has become a significant public health concern in Sri Lanka due to the growing aging population. This has placed a heavy burden on family caregivers, particularly those caring for older individuals with multiple chronic conditions. Recognizing this challenge, the present study aimed to evaluate the psychometric properties of the Sinhala version of the 10-item short form of the Burden Scale for Family Caregivers (BSFC-s) and assess caregiver burden and associated factors among caregivers of older people aged over 65 years with multimorbidity.</p><p><strong>Methods: </strong>The BSFC-s was cross-culturally adapted following standard guidelines and administered to consecutively selected 178 family caregivers involved in the long-term care of older patients (aged ≥ 65 years) who were regular attendees of medical and neurology clinics at the National Hospital Galle, Sri Lanka. The validated Sinhala version of the Short Form-36 questionnaire (SF-36) was also administered simultaneously. After two weeks, 60 caregivers were re-assessed using the BSFC-s. The psychometric properties, including reliability and validity, as well as floor and ceiling effects, were evaluated. The final version of the BSFC-s was then administered to 270 informal family caregivers in the Gampaha District, Sri Lanka.</p><p><strong>Results: </strong>The study revealed that the internal consistency of the Sinhala version of the BSFC-s, measured by Cronbach's alpha, was 0.90, with item-total correlations ranging from 0.38 to 0.82. The test-retest reliability, assessed using the intra-class correlation coefficient, was 0.99 (95% CI: 0.99-1.00; p < 0.001). Principal component analysis revealed two factors explaining 65.8% of the cumulative variance. BSFC-s scores showed a strong negative correlation with SF-36 scores (r = -0.81, p < 0.001), indicating a good concurrent validity. Neither floor nor ceiling effects were observed. Among the 270 family caregivers, 78.1% reported a high level of burden, while 21.1% reported moderate burden. Caregiver burden was significantly associated with low educational level (p = 0.032), low monthly income (p = 0.041), and unemployment status (p < 0.001) of the caregiver.</p><p><strong>Conclusion: </strong>The Sinhala version of the BSFC-s demonstrated strong reliability and validity, making it a suitable tool for assessing caregiver burden in Sri Lanka. Most caregivers reported high levels of subjective burden, particularly those with lower socio-demographic status.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"32"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcome changes in sarcopenic obesity: a meta-analysis of exercise training methods.","authors":"Lei Chen, Haojing Zhou, Yichen Gong, Yi Tang, Hai Su, Zhongyi Zhang, Peijian Tong, Guoqian Chen","doi":"10.1186/s12877-024-05655-1","DOIUrl":"https://doi.org/10.1186/s12877-024-05655-1","url":null,"abstract":"<p><strong>Aim: </strong>Assessing the effect of various forms of exercise training on patients with sarcopenic obesity.</p><p><strong>Methods: </strong>Two independent reviewers systematically searched English and Chinese databases (PubMed, Embase, Cochrane Library, Web of Science, CNKI) for randomized controlled trials on various exercise training effects in sarcopenic obesity patients until October 2023. Reference materials and grey literature were also included. Selected studies underwent screening, data extraction, and quality assessment. Meta-analysis was conducted using Review Manager 5.4 software.</p><p><strong>Results: </strong>A total of 8 studies were included in the final analysis. The Meta-analysis results indicated that resistance training (RT) significantly improved grip strength (MD = 3.85, 95%CI: 1.50 to 6.20, P < 0.01), percentage of body fat (MD = -2.96, 95%CI: -4.19 to -1.74, P < 0.01), walking speed (MD = 0.23, 95%CI: 0.01 to 0.46, P = 0.04), IGF-1(MD = 0.79, 95%CI: 0.05 to 1.52, P = 0.04) and knee extension strength (MD = 4.85, 95%CI: 1.97 to 7.72, P < 0.01). There was no statistically significant difference observed in weight (MD = -0.61, 95%CI: -4.06 to 2.84, P = 0.73). Aerobic training (AT) resulted in a significant reduction in weight among patients with SO (MD = -6.07, 95%CI: -9.89 to -2.25, P < 0.01), while no statistically significant differences were observed in other outcome measures. Mixed training (MT) significantly improved percentage of body fat (MD = -2.42, 95%CI: -3.58 to -1.26, P < 0.01), weight (MD = -4.40, 95%CI: -8.40 to -0.40, P = 0.03), IGF-1 (MD = 1.01, 95%CI: 0.45 to 1.56, P < 0.01), and walking speed (MD = 0.15, 95%CI: 0.04 to 0.26, P < 0.01). However, no statistically significant differences were observed in grip strength (MD = -0.70, 95%CI: -4.00 to 2.60, P = 0.68) and knee extension strength (MD = 1.73, 95%CI: -1.31 to 4.78, P = 0.26). RT, AT, and MT exercise could not significantly improve the level of serum IL-6 in patients with SO, and the difference was not statistically significant [MD = -0.01,95%CI:-0.27 to 0.24, P = 0.92].</p><p><strong>Conclusion: </strong>Various exercise training methods have differing effects on muscle-reducing obesity treatment. Compared to aerobic training, resistance training, and mixed training may offer more pronounced improvements, enhancing physical functioning in sarcopenic obesity patients. This underscores the clinical significance of exercise intervention in treating muscle-reducing obesity, suggesting future studies explore exercise intervention's role and mechanism, particularly related to IGF-1, IL-6, and other cytokines.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"33"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of biological sex and long-term outcomes in older patients with physical restraint at the emergency department.","authors":"Laetitia Manfredini, Marion Pépin, Pradeebane Vaittinada Ayar, Matthieu Gay, Marie Certin, Prabakar Vaittinada Ayar","doi":"10.1186/s12877-025-05689-z","DOIUrl":"10.1186/s12877-025-05689-z","url":null,"abstract":"<p><strong>Background: </strong>The worldwide population is ageing and self-arm can be prevented with many techniques. Among them coercive measure consisting of physical restraint (PR) is one of the techniques. This study aims to assess the effects of the biological sex on the long-term survival after PR in geriatric patients during the initial emergency department (ED) visit.</p><p><strong>Methods: </strong>This retrospective study included patients between November 2019 to March 2021. All consecutive hospitalized patients after emergency department visit older than 75 years with PR were included. The population was compared according to the biological sex. One-year all-cause mortality was plotted with the Kaplan-Meier curve. Hazard ratios (HRs) for 1-year mortality were calculated using a Cox proportional hazards regression model. Mortality was monitored over a 3-year period.</p><p><strong>Results: </strong>PR was used in 149 patients representing 4.6% of 3210 hospitalized patients older than 75 years after ED visit. Women represented 52% of the study population. Compared to men, women were older [median (IQR) age 89 (85-93) vs. 85 (81-90) years, P = 0.002]. Women more often presented dementia (93 vs. 80%, P = 0.031). Both sexes presented the same limited independence. All-cause mortality was significantly lower for women than men after one year (25 vs. 51%, respectively, P = < 0.001). Likewise, adjusted HR of 1-year all-cause mortality was higher in men [a HR 3.4 (95% confidence interval 1.7-7.1), P < 0.001].</p><p><strong>Conclusion: </strong>This study suggested that the use of physical restraint in older adults was a more related factor of mortality in men than women. Women were older with lower expectancy life but PR use seemed to be a sign of global health decline in men. Further prospective studies are needed to assess if mortality after PR use is a cause or a consequence of a global health decline.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"30"},"PeriodicalIF":3.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction models for falls in hospitalized older patients: a systematic review and meta-analysis.","authors":"Anli Mao, Jie Su, Mingzhu Ren, Shuying Chen, Huafang Zhang","doi":"10.1186/s12877-025-05688-0","DOIUrl":"10.1186/s12877-025-05688-0","url":null,"abstract":"<p><strong>Background: </strong>Existing fall risk assessment tools in clinical settings often lack accuracy. Although an increasing number of fall risk prediction models have been developed for hospitalized older patients in recent years, it remains unclear how useful these models are for clinical practice and future research.</p><p><strong>Objectives: </strong>To systematically review published studies of fall risk prediction models for hospitalized older adults.</p><p><strong>Methods: </strong>A search was performed of the Web of Science, PubMed, Cochrane Library, CINAHL, MEDLINE, and Embase databases: to retrieve studies of predictive models related to falls in hospitalized older adults from their inception until January 11, 2024. Extraction of data from included studies, including study design, data sources, sample size, predictors, model development and performance, etc. Risk of bias and applicability were assessed using the Prediction Model Risk of Bias Assessment Tool (PROBAST) checklist.</p><p><strong>Results: </strong>A total of 8086 studies were retrieved, and after screening, 13 prediction models from 13 studies were included. Four models were externally validated. Eight models reported discrimination metrics and two models reported calibration metrics. The most common predictors of falls were mobility, fall history, medications, and psychiatric disorders. All studies indicated a high risk of bias, primarily due to inadequate study design and methodological flaws. The AUC values of 8 models ranged from 0.630 to 0.851.</p><p><strong>Conclusions: </strong>In the present study, all included studies had a high risk of bias, primarily due to the lack of prospective study design, inappropriate data analysis, and the absence of robust external validation. Future studies should prioritize the use of rigorous methodologies for the external validation of fall risk prediction models in hospitalized older adults.</p><p><strong>Trial registration: </strong>The study was registered in the International Database of Prospectively Registered Systematic Reviews (PROSPERO) CRD42024503718.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"29"},"PeriodicalIF":3.4,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study.","authors":"Esra Cataltepe, Eda Ceker, Ayse Fadiloglu, Fatih Gungor, Nermin Karakurt, Zekeriya Ulger, Hacer Dogan Varan","doi":"10.1186/s12877-025-05686-2","DOIUrl":"10.1186/s12877-025-05686-2","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains a challenge.</p><p><strong>Aim: </strong>Our study aims to investigate the relationship between sarcopenia and the Systemic Immune-Inflammation Index (SII), a comprehensive indicator of inflammation.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 632 patients. All participants underwent a comprehensive geriatric assessment. Sarcopenia was assessed through the evaluation of handgrip strength and calf circumference. To determine the SII, we used the formula: Platelet count (10⁹/mm³)×Neutrophil count (10⁹/mm³) / Lymphocyte count (10⁹/mm³).</p><p><strong>Results: </strong>The average age of the participants was 74.8 ± 6.4, and 62.3% (n = 394) were female. Patients were grouped as non-sarcopenic and sarcopenic. The non-sarcopenic group had 536 patients (84.8%), while the sarcopenic group comprised 96 patients (15.2%). Sarcopenic patients showed a higher median SII score than the non-sarcopenic group (p < 0.001). Multivariate logistic regression analysis revealed that the SII score was significantly and independently associated with sarcopenia even after adjusting for potential confounding factors (β = 1.002, 95% CI = 1.001-1.003, p < 0.001). The ROC analysis identified the optimal cut-off for SII in predicting sarcopenia as > 765. At this threshold, the negative predictive values were determined to be 88.1%, with a specificity of 88%.</p><p><strong>Conclusion: </strong>SII is significantly associated with sarcopenia in a geriatric outpatient population, and a population-specific SII cut-off may serve as a novel, simple, and practical biomarker for diagnosing sarcopenia.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"28"},"PeriodicalIF":3.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11727228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prediction study on the occurrence risk of heart disease in older hypertensive patients based on machine learning.","authors":"Fei Si, Qian Liu, Jing Yu","doi":"10.1186/s12877-025-05679-1","DOIUrl":"10.1186/s12877-025-05679-1","url":null,"abstract":"<p><strong>Objective: </strong>Constructing a predictive model for the occurrence of heart disease in elderly hypertensive individuals, aiming to provide early risk identification.</p><p><strong>Methods: </strong>A total of 934 participants aged 60 and above from the China Health and Retirement Longitudinal Study with a 7-year follow-up (2011-2018) were included. Machine learning methods (logistic regression, XGBoost, DNN) were employed to build a model predicting heart disease risk in hypertensive patients. Model performance was comprehensively assessed using discrimination, calibration, and clinical decision curves.</p><p><strong>Results: </strong>After a 7-year follow-up of 934 older hypertensive patients, 243 individuals (26.03%) developed heart disease. Older hypertensive patients with baseline comorbid dyslipidemia, chronic pulmonary diseases, arthritis or rheumatic diseases faced a higher risk of future heart disease. Feature selection significantly improved predictive performance compared to the original variable set. The ROC-AUC for logistic regression, XGBoost, and DNN were 0.60 (95% CI: 0.53-0.68), 0.64 (95% CI: 0.57-0.71), and 0.67 (95% CI: 0.60-0.73), respectively, with logistic regression achieving optimal calibration. XGBoost demonstrated the most noticeable clinical benefit as the threshold increased.</p><p><strong>Conclusion: </strong>Machine learning effectively identifies the risk of heart disease in older hypertensive patients based on data from the CHARLS cohort. The results suggest that older hypertensive patients with comorbid dyslipidemia, chronic pulmonary diseases, and arthritis or rheumatic diseases have a higher risk of developing heart disease. This information could facilitate early risk identification for future heart disease in older hypertensive patients.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"27"},"PeriodicalIF":3.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of physiological status, community participation, and daily activity function to sleep quality for outpatient dynapenic older people.","authors":"Hsiao-Chi Tsai, Shu-Fang Chang","doi":"10.1186/s12877-024-05622-w","DOIUrl":"10.1186/s12877-024-05622-w","url":null,"abstract":"<p><strong>Background: </strong>The global aging population has increased dynapenia prevalence, leading to mobility issues and poor sleep quality among older adults. Despite its impact, research on sleep quality in dynapenic outpatients is limited. This study investigates how physiological status, community participation, and daily activity function influence sleep quality in this group.</p><p><strong>Methods: </strong>This cross-sectional study employed purposive sampling to collect data from 192 dynapenic older outpatients in October 2022, assessing their basic attributes, physiological status, community participation, daily activity function, and sleep quality. Data were analyzed using SPSS 25.0 for descriptive statistics, independent samples t-tests, chi-square tests, and logistic regression analysis.</p><p><strong>Results: </strong>Findings indicated significant correlations between sleep quality and gender (X² = 11.340, p < .001), occupational status (X² = 13.378, p < .05), residence (X² = 6.265, p < .05), medication intake (X² = 7.250, p < .05), smoking history (X² = 6.695, p < .01), instrumental activities of daily living (X² = 12.556, p < .01), activities of daily living (t = 2.74, p < .01), instrumental activities of daily living (t = 3.60, p < .001), skeletal muscle mass (t = 2.94, p < .01), skeletal muscle index (t = 2.65, p < .01), grip strength (t = 3.61, p < .001), and walking speed (t = 2.09, p < .05). Furthermore, the type of occupational status (OR = 6.608, 95% CI = 1.124-3.744, p < .05), medication intake (OR = 3.916, 95% CI = 1.682-9.114, p < .05), and grip strength (OR = 0.891, 95% CI = 0.797-0.996, p < .05) were significant predictors of sleep quality in dynapenic older patients.</p><p><strong>Conclusion: </strong>This cross-sectional study reveals significant correlations between sleep quality and key factors such as physiological status, community participation, and daily functional activities in older adults with dynapenia. These findings underscore the importance of addressing these determinants to enhance sleep quality in this population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"26"},"PeriodicalIF":3.4,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}