BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-06151-w
Jian-Hui Zhang, Jie Liu, Qian Chen, Dan-Dan Ruan, Li-Sheng Liao, Kai-Ping Lin, Xiao-Ling Zheng, Jie-Wei Luo, Li Zhang
{"title":"A rare concurrence of monoclonal gammopathies in an older adult with tubulointerstitial nephritis and uveitis syndrome.","authors":"Jian-Hui Zhang, Jie Liu, Qian Chen, Dan-Dan Ruan, Li-Sheng Liao, Kai-Ping Lin, Xiao-Ling Zheng, Jie-Wei Luo, Li Zhang","doi":"10.1186/s12877-025-06151-w","DOIUrl":"10.1186/s12877-025-06151-w","url":null,"abstract":"<p><strong>Background: </strong>Tubulointerstitial nephritis and uveitis (TINU) syndrome is prevalent among adolescent females and less prevalent among the older people. Additionally, although both disorders are linked to immune modulation, clinical instances of simultaneous diagnosis of TINU syndrome and monoclonal gammopathies (MG) are exceedingly rare. In this case report, we present a rare concurrence of monoclonal gammopathies in an older adult with TINU syndrome.</p><p><strong>Case presentation: </strong>A 74-year-old woman with chronic bilateral anterior uveitis and a non-oliguric acute kidney injury developed TINU syndrome. Unexpectedly, immunofixation electrophoresis testing confirmed MG in the patient. Her renal histology showed tubulointerstitial degeneration, confirming TINU syndrome with MG. The patient tended to have monoclonal gammopathy of undetermined significance because her renal vascular light chain Kappa immunofluorescence showed significant positivity but no glomerular or tubular damage from monoclonal immunoglobulin deposition. The patient's renal impairment was principally attributed to TINU syndrome, and after glucocorticoid treatment, ocular symptoms stabilized, renal impairment improved, and urine protein remained consistently negative.</p><p><strong>Conclusions: </strong>The high incidence of disease in the old population results in increased disease complexity. This report emphasizes that TINU syndrome might be complicated by various additional conditions, including the unusual occurrence of coupled MG. A renal tissue biopsy is crucial for a differential diagnosis in cases of severe kidney injury. Patients with TINU and MG present distinct clinical manifestations and renal damage pathologies. The diagnosis of these patients requires consideration of clinical data and renal pathological alterations to guide treatment planning.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"472"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-06079-1
Gary Mitchell, James McMahon, Lana Cook, Oonagh McCloy, Paul Tierney, David R Thompson, Laura Creighton, Stephanie Craig, Elizabeth Henderson, Loreena Hill, Jan Cameron, Doris Yu, Debra K Moser, Karen Spilsbury, Nittaya Srisuk, Jos M G A Schols, Mariëlle van der Velden-Daamen, Christine Brown Wilson
{"title":"Experiences of care home staff in the delivery of heart failure care: a grounded theory.","authors":"Gary Mitchell, James McMahon, Lana Cook, Oonagh McCloy, Paul Tierney, David R Thompson, Laura Creighton, Stephanie Craig, Elizabeth Henderson, Loreena Hill, Jan Cameron, Doris Yu, Debra K Moser, Karen Spilsbury, Nittaya Srisuk, Jos M G A Schols, Mariëlle van der Velden-Daamen, Christine Brown Wilson","doi":"10.1186/s12877-025-06079-1","DOIUrl":"10.1186/s12877-025-06079-1","url":null,"abstract":"<p><strong>Background: </strong>Heart failure is a complex syndrome affecting 64 million people globally, with an average patient age of 76 years. Management challenges include medication titration difficulties and patient self-management issues. Care homes, housing approximately 20% of residents with heart failure, face unique challenges in managing this condition. This study aimed to investigate care home staff experiences in supporting residents with heart failure.</p><p><strong>Methods: </strong>A Glaserian grounded theory approach was employed to explore perceptions, challenges, and strategies used by care home staff in supporting residents with heart failure. Twenty care home staff members from Northern Ireland, with varied roles and experience levels, participated in online semi-structured interviews. These interviews were audio-recorded and transcribed verbatim. Data collection and analysis occurred concurrently, following theoretical sampling principles, between February 2023 and March 2024. A three-stage coding process (open, axial, and selective) was used for analysis. Rigour was ensured through member checking, data source triangulation, and reflexivity. Ethical approval was obtained prior to data collection.</p><p><strong>Results: </strong>Three main categories were developed from the data: (1) Training, (2) Support, and (3) Communication. Training revealed that care home staff received limited education on heart failure management, primarily focused on acute settings rather than the chronic care needed in care homes. Support highlighted the various facilitators and barriers staff faced in making clinical decisions regarding heart failure care. Communication addressed the experiences of staff in engaging residents and their families about managing heart failure. These categories linked to the core category of (C) Empowerment, which encompassed the challenges staff faced in training, support, and communication. Empowerment illustrated how staff navigated these obstacles to provide effective heart failure care within the unique context of care homes.</p><p><strong>Discussion: </strong>This study highlights significant challenges in managing heart failure in care homes, including inadequate training, limited professional development, and insufficient support systems. Key barriers include a lack of specialist education tailored to long-term care settings and restricted access to heart failure specialists. Effective communication and proactive care were identified as critical needs, alongside holistic care approaches. Addressing these gaps through targeted education, specialist integration, and evidence-based strategies could empower staff, optimise care quality, and potentially improve outcomes for residents.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"446"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibrinogen-to-albumin ratio and long-term mortality in oldest-old patients undergoing percutaneous coronary intervention.","authors":"Yalin Cheng, Huimin Li, Chenguang Yang, Haiyang Gao, Peng Li, Wanrong Zhu, Yuzhu Lu, Fusui Ji, Xue Yu, Wenduo Zhang","doi":"10.1186/s12877-025-06111-4","DOIUrl":"10.1186/s12877-025-06111-4","url":null,"abstract":"<p><strong>Background: </strong>The fibrinogen-to-albumin ratio (FAR), a novel inflammatory marker, has demonstrated prognostic utility in cardiovascular diseases. However, its role in risk stratification among oldest-old patients (≥ 80 years) undergoing percutaneous coronary intervention (PCI) remains poorly established.</p><p><strong>Methods: </strong>This single-center retrospective cohort study enrolled 641 consecutive patients aged ≥ 80 years with coronary artery disease who underwent PCI between 2015 and 2021. Based on the median FAR value (0.079), patients were divided into higher FAR and lower FAR groups. The endpoints were cardiovascular and all-cause mortality. Multivariable Cox models and restricted cubic splines assessed the associations between FAR and endpoints.</p><p><strong>Results: </strong>During a median follow-up of 61 months, 237 deaths (37%) were recorded, of which, 124 (19.3%) were due to cardiovascular disease. The 1-year mortality was 9.3% and 5-year mortality was 27.4%. Kaplan-Meier analysis demonstrated higher FAR levels were significantly associated with increased risk of both cardiovascular and all-cause mortality (log-rank p < 0.001). According to the restricted cubic spline, the association between FAR and mortality was J-shaped. Higher FAR (> 0.079) independently predicted cardiovascular mortality (adjusted HR = 1.49, 95% CI:1.01-2.19, p = 0.045). When tested as a continuous variable, higher FAR levels were associated with a higher risk of cardiovascular (HR = 1.23, 95% CI: 1.04-1.47, p = 0.018) and all-cause mortality (HR = 1.12, 95%CI: 0.98-1.27, p = 0.090) in fully adjusted models. Subgroup analysis revealed that the association between higher FAR levels and increased cardiovascular mortality was significantly stronger in patients with triple-vessel disease (interaction p = 0.039). The associations between FAR and cardiovascular mortality remained robust in the Fine and Gray competing models (HR = 1.31, 95%CI: 1.13-1.52, p = 0.003).</p><p><strong>Conclusion: </strong>Higher FAR levels are associated with increased risks of cardiovascular and all-cause mortality in oldest-old patients undergoing PCI. These findings support the potential of FAR for risk stratification in geriatric cardiology.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"460"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-06108-z
Lei Xu, Jia Wang, Caixiu Xue, Ke Yang, Xiaohui Xie, Wansha Zhou, Lianhong Wang
{"title":"Status and factors associated with health service utilization among older adults in China: a recent national population-based survey.","authors":"Lei Xu, Jia Wang, Caixiu Xue, Ke Yang, Xiaohui Xie, Wansha Zhou, Lianhong Wang","doi":"10.1186/s12877-025-06108-z","DOIUrl":"10.1186/s12877-025-06108-z","url":null,"abstract":"<p><strong>Background: </strong>Accelerated population aging and the growing prevalence of various geriatric diseases in China have placed older adults in a vulnerable position regarding access to health services, including medical care and health checkup services. This study aimed to investigate the use of health services by older adults and its influencing factors.</p><p><strong>Methods: </strong>A total of 9401 respondents aged 60 years and older from the 2020 wave (wave 5) of the China Health and Retirement Longitudinal Study (CHARLS) were included. Employing the Behavioral Model of Health Service Use as a framework, the study categorized the determinants of health service utilization among the elderly into three distinct segments: predisposing factors, enabling factors, and needs-based factors. Multiple logistic regression was used to examine three factors affecting the use of medical care services.</p><p><strong>Results: </strong>The rate of utilization of health services (including medical care and health checkup services) among older adults was 33.34%. The utilization rates of outpatient visits, hospitalization care, and health checkup services were 21.5%, 23.2%, and 55.30%, respectively. Factors influencing the use of health services varied by different service types. Needs-based factors, including chronic diseases and self-perceived health status, played an essential role in medical care services. Predisposing factors (age, gender, personal income), enabling factors (medical insurance, social insurance), and needs factors (chronic diseases, ADL) will all significantly health service utilization among older adults.</p><p><strong>Conclusion: </strong>The overall level of health service utilization among older adults is low, so policies and decision-makers can consider improving the development of targeted measures for different service types to increase the utilization rate of medical care services for the elderly and promote the health equity of vulnerable groups.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"439"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-06065-7
Ming-Yueh Tseng, Jersey Liang, Ying-Jen Chen, Chi-Chuan Wu, Yea-Ing L Shyu
{"title":"Influences of social support following hip-fracture surgery for older adults with cognitive impairment and their family caregivers.","authors":"Ming-Yueh Tseng, Jersey Liang, Ying-Jen Chen, Chi-Chuan Wu, Yea-Ing L Shyu","doi":"10.1186/s12877-025-06065-7","DOIUrl":"10.1186/s12877-025-06065-7","url":null,"abstract":"<p><strong>Background: </strong>Social support can impact family caregivers and influence the care receiver's recovery from surgery following hospital discharge. This study aimed to explore the influence of perceived social support on outcomes for dyads of older adults with cognitive impairment recovering from hip fracture surgery and their family caregivers.</p><p><strong>Methods: </strong>This secondary analysis utilized data from a single-blind clinical trial involving 131 dyads randomly assigned to an intervention or control group. Perceived social support was assessed one month post-discharge using the Medical Outcomes Study Social Support Survey (MOS-SSS) and categorized as good (score = 95) or poor (< 95). Outcomes measured at 1, 3, 6, and 12 months included care receiver-specific outcomes (hip range of motion, muscle strength, nutritional status, depressive symptoms, and health-related quality of life [HRQoL]) and caregiver-specific outcomes (competence, self-efficacy, and HRQoL). The influence of good social support compared with poor social support on outcomes for care receivers and caregivers was analyzed with hierarchical linear modeling as a function of GSS and controlling for covariates of group assignment, pre-fracture activities of daily living of care receivers, and attrition.</p><p><strong>Results: </strong>Care receivers with perceived good social support showed significantly better trajectories in hip range of motion, muscle strength, nutritional status, depressive symptoms, and MCS-HRQoL. Caregivers with good social support demonstrated significantly higher PCS-HRQoL and MCS-HRQoL scores, although no differences in caregiver competence or self-efficacy were observed. However, caregivers whose care receivers had good social support exhibited significantly higher competence and self-efficacy at three months post-discharge, with effects sustained over 12 months.</p><p><strong>Conclusions: </strong>Good perceived social support positively influenced recovery trajectories for older adults with cognitive impairment and improved HRQoL for both care receivers and caregivers, highlighting the importance of developing targeted interventions to enhance social support during post-surgical recovery for this vulnerable population.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"469"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of telemedicine in enhancing palliative care for older adults: opportunities and challenges.","authors":"Roni Chaim Mukamal, Laiane Moraes Dias, Thiago Dias Sarti, Rui Nunes, Guilhermina Rego","doi":"10.1186/s12877-025-06041-1","DOIUrl":"10.1186/s12877-025-06041-1","url":null,"abstract":"<p><strong>Background and objective: </strong>Telemedicine holds promise for older adults with chronic and complex conditions, particularly those in need of palliative care. However, more information is needed about the perceptions of patients and their caregivers regarding this technology for providing care. Therefore, this study aims to explore the experience of non-oncologic older adult patients in palliative care with telemedicine.</p><p><strong>Methods: </strong>We followed Arksey and O'Malley's five-stage scoping review approach and conducted searches in Medline, Scopus, and Web of Science databases. Key concepts included: \"telemedicine\" or \"telehealth\"; \"elderly\" or \"old age\" or \"geriatric\"; \"palliative care\" and NO \"cancer\" and were included articles written in English or Portuguese from the last five years.</p><p><strong>Results: </strong>Eighteen articles were included out of 137 abstracts selected. Most studies focused on elderly individuals in homebound settings, nursing homes, or long-term care facilities. The experiences reported in many articles were positive, with patients and caregivers expressing a willingness to use telemedicine. It was particularly convenient for patients in rural areas. However, several barriers were identified, such as difficulties in using and accessing technology and concerns about privacy, influencing the willingness to use telemedicine.</p><p><strong>Conclusions: </strong>Telemedicine can be beneficial in the care of older adults with non-oncologic chronic disease, multimorbidity, and life-threatening conditions. Nevertheless, understanding this barrier and searching for solutions from the patients' perspectives is essential for integrating telemedicine into their care. More studies involving older adults palliative care patients are needed to explore this area further.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"474"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-05907-8
Yueming Zhang, Siyang Han, Yaolin Xu, Liang Liu, Wenchuan Wu, Lei Zhang, Chenye Shi, Chao Song, Dansong Wang, Wenhui Lou
{"title":"Pancreatic surgery is safe in elderly patients with PDAC.","authors":"Yueming Zhang, Siyang Han, Yaolin Xu, Liang Liu, Wenchuan Wu, Lei Zhang, Chenye Shi, Chao Song, Dansong Wang, Wenhui Lou","doi":"10.1186/s12877-025-05907-8","DOIUrl":"10.1186/s12877-025-05907-8","url":null,"abstract":"<p><strong>Background: </strong>In an aging society, more and more elderly people are diagnosed with pancreatic ductal adenocarcinoma (PDAC), unfortunately, many of these patients didn't receive proper treatment compared to their younger counterparts. The safety of surgical intervention in elderly pancreatic cancer patients remains a subject of ongoing debate.</p><p><strong>Methods: </strong>We retrospectively analyzed PDAC patients who underwent radical resection between 2012 and 2021 at Zhongshan Hospital, Fudan University. Patients were categorized into two groups: non-elderly (< 70 years) and elderly (≥ 70 years). We compared operation-related factors and postoperative complications between the two groups. Additionally, subgroup analysis was conducted to assess the impact of inflammatory-nutritional status on both elderly and non-elderly patients.</p><p><strong>Results: </strong>A total of 892 pancreatic cancer patients who underwent radical resection were included, consisting of 256 elderly and 636 non-elderly patients. Our study revealed that elderly pancreatic cancer patients had an earlier 8th edition American Joint Committee on Cancer (AJCC) T stage (T3 + T4, 10.6% vs. 18.7%) and N stage (N0, 68.2% vs. 55.2%), a higher American Society of Anesthesiologists (ASA) grade (grade 2 + grade 3, 92.6% vs. 87.7%), lower inflammatory markers (lymphocyte count and lymphocyte to monocyte ratio) and poorer nutritional status (total protein, albumin, prealbumin, hemoglobin, transferrin, platelet). The incidence of postoperative complications including reoperation, postoperative pancreatic fistula, pulmonary embolism, surgical site infection and post-pancreatectomy hemorrhage, was comparable between the two groups, except for delayed gastric emptying (16.4% vs. 22.8%, p = 0.0360). Furthermore, poorer inflammatory-nutritional status was frequently associated with more complex surgical procedures, including longer surgical durations, greater intraoperative reported blood loss, and a higher number of resected lymph nodes, particularly in non-elderly patients.</p><p><strong>Conclusion: </strong>With comprehensive preoperative evaluation and careful postoperative care, pancreatic surgery is safe for elderly patients in experienced pancreatic cancer centers.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"438"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relationship between grip strength, 6 minute walking distance and working memory in older adults with mild cognitive impairment: an fNIRS study.","authors":"Peng Wang, Yanran Si, Zhidong Cai, Wanting Jiang, Xin Xin, Shufan Li, Shuqi Jia, Qing Liu, Xing Wang","doi":"10.1186/s12877-025-06080-8","DOIUrl":"10.1186/s12877-025-06080-8","url":null,"abstract":"<p><strong>Objective: </strong>Functional near-infrared spectroscopy (fNIRS) was employed to explore the potential relationship between grip strength, 6-minute walking distance (6MWD), and working memory in older adults with mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>Participants aged 60 years and above were recruited and assessed using the Montreal Cognitive Assessment (MoCA). Grip strength and 6MWD were measured, and fNIRS was utilized to monitor blood flow changes in the prefrontal lobe during an N-back task.</p><p><strong>Results: </strong>A total of 72 participants were recruited, aged between 70 and 95 years, with MoCA scores ranging from 10 to 25 points. The MoCA score was most strongly correlated with 1-back performance (r = -0.423, p < 0.001), followed by 0-back performance, and showed no significant correlation with 2-back performance. The activation levels of several channels in the left dorsolateral prefrontal cortex (ch17, ch19, ch23), right dorsolateral prefrontal cortex (ch8), and right ventrolateral prefrontal cortex (ch2) were significantly higher in the high-performance group for 1-back compared to the low-performance group (p = 0.016, p = 0.008, p = 0.013; p = 0.018; p = 0.043). Grip strength and 6MWD were both significantly correlated with working memory performance under all three levels of cognitive load, with the strongest correlation observed for 1-back performance (grip strength: r = -0.377, p = 0.001; 6MWD: r = -0.382, p = 0.001). Grip strength was positively correlated with the activation levels of ch17 and ch19 (r = 0.234, p = 0.048; r = 0.249, p = 0.035), and significant inter-group differences were found for the activation level of ch19 (p = 0.032). Similarly, 6MWD was positively correlated with the activation levels of ch17 and ch2 (r = 0.312, p = 0.008; r = 0.256, p = 0.030), with significant inter-group differences observed in the activation levels of ch17, ch19, and ch2 (p = 0.007; p = 0.022; p = 0.029).</p><p><strong>Conclusion: </strong>Cognitive decline in older adults with MCI was associated with a decline in working memory, with 1-back performance being the most sensitive measure. The brain mechanisms underlying this sensitivity involved higher activation levels in the left dorsolateral prefrontal cortex, right dorsolateral prefrontal cortex, and right ventrolateral prefrontal cortex. Older adults with stronger muscle strength and better cardiopulmonary function maintained better working memory, with higher activation levels in the left dorsolateral prefrontal cortex. However, the specific activation channels were not entirely consistent across individuals.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"437"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-06095-1
Qin-Fen Chen, Chao Ni, Yalan Jiang, Lifen Chen, Hetong Liao, Jiaqi Gao, Xuemei Qin, Sipei Pan, Xiaoqian Luan, Yili Wu, Xiao-Dong Zhou, Weihong Song
{"title":"Global burden of disease and its risk factors for adults aged 70 and older across 204 countries and territories: a comprehensive analysis of the Global Burden of Disease Study 2021.","authors":"Qin-Fen Chen, Chao Ni, Yalan Jiang, Lifen Chen, Hetong Liao, Jiaqi Gao, Xuemei Qin, Sipei Pan, Xiaoqian Luan, Yili Wu, Xiao-Dong Zhou, Weihong Song","doi":"10.1186/s12877-025-06095-1","DOIUrl":"10.1186/s12877-025-06095-1","url":null,"abstract":"<p><strong>Background: </strong>The global older population has been rapidly increasing in recent decades, presenting substantial economic and social challenges.</p><p><strong>Aims: </strong>This study aims to examine the global disease burden and the associated risk factors among the population aged 70 and older across different regions.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease Study (GBD) database were used to analyze global deaths, disability-adjusted life years (DALYs), and average annual percentage changes to assess disease burden and associated risk factors.</p><p><strong>Results: </strong>In 2021, the global population aged 70 and older reached 494.4 (95%UI 482.1-508.2) million. Death and DALY rates have declined by 9.2% (95%CI 5.3-12.7) and 11.0% (95%CI 7.7-14.0) from 1990 to 2021, respectively. However, the global death rate increased to 7,062 per 100,000 population, with DALY rates rising to 125,042 per 100,000. A strong correlation exists between socio-demographic index (SDI) and DALY rates. Regions with lower SDI levels, particularly low and low-middle SDI regions, showed higher DALY rates, reaching 189,563 and 165,080 per 100,000, respectively. The leading causes of death among the older included ischemic heart disease, stroke, COVID-19, and chronic obstructive pulmonary disease. The primary risk factors contributing to DALYs were high systolic blood pressure, air pollution, and tobacco use.</p><p><strong>Conclusions: </strong>The global disease burden among adults aged 70 and older has shown declines in death and DALY rates, yet remains a significant challenge exacerbated by population growth, especially in less developed regions. Implementing preventive strategies that target primary risk factors early and enhancing treatment of underlying conditions are crucial.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"462"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BMC GeriatricsPub Date : 2025-07-02DOI: 10.1186/s12877-025-06021-5
Hongsoo Kim, Young-Il Jung, Seungyeon Chun
{"title":"Reliability and validity of the interRAI Check-Up Self-Reported (CUSR) Assessment.","authors":"Hongsoo Kim, Young-Il Jung, Seungyeon Chun","doi":"10.1186/s12877-025-06021-5","DOIUrl":"10.1186/s12877-025-06021-5","url":null,"abstract":"<p><strong>Background: </strong>As the global population ages, the need for community-based tools to assess the functional status and care needs of older adults is increasing. This study examined the reliability, validity, and feasibility of the interRAI Check-Up Self-Reported (CUSR) in a low-income urban district in Seoul, South Korea.</p><p><strong>Methods: </strong>A total of 158 older adults participated in this study. The interRAI CUSR was administered by trained lay interviewers, and psychometric testing was conducted using interrater reliability, test-retest reliability, and criterion validity measures. The study assessed the agreement between self-reported and clinician-administered assessments as well as participant feedback on feasibility and acceptability.</p><p><strong>Results: </strong>The interRAI CUSR demonstrated good psychometric properties, with interrater reliability scores (mean kappa = 0.97, Gwet's AC1 = 0.99) and test-retest reliability (mean kappa = 0.76, Gwet's AC1 = 0.94), indicating high levels of agreement. Criterion validity showed strong correlations with the items in the interRAI Check-Up (CU) administered by clinicians. The participants reported that the tool was easy to use and accurately reflected their health status. Overall, the interRAI CUSR was found to be a reliable and feasible tool for generally healthy, pre-frail older adults residing in low-income communities.</p><p><strong>Conclusion: </strong>The interRAI CUSR is a valuable tool for assessing the functional status of older adults living independently in low-income communities. By enabling self-assessment with the support of laypersons, this tool may reduce the burden on health care professionals and enhance community-based care. Further research is required to expand its applicability to diverse settings and populations.</p>","PeriodicalId":9056,"journal":{"name":"BMC Geriatrics","volume":"25 1","pages":"475"},"PeriodicalIF":3.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}