BJPsych Open最新文献

{"title":"Mental health symptoms following a pregnancy complicated by cardiovascular disease: scoping review.","authors":"Iris Becene, Stephanie Vartany, Alyssa Grimshaw, Sona Jasani","doi":"10.1192/bjo.2026.12051","DOIUrl":"10.1192/bjo.2026.12051","url":null,"abstract":"<p><strong>Background: </strong>Pre-existing cardiovascular disease (CVD) affects 1-4% of pregnancies in the USA and is associated with maternal morbidity. High-risk pregnancies with increased medical supervision are associated with poor postpartum mental health, although the prevalence in those with CVD is unclear.</p><p><strong>Aims: </strong>This scoping review aimed to synthesise estimates of post-pregnancy mental health outcomes among people with pre-existing CVD.</p><p><strong>Method: </strong>Cochrane Library, Ovid Medline, Ovid EMBASE, Scopus, Google Scholar and Web of Science Core Collection were searched to identify relevant published literature, using controlled vocabulary and keywords for post-pregnancy mental health and CVD in pregnancy. The search was not limited by publication type, year or study design. Studies that included an assessment of post-pregnancy depression, anxiety or post-traumatic stress disorder (PTSD) symptoms after a pregnancy complicated by pre-existing CVD were included.</p><p><strong>Results: </strong>Of the 1591 studies screened, 7 met the inclusion criteria. In patients with pre-existing CVD, 4 studies assessed depressive symptoms and found a prevalence of 10.4-32.2%; 2 studies assessed anxiety symptoms and found a prevalence of 22.0-28.5%; and 1 study assessed PTSD and found a prevalence of 26.4% for mild symptoms and 18.2% for moderate symptoms.</p><p><strong>Conclusions: </strong>The prevalence of post-pregnancy depression, anxiety and PTSD symptoms among people with pre-existing CVD may be similar to, or higher than, estimates from the general population. However, there was high heterogeneity in the included studies. More research is needed to determine if there is an increased risk of postpartum mental health disorders for pregnant people with pre-existing CVD.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e197"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of in-patient mental health rehabilitation services provided by the NHS and independent sector in England: patient and service characteristics.","authors":"Helen Killaspy, Christian Dalton-Locke, Mariam Adeleke, Nia Barber, Bella Branch, Caroline Sarah Clarke, Gerard Leavey, Artemis Igoumenou, Katherine Barrett, Megan Downey, Sophie Thomas, Jing Yi Jessica Weng, Rumana Z Omar","doi":"10.1192/bjo.2026.12047","DOIUrl":"10.1192/bjo.2026.12047","url":null,"abstract":"<p><strong>Background: </strong>In-patient mental health rehabilitation services provide specialist care to adults with complex psychosis. In England, there are more than 350 such services, half provided by the National Health Service (NHS) and half by the independent sector.</p><p><strong>Aims: </strong>To investigate whether NHS and independent sector in-patient mental health rehabilitation services differ.</p><p><strong>Method: </strong>We recruited a random sample of NHS and independent sector services across England. We collected cross-sectional data regarding service and patient characteristics through interviews with patients, clinicians and managers, and from healthcare record reviews.</p><p><strong>Results: </strong>We recruited 411 patients from 48 NHS services and 172 patients from 20 independent sector services. Service characteristics, including standardised quality scores, were similar. Most patients had a diagnosis of schizophrenia (NHS <i>n</i> = 237, 57.7%; independent sector <i>n</i> = 99, 57.6%) or schizoaffective disorder (NHS <i>n</i> = 88, 21.4%; independent sector <i>n</i> = 32, 18.6%). More than half had at least one comorbid condition, but more independent sector patients had at least two (NHS 131 of 411, 31.9%; independent sector 80 of 172, 46.5%; <i>P</i> = 0.001). Current admissions were twice as long for independent sector patients (NHS mean 1.2 years [s.d. 1.5]; independent sector mean 2.4 years [s.d. 2.8]). Standardised ratings of patients' quality of life, autonomy, time use, satisfaction with care, social and everyday functioning, and challenging behaviours were similar. However, independent sector patients had more needs (NHS mean 6.5 [s.d. 3.2]; independent sector mean 7.9 [s.d. 3.9]; <i>P</i> < 0.001) and more had a history of fire setting (NHS 32, 7.9%; independent sector 28, 17.2%; <i>P</i> = 0.001).</p><p><strong>Conclusions: </strong>Both NHS and independent sector in-patient rehabilitation services support people with complex psychosis, but independent sector patients may have more complex conditions, which could explain their longer admissions.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e196"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delays and disparities in access to secure psychiatric services in England: national study of referrals and access assessments.","authors":"Sarah-Jayne Leonard, Jana Bowden, Florian Walter, Jon Fernando Carey, Louise Robinson, Caroline Logan, Ruth McDonald, Jennifer Shaw, Jane Senior","doi":"10.1192/bjo.2026.12053","DOIUrl":"10.1192/bjo.2026.12053","url":null,"abstract":"<p><strong>Background: </strong>Secure psychiatric services (SPS) are vital for people with severe mental disorders who pose significant risks, yet national evidence on referral pathways, acceptance and timeliness of admission is limited. Delays and variability in access are especially concerning in prisons, where mental health crises are frequent and alternatives limited.</p><p><strong>Aims: </strong>This study presents the first national analysis of SPS referral and admission patterns in England following the introduction of provider collaboratives. It identifies predictors of referral acceptance and delays across the referral-to-admission pathway to inform equity and performance improvement.</p><p><strong>Method: </strong>Data were drawn from 149 low-secure and 98 medium-secure services across 15 provider collaboratives, encompassing 1356 referrals. Multivariable models examined predictors of acceptance and delay, benchmarked against national policy standards.</p><p><strong>Results: </strong>Almost half of referrals originated from prisons (46%, <i>n</i> = 529), with 55% accepted. Acceptance was associated with gender, legal status, Mental Health Act status, prior secure admission, diagnosis, referral origin and reason for referral, but not with ethnicity or urgency. Substantial site-level variation reflected local practice and resources. Delays were widespread: fewer than a third of urgent referrals were assessed within 2 days, and only 19-25% of accepted prison referrals met recommended assessment and admission targets. Although prison referrals were processed more quickly than community or SPS referrals, national standards were seldom achieved.</p><p><strong>Conclusions: </strong>Access to SPS remains inconsistent, with substantial variation in acceptance and widespread delays across referral pathways. Despite faster processing of prison referrals, national assessment and admission standards were rarely met, particularly for this group. These findings highlight gaps between policy expectations and practice, indicating a need for improved adherence to national timeframes, greater standardisation of decision-making and enhanced system oversight, to reduce inequities in access.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e198"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 Diabetes and Disordered Eating - the Rising T1DE: Evolution of a New Service Within a Specialist Eating Disorder Service (SEDU) - ERRATUM.","authors":"Mike Apio, Wiebke Hollemann, Jana Ondrova Farmer, Kruti Pandit, Aisha Kibirige","doi":"10.1192/bjo.2026.12075","DOIUrl":"10.1192/bjo.2026.12075","url":null,"abstract":"","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e194"},"PeriodicalIF":4.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>ALDH2 rs671</i> and <i>ADH1B rs1229984</i> polymorphisms on habitual alcohol use: evidence from a large Taiwanese cohort.","authors":"Mu-En Liu, Yu-Ting Yan, Yu-Tung Tien, Wei-Ming Liu, Ding-Lieh Liao, Po-Hsiu Kuo, Shih-Jen Tsai","doi":"10.1192/bjo.2026.12042","DOIUrl":"10.1192/bjo.2026.12042","url":null,"abstract":"<p><strong>Background: </strong>Two functional genetic polymorphisms, <i>ADH1B rs1229984</i> and <i>ALDH2 rs671</i>, play key roles in ethanol metabolism and are especially prevalent in East Asian populations. The <i>rs1229984</i> variant accelerates the conversion of ethanol to acetaldehyde, whereas <i>rs671</i> reduces enzymatic activity for converting acetaldehyde into acetic acid. These variants affect alcohol use disorder risk and have been implicated in various systemic conditions.</p><p><strong>Aims: </strong>To investigate the broader associations of <i>ADH1B rs1229984</i> and <i>ALDH2 rs671</i> with habitual alcohol use in large, unselected populations.</p><p><strong>Method: </strong>We analysed data from 146 374 Taiwanese adults (aged 20-90 years) enrolled in the Taiwan Biobank.</p><p><strong>Results: </strong>Both variants showed clear associations with habitual alcohol use. The <i>ADH1B rs1229984</i> CC genotype was associated with a higher prevalence of drinking, indicating a substantial contribution to alcohol-related behaviour. The <i>ALDH2 rs671</i> A allele was linked to markedly reduced drinking, reflecting known intolerance among carriers rather than implying a uniformly larger effect than <i>ADH1B</i>. Beyond alcohol use, <i>rs671</i> showed a protective association with gout, whereas <i>rs1229984</i> was not significantly associated with chronic diseases after correction.</p><p><strong>Conclusions: </strong>In this large population sample, both <i>ADH1B rs1229984</i> and <i>ALDH2 rs671</i> demonstrate meaningful, genotype-dependent effects on habitual alcohol use. Their combined effects underscore the importance of evaluating gene-gene interactions rather than attributing disproportionate influence to a single locus.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e192"},"PeriodicalIF":4.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing treatment home for adolescents with eating disorders.","authors":"Laura Coglan, Gillian Combe, Lorna McGuigan, Agnes Ayton","doi":"10.1192/bjo.2026.12038","DOIUrl":"10.1192/bjo.2026.12038","url":null,"abstract":"<p><strong>Background: </strong>The increasing demand for adolescent eating disorder services during and following the COVID-19 pandemic necessitated alternative treatment approaches. Traditional in-patient and daycare settings faced challenges, including resource limitations and geographical accessibility.</p><p><strong>Aims: </strong>To describe and evaluate the outcomes of the Hospital at Home (H@H) service, an innovative, virtual, intensive treatment programme designed to prevent in-patient admissions or shorten length of in-patient stay.</p><p><strong>Method: </strong>A prospective cohort of 71 consecutive admissions from October 2021 to December 2024 was established. Data included percentage median body mass index (%mBMI), Eating Disorders Examination Questionnaire (EDE-Q), Children's Global Assessment Scale (CGAS) and any readmissions for in-patient treatment within the following 6 months. Qualitative feedback was also sought from staff and a sample of patients and family members.</p><p><strong>Results: </strong>Of the 71 admissions to H@H, only 9 (13%) required hospitalisation. Mean %mBMI increased significantly, from 82.4% (s.d. 8.17) on admission to 90.07% (s.d. 9.44) on discharge (<i>p</i> < 0.001, 95% CI 5.67 to 9.61). Global EDE-Q score improved significantly, from 3.75 (s.d. 1.32) on admission to 2.62 (s.d. 1.45) on discharge (<i>p</i> < 0.001, 95% CI -1.47 to -0.78). Average CGAS improved significantly, from 38.7 (s.d. 7.4) on admission to 51.8 (s.d. 14.2) on discharge (<i>p</i> < 0.001, 95% CI 10.06 to 16.11). Families and patients reported high satisfaction with the virtual care model.</p><p><strong>Conclusions: </strong>This innovative model prevented hospital admissions, demonstrating clinical benefits and high user satisfaction. Expansion and further research are recommended to explore the long-term clinical outcomes and cost-effectiveness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e193"},"PeriodicalIF":4.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prospective incidence of treatment-resistant schizophrenia: analysis of the CATIE trial using the TRRIP consensus.","authors":"Dan W Joyce, Sajitha Nair, Alexis E Cullen, Rodrigo Bressan, Sukhi Shergill","doi":"10.1192/bjo.2026.12041","DOIUrl":"10.1192/bjo.2026.12041","url":null,"abstract":"<p><strong>Background: </strong>The true incidence of treatment-resistant schizophrenia (TRS) remains uncertain, largely because earlier studies relied on heterogeneous definitions and retrospective assessments. The Treatment Response and Resistance in Psychosis (TRRIP) consensus established standardised diagnostic criteria, but these have rarely been applied prospectively.</p><p><strong>Aims: </strong>To estimate the incidence of TRS prospectively by using operationalised TRRIP criteria within a large community-based trial, and to examine whether baseline demographic or clinical variables predict its emergence.</p><p><strong>Method: </strong>We applied TRRIP criteria to 1334 participants with chronic schizophrenia enrolled in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. TRS was defined as persistent symptoms and functional impairment following two adequate antipsychotic trials, each meeting TRRIP thresholds for duration, dose and adherence. Incidence was estimated with bootstrap resampling, and logistic regression examined associations between baseline variables and TRS onset.</p><p><strong>Results: </strong>Of 1334 participants, 782 (58.6%) met TRRIP absolute symptom thresholds at baseline; 77 (9.8%) fulfilled full criteria for TRS during follow-up. The incidence rate was 5.68 per 100 person-years (95% CI 4.51-7.02) overall and 9.20 per 100 person-years (95% CI 7.43-11.39) among above-threshold participants. Higher baseline Positive and Negative Syndrome Scale positive and negative subscale scores and greater global illness severity were associated with TRS, although predictive performance was poor.</p><p><strong>Conclusions: </strong>This first prospective application of TRRIP criteria to a randomised trial data-set provides robust estimates of TRS incidence. Routine clinical and demographic variables have limited predictive value, supporting the need for longitudinal, biologically informed studies that use TRRIP-aligned frameworks.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e191"},"PeriodicalIF":4.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are antidepressants held to a different standard?","authors":"Ovais Wadoo, Yasser Saeed Khan, Javed Latoo, Abdul Majid Gania, Majid Alabdulla","doi":"10.1192/bjo.2026.12043","DOIUrl":"10.1192/bjo.2026.12043","url":null,"abstract":"<p><p>This Editorial examines the continuing debate over the efficacy and outcomes of antidepressants, focusing on how evidence is interpreted and applied in clinical practice. Although concerns about uncertainty, heterogeneity and contested outcome measures are valid, these challenges are not unique to psychiatry, but are common across medical specialties. The Editorial discusses issues in evidence synthesis, the distinction between statistical significance and clinical relevance, the translation of global trial data into real-world settings and the influence of public and digital discourse. It emphasises balanced interpretation, transparent risk-benefit communication and shared decision-making, to avoid simplistic conclusions about treatment effectiveness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e190"},"PeriodicalIF":4.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of patient-provider gender concordance on mental health outcomes: scoping review.","authors":"James Lanni, Jason Denoncourt, Becky Baltich Nelson, Rebecca Drouhard, Stephany Eierle","doi":"10.1192/bjo.2026.12036","DOIUrl":"10.1192/bjo.2026.12036","url":null,"abstract":"<p><strong>Background: </strong>Mental health concerns are common. Despite this, evidence on the impact of patient-provider gender concordance on mental health outcomes remains limited.</p><p><strong>Aims: </strong>This review aims to explore the literature on the role of patient-provider gender concordance in mental health across diverse clinical contexts and populations.</p><p><strong>Method: </strong>We conducted a preregistered scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. A comprehensive literature search was performed across MEDLINE, PsycINFO, Cochrane Library and Scopus. Study selection and screening were completed using Covidence. Two independent reviewers applied predefined criteria. Data extraction captured study characteristics, demographics, mental health conditions, interventions and outcomes. Given substantial methodological heterogeneity, findings were synthesised narratively and organised by diagnostic category.</p><p><strong>Results: </strong>This review included 33 studies representing 562 890 patients. Most studies used cohort designs to examine psychotherapy interventions in out-patient settings. Many did not specify diagnoses, although substance use and depressive disorders were common. Results were highly mixed across diagnostic categories. For general mental health, most studies found neutral or inconsistent effects. However, substance use disorder populations showed more consistent benefits, particularly for male patients in gender-matched dyads, who demonstrated improved retention, therapeutic alliance and abstinence.</p><p><strong>Conclusions: </strong>This review reveals that gender concordance effects in mental healthcare are context dependent. Whereas male patients with substance use disorders may benefit from gender matching, most evidence suggests neutral or mixed effects. Gaps in the literature include limited non-binary representation and insufficient attention to intersectional factors. Future research should employ more rigorous methods, expand beyond binary genders and investigate the mechanisms underlying observed effects.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e189"},"PeriodicalIF":4.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal genetic liability for neuroticism and breastfeeding intention, initiation and maintenance.","authors":"Elizabeth C Braithwaite, Amy Campbell, Holly Fraser, Nicky Wright, Jasmine Hearn, Jennifer McGahan, Lucy Bowes, Alex S F Kwong, Hannah Sallis, Rebecca M Pearson","doi":"10.1192/bjo.2026.12046","DOIUrl":"10.1192/bjo.2026.12046","url":null,"abstract":"<p><strong>Background: </strong>Relationships between maternal mental health and breastfeeding outcomes are complex, with evidence of bi-directional effects complicated by culturally specific residual confounding and selection bias.</p><p><strong>Aims: </strong>This study aimed to examine, for the first time, associations between maternal genetic liability for neuroticism and breastfeeding intention, initiation and maintenance.</p><p><strong>Method: </strong>We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective birth cohort. Maternal genotype data were used to create polygenic scores (PGS) for neuroticism. Mothers self-reported breastfeeding intentions at 32 weeks gestation, breastfeeding initiation within the first week after birth and maintenance of breastfeeding to 6 months after birth. We examined associations between maternal genetic liability for neuroticism and breastfeeding outcomes by using unadjusted logistic regression models (<i>n</i> = 4611). We also examined associations between paternal genetic liability for neuroticism and breastfeeding outcomes as a negative control (<i>n</i> = 1446).</p><p><strong>Results: </strong>There was evidence that genetic liability for neuroticism was associated with lower odds for breastfeeding maintenance (odds ratio 0.86, 95% CI 0.83-0.94, <i>p</i> < 0.001), with no evidence for associations with intention or initiation. That is, mothers with higher genetic liability for neuroticism were less likely to maintain breastfeeding to 6 months postpartum. There were no associations between paternal PGS for neuroticism and breastfeeding outcomes.</p><p><strong>Conclusions: </strong>The specificity of links between neuroticism and maintenance of breastfeeding could direct targeting of efforts to support women with emotional difficulties in maintaining breastfeeding. This is important because currently, most efforts to support breastfeeding women focus on intention and initiation.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e188"},"PeriodicalIF":4.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}