BJPsych Open最新文献

{"title":"Circulating inflammatory and neurotrophic markers as moderators and/or mediators of cognitive remediation outcome in people with bipolar disorders.","authors":"Rebecca Strawbridge, Dimosthenis Tsapekos, Allan H Young","doi":"10.1192/bjo.2024.818","DOIUrl":"10.1192/bjo.2024.818","url":null,"abstract":"<p><strong>Background: </strong>Immune dysregulation appears involved in affective disorder pathophysiology. Inflammatory biomarkers have been linked with the cognitive impairment observed in people with bipolar disorders and as such are candidate markers that may improve with, and/or predict outcomes to, cognitive remediation therapies (CRT).</p><p><strong>Aims: </strong>Nine candidate biomarkers were examined as putative mediators and/or moderators to improvements following CRT compared with treatment as usual (TAU) from a randomised controlled trial.</p><p><strong>Method: </strong>Euthymic adults with bipolar disorders who had been randomised to CRT (<i>n</i> = 23) or TAU (<i>n</i> = 21) underwent blood testing before and after a 12 week intervention period. Five cytokines and four growth factor proteins, selected <i>a priori</i>, were examined in association with global cognition and psychosocial functioning outcomes.</p><p><strong>Results: </strong>CRT attenuated a reduction in the brain-derived neurotrophic factor (BDNF), basic fibroblast growth factor and vascular endothelial growth factor-C compared to TAU. For the BDNF, lower baseline levels predicted better functional outcomes across the sample but was more pronounced in TAU versus CRT participants and indicated larger CRT effects in those with a higher BDNF. A moderation effect was also apparent for tumour necrosis factor-β and interleukin-16, with greater CRT versus TAU effects on functioning for participants with lower baseline levels.</p><p><strong>Conclusions: </strong>Although preliminary, results suggest that CRT may exert some protective biological effects, and that people with lower levels of neurotrophins or cytokines may benefit more from CRT. We note an absence of associations with cognitive (versus functional) outcomes. These findings require further examination in large well-controlled studies.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e225"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Externally validated clinical prediction models for estimating treatment outcomes for patients with a mood, anxiety or psychotic disorder: systematic review and meta-analysis.","authors":"Desi G Burghoorn, Sanne H Booij, Robert A Schoevers, Harriëtte Riese","doi":"10.1192/bjo.2024.789","DOIUrl":"10.1192/bjo.2024.789","url":null,"abstract":"<p><strong>Background: </strong>Suboptimal treatment outcomes contribute to the high disease burden of mood, anxiety or psychotic disorders. Clinical prediction models could optimise treatment allocation, which may result in better outcomes. Whereas ample research on prediction models is performed, model performance in other clinical contexts (i.e. external validation) is rarely examined. This gap hampers generalisability and as such implementation in clinical practice.</p><p><strong>Aims: </strong>Systematically appraise studies on externally validated clinical prediction models for estimated treatment outcomes for mood, anxiety and psychotic disorders by (1) reviewing methodological quality and applicability of studies and (2) investigating how model properties relate to differences in model performance.</p><p><strong>Method: </strong>The review and meta-analysis protocol was prospectively registered with PROSPERO (registration number CRD42022307987). A search was conducted on 8 November 2021 in the databases PubMED, PsycINFO and EMBASE. Random-effects meta-analysis and meta-regression were conducted to examine between-study heterogeneity in discriminative performance and its relevant influencing factors.</p><p><strong>Results: </strong>Twenty-eight studies were included. The majority of studies (<i>n</i> = 16) validated models for mood disorders. Clinical predictors (e.g. symptom severity) were most frequently included (<i>n</i> = 25). Low methodological and applicability concerns were found for two studies. The overall discrimination performance of the meta-analysis was fair with wide prediction intervals (0.72 [0.46; 0.89]). The between-study heterogeneity was not explained by number or type of predictors but by disorder diagnosis.</p><p><strong>Conclusions: </strong>Few models seem ready for further implementation in clinical practice to aid treatment allocation. Besides the need for more external validation studies, we recommend close examination of the clinical setting before model implementation.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e221"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and neurocognitive profiles of a combined clinical high risk for psychosis and clinical control sample: latent class analysis.","authors":"Miriam Stüble, Frauke Schultze-Lutter, Michael Kaess, Maurizia Franscini, Nina Traber-Walker, Petra Walger, Benno G Schimmelmann, Kai Vogeley, Joseph Kambeitz, Jochen Kindler, Chantal Michel","doi":"10.1192/bjo.2024.815","DOIUrl":"10.1192/bjo.2024.815","url":null,"abstract":"<p><strong>Background: </strong>The clinical high-risk (CHR) state for psychosis demonstrates considerable clinical heterogeneity, presenting challenges for clinicians and researchers alike. Basic symptoms, to date, have largely been ignored in explorations of clinical profiles.</p><p><strong>Aims: </strong>We examined clinical profiles by using a broader spectrum of CHR symptoms, including not only (attenuated) psychotic, but also basic symptoms.</p><p><strong>Method: </strong>Patients (<i>N</i> = 875) of specialised early intervention centres for psychosis in Germany and Switzerland were assessed with the Schizophrenia Proneness Instruments and the Structured Interview for Psychosis-Risk Syndromes. Latent class analysis was applied to CHR symptoms to identify clinical profiles. Additionally, demographics, other symptoms, current non-psychotic DSM-IV axis I disorders and neurocognitive variables were assessed to further describe and compare the profiles.</p><p><strong>Results: </strong>A three-class model was best fitting the data, whereby basic symptoms best differentiated between the profiles (η² = 0.08-0.52). Class 1 had a low probability of CHR symptoms, the highest functioning and lowest other psychopathology, neurocognitive deficits and transition-to-psychosis rate. Class 2 had the highest probability of basic and (attenuated) positive symptoms (excluding hallucinations), lowest functioning, highest symptom load, most neurocognitive deficits and highest transition rate (55.1%). Class 3 was mostly characterised by attenuated hallucination, and was otherwise intermediate between the other two classes. Comorbidity rates were comparable across classes, with some class differences in diagnostic categories.</p><p><strong>Conclusions: </strong>Our profiles based on basic and (attenuated) psychotic symptoms provide clinically useful entities by parsing out heterogeneity in clinical presentation. In future, they could guide class-specific intervention.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e226"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of admission to hospital for self-harm after admission to hospital for COVID-19: French nationwide longitudinal study.","authors":"Philippe Pirard, Valentina Decio, Baptiste Pignon, Olivier Bouaziz, Vittorio Perduca, Viviane Kovess-Masfety, Emmanuelle Corruble, Francis Chin, Pierre A Geoffroy, Yann Le Strat, Jonathan Messika, Nolwenn Regnault, Sarah Tebeka","doi":"10.1192/bjo.2024.786","DOIUrl":"10.1192/bjo.2024.786","url":null,"abstract":"<p><strong>Background: </strong>Assessing the risk of subsequent self-harm after hospitalisation for COVID-19 is critical for mental health care planning during and after the pandemic.</p><p><strong>Aims: </strong>This study aims to compare the risk of admission to hospital for self-harm within 12 months following a COVID-19 hospitalisation during the first half of 2020, with the risk following hospitalisations for other reasons.</p><p><strong>Method: </strong>Using the French administrative healthcare database, logistic regression models were employed to analyse data from patients admitted to hospitals in metropolitan France between January and June 2020. The analysis included adjustments for sociodemographic factors, psychiatric history and the level of care received during the initial hospital stay.</p><p><strong>Results: </strong>Of the 96 313 patients hospitalised for COVID-19, 336 (0.35%) were subsequently admitted for self-harm within 12 months, compared to 20 135 (0.72%) of 2 797 775 patients admitted for other reasons. This difference remained significant after adjusting for sociodemographic factors (adjusted odds ratio (aOR) = 0.66, 95% CI: 0.59-0.73), psychiatric disorder history (aOR = 0.65, 95% CI: 0.58-0.73) and the level of care received during the initial hospital stay (aOR = 0.70, 95% CI: 0.63-0.78). History of psychiatric disorders and intensive care were strongly correlated with increased risk, while older age was inversely associated with self-harm admissions.</p><p><strong>Conclusions: </strong>Hospitalisation for COVID-19 during the early pandemic was linked to a lower risk of subsequent self-harm than hospitalisation for other reasons. Clinicians should consider psychiatric history and intensive care factors in evaluating the risk of future suicide.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e215"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency department presentations and admission for common mental disorders following agency-notified child maltreatment at 40-year follow-up: results from the Childhood Adversity and Lifetime Morbidity study.","authors":"Steve Kisely, Claudia Bull, Mike Trott, Urska Arnautovska, Dan Siskind, Nicola Warren, Jake Moses Najman","doi":"10.1192/bjo.2024.776","DOIUrl":"10.1192/bjo.2024.776","url":null,"abstract":"<p><strong>Background: </strong>Most evidence on associations between child maltreatment and subsequent common mental disorders (CMDs) comes from retrospective studies. Such findings may be affected by recall bias. Prospective studies of reports to statutory agencies are less common and may be subject to attrition bias.</p><p><strong>Aim: </strong>To examine the associations of child maltreatment with emergency department presentations and in-patient admissions for CMDs in individuals up to 40 years old.</p><p><strong>Method: </strong>Queensland-wide administrative health data were linked to a prospective birth cohort, including agency-reported and substantiated notifications of child maltreatment. Outcomes were emergency department presentations and in-patient admissions for CMDs.</p><p><strong>Results: </strong>There were 6087 participants, of which 10.1% had been the subject of a child maltreatment notification. Admissions for CMDs occurred in 198 participants (3.3%) and emergency department presentations in 291 (4.8%). In the adjusted analysis, substantiated child maltreatment was associated with both admissions (odds ratio 1.92; 95% CI = 1.19-3.00) and emergency department presentations (odds ratio 2.10; 95% CI = 1.45-3.03). All agency-reported and substantiated child maltreatment subtypes (neglect, physical, sexual and emotional abuse) were associated with emergency department presentations for CMDs and notifications for more than one child maltreatment subtype. In the subgroup analysis, child maltreatment was associated with emergency department presentations for both anxiety (odds ratio 2.73; 95% CI = 1.68-4.43) and depression (odds ratio 2.23; 95% CI = 1.62-3.26) but with admissions only for depression (odds ratio 2.10; 95% CI = 1.15-3.84).</p><p><strong>Conclusions: </strong>Child maltreatment is associated with both emergency department presentations and hospital admissions for CMDs in individuals up to 40 years old. Screening for child maltreatment in people presenting to hospital with CMDs may be indicated, as well as a greater awareness that survivors of child maltreatment may be at higher risk of developing such symptoms.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e220"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide in mental health patients in the UK between 2005 and 2021: study of methods and clinical characteristics to inform prevention.","authors":"Pauline Rivart, Lana Bojanić, Pauline Turnbull, Louis Appleby, Nav Kapur, Isabelle M Hunt","doi":"10.1192/bjo.2024.822","DOIUrl":"10.1192/bjo.2024.822","url":null,"abstract":"<p><strong>Background: </strong>Tackling methods of suicide and limiting access to lethal means remain priority areas of suicide prevention strategies. Although mental health services are a key setting for suicide prevention, no recent studies have explored methods used by mental health patients.</p><p><strong>Aims: </strong>To investigate associations between main suicide methods and social, behavioural and clinical characteristics in patients with mental illness to inform prevention and improve patient safety.</p><p><strong>Method: </strong>Data were collected as part of the National Confidential Inquiry into Suicide and Safety in Mental Health. We examined the main suicide methods of 26 766 patients in the UK who died within 12 months of contact with mental health services during 2005-2021. Associations between suicide methods and patient characteristics were investigated using chi-square tests and univariate and multivariate logistic regression.</p><p><strong>Results: </strong>Suicide methods were associated with particular patient characteristics: hanging was associated with a short illness history, recent self-harm and depression; self-poisoning with substance misuse, personality disorder and previous self-harm; and both jumping and drowning with ethnic minority groups, schizophrenia and in-patient status.</p><p><strong>Conclusions: </strong>A method-specific focus may contribute to suicide prevention in clinical settings. Hanging deaths outside of wards may be difficult to prevent but our study suggests patients with recent self-harm or in the early stages of their illness may be more at risk. Patients with complex clinical histories at risk of suicide by self-poisoning may benefit from integrated treatment with substance use services. Environmental control initiatives are likely to be most effective for those at risk of jumping or drowning.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e228"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health and its wider determinants in young people in the UK during 12 months of the COVID-19 pandemic: repeated cross-sectional representative survey.","authors":"Olivier Y Rouquette, Dana Dekel, Abdul-Moiz Siddiqi, Catherine Seymour, Lauren Weeks, Ann John","doi":"10.1192/bjo.2024.726","DOIUrl":"10.1192/bjo.2024.726","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic posed an unprecedented global challenge, with past evidence suggesting negative psychological effects with the additional concern that social and physical restrictions might disproportionately affect adolescents.</p><p><strong>Aims: </strong>To explore mental health and its wider determinants in young people in the UK during 1 year of the COVID-19 pandemic (August 2020-August 2021).</p><p><strong>Method: </strong>A representative sample of 11 898 participants (48.7% female) aged between 13 and 19 years (mean = 16.1) participated in five waves of data collection. Using validated self-reported questionnaires for loneliness, anxiety and depression, this survey measured the extent and nature of the mental health impacts of the coronavirus pandemic and help-seeking behaviours, and changes over time.</p><p><strong>Results: </strong>Young people experienced higher levels of anxiety during the summer and fall 2020, followed by higher levels of depression during the winter 2020-2021, with loneliness gradually increasing then peaking during the spring and summer of 2021. Young people who were older, female, with pre-existing mental-health issues and experiencing financial difficulties were at higher risk of anxiety, depression and loneliness. Help-seeking behaviours reduced the risk of depression and loneliness.</p><p><strong>Conclusions: </strong>The COVID-19 pandemic had substantial impact on young people, whether on their mental health, their social contacts and interactions or their perspective on what the future holds for them. Young people strongly advocated for better teacher training, and a better integration of mental health services, particularly within their schools.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e214"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of healthcare workers' mental health during Western Australia's unique policy response to COVID-19.","authors":"Elizabeth A Newnham, Enrique L P Mergelsberg, Susanne Stanley, Sean Hood, Jessica Tearne, Antonio Celenza, Teresa Stevenson, Nahal Mavaddat, Gavin Demore, Hyranthi Kavanagh, Peter M McEvoy","doi":"10.1192/bjo.2024.809","DOIUrl":"10.1192/bjo.2024.809","url":null,"abstract":"<p><strong>Background: </strong>Western Australia's response to the COVID-19 pandemic was swift and effective in implementing public health protections and preventing the spread of the virus for the first 2 years. However, healthcare staff continued to be at increased risk of mental health concerns.</p><p><strong>Aims: </strong>To investigate the longitudinal patterns of post-traumatic stress symptoms (PTSS), depression and anxiety among healthcare workers in Western Australia, and the risk and protective factors associated with changes in status during the first wave.</p><p><strong>Method: </strong>Participants comprised 183 healthcare staff working at tertiary hospitals and major clinics across Perth, for whom longitudinal data were available. Questionnaire data were collected before Western Australia's first major COVID-19 community wave in early 2022 and following the first wave in late 2022. Online surveys comprised validated measures assessing psychological symptoms, risk and protective factors, and original measures of workplace factors.</p><p><strong>Results: </strong>Overall rates of PTSS, depression and anxiety remained stable across the two assessment points. However, latent growth models revealed that those with lower PTSS, depression or anxiety symptoms at baseline reported a larger increase in symptoms over time, and those with higher symptoms at baseline had a smaller decline over time, indicating a 'catch-up' effect. Workplace stressors, sleep difficulties and trauma exposure were key risk factors for changes in psychological symptoms from baseline, and workplace and social supports played protective roles.</p><p><strong>Conclusions: </strong>Improvements in systemic workplace factors are needed to support healthcare workers' mental health during periods of acute stress, even in settings with high levels of emergency preparedness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e222"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extremism, racism and riots: exploring the political, social and cultural determinants of poor mental health.","authors":"Kamaldeep Bhui, Dianndra Roberts, Myrna Lashley, Edgar Jones, Kenneth R Kaufman","doi":"10.1192/bjo.2024.830","DOIUrl":"10.1192/bjo.2024.830","url":null,"abstract":"<p><p>The UK has seen an outbreak of riots after the death of three children in a knife attack. Misinformation about the suspect's heritage and religion was spread by social media, which was then used to incite violence and racism resulting in damage to property, terror and injuries. We put forward arguments that this was an extremist act and draw on the literature on terrorism, extremism and identity to put forward a deeper analysis of how this happened and what can be done to prevent future riots. We bring an interdisciplinary perspective drawing on research from social, cultural, psychological and political perspectives.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e224"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in cardiac mIBG scintigraphy in mild cognitive impairment with Lewy bodies.","authors":"Gemma Greenfinch, Calum A Hamilton, Paul C Donaghy, Michael Firbank, Nicola A Barnett, Louise Allan, George S Petrides, John-Paul Taylor, John T O'Brien, Alan J Thomas","doi":"10.1192/bjo.2024.766","DOIUrl":"10.1192/bjo.2024.766","url":null,"abstract":"<p><p>The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was -5.2% (range: -23.8% to +7.0%). The interpolated mean annual change in uptake was -1.6%.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"10 6","pages":"e223"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}