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Recovery, completion and further referral after Improving Access to Psychological Therapies in Norfolk and Waveney. 在诺福克和韦弗尼改善心理治疗后的康复、完成和进一步转诊。
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-07-07 DOI: 10.1192/bjo.2025.10045
Amanda Burke, Max Bachmann, Charlotte E L Jones, Julii Brainard, Zillur Rahman Shabuz, Alice M Dalton, Rachel Cullum, Nick Steel
{"title":"Recovery, completion and further referral after Improving Access to Psychological Therapies in Norfolk and Waveney.","authors":"Amanda Burke, Max Bachmann, Charlotte E L Jones, Julii Brainard, Zillur Rahman Shabuz, Alice M Dalton, Rachel Cullum, Nick Steel","doi":"10.1192/bjo.2025.10045","DOIUrl":"10.1192/bjo.2025.10045","url":null,"abstract":"<p><strong>Background: </strong>Improving Access to Psychological Therapies (IAPT), an NHS England service providing talking therapies, is meeting its target recovery rate of 50%. However, engagement in treatment, as well as recovery rates, may be lower for some groups.</p><p><strong>Aims: </strong>To assess variation in treatment completion and recovery rates by demographic and socioeconomic group and to describe rates of further referrals for patients to IAPT and secondary mental health services.</p><p><strong>Method: </strong>Using 121 548 administrative records for 2019-2020 and 2022-2023 for the Norfolk and Waveney area, we estimated associations of age, gender, ethnicity and deprivation with the likelihood of treatment completion and recovery using logistic regression modelling. We also described rates of further referrals.</p><p><strong>Results: </strong>Younger people and those living in deprived areas were less likely to recover or complete treatment, with those aged 16-17 years (<i>n</i> = 735) having the lowest adjusted odds for recovery (adjusted odds ratio = 0.5, 95% CI: 0.5-0.6) compared with those aged 36-70 years, and those aged 18-24 years (<i>n</i> = 23 563) having the lowest rate of completion (adjusted odds ratio = 0.5, 95% CI: 0.5-0.6). Further referrals before April 2022 were recorded for 45.4% of 6513 patients who had completed treatment and 68.8% of 9469 who had not completed treatment, and for 39.4% of 2007 recovered patients in 2019-2020 and 53.1% of 1586 who had not recovered. Non-completers had relatively more further referrals to secondary mental health services compared with completers (43.6% <i>v</i>. 22.8%; <i>P</i> < 0.01).</p><p><strong>Conclusions: </strong>Younger people and those living in deprived areas have lower recovery and completion rates. Those who have completed treatment and not recovered have higher rates of further referrals.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e140"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Let's Talk About Voices: randomised controlled crossover study of a resource to support mental health workers in supporting voice-hearers. 让我们谈谈声音:一项支持精神卫生工作者支持声音听者的资源的随机对照交叉研究。
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-07-07 DOI: 10.1192/bjo.2025.10071
Anne Honey, Justin Newton Scanlan, Lyndal Sherwin, Haylee Zink, Karen Wells, Glenda Jessup, Nicola Hancock
{"title":"Let's Talk About Voices: randomised controlled crossover study of a resource to support mental health workers in supporting voice-hearers.","authors":"Anne Honey, Justin Newton Scanlan, Lyndal Sherwin, Haylee Zink, Karen Wells, Glenda Jessup, Nicola Hancock","doi":"10.1192/bjo.2025.10071","DOIUrl":"10.1192/bjo.2025.10071","url":null,"abstract":"<p><strong>Background: </strong>Easily accessible, impactful, evidence-based resources are needed to assist mental health workers to best support voice-hearers in managing and living well with voices. Let's Talk About Voices (LTAV) is an innovative suite of resources designed for mental health workers to use in supporting voice-hearers.</p><p><strong>Aim: </strong>This study aimed to assess the impact of LTAV on mental health workers' self-reported capacity to work with voice-hearers.</p><p><strong>Method: </strong>A randomised, controlled crossover design was used, with assessment at three time points. The assessment measure was co-developed by researchers, clinicians, peer workers and voice-hearers based on the aims of LTAV and the Theory of Planned Behaviour. Participants were randomised into two groups. The immediate group received access to LTAV following the first assessment; the delayed group received access following the second assessment. In total, 256 mental health workers commenced the study, with 120 completing all assessments.</p><p><strong>Results: </strong>Between-group comparisons for change between times 1 and 2 found a significant difference with a large effect size (<i>F</i> = 40.2, <i>P</i> < 0.001, <i>η<sub>p</sub></i><sup>2</sup> = 0.19). Significance remained on intention-to-treat analysis (<i>F</i> = 22.9, <i>P</i> < 0.001, <i>η<sub>p</sub></i><sup>2</sup> = 0.08). Pairwise repeated-measures comparisons found a significant increase in scores for both groups following access to LTAV, which was sustained at follow-up. Fourteen of 24 individual items showed significant change. Changes were consistent across professions, work settings and experience working with voice-hearers, but those with less confidence in working with voice-hearers on intake showed significantly stronger improvements.</p><p><strong>Conclusions: </strong>This research indicates that LTAV has the potential to substantially improve mental health workers' attitudes and confidence in supporting voice-hearers.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e139"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bidirectional associations among positive affect, anhedonia and meaning in life during major depressive episode: ecological momentary assessment study in unipolar and bipolar individuals and healthy controls. 重度抑郁发作期间积极情绪、快感缺乏和生活意义的双向关联:单极和双相个体及健康对照的生态瞬时评估研究
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-07-07 DOI: 10.1192/bjo.2025.10067
Heidi Ka Ying Lo, Roger S McIntyre, Iris Wai Tung Tsui, Fiona Yan Yee Ho, Ting Kin Ng, Corine Sau Man Wong, Suet Ying Yuen, Chit Tat Lee, Chun Yin Poon, Inez Myin-Germeys, Ka Fai Chung
{"title":"Bidirectional associations among positive affect, anhedonia and meaning in life during major depressive episode: ecological momentary assessment study in unipolar and bipolar individuals and healthy controls.","authors":"Heidi Ka Ying Lo, Roger S McIntyre, Iris Wai Tung Tsui, Fiona Yan Yee Ho, Ting Kin Ng, Corine Sau Man Wong, Suet Ying Yuen, Chit Tat Lee, Chun Yin Poon, Inez Myin-Germeys, Ka Fai Chung","doi":"10.1192/bjo.2025.10067","DOIUrl":"10.1192/bjo.2025.10067","url":null,"abstract":"<p><strong>Background: </strong>Diagnostic accuracy is an unmet need for major depressive disorder (MDD) and major depressive episode (MDE) in bipolar disorder. Very limited research has evaluated bipolar disorder/MDE and MDD using ecological momentary assessment (EMA) time-series data.</p><p><strong>Aims: </strong>We aimed to examine differentiating phenomenological characteristics in positive affect dynamics, and temporal relationships with pleasure towards current activity and meaning in life (MIL), among MDD, MDE/bipolar disorder and healthy controls using EMA.</p><p><strong>Method: </strong>Participants (<i>N</i> = 88, mean age 28.7 years, 69% female), including individuals with MDD (<i>n</i> = 29) and MDE/bipolar disorder (<i>n</i> = 29) and healthy controls (<i>n</i> = 30), were assessed for positive affect, pleasure and MIL 5 times daily over a 2-week period. Multilevel modelling analysis was conducted, with estimation of first-order autoregressive model structure and time-lagged relationship between pleasure and positive affect.</p><p><strong>Results: </strong>From 4632 EMA observations, positive affect dynamics (inertia, variability and instability) did not differ significantly across groups (all <i>P</i> > 0.05). Although all groups demonstrated a bidirectional relationship between positive affect and pleasure, for MDE/bipolar disorder, both pleasure<sub><i>t</i> - 1</sub> (<i>β</i> = -0.11, <i>t</i>[51.09] = -2.31, <i>P</i> = 0.025) and positive affect<sub><i>t</i> - 1</sub> (<i>β</i> = -0.13, <i>t</i>[56.54] = -2.30, <i>P</i> = 0.025) predicted subsequent MIL less significantly than for MDD and healthy controls.</p><p><strong>Conclusion: </strong>Individuals with MDE/bipolar disorder, but not MDD, had less self-reported MIL from positive affect and pleasure. There is little evidence that emotional experience alone characterises the pathophysiology between MDD and MDE/bipolar disorder; such investigation may be limited by within-group heterogeneity. Our findings provide a new perspective on using a time-series approach beyond bimodal measures in EMA to differentiate bipolar disorder/MDE and MDD.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e141"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions of Brazil's Bolsa Família cash transfer programme, life opportunities and mental health in the lives of young adults from the outskirts of São Paulo: qualitative study. 对巴西Bolsa Família现金转移支付方案、生活机会和<s:1>圣保罗郊区年轻人生活中的心理健康的看法:定性研究。
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-06-30 DOI: 10.1192/bjo.2025.10056
Paulo Malvasi, Sara Evans-Lacko, Eva Cyhlarova, Alicia Matijasevich, David McDaid, Cristiane Silvestre Paula
{"title":"Perceptions of Brazil's Bolsa Família cash transfer programme, life opportunities and mental health in the lives of young adults from the outskirts of São Paulo: qualitative study.","authors":"Paulo Malvasi, Sara Evans-Lacko, Eva Cyhlarova, Alicia Matijasevich, David McDaid, Cristiane Silvestre Paula","doi":"10.1192/bjo.2025.10056","DOIUrl":"10.1192/bjo.2025.10056","url":null,"abstract":"<p><strong>Backgound: </strong>Cash transfer programmes (CTPs) provide financial support to alleviate poverty and promote economic stability. The Bolsa Família Programme (BFP), a Brazilian initiative and the world's largest CTP by number of beneficiaries, aims to improve living conditions. While poverty is closely linked to poor mental health, evidence regarding the specific effects of CTPs on young adults' mental health remains limited, underscoring the need for further research.</p><p><strong>Aims: </strong>To understand the meaning attributed to the BFP by young adults regarding their future aspirations and mental health, as well as perspectives from providers.</p><p><strong>Method: </strong>This qualitative study was conducted at the outskirts of São Paulo city, involving 12 in-depth interviews with young adults aged 18-24 years and 2 focus groups comprising 17 health and social assistance professionals.</p><p><strong>Results: </strong>Thematic analysis identified four themes according with interviews and focus groups: (a) perceptions about poverty (hopelessness and lack of opportunities); (b) impact of poverty on mental health (anxiety, unpredictability and hopelessness as consequences of living in poverty); (c) young adults' needs and aspirations (job opportunities as the main expectation for a better future); and (d) BFP limitations and opportunities for improvement (BFP perceived as just one of the survival strategies but not impacting life opportunities for young adults).</p><p><strong>Conclusions: </strong>The BFP was valued as essential for meeting poor families' basic needs. Employment opportunities were central to young adults' expectations, often causing anguish and anxiety. Expanding the BFP to include employment and income-generation policies could better support the mental health and life opportunities of vulnerable youth.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e135"},"PeriodicalIF":3.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors influencing physical healthcare quality for people with intellectual disabilities: psychiatry multidisciplinary team perspective. 影响智力残疾者身体保健质量的因素:精神病学多学科团队视角。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-06-30 DOI: 10.1192/bjo.2025.10051
Madiha Majid, Stefan Rennick-Egglestone, Bronwyn Harris, Ashok Roy, Hayley Crawford
{"title":"Factors influencing physical healthcare quality for people with intellectual disabilities: psychiatry multidisciplinary team perspective.","authors":"Madiha Majid, Stefan Rennick-Egglestone, Bronwyn Harris, Ashok Roy, Hayley Crawford","doi":"10.1192/bjo.2025.10051","DOIUrl":"10.1192/bjo.2025.10051","url":null,"abstract":"<p><strong>Background: </strong>There is a need for better collaborative care between services to improve healthcare provision for people with intellectual disabilities. In the UK, the learning disability psychiatry multidisciplinary team (MDT) is a specialist team responsible for providing and coordinating care for people with intellectual disabilities.</p><p><strong>Aims: </strong>To document learning disability MDT perspectives on factors influencing healthcare quality for people with intellectual disabilities.</p><p><strong>Method: </strong>Healthcare professionals who were members of a learning disability MDT within a National Health Service Trust in the West Midlands were purposively sampled for interview (<i>n</i> = 11). Participants included psychiatrists, nurses, occupational therapists and speech and language therapists. Data were analysed thematically using Braun and Clarke's six-stage approach.</p><p><strong>Results: </strong>Factors influencing the quality of healthcare provision included: the learning disability MDT working to overcome systemic barriers; the consequences of specific failures within mainstream healthcare services, such as diagnostic overshadowing; inadequate use of information collated in health passports; and inadequate capacity assessments of people with intellectual disabilities. Improvements in healthcare provision for people with intellectual disabilities require better accessibility to healthcare and better training for healthcare professionals so they can understand the health needs of people with intellectual disabilities.</p><p><strong>Conclusions: </strong>A rapid review of practices around health passports for people with intellectual disabilities should be conducted. Healthcare professionals working in mainstream healthcare services need an increased awareness of the harms of diagnostic overshadowing and inadequate capacity assessments. Conclusions are based on findings from MDTs within one health board; future work may focus on understanding perspectives from different teams.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e137"},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interrater reliability of the DSM-5 and ICD-11 Criterion A for PTSD and complex PTSD in parents of children with autism using the Life Events Checklist - ERRATUM. DSM-5和ICD-11标准A对自闭症儿童父母PTSD和复杂PTSD的信度评估使用生活事件检查表-勘误
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-06-30 DOI: 10.1192/bjo.2025.53
Kylie Hinde, Gert Martin Hald, David Hallford, Theis Lange, Mikkel Christoffer Berg B Arendt, Silvia Pavan, David Austin
{"title":"Interrater reliability of the DSM-5 and ICD-11 Criterion A for PTSD and complex PTSD in parents of children with autism using the Life Events Checklist - ERRATUM.","authors":"Kylie Hinde, Gert Martin Hald, David Hallford, Theis Lange, Mikkel Christoffer Berg B Arendt, Silvia Pavan, David Austin","doi":"10.1192/bjo.2025.53","DOIUrl":"10.1192/bjo.2025.53","url":null,"abstract":"","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e138"},"PeriodicalIF":3.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomised controlled feasibility trial comparing culturally adapted psychoeducation and treatment as usual for persons with bipolar disorders in Nigeria. 一项随机对照可行性试验,比较尼日利亚双相情感障碍患者的文化适应性心理教育和常规治疗。
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-06-27 DOI: 10.1192/bjo.2025.66
Dung Ezekiel Jidong, M Ishrat Husain, Tarela Juliet Ike, Ameer Khoso, Maigari Yusufu Taru, Charles Nnaemeka Nwoga, Christopher Francis, Shadrack B Mwankon, John Ezekiel Jidong, Juliet Y Pwajok, Suleman Shakoor, Atta Muhammad Asif, Siqi Xue, Nusrat Husain
{"title":"A randomised controlled feasibility trial comparing culturally adapted psychoeducation and treatment as usual for persons with bipolar disorders in Nigeria.","authors":"Dung Ezekiel Jidong, M Ishrat Husain, Tarela Juliet Ike, Ameer Khoso, Maigari Yusufu Taru, Charles Nnaemeka Nwoga, Christopher Francis, Shadrack B Mwankon, John Ezekiel Jidong, Juliet Y Pwajok, Suleman Shakoor, Atta Muhammad Asif, Siqi Xue, Nusrat Husain","doi":"10.1192/bjo.2025.66","DOIUrl":"10.1192/bjo.2025.66","url":null,"abstract":"<p><strong>Background: </strong>Bipolar disorders are a major cause of disability worldwide, with most of the disease burden attributed to those in low- and middle-income countries, including Nigeria. There is limited evidence on culturally appropriate interventions for bipolar disorders in Nigeria.</p><p><strong>Aims: </strong>The study aims to examine the feasibility, and acceptability of culturally adapted psychoeducation (CaPE) for treating bipolar disorders.</p><p><strong>Method: </strong>A randomised controlled trial (RCT) compared CaPE plus treatment as usual (TAU) with TAU alone among 34 persons with bipolar disorders in Jos, Nigeria. CaPE comprised 12 group sessions of in-person psychoeducation lasting approximately 90 min each, delivered on a weekly basis by clinical researchers supervised by clinical psychologists and consultant psychiatrists. The primary outcome was feasibility, measured by participants' recruitment and retention rates. Other outcomes included acceptability as measured by the Service Satisfaction Scale (SSS), Brief Bipolar Disorder Symptom Scale (BBDSS), Patient Health Questionnaire (PHQ-9) and Quality-of-Life scale (EQ5D). Outcomes were assessed at baseline and weeks 12 and 24. Focus group (<i>n</i> = 10) and individual interviews (<i>n</i> = 5) were conducted with the CaPE + TAU group, recorded, transcribed verbatim and analysed using interpretative phenomenological analysis.</p><p><strong>Results: </strong>The CaPE+TAU group (<i>n</i> = 17) recorded a high participant recruitment and retention rate of 86% across 12 sessions, and also recorded a higher level of satisfaction with SSS compared with the TAU alone group; 87.5% indicated very satisfied compared with 66.7% indicated not sure in the TAU group. In terms of clinical outcomes, for PHQ-9 scores the intervention group showed a reduction from baseline to end of intervention (EOI) and follow-up, with differences of -12.01 and -7.39, respectively (both <i>P</i> < 0.001). The EQ5D index showed a notable improvement in the intervention group at both EOI and follow-up (<i>P</i> < 0.001). Lastly, BBDS scores decreased significantly in the CaPE+TAU group at both EOI and follow-up, with differences of -21.45 and -15.76 (both <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>The RCT of CaPE is a feasible, acceptable and culturally appropriate treatment option for bipolar disorders in Nigeria. Further adequately powered RCTs evaluating the intervention's clinical and cost-effectiveness are warranted.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e133"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of physical health comorbidities in autistic adults: clinical nested cross-sectional study - CORRIGENDUM. 自闭症成人身体健康合并症的风险:临床嵌套横断面研究-勘误。
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-06-27 DOI: 10.1192/bjo.2025.57
Megan Hunt, Jack F G Underwood, Leon Hubbard, Jeremy Hall
{"title":"Risk of physical health comorbidities in autistic adults: clinical nested cross-sectional study - CORRIGENDUM.","authors":"Megan Hunt, Jack F G Underwood, Leon Hubbard, Jeremy Hall","doi":"10.1192/bjo.2025.57","DOIUrl":"10.1192/bjo.2025.57","url":null,"abstract":"","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e134"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alterations of cerebral intrinsic activity in first-episode, drug-naive patients with major depressive disorder. 首次用药的重性抑郁症患者脑内在活动的改变
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-06-27 DOI: 10.1192/bjo.2025.65
Xiaoxiao Hu, Xinyu Hu, Hailong Li, Lianqing Zhang, Lu Lu, Xuan Bu, Shi Tang, Qiyong Gong, Xiaoqi Huang
{"title":"Alterations of cerebral intrinsic activity in first-episode, drug-naive patients with major depressive disorder.","authors":"Xiaoxiao Hu, Xinyu Hu, Hailong Li, Lianqing Zhang, Lu Lu, Xuan Bu, Shi Tang, Qiyong Gong, Xiaoqi Huang","doi":"10.1192/bjo.2025.65","DOIUrl":"10.1192/bjo.2025.65","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a leading cause of disability worldwide. Investigating early-stage alterations in cerebral intrinsic activity among drug-naive patients may enhance our understanding of MDD's neurobiological mechanisms and contribute to early diagnosis and intervention.</p><p><strong>Aims: </strong>To examine alterations in the amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive MDD individuals and explore associations between ALFF changes and clinical parameters, including depression severity and illness duration.</p><p><strong>Method: </strong>A total of 30 first-episode, drug-naive MDD individuals (mean illness duration 14 weeks) and 52 healthy controls were included in this study. Resting-state functional magnetic resonance imaging was used to obtain whole-brain ALFF measurements. Voxel-based ALFF maps were compared between MDD and healthy control groups using a two-sample <i>t</i>-test. Simple regression analysis was performed to assess associations between ALFF and clinical measures, including Hamilton Rating Scale for Depression (HAMD) scores and illness duration.</p><p><strong>Results: </strong>MDD individuals exhibited significantly increased ALFF in the dorsal anterior cingulate cortex and vermal subregion V3 of the cerebellum. Additionally, ALFF in the right dorsolateral prefrontal cortex was negatively correlated with HAMD scores (<i>r</i> = -0.591, <i>P</i> < 0.001). However, no significant association was found between ALFF and illness duration.</p><p><strong>Conclusions: </strong>This study demonstrates early-stage ALFF alterations in drug-naive MDD patients, particularly in brain regions implicated in cognitive and emotional regulation. These findings suggest potential neuroimaging biomarkers for the early diagnosis and intervention of MDD.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e136"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How negative life events affect emotional eating in Chinese adolescents: moderated mediation model. 负性生活事件对青少年情绪性饮食的影响:有调节的中介模型。
IF 3.9 3区 医学
BJPsych Open Pub Date : 2025-06-27 DOI: 10.1192/bjo.2025.63
Rong Tan, Tao Huang, Yiru Li, Yuhe Zhang, Xijin Li, Xuanxuan Lin, Zhenjiang Liao, Qiuping Huang
{"title":"How negative life events affect emotional eating in Chinese adolescents: moderated mediation model.","authors":"Rong Tan, Tao Huang, Yiru Li, Yuhe Zhang, Xijin Li, Xuanxuan Lin, Zhenjiang Liao, Qiuping Huang","doi":"10.1192/bjo.2025.63","DOIUrl":"10.1192/bjo.2025.63","url":null,"abstract":"<p><strong>Background: </strong>Emotional eating, the tendency to eat in response to negative emotions, is rising among adolescents and linked to obesity and mental health issues. While negative life events contribute to emotional eating, the roles of self-control and social support remain unclear.</p><p><strong>Aims: </strong>This study examined the relationship between negative life events and emotional eating in adolescents, testing self-control as a mediator and perceived social support as a moderator.</p><p><strong>Method: </strong>A sample of 740 Chinese high school students (aged 14-18) completed validated measures of negative life events, self-control, perceived social support, and emotional eating. Data were analyzed using SPSS 25.0 (IBM Corp., Armonk, New York, USA)and PROCESS macro for mediation/moderation effects.</p><p><strong>Results: </strong>Negative life events predicted higher emotional eating (<i>β</i> = 0.11, <i>p</i> < 0.01), while lower self-control mediated this relationship (<i>β</i> = -0.15, <i>p</i> < 0.001). Perceived social support moderated the association (<i>β</i> = -0.09, <i>p</i> < 0.05), weakening it among adolescents with stronger support.</p><p><strong>Conclusions: </strong>Negative life events increase emotional eating, but self-control and social support play key roles. Interventions targeting these factors may reduce emotional eating and improve adolescent well-being.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e131"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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