BJPsych Open最新文献

Twenty-five year trend in antipsychotic medication prescribing in England: challenges and opportunities. 英国抗精神病药物处方25年趋势：挑战与机遇。

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-16 DOI: 10.1192/bjo.2025.10073

Hannah Newman, David Branford, Richard Laugharne, Richard Byng, Rohit Shankar

{"title":"Twenty-five year trend in antipsychotic medication prescribing in England: challenges and opportunities.","authors":"Hannah Newman, David Branford, Richard Laugharne, Richard Byng, Rohit Shankar","doi":"10.1192/bjo.2025.10073","DOIUrl":"https://doi.org/10.1192/bjo.2025.10073","url":null,"abstract":"Background: Antipsychotics are primarily indicated for psychotic disorders. There is increasing concern regarding their potential overuse for other conditions.Aims: To examine the change in the number of community prescriptions and corresponding costs for antipsychotics per head of population over 25 years (1998-2022) in England.Method: The data for 1998-2022 were obtained from two separate resources from the OpenPrescribing database: from 1998 to 2016 from their long-term trends data-set; and for 2017-2022 from the monthly medication prescribing data. The relevant British National Formulary subcategories 4.2.1 'antipsychotic drugs' and 4.2.2 'antipsychotic depot injections' were selected. The annual differences in prescriptions and the mean average annual increase were calculated. Scatter plots to visualise the yearly trend and Spearman testing to assess the strength of the correlations were done. The total annual costs of these medications were calculated for this time period.Results: The annual mean increase in the number of prescriptions was 287 548 in raw numbers and 4.27 per 1000 population. There is a statistically significant and strong positive relationship between time and the prescriptions of antipsychotics per 1000 population (Spearman correlation coefficient 0.995, P ≤ 0.001). This increasing trend is driven by the increase in oral antipsychotic drug prescriptions over time (Spearman correlation coefficient 0.995, P ≤ 0.001). Antipsychotic drug costs increased until 2011, reduced until 2016 and rose again during 2020-2022.Conclusions: This analysis suggests a worrying increasing trend in antipsychotic medication prescribing. Potential causal factors include off-licence use. Clinical practice and research implications are discussed.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e151"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Service use, healthcare costs and productivity losses of functional cognitive disorder in a sample of attenders to out-patient cognitive, neurology and memory clinics. 认知、神经和记忆门诊病人的服务使用、医疗成本和功能性认知障碍的生产力损失

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-16 DOI: 10.1192/bjo.2025.10766

Barbara Barrett, Joan Agwuna, Sarah Cope, Mark J Edwards, Norman Poole

{"title":"Service use, healthcare costs and productivity losses of functional cognitive disorder in a sample of attenders to out-patient cognitive, neurology and memory clinics.","authors":"Barbara Barrett, Joan Agwuna, Sarah Cope, Mark J Edwards, Norman Poole","doi":"10.1192/bjo.2025.10766","DOIUrl":"https://doi.org/10.1192/bjo.2025.10766","url":null,"abstract":"Background: People with functional disorders often receive high levels of healthcare resource use yet have poor outcomes. The health service costs and productivity losses of functional cognitive disorders (FCD) is unknown.Aims: This study aims to report the cost to health services and productivity losses of FCD.Method: Examination of healthcare service use and productivity losses in a sample of individuals with FCD who had attended a specialist out-patient clinic in south London.Results: The findings revealed high rates of healthcare use, including frequent contact with general practitioners, psychologists and hospital services, as well as work absences. The total estimated cost of healthcare and productivity losses per individual over 6 months was £1114.Conclusions: These results highlight the need for effective and efficient diagnostic pathways, targeted and effective interventions, and improved support for individuals with FCD.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e152"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indigenous-non-Indigenous disparities in health and social outcomes 5 years after first episode psychosis: national cohort study - CORRIGENDUM. 首次精神病发作后5年土著人与非土著人在健康和社会结果方面的差异：国家队列研究-勘误表

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-16 DOI: 10.1192/bjo.2025.10064

Ruth Cunningham, Frederieke Petrović-van der Deen, Sheree Gibb, Marie Crowe, Jenni Manuel, Suzanne Pitama, Sue Crengle, Richard Porter, Cameron Lacey

引用次数: 0

Perception of economic inequality and its association with depressive symptoms and suicide ideation among young adults in South Korea. 韩国年轻人对经济不平等的认知及其与抑郁症状和自杀意念的关系

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-14 DOI: 10.1192/bjo.2025.785

Minjae Choi, Joshua Kirabo Sempungu, Joon Hee Han, Mi-Hyui Kim, Eun Hae Lee, Yo Han Lee

{"title":"Perception of economic inequality and its association with depressive symptoms and suicide ideation among young adults in South Korea.","authors":"Minjae Choi, Joshua Kirabo Sempungu, Joon Hee Han, Mi-Hyui Kim, Eun Hae Lee, Yo Han Lee","doi":"10.1192/bjo.2025.785","DOIUrl":"https://doi.org/10.1192/bjo.2025.785","url":null,"abstract":"Background: Inequality can increase the risk of poor mental health. Objective measures explain the effects of socioeconomic disparities, but individuals may perceive inequality differently.Aim: We aimed to investigate the association between the perception of economic inequality and depressive symptoms and suicide ideation.Method: We used data from the Survey of Korean Youths' Lives, a nationally representative cross-sectional study of 14 918 young adults aged 19-34 years in South Korea. Multivariate logistic regression analysis was conducted to assess the association between perceived economic inequalities (i.e. income inequality and inequality of intergenerational mobility) and depressive symptoms/suicide ideation. Additionally, subgroup analyses were performed based on objective and subjective income levels.Results: Young adults with a high perception of economic inequality were more likely to experience depressive symptoms and suicide ideation. For example, those with a high perception of intergenerational mobility inequality had higher odds of depressive symptoms (odds ratio 1.82, 95% CI 1.49, 2.23) and suicide ideation (odds ratio 1.87, 95% CI 1.35, 2.60). Statistical evidence showed no interaction between the perception of inequalities and income, suggesting that a high perception of inequalities is associated with depressive symptoms and suicidal ideation, regardless of income. Nevertheless, the strongest association with poor mental health was observed in those with high perceived inequality and low income.Conclusions: This study shows that the way young adults perceive economic inequality could affect their depressive symptoms and suicidal ideation. The findings highlight the importance of reducing these perceptions and addressing economic inequalities to improve mental health.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e148"},"PeriodicalIF":3.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of high- and low-risk drinking after group treatment for alcohol use disorder. 酒精使用障碍群体治疗后高、低风险饮酒的预测因素

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-14 DOI: 10.1192/bjo.2025.10047

Kristoffer Høiland, Espen Kristian Ajo Arnevik, Lien My Diep, Tove Mathisen, Anette Søgaard Nielsen, Jens Egeland

{"title":"Predictors of high- and low-risk drinking after group treatment for alcohol use disorder.","authors":"Kristoffer Høiland, Espen Kristian Ajo Arnevik, Lien My Diep, Tove Mathisen, Anette Søgaard Nielsen, Jens Egeland","doi":"10.1192/bjo.2025.10047","DOIUrl":"https://doi.org/10.1192/bjo.2025.10047","url":null,"abstract":"Background: Understanding the factors influencing alcohol use disorder (AUD) treatment outcomes is essential. More knowledge about patient characteristics that predict treatment outcomes can help personalise interventions, improve treatment planning and address the needs of specific subgroups. The frequency of treatment attendance may also affect drinking outcomes after treatment. Despite research efforts, uncertainty remains about how patient factors and treatment attendance influence treatment outcomes.Aims: To examine how patient factors and treatment attendance predict high- or low-risk drinking at the end of treatment.Method: We used data (N = 92) from a multisite observational study of treatment-seeking individuals with AUD attending group treatment. Sociodemographic measures, alcohol and substance use measures, cognitive functioning, psychological distress, personality functioning and quality of life were screened in univariate analyses. Significant variables were entered into a binary logistic regression model.Results: Individuals with a higher percentage of treatment attendance (odds ratio 0.96 [95% CI 0.93, 0.96]) and with greater responsiblity scores on the Severity Indices of Personality Functioning (odds ratio 0.30 [95% CI 0.14, 0.64]) had a decreased likelihood of high-risk drinking at treatment end. Substance use, psychological distress and cognitive functioning were not associated with drinking levels at the end of treatment.Conclusion: A higher percentage of treatment attendance has a minor effect on drinking levels. Being more responsible, as reflected in higher scores on the responsibility domain, reduces the likelihood of high-risk drinking at the end of treatment. Clinicians are encouraged to screen and assess personality functioning when planning treatment for individuals with AUD.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e150"},"PeriodicalIF":3.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grief, bereavement and prolonged grief disorder: scoping and mapping the evidence. 悲伤，丧亲之痛和长期悲伤障碍：范围和映射的证据。

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-11 DOI: 10.1192/bjo.2025.10050

Gary Raine, Claire Khouja, Meena Khatwa, Helen Fulbright, Katy Sutcliffe, Amanda J Sowden

{"title":"Grief, bereavement and prolonged grief disorder: scoping and mapping the evidence.","authors":"Gary Raine, Claire Khouja, Meena Khatwa, Helen Fulbright, Katy Sutcliffe, Amanda J Sowden","doi":"10.1192/bjo.2025.10050","DOIUrl":"10.1192/bjo.2025.10050","url":null,"abstract":"Background: Some individuals experience abnormally persistent and intense symptoms of grief that significantly interfere with daily functioning. This condition has been described using terms such as complicated or prolonged grief and prolonged grief disorder (PGD).Aims: To identify the availability of evidence addressing a range of policy relevant issues related to grief, bereavement and PGD. In this paper we focus on the availability of evidence from systematic reviews.Method: We searched 12 databases and the websites of 18 grief- or bereavement-related organisations. Using key characteristics extracted from included reviews, we produced a high-level overview of the available evidence that enabled potential research gaps to be identified.Results: We identified 212 reviews - 103 focused on people's experiences of grief/bereavement including service use; 22 reported on PGD prevalence, 42 on PGD risk factors, 37 on factors that influence grief more broadly and 80 on the effectiveness of grief-related interventions. Fifty-five reviews focused on multiple issues of interest. Half of reviews focused on a specific cause/type of death (n = 108). Of these reviews, most focused on three main causes/types of death: a specific health condition or terminal illness (n = 36), perinatal loss (n = 34) and suicide (n = 20).Conclusions: We identified a large number of reviews, but key evidence gaps exist, particularly in relation to intervention cost-effectiveness and social, organisational or structural-level interventions that are needed for addressing inequities and other modifiable factors that can impair grieving and potentially increase the risk of PGD.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e149"},"PeriodicalIF":3.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune DNA methylation in depression: cross-sectional and longitudinal study. 抑郁症的免疫DNA甲基化：横断面和纵向研究。

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-10 DOI: 10.1192/bjo.2025.10065

Marisol Herrera-Rivero, Matthias Nauck, Klaus Berger, Bernhard T Baune

{"title":"Immune DNA methylation in depression: cross-sectional and longitudinal study.","authors":"Marisol Herrera-Rivero, Matthias Nauck, Klaus Berger, Bernhard T Baune","doi":"10.1192/bjo.2025.10065","DOIUrl":"10.1192/bjo.2025.10065","url":null,"abstract":"Background: Immune dysregulation contributes to the pathophysiology of depression and is a potential link between depression and comorbid medical conditions. DNA methylation is a dynamic transcriptional regulator of the immune system.Aims: To study changes in DNA methylation of disease- and comorbidity-associated immune genes in patients with and without depression diagnoses from the German BiDirect Study.Method: We performed a cross-sectional (baseline, y0) and longitudinal (consecutive assessments at 3-year intervals, y0, y3, y6) differential methylation analyses of 382 immune-related genes associated with depression, obesity, diabetes and/or gout in 276 patients with depression and in 207 individuals without a lifetime depression diagnosis from the BiDirect Study. In addition, we applied unsupervised clustering to identify subgroups of individuals with depression based on longitudinal methylation patterns.Results: There were no significant methylation changes between individuals with depression and controls at baseline. Follow-up analyses used to assess the top (P < 0.05) 151 methylation probes longitudinally identified 42 CpG sites that showed time-dependent changes associated with depression, and defined 3 depression clusters with differential profiles of serum inflammation markers at baseline. The implicated genes corresponded in the majority to those associated with diabetes risk, and were enriched in processes relevant for haematopoiesis.Conclusions: Our results suggest that immune dysregulation associated with DNA methylation profiles contributes to the pathophysiology of depression and is a plausible link to chronic medical conditions such as diabetes.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e129"},"PeriodicalIF":3.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal cannabis for tics in adolescents with Tourette syndrome. 药用大麻治疗抽动症青少年抽动症。

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-10 DOI: 10.1192/bjo.2025.35

Valsamma Eapen, Ping-I Lin, Kaitlyn Taylor, Eunice Chan, Paul Chay, Noel Cranswick, Amy Ka, Feroza Khan, Jonathan M Payne, Chidambaram Prakash, Ramya Velalagan, Daryl Efron

{"title":"Medicinal cannabis for tics in adolescents with Tourette syndrome.","authors":"Valsamma Eapen, Ping-I Lin, Kaitlyn Taylor, Eunice Chan, Paul Chay, Noel Cranswick, Amy Ka, Feroza Khan, Jonathan M Payne, Chidambaram Prakash, Ramya Velalagan, Daryl Efron","doi":"10.1192/bjo.2025.35","DOIUrl":"10.1192/bjo.2025.35","url":null,"abstract":"Medicinal cannabis has been trialled for Tourette syndrome in adults, but it has not been studied in adolescents. This open-label, single-arm trial study evaluated the feasibility, acceptability and signal of efficacy of medicinal cannabis in adolescents (12-18 years), using a Δ9-tetrahydrocannabinol:cannabidiol ratio of 10:15, with dose varying from 5 to 20 mg/day based on body weight and response. The study demonstrated feasibility of recruitment, acceptability of study procedures, potential benefits and a favourable safety profile, with no serious adverse events. Commonly reported adverse events were tiredness and drowsiness, followed by dry mouth. Statistically significant improvement was observed in parent and clinician reports on tics (paired t-test P = 0.003), and behavioural and emotional issues (paired t-test P = 0.048) and quality of life as reported by the parent and young person (paired t-test P = 0.027 and 0.032, respectively). A larger-scale, randomised controlled trial is needed to validate these findings.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e145"},"PeriodicalIF":3.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of CD33 genetic variants with neurocognitive profiles in chronic viral hepatitis. 慢性病毒性肝炎患者CD33基因变异与神经认知特征的关系

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-10 DOI: 10.1192/bjo.2025.10048

Wei-Fang Tsai, Rwei-Ling Yu, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Yu-Wen Alvin Huang, Chun-Hsiang Tan

{"title":"Association of CD33 genetic variants with neurocognitive profiles in chronic viral hepatitis.","authors":"Wei-Fang Tsai, Rwei-Ling Yu, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Yu-Wen Alvin Huang, Chun-Hsiang Tan","doi":"10.1192/bjo.2025.10048","DOIUrl":"10.1192/bjo.2025.10048","url":null,"abstract":"Background: CD33 has been implicated in the pathogenesis of Alzheimer's disease primarily through its role in inhibiting the clearance of beta-amyloid (Aβ). However, genetic studies yield mixed results and it is unclear whether the impact of CD33 is specific to Alzheimer's disease or related to broader neurodegenerative processes. Interestingly, CD33 has also been shown to interact with the hepatitis B (HBV) and C viruses (HCV).Aims: This study aims to investigate the effects of CD33 single-nucleotide polymorphisms (SNPs) on cognitive functions across diverse populations, including healthy controls, individuals with chronic HBV or HCV and those diagnosed with Parkinson's disease.Method: We genotyped CD33 SNPs in 563 participants using the Affymetrix platform. Participants' cognitive functions were cross-sectionally assessed using a neuropsychological test battery spanning six domains.Results: Our analysis revealed that CD33 SNP variations had no significant cognitive impact on healthy individuals or Parkinson's disease patients. However, chronic HBV and HCV patients exhibited significant cognitive differences, particularly in memory, related to CD33 SNP genotypes. Moderation analysis indicated a heightened influence of CD33 SNPs on cognitive functions in chronic HBV and HCV individuals. Our data also suggest that inflammation severity may modulate the cognitive effects in hepatitis patients with specific CD33 SNPs.Conclusions: This study highlights the importance of CD33 SNPs in cognitive outcomes, emphasising their role in the context of chronic viral hepatitis. It contributes to understanding the cognitive profiles influenced by CD33 SNPs and posits CD33's potential contribution to neurodegenerative disease progression, potentially intensified by HBV/HCV-induced inflammation.","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 4","pages":"e147"},"PeriodicalIF":3.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fragmentation in adolescent health care provision. 青少年保健服务不完整。

IF 3.9 3区医学

BJPsych Open Pub Date : 2025-07-08 DOI: 10.1192/bjo.2025.10059

Mina Fazel, Emma Soneson

引用次数: 0