BJPsych Open最新文献

{"title":"Preference-based crisis care is an infrastructure problem: lessons from joint crisis plans and advance choice documents for Japan.","authors":"Teruyuki Nomura, Shunsuke Kanou","doi":"10.1192/bjo.2026.12059","DOIUrl":"10.1192/bjo.2026.12059","url":null,"abstract":"<p><p>Crisis planning based on stated treatment preferences should not be judged by trials that never verified delivery infrastructure. Lessons from UK joint crisis plans and advance choice documents (ACDs) suggest outcomes depend on facilitation, accessibility, specificity and exception governance. Japan should test ACDs as measurable crisis-care infrastructure, not paperwork.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e199"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographics and clinical outcomes of autistic children and adolescents receiving psychiatric in-patient care in the Thames Valley from 2019 to 2024: retrospective cohort study.","authors":"Samuel Lloyd-White, Rohan Borschmann, Alice Rorke, Eloise Stark, Gillian Combe","doi":"10.1192/bjo.2026.12039","DOIUrl":"10.1192/bjo.2026.12039","url":null,"abstract":"<p><strong>Background: </strong>Many autistic adolescents receive in-patient psychiatric care from services that are ill-equipped to meet neurodivergent needs. However, the outcomes for autistic adolescents accessing in-patient care remain poorly understood.</p><p><strong>Aims: </strong>To document the demographics and clinical outcomes of autistic adolescents referred to in-patient psychiatric services over a 5-year period and compare these with those of their allistic peers accessing the same services.</p><p><strong>Method: </strong>We conducted a retrospective cohort study involving all adolescents (aged 12-17 years inclusive) referred for in-patient psychiatric care through the Thames Valley Provider Collaborative between 1 April 2019 and 31 March 2024. Clinical characteristics and outcomes of referrals for autistic and allistic adolescents were collected and summarised from routine service data. Inferential statistics (including <i>t</i>-tests and chi-squared tests) were used to compare characteristics between the autistic and allistic groups.</p><p><strong>Results: </strong>Autistic adolescents were more likely than their allistic peers to be referred in an emergency (24.6 <i>v</i>. 16.6%) and for risk management (53.7 <i>v</i>. 33.5%). Autistic adolescents without an eating disorder had longer average length of stay than their peers (146.1 <i>v.</i> 97.5 days) and were more likely to be discharged to more secure settings following admission (12.9 <i>v</i>. 7.7%). Emerging evidence from routine outcome measures suggests less positive progress during in-patient care and greater impairment among autistic adolescents at both admission and discharge.</p><p><strong>Conclusions: </strong>There are important differences in outcomes from psychiatric in-patient admissions between autistic and allistic adolescents. Greater work is needed to understand these differences and the factors influencing treatment success for autistic adolescents.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e195"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health symptoms following a pregnancy complicated by cardiovascular disease: scoping review.","authors":"Iris Becene, Stephanie Vartany, Alyssa Grimshaw, Sona Jasani","doi":"10.1192/bjo.2026.12051","DOIUrl":"10.1192/bjo.2026.12051","url":null,"abstract":"<p><strong>Background: </strong>Pre-existing cardiovascular disease (CVD) affects 1-4% of pregnancies in the USA and is associated with maternal morbidity. High-risk pregnancies with increased medical supervision are associated with poor postpartum mental health, although the prevalence in those with CVD is unclear.</p><p><strong>Aims: </strong>This scoping review aimed to synthesise estimates of post-pregnancy mental health outcomes among people with pre-existing CVD.</p><p><strong>Method: </strong>Cochrane Library, Ovid Medline, Ovid EMBASE, Scopus, Google Scholar and Web of Science Core Collection were searched to identify relevant published literature, using controlled vocabulary and keywords for post-pregnancy mental health and CVD in pregnancy. The search was not limited by publication type, year or study design. Studies that included an assessment of post-pregnancy depression, anxiety or post-traumatic stress disorder (PTSD) symptoms after a pregnancy complicated by pre-existing CVD were included.</p><p><strong>Results: </strong>Of the 1591 studies screened, 7 met the inclusion criteria. In patients with pre-existing CVD, 4 studies assessed depressive symptoms and found a prevalence of 10.4-32.2%; 2 studies assessed anxiety symptoms and found a prevalence of 22.0-28.5%; and 1 study assessed PTSD and found a prevalence of 26.4% for mild symptoms and 18.2% for moderate symptoms.</p><p><strong>Conclusions: </strong>The prevalence of post-pregnancy depression, anxiety and PTSD symptoms among people with pre-existing CVD may be similar to, or higher than, estimates from the general population. However, there was high heterogeneity in the included studies. More research is needed to determine if there is an increased risk of postpartum mental health disorders for pregnant people with pre-existing CVD.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e197"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of in-patient mental health rehabilitation services provided by the NHS and independent sector in England: patient and service characteristics.","authors":"Helen Killaspy, Christian Dalton-Locke, Mariam Adeleke, Nia Barber, Bella Branch, Caroline Sarah Clarke, Gerard Leavey, Artemis Igoumenou, Katherine Barrett, Megan Downey, Sophie Thomas, Jing Yi Jessica Weng, Rumana Z Omar","doi":"10.1192/bjo.2026.12047","DOIUrl":"10.1192/bjo.2026.12047","url":null,"abstract":"<p><strong>Background: </strong>In-patient mental health rehabilitation services provide specialist care to adults with complex psychosis. In England, there are more than 350 such services, half provided by the National Health Service (NHS) and half by the independent sector.</p><p><strong>Aims: </strong>To investigate whether NHS and independent sector in-patient mental health rehabilitation services differ.</p><p><strong>Method: </strong>We recruited a random sample of NHS and independent sector services across England. We collected cross-sectional data regarding service and patient characteristics through interviews with patients, clinicians and managers, and from healthcare record reviews.</p><p><strong>Results: </strong>We recruited 411 patients from 48 NHS services and 172 patients from 20 independent sector services. Service characteristics, including standardised quality scores, were similar. Most patients had a diagnosis of schizophrenia (NHS <i>n</i> = 237, 57.7%; independent sector <i>n</i> = 99, 57.6%) or schizoaffective disorder (NHS <i>n</i> = 88, 21.4%; independent sector <i>n</i> = 32, 18.6%). More than half had at least one comorbid condition, but more independent sector patients had at least two (NHS 131 of 411, 31.9%; independent sector 80 of 172, 46.5%; <i>P</i> = 0.001). Current admissions were twice as long for independent sector patients (NHS mean 1.2 years [s.d. 1.5]; independent sector mean 2.4 years [s.d. 2.8]). Standardised ratings of patients' quality of life, autonomy, time use, satisfaction with care, social and everyday functioning, and challenging behaviours were similar. However, independent sector patients had more needs (NHS mean 6.5 [s.d. 3.2]; independent sector mean 7.9 [s.d. 3.9]; <i>P</i> < 0.001) and more had a history of fire setting (NHS 32, 7.9%; independent sector 28, 17.2%; <i>P</i> = 0.001).</p><p><strong>Conclusions: </strong>Both NHS and independent sector in-patient rehabilitation services support people with complex psychosis, but independent sector patients may have more complex conditions, which could explain their longer admissions.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e196"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delays and disparities in access to secure psychiatric services in England: national study of referrals and access assessments.","authors":"Sarah-Jayne Leonard, Jana Bowden, Florian Walter, Jon Fernando Carey, Louise Robinson, Caroline Logan, Ruth McDonald, Jennifer Shaw, Jane Senior","doi":"10.1192/bjo.2026.12053","DOIUrl":"10.1192/bjo.2026.12053","url":null,"abstract":"<p><strong>Background: </strong>Secure psychiatric services (SPS) are vital for people with severe mental disorders who pose significant risks, yet national evidence on referral pathways, acceptance and timeliness of admission is limited. Delays and variability in access are especially concerning in prisons, where mental health crises are frequent and alternatives limited.</p><p><strong>Aims: </strong>This study presents the first national analysis of SPS referral and admission patterns in England following the introduction of provider collaboratives. It identifies predictors of referral acceptance and delays across the referral-to-admission pathway to inform equity and performance improvement.</p><p><strong>Method: </strong>Data were drawn from 149 low-secure and 98 medium-secure services across 15 provider collaboratives, encompassing 1356 referrals. Multivariable models examined predictors of acceptance and delay, benchmarked against national policy standards.</p><p><strong>Results: </strong>Almost half of referrals originated from prisons (46%, <i>n</i> = 529), with 55% accepted. Acceptance was associated with gender, legal status, Mental Health Act status, prior secure admission, diagnosis, referral origin and reason for referral, but not with ethnicity or urgency. Substantial site-level variation reflected local practice and resources. Delays were widespread: fewer than a third of urgent referrals were assessed within 2 days, and only 19-25% of accepted prison referrals met recommended assessment and admission targets. Although prison referrals were processed more quickly than community or SPS referrals, national standards were seldom achieved.</p><p><strong>Conclusions: </strong>Access to SPS remains inconsistent, with substantial variation in acceptance and widespread delays across referral pathways. Despite faster processing of prison referrals, national assessment and admission standards were rarely met, particularly for this group. These findings highlight gaps between policy expectations and practice, indicating a need for improved adherence to national timeframes, greater standardisation of decision-making and enhanced system oversight, to reduce inequities in access.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e198"},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 Diabetes and Disordered Eating - the Rising T1DE: Evolution of a New Service Within a Specialist Eating Disorder Service (SEDU) - ERRATUM.","authors":"Mike Apio, Wiebke Hollemann, Jana Ondrova Farmer, Kruti Pandit, Aisha Kibirige","doi":"10.1192/bjo.2026.12075","DOIUrl":"10.1192/bjo.2026.12075","url":null,"abstract":"","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e194"},"PeriodicalIF":4.0,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>ALDH2 rs671</i> and <i>ADH1B rs1229984</i> polymorphisms on habitual alcohol use: evidence from a large Taiwanese cohort.","authors":"Mu-En Liu, Yu-Ting Yan, Yu-Tung Tien, Wei-Ming Liu, Ding-Lieh Liao, Po-Hsiu Kuo, Shih-Jen Tsai","doi":"10.1192/bjo.2026.12042","DOIUrl":"10.1192/bjo.2026.12042","url":null,"abstract":"<p><strong>Background: </strong>Two functional genetic polymorphisms, <i>ADH1B rs1229984</i> and <i>ALDH2 rs671</i>, play key roles in ethanol metabolism and are especially prevalent in East Asian populations. The <i>rs1229984</i> variant accelerates the conversion of ethanol to acetaldehyde, whereas <i>rs671</i> reduces enzymatic activity for converting acetaldehyde into acetic acid. These variants affect alcohol use disorder risk and have been implicated in various systemic conditions.</p><p><strong>Aims: </strong>To investigate the broader associations of <i>ADH1B rs1229984</i> and <i>ALDH2 rs671</i> with habitual alcohol use in large, unselected populations.</p><p><strong>Method: </strong>We analysed data from 146 374 Taiwanese adults (aged 20-90 years) enrolled in the Taiwan Biobank.</p><p><strong>Results: </strong>Both variants showed clear associations with habitual alcohol use. The <i>ADH1B rs1229984</i> CC genotype was associated with a higher prevalence of drinking, indicating a substantial contribution to alcohol-related behaviour. The <i>ALDH2 rs671</i> A allele was linked to markedly reduced drinking, reflecting known intolerance among carriers rather than implying a uniformly larger effect than <i>ADH1B</i>. Beyond alcohol use, <i>rs671</i> showed a protective association with gout, whereas <i>rs1229984</i> was not significantly associated with chronic diseases after correction.</p><p><strong>Conclusions: </strong>In this large population sample, both <i>ADH1B rs1229984</i> and <i>ALDH2 rs671</i> demonstrate meaningful, genotype-dependent effects on habitual alcohol use. Their combined effects underscore the importance of evaluating gene-gene interactions rather than attributing disproportionate influence to a single locus.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e192"},"PeriodicalIF":4.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing treatment home for adolescents with eating disorders.","authors":"Laura Coglan, Gillian Combe, Lorna McGuigan, Agnes Ayton","doi":"10.1192/bjo.2026.12038","DOIUrl":"10.1192/bjo.2026.12038","url":null,"abstract":"<p><strong>Background: </strong>The increasing demand for adolescent eating disorder services during and following the COVID-19 pandemic necessitated alternative treatment approaches. Traditional in-patient and daycare settings faced challenges, including resource limitations and geographical accessibility.</p><p><strong>Aims: </strong>To describe and evaluate the outcomes of the Hospital at Home (H@H) service, an innovative, virtual, intensive treatment programme designed to prevent in-patient admissions or shorten length of in-patient stay.</p><p><strong>Method: </strong>A prospective cohort of 71 consecutive admissions from October 2021 to December 2024 was established. Data included percentage median body mass index (%mBMI), Eating Disorders Examination Questionnaire (EDE-Q), Children's Global Assessment Scale (CGAS) and any readmissions for in-patient treatment within the following 6 months. Qualitative feedback was also sought from staff and a sample of patients and family members.</p><p><strong>Results: </strong>Of the 71 admissions to H@H, only 9 (13%) required hospitalisation. Mean %mBMI increased significantly, from 82.4% (s.d. 8.17) on admission to 90.07% (s.d. 9.44) on discharge (<i>p</i> < 0.001, 95% CI 5.67 to 9.61). Global EDE-Q score improved significantly, from 3.75 (s.d. 1.32) on admission to 2.62 (s.d. 1.45) on discharge (<i>p</i> < 0.001, 95% CI -1.47 to -0.78). Average CGAS improved significantly, from 38.7 (s.d. 7.4) on admission to 51.8 (s.d. 14.2) on discharge (<i>p</i> < 0.001, 95% CI 10.06 to 16.11). Families and patients reported high satisfaction with the virtual care model.</p><p><strong>Conclusions: </strong>This innovative model prevented hospital admissions, demonstrating clinical benefits and high user satisfaction. Expansion and further research are recommended to explore the long-term clinical outcomes and cost-effectiveness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e193"},"PeriodicalIF":4.0,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prospective incidence of treatment-resistant schizophrenia: analysis of the CATIE trial using the TRRIP consensus.","authors":"Dan W Joyce, Sajitha Nair, Alexis E Cullen, Rodrigo Bressan, Sukhi Shergill","doi":"10.1192/bjo.2026.12041","DOIUrl":"10.1192/bjo.2026.12041","url":null,"abstract":"<p><strong>Background: </strong>The true incidence of treatment-resistant schizophrenia (TRS) remains uncertain, largely because earlier studies relied on heterogeneous definitions and retrospective assessments. The Treatment Response and Resistance in Psychosis (TRRIP) consensus established standardised diagnostic criteria, but these have rarely been applied prospectively.</p><p><strong>Aims: </strong>To estimate the incidence of TRS prospectively by using operationalised TRRIP criteria within a large community-based trial, and to examine whether baseline demographic or clinical variables predict its emergence.</p><p><strong>Method: </strong>We applied TRRIP criteria to 1334 participants with chronic schizophrenia enrolled in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study. TRS was defined as persistent symptoms and functional impairment following two adequate antipsychotic trials, each meeting TRRIP thresholds for duration, dose and adherence. Incidence was estimated with bootstrap resampling, and logistic regression examined associations between baseline variables and TRS onset.</p><p><strong>Results: </strong>Of 1334 participants, 782 (58.6%) met TRRIP absolute symptom thresholds at baseline; 77 (9.8%) fulfilled full criteria for TRS during follow-up. The incidence rate was 5.68 per 100 person-years (95% CI 4.51-7.02) overall and 9.20 per 100 person-years (95% CI 7.43-11.39) among above-threshold participants. Higher baseline Positive and Negative Syndrome Scale positive and negative subscale scores and greater global illness severity were associated with TRS, although predictive performance was poor.</p><p><strong>Conclusions: </strong>This first prospective application of TRRIP criteria to a randomised trial data-set provides robust estimates of TRS incidence. Routine clinical and demographic variables have limited predictive value, supporting the need for longitudinal, biologically informed studies that use TRRIP-aligned frameworks.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e191"},"PeriodicalIF":4.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are antidepressants held to a different standard?","authors":"Ovais Wadoo, Yasser Saeed Khan, Javed Latoo, Abdul Majid Gania, Majid Alabdulla","doi":"10.1192/bjo.2026.12043","DOIUrl":"10.1192/bjo.2026.12043","url":null,"abstract":"<p><p>This Editorial examines the continuing debate over the efficacy and outcomes of antidepressants, focusing on how evidence is interpreted and applied in clinical practice. Although concerns about uncertainty, heterogeneity and contested outcome measures are valid, these challenges are not unique to psychiatry, but are common across medical specialties. The Editorial discusses issues in evidence synthesis, the distinction between statistical significance and clinical relevance, the translation of global trial data into real-world settings and the influence of public and digital discourse. It emphasises balanced interpretation, transparent risk-benefit communication and shared decision-making, to avoid simplistic conclusions about treatment effectiveness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"12 4","pages":"e190"},"PeriodicalIF":4.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}