BJPsych Open最新文献

{"title":"Prevalence and correlates of prolonged grief disorder symptom severity in a large sample of Italian adults.","authors":"Alessandro Musetti, Christian Franceschini, Maria C Quattropani, Holly G Prigerson, Vittorio Lenzo","doi":"10.1192/bjo.2025.10763","DOIUrl":"10.1192/bjo.2025.10763","url":null,"abstract":"<p><strong>Background: </strong>Literature has shown that a significant minority of bereaved people are at risk of prolonged grief disorder (PGD). However, studies on its prevalence and correlates within Italian samples remain scarce.</p><p><strong>Aims: </strong>This study aimed to explore the prevalence and correlates of PGD symptom severity among 1603 bereaved Italian adults.</p><p><strong>Method: </strong>Self-reported data on PGD, suicidal ideation, depression, anxiety and stress were gathered. Descriptive characteristics and bereavement-related information were also collected.</p><p><strong>Results: </strong>Among participants who lost a close other person at least 12 months prior, the prevalence of probable PGD and severe suicidal ideation was 7.7% (<i>n</i> = 104) and 0.7% (<i>n</i> = 9), respectively. The overall prevalence of severe suicidal ideation in the sample was 4.5%, rising to 18.2% among those with probable PGD. The probable PGD diagnosis showed minimal agreement with reported depression (phi = 0.25), anxiety (phi = 0.19), and stress (phi = 0.26), suggesting potentially limited overlap and supporting their distinctiveness. The severity of PGD symptoms was significantly positively associated with older age and suicidal ideation, and negatively associated with lower educational background and time since loss. PGD severity also varied by kinship, cause of death and place of residence. Specifically, bereaved individuals who lost a grandparent due to natural causes associated with ageing and lived in small- to medium-sized cities reported lower PGD symptom severity relative to others.</p><p><strong>Conclusions: </strong>These findings contribute to the understanding of PGD symptomatology in bereaved individuals in Italy, although the results may not generalise to the entire Italian population.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e162"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulsivity and aggression in suicide across age and sex: case-control study.","authors":"Sergio Sanz-Gómez, Constanza Vera-Varela, Diego de-la-Vega-Sánchez, María Luisa Barrigón, Adrián Alacreu-Crespo, Julio A Guija, Ana Sánchez, Santiago de León, Enrique Baca-García, Lucas Giner","doi":"10.1192/bjo.2025.10076","DOIUrl":"10.1192/bjo.2025.10076","url":null,"abstract":"<p><strong>Background: </strong>Impulsivity and aggression are known risk factors for suicide, with observed age and sex differences in their impact.</p><p><strong>Aims: </strong>To explore variations in impulsivity and aggression based on sex and age and examine their roles in predicting suicide.</p><p><strong>Method: </strong>We examined 582 participants (406 individuals who died by suicide, 176 non-suicidal sudden-death controls) using the psychological autopsy method. Measures of impulsivity and aggression included the Barratt Impulsiveness Scale (BIS) and the Brown-Goodwin History of Aggression (BGHA). Participants were categorised into four groups: suicide male, control male, suicide female and control female. For group comparisons, we used analyses of variance and Spearman's rank correlation to assess the relationship between age and BIS and/or BGHA ratings. Stepwise logistic regression was used to identify predictors of suicide for each sex.</p><p><strong>Results: </strong>Higher levels of BIS and BGHA ratings were found in the suicide group compared with controls (BIS: 51.3 <i>v</i>. 42.2, <i>P</i> = 0.002, <i>η</i>² = 0.017; BGHA: 7.1 <i>v</i>. 4.1, <i>P</i> < 0.001, <i>η</i>² = 0.028), with no significant sex differences. BIS and BGHA ratings decreased with age in the suicide groups (suicide male: impulsivity <i>ρ</i> = -0.327, <i>P</i> < 0.001; suicide female: aggression <i>ρ</i> = -0.175, <i>P</i> = 0.038) but not among controls. Logistic regression analysis revealed that for men, aggression (odds ratio 1.072, 95% CI: 1.032-1.112) was a key predictor. For women, younger age (odds ratio 0.970, 95% CI: 0.948-0.993), low BIS impulsivity ratings (odds ratio 1.018, 95% CI: 1.001-1.036) and living with children (odds ratio 0.448, 95% CI: 0.208-0.966) were protective factors.</p><p><strong>Conclusions: </strong>Impulsive and aggressive behaviours are critical factors in suicide risk among younger individuals, indicating an age effect but no sex dimorphism, with aggressive behaviours being a better predictor for men and impulsive and aggressive behaviours for women.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e167"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of and sex distribution in specific phobia subtypes in a treatment-seeking sample.","authors":"David Veale, Charles Beeson, Andriani Papageorgiou","doi":"10.1192/bjo.2025.10767","DOIUrl":"10.1192/bjo.2025.10767","url":null,"abstract":"<p><strong>Background: </strong>Specific phobias are common in the community, and much is known from epidemiological surveys about their subtypes and sex ratio.</p><p><strong>Aims: </strong>To determine the subtypes and sex ratio in a treatment-seeking sample of people with a specific phobia.</p><p><strong>Method: </strong>Patients with a specific phobia were identified by a retrospective search of clinical case records from patient notes in electronic health records at the South London and Maudsley NHS Foundation Trust (the largest secondary mental healthcare provider in Europe).</p><p><strong>Results: </strong>We identified 1017 patients over 5 years as having a specific phobia. The adult female to male sex frequency ratio for having any specific phobia was 3.9, with the ratio of specific phobia subtypes ranging from 2.4 (natural environment) to 8.2 (animal). The child female to male ratio of specific phobia subtypes ranged from 0.7 (natural environment) to 1.8 (other subtypes). Phobia of vomiting was the most common specific phobia presenting in both adults (<i>n</i> = 161, 17.8% of all specific phobias) and children (<i>n</i> = 26, 23.4%). In adults with a phobia of vomiting, the female to male ratio was 9.1 compared with 3.4 in all other specific phobias, and 4.2 versus 0.98 for children.</p><p><strong>Conclusions: </strong>There is a stark contrast between the apparent prevalence of phobia of vomiting in epidemiological surveys and being the most common presentation clinically. A very high female to male ratio in phobia of vomiting and animals in adults seeking treatment is also in contrast to findings in the community. This has implications for clinician training and public education.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e164"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential neural activity associated with emotion reactivity and regulation in young adults with non-suicidal self-injury.","authors":"Gyumyoung Kim, Hyemin Shin, Ji-Won Hur","doi":"10.1192/bjo.2025.10765","DOIUrl":"10.1192/bjo.2025.10765","url":null,"abstract":"<p><strong>Background: </strong>Emotional processing difficulties represent the core psychopathology of non-suicidal self-injury (NSSI), yet the underlying neural mechanisms remain unclear.</p><p><strong>Aims: </strong>To investigate neural alterations associated with emotion reactivity and regulation in individuals with NSSI and examine whether emotional valence is related to these neural patterns.</p><p><strong>Method: </strong>During functional magnetic resonance imaging scans, unmedicated young adults with NSSI (<i>n</i> = 29) and matched controls (<i>n</i> = 25) completed an emotion regulation task in which they viewed pictures of different emotional categories with instructions to either attend to or regulate their emotions.</p><p><strong>Results: </strong>Individuals with NSSI showed increased neural activation in the right superior temporal gyrus (STG), right parahippocampal gyrus and right supramarginal gyrus during negative emotion reactivity and increased activation in the right middle temporal gyrus and left STG during positive emotion reactivity. Conversely, those with NSSI exhibited reduced activation in the left supplementary motor area, left inferior frontal gyrus, right putamen, right thalamus and right STG during negative emotion regulation and reduced activation in the left ventral striatum during positive emotion regulation. Notably, both hyperactivation of the STG during negative emotion reactivity and hypoactivation of the supplementary motor area during negative emotion regulation were associated with emotion dysregulation in individuals with NSSI.</p><p><strong>Conclusions: </strong>We observed distinct neural patterns of emotional processing among individuals with NSSI, characterised by hyperactivation during emotion reactivity and hypoactivation during emotion regulation. Our findings provide a neurophysiological basis for therapeutic interventions that facilitate adaptive emotional processing in individuals with NSSI.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e163"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The thematic series on the psychosocial and mental health impacts of terrorism and collective violence: narrative review of common themes from diverse events, places and research methods.","authors":"Richard Williams, Caroline Bell, Kenneth R Kaufman","doi":"10.1192/bjo.2025.10061","DOIUrl":"10.1192/bjo.2025.10061","url":null,"abstract":"<p><p>Thematic series were introduced to <i>BJPsych Open</i> by the current Editor-in-Chief to address key topics in psychiatry and mental health, specifically considering the impact on the global burden of diseases with associated treatments, outcomes, policy and research priorities. The increasing submission to <i>BJPsych Open</i> of articles about the psychosocial and mental health impacts of terrorism and collective violence naturally led to this thematic series. This paper introduces the journal's series of published papers about terrorism and collective violence. While we identify the topics covered by the series and hope to generate conversation, this paper does not report a systematic review of the series. The thematic series consists of 13 articles; 9 were open submissions and 4 were commissioned. They include this review, an editorial concerning research methods and 11 papers reporting how people have responded to terrorist and violent incidents in 4 countries. Including this review, one paper was published in 2020, three in 2022, two in 2023, five in 2024 and two in 2025. The commissioned papers were added to broaden coverage of the Utøya attack on young people in Norway, and the shootings in Christchurch, New Zealand in 2019. Our intention was to enable the papers on these two incidents to sit alongside papers already submitted about them and the Manchester Arena bombing as well as articles about attacks in Germany. We begin by introducing the papers and comment in the discussion on a series of topics that we have selected as prominent in the series.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e169"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant catatonia in an adolescent with pogo transposable element derived with zinc finger domain (POGZ) gene mutation: case report.","authors":"Liron Leibovitch, Alon Gorenshtein, Erez Bibi, Ayala Uri","doi":"10.1192/bjo.2025.10807","DOIUrl":"10.1192/bjo.2025.10807","url":null,"abstract":"<p><strong>Background: </strong>Malignant catatonia represents a severe and life-threatening neuropsychiatric syndrome that demands prompt recognition and intervention. This condition poses particular diagnostic and management challenges in adolescents, especially when genetic predispositions and neurodevelopmental vulnerabilities complicate the clinical picture.</p><p><strong>Aims: </strong>This report examines a complex case of malignant catatonia in a 17-year-old female with developmental delay but no prior psychiatric diagnoses, who developed severe cognitive and behavioural deterioration. We explore the diagnostic complexities, therapeutic challenges and potential genetic contributions to her presentation.</p><p><strong>Method: </strong>We present a comprehensive case analysis documenting clinical progression, treatment responses and genetic findings through whole-exome sequencing. The patient's journey spans from initial presentation to long-term follow-up, with systematic assessment using standardised catatonia rating scales.</p><p><strong>Results: </strong>The patient's condition manifested as severe psychomotor impairment, mutism and autonomic instability, showing minimal response to initial treatment. Electroconvulsive therapy yielded significant but temporary amelioration of symptoms. Genetic analysis revealed a heterozygous mutation in the pogo transposable element derived with zinc finger domain (POGZ) gene - a gene implicated in neurodevelopmental disorders - suggesting this variant contributed to her neurobiological vulnerability. Concurrent features of functional neurological disorder further compounded the diagnostic complexity, illustrating the intricate interplay between genetic susceptibility and clinical presentation.</p><p><strong>Conclusions: </strong>This case illuminates the challenges clinicians face when diagnosing and treating complex neuropsychiatric presentations in adolescents, particularly when genetic predispositions intersect with functional neurological symptoms. The findings emphasise how comprehensive, multidisciplinary approaches remain essential for optimal patient care. Moreover, this case highlights the selective utility of genetic investigation in elucidating potential underpinnings of complex, treatment-resistant malignant catatonia, whilst demonstrating that genetic variants may confer vulnerability rather than direct causation.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e170"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid tranquillisation for psychiatric in-patients with a diagnosis of personality disorder: under-recognised issue.","authors":"Carol Paton, Mike J Crawford, Matthew Hartley, Clive E Adams, Elena M Edokpolor Pernia, Olivia Rendora, Thomas R E Barnes","doi":"10.1192/bjo.2025.10052","DOIUrl":"10.1192/bjo.2025.10052","url":null,"abstract":"<p><strong>Background: </strong>Clinical guidelines for personality disorder emphasise the importance of patients being supported to develop psychological skills to help them manage their symptoms and behaviours. But where these mechanisms fail, and hospital admission occurs, little is known about how episodes of acutely disturbed behaviour are managed.</p><p><strong>Aims: </strong>To explore the clinical characteristics and management of episodes of acutely disturbed behaviour requiring medication in in-patients with a diagnosis of personality disorder.</p><p><strong>Method: </strong>Analysis of clinical audit data collected in 2024 by the Prescribing Observatory for Mental Health, as part of a quality improvement programme addressing the pharmacological management of acutely disturbed behaviour. Data were collected from clinical records using a bespoke proforma.</p><p><strong>Results: </strong>Sixty-two mental health Trusts submitted data on 951 episodes of acutely disturbed behaviour involving patients with a personality disorder, with this being the sole psychiatric diagnosis in 471 (50%). Of the total, 782 (82%) episodes occurred in female patients. Compared with males, episodes in females were three times more likely to involve self-harming behaviour or be considered to pose such a risk (22% and 70% respectively: <i>p</i> < 0.001). Parenteral medication (rapid tranquillisation) was administered twice as often in episodes involving females than in males (64 and 34% respectively: <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Our findings suggest that there are a large number of episodes of acutely disturbed behaviour on psychiatric wards in women with a diagnosis of personality disorder. These episodes are characterised by self-harm and regularly prompt the administration of rapid tranquillisation. This has potential implications for service design, staff training, and research.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e161"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous vagal nerve stimulation for the treatment of trauma- and stressor-related disorders: systematic review of randomised controlled studies.","authors":"Tarek Benzouak, Chad Danyluck, Sasha Gunpat, Steve E Amougou, Rami A Hamoudeh, Michael A Prudencio-Brunello, Jude Nachabe, Febin Edwin, Steve Kisely, Sanjay Rao","doi":"10.1192/bjo.2025.10057","DOIUrl":"10.1192/bjo.2025.10057","url":null,"abstract":"<p><strong>Background: </strong>Vagal nerve stimulation (VNS) has recently emerged as a prospective therapeutic approach for addressing trauma- and stressor-related disorders (TSRDs).</p><p><strong>Aims: </strong>We assessed findings from randomised controlled trials for the safety and efficacy of VNS as a viable treatment for TSRDs.</p><p><strong>Method: </strong>We systematically searched Medline, Embase, PsycINFO, CINAHL, Web of Science, Cochrane Central databases, trial registries, preprint servers and Google Scholar from inception to December 2023. Rayyan software was used for screening procedures. Two reviewers independently completed data extraction based on the inclusion criteria.</p><p><strong>Results: </strong>We synthesised data by using a narrative approach. A total of 322 abstracts were identified and assessed, and seven studies were included in the review. Based on evidence synthesis, the present state of VNS as a treatment intervention for TSRDs, namely post-traumatic stress disorder (PTSD), is limited and does not meet clinical expectations. The overall certainty of evidence was very low. However, evidence shows that VNS may alter and reduce specific aspects associated with PTSD phenomenology, including the reduction of anger responses and the attenuation of hyperarousal during psychological interventions.</p><p><strong>Conclusions: </strong>Although preliminary analyses provide evidence that transcutaneous VNS temporarily increases parasympathetic activity under specific conditions, these effects appear to be short-lasting, and the impact of repeated administration on long-term autonomic function remains unknown. Future randomised control trials should evaluate the therapeutic efficacy of VNS for treating TSRDs.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e165"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A structured lifestyle intervention to reduce cardiometabolic risk factors in individuals with obsessive-compulsive disorder: feasibility trial.","authors":"Anna Holmberg, Matthias Lidin, Dante Lenninger, Sofia Asplund, Catharina Lavebratt, Christian Rück, Lina Martinsson, David Mataix-Cols, Lorena Fernández de la Cruz","doi":"10.1192/bjo.2025.10774","DOIUrl":"10.1192/bjo.2025.10774","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder (OCD) is associated with an increased risk of cardiometabolic disorders. We developed a lifestyle intervention, named LIFT, aimed at improving lifestyle habits (physical activity, diet, alcohol and tobacco use, stress, sleep) and reducing cardiometabolic risk factors in OCD.</p><p><strong>Aims: </strong>This study aimed to establish the feasibility and acceptability of LIFT, evaluate its preliminary efficacy and explore experiences of participation.</p><p><strong>Method: </strong>Individuals with OCD and at least three cardiometabolic risk factors (e.g. physical inactivity, unhealthy diet, overweight/obesity, dyslipidaemia) were offered LIFT, consisting of one individual session to set individual goals, six educational group sessions and 12 exercise group sessions, delivered over 3 months. We collected baseline, post-intervention and 3-month follow-up measures. Preliminary efficacy variables were analysed with linear mixed models and within-group effect sizes. Qualitative interviews were conducted.</p><p><strong>Results: </strong>Out of 147 screened individuals, 25 were included (68% women, mean age 37.4, s.d. = 10.9). Credibility and satisfaction were high, attrition rates were low (16%) and the programme was generally safe. Recruitment and adherence to the intervention were challenging. Statistically significant improvements were observed in dietary habits, alcohol consumption, stress, OCD symptom severity and general functioning (within-group effect sizes ranging from 0.27 to 0.56). No changes were observed in physical activity, sleep or any physiological or laboratory measures.</p><p><strong>Conclusions: </strong>Overall, LIFT was a feasible intervention for individuals with OCD. Effects on lifestyle habits, mental health and functioning are promising. Fully powered randomised controlled trials are needed to evaluate its efficacy and cost-effectiveness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e171"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group cognitive stimulation therapy for people with intellectual disability and dementia: feasibility randomised controlled trial.","authors":"Afia Ali, Cheryl Francis, Sarah Hoare, Joanna Carter, Nia Goulden, Caroline S Clarke, Georgina Charlesworth, Zoe Hoare, Danny Acton, Shafia Khanum, Akinwande Onafalujo, Adebayo Jejeloye, Kate Brackley, Elisa Aguirre, Aimee Spector","doi":"10.1192/bjo.2025.10764","DOIUrl":"10.1192/bjo.2025.10764","url":null,"abstract":"<p><strong>Background: </strong>Group cognitive stimulation therapy (CST) has been shown to improve cognition and quality of life of people with dementia in multiple trials, but there has been scant research involving people with intellectual disability and dementia. This study aimed to assess the feasibility of conducting a randomised controlled trial of group CST for this population.</p><p><strong>Aims: </strong>To assess the feasibility of participant recruitment and retention, the appropriateness of outcome measures, and the feasibility of group CST (adherence, fidelity, acceptability), as well as the feasibility of collecting data for an economic evaluation.</p><p><strong>Method: </strong>Participants were recruited from six National Health Service trusts in England and randomised to group CST plus treatment as usual (TAU) or TAU only. Cognition, quality of life, depression, and use of health and social care services were measured at baseline and at 8-9 weeks. Qualitative interviews with participants, carers and facilitators were used to explore facilitators of and barriers to delivery of CST. Trial registration number: ISRCTN88614460.</p><p><strong>Results: </strong>We obtained consent from 46 participants, and 34 (73.9%) were randomised: 18 to CST and 16 to TAU. All randomised participants completed follow-up. Completion rates of outcome measures (including health economic measures) were adequate; 75.7% of sessions were delivered, and 56% of participants attended ten or more. Fidelity of delivery was of moderate quality. CST was acceptable to all stakeholders; barriers included travel distance, carer availability and sessions needing further adaptations. The estimated cost per participant of delivering CST was £602.</p><p><strong>Conclusions: </strong>There were multiple challenges including recruitment issues, a large dropout rate before randomisation and practical issues affecting attendance. These issues would need to be addressed before conducting a larger trial.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e168"},"PeriodicalIF":3.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}