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Psychiatrists' attitudes and knowledge towards treating asylum seeker and refugee subjects in the UK. 精神科医生对治疗英国寻求庇护者和难民受试者的态度和知识。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-22 DOI: 10.1192/bjo.2025.10812
Dominique Tham, Alua Yeskendir, Hugh Grant-Peterkin, Yasir Hameed, Mishka Pillay, James B Kirkbride
{"title":"Psychiatrists' attitudes and knowledge towards treating asylum seeker and refugee subjects in the UK.","authors":"Dominique Tham, Alua Yeskendir, Hugh Grant-Peterkin, Yasir Hameed, Mishka Pillay, James B Kirkbride","doi":"10.1192/bjo.2025.10812","DOIUrl":"10.1192/bjo.2025.10812","url":null,"abstract":"<p><strong>Background: </strong>Over 1% of the world's population have been forcibly displaced. Asylum seekers and refugees (ASR) are at higher risk of serious mental illnesses. Despite a high need for care, little is known about the attitudes, knowledge and competencies of psychiatrists who may treat ASR subjects.</p><p><strong>Aims: </strong>The study aimed to identify perceived gaps in psychiatric training that could help guide medical education and policymaking related to treating ASR mental health.</p><p><strong>Method: </strong>We conducted the first national survey of UK-based psychiatrists to assess attitudes, knowledge and competencies around treating ASR subjects. The online survey was sent to all psychiatrists (<i>N</i> = 18 182) and registered trainees (<i>N</i> = 4700) on the Royal College of Psychiatrists databases in 2022. We used exploratory and confirmatory factor analyses to identify the optimal factor structure underlying the questionnaire. Variations in scores on extracted latent constructs by sociodemographic and clinical variables were explored using linear regression.</p><p><strong>Results: </strong>Data from 609 psychiatrists (77%) and trainees (22%) were included in the final analysis. We identified four latent constructs concerning perceived knowledge, positive attitudes, negative attitudes and perceived distress. Only 42% of respondents felt they had sufficient knowledge to work competently with ASR subjects, and 34.7% found the work emotionally distressing. Greater knowledge predicted both more positive (<i>β</i> = 0.26, 95% CI: 0.20-0.33) and more negative (<i>β</i> = 0.17, 95% CI: 0.09-0.26) attitudes, and was associated with less self-reported distress among psychiatrists (<i>β</i> = -0.34, 95% CI: -0.43 to -0.21). Female psychiatrists reported more distress related to treating ASR subjects (<i>β</i> = 0.29, 95% CI: 0.14-0.44).</p><p><strong>Conclusions: </strong>Less than half of psychiatrists in this survey believed they possessed adequate knowledge to treat ASR subjects, and some found working with such individuals distressing. Our results suggest that these issues could be mitigated by improving knowledge related to treating ASR subjects.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e189"},"PeriodicalIF":3.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injectable contraceptive use in women with intellectual disability: narrative review and service evaluation. 智力残疾妇女注射避孕药的使用:叙述回顾和服务评价。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-20 DOI: 10.1192/bjo.2025.786
Marianne Bergman, Alaa Martin
{"title":"Injectable contraceptive use in women with intellectual disability: narrative review and service evaluation.","authors":"Marianne Bergman, Alaa Martin","doi":"10.1192/bjo.2025.786","DOIUrl":"10.1192/bjo.2025.786","url":null,"abstract":"<p><strong>Background: </strong>Intellectual disability is defined as an IQ of 70 or below. Women with intellectual disability frequently experience menstrual distress leading to the use of hormonal medications such as depot medroxyprogesterone acetate (DMPA). Despite risks such as reduced bone mineral density (BMD) and weight gain, DMPA is widely used in this cohort, prompting investigation into its suitability and risks.</p><p><strong>Aims: </strong>A narrative review and local service evaluation were conducted to determine whether clinical management reflected recommendations in the literature.</p><p><strong>Method: </strong>PsycINFO and Medline were searched for articles post-1995 on contraception in menstruating women with intellectual disability. Contraceptive use in 100 randomly selected women was evaluated. Data were collected on physical health issues, general practitioner records were reviewed for contraceptive administration and risk discussions, and surveys assessed risk understanding and satisfaction.</p><p><strong>Results: </strong>The review identified 27 papers with higher DMPA use in the intellectual disability population compared to the general population, and specific BMD risks. The case series found 23 women with intellectual disability using DMPA, and revealed knowledge gaps in risk and monitoring, inappropriate use given individual risk, and poor proactive risk management.</p><p><strong>Conclusions: </strong>Findings indicate disproportionate DMPA use in women with intellectual disability, with inadequate clinical justification and risk awareness. Many women and carers were unaware of BMD risks, and DMPA alternatives were rarely considered. Individualised contraceptive management and closer review of DMPA use in this cohort is needed. Monitoring could include dual X-ray absorptiometry (DEXA) scans, vitamin D and calcium supplementation, and weight management. Further research is needed into higher DMPA use and risks within this population.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e188"},"PeriodicalIF":3.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and acceptability of the Community Outpatient Psychotherapy Engagement Service for Self-harm (COPESS): randomised controlled trial. 自我伤害社区门诊心理治疗参与服务(COPESS)的可行性和可接受性:随机对照试验
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-20 DOI: 10.1192/bjo.2025.10780
Pooja Saini, Anna Hunt, Caroline Clements, Mark Gabbay, Catherine Mills, Kari Kvamme-Mitchell, Naheed Tahir, Helen Mulholland, Cecil Kullu, Mark Hann, Rui Duarte, Andrea Murphy, Else Guthrie, Peter Taylor
{"title":"Feasibility and acceptability of the Community Outpatient Psychotherapy Engagement Service for Self-harm (COPESS): randomised controlled trial.","authors":"Pooja Saini, Anna Hunt, Caroline Clements, Mark Gabbay, Catherine Mills, Kari Kvamme-Mitchell, Naheed Tahir, Helen Mulholland, Cecil Kullu, Mark Hann, Rui Duarte, Andrea Murphy, Else Guthrie, Peter Taylor","doi":"10.1192/bjo.2025.10780","DOIUrl":"10.1192/bjo.2025.10780","url":null,"abstract":"<p><strong>Background: </strong>Self-harm is widespread and often occurs in the community without resulting in hospital presentation. Individuals with depressive symptoms are at elevated risk. There are limited self-harm interventions designed for community and primary care settings. The Community Outpatient Psychological Engagement Service for Self-harm (COPESS) is a brief talking therapy intervention for self-harm based in community settings.</p><p><strong>Aims: </strong>To assess the feasibility of evaluating the COPESS intervention in a community setting in relation to participant recruitment, retention, data collection and the acceptability of the intervention.</p><p><strong>Method: </strong>We used a mixed-method approach and a single-blind randomised controlled trial design with 1:1 allocation to either COPESS plus treatment as usual or treatment as usual alone. Adults with depressive symptoms and self-harm in the past 6 months were recruited from general practices. Secondary outcome measures were assessed at baseline and 1 month, 2 months and 3 months after randomisation. The trial was pre-registered on clinicaltrials.gov (NCT04191122) on 9 December 2019.</p><p><strong>Results: </strong>Fifty-five people were randomised (of an initial target of 60). Retention rates at follow-up assessments were high (>75%), as was attendance by all participants for all therapy sessions (93%). At 3 months, there were trends towards lower levels of self-harm urges, depressive symptoms and distress in the COPESS group compared with controls. Fidelity to the manualised COPESS therapy was moderate to high.</p><p><strong>Conclusions: </strong>All progression criteria were met, supporting further evaluation of the intervention in a full-scale efficacy and/or cost-effectiveness trial. These findings add to the growing evidence base supporting the utility of brief psychological interventions for self-harm. COPESS has potential as a brief primary-care-based intervention for those struggling with self-harm.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e190"},"PeriodicalIF":3.5,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specialist mental health crisis centres in England: a step forward or a stumble in the dark? 英国专业心理健康危机中心:向前迈进一步还是在黑暗中蹒跚前行?
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-19 DOI: 10.1192/bjo.2025.10820
Yasser Saeed Khan, Subodh Dave, Mohammed Al-Uzri, Javed Latoo, Ovais Wadoo
{"title":"Specialist mental health crisis centres in England: a step forward or a stumble in the dark?","authors":"Yasser Saeed Khan, Subodh Dave, Mohammed Al-Uzri, Javed Latoo, Ovais Wadoo","doi":"10.1192/bjo.2025.10820","DOIUrl":"10.1192/bjo.2025.10820","url":null,"abstract":"<p><p>The recent proposal by NHS England to establish specialist mental health crisis centres has prompted considerable discussion. This editorial examines the initiative, which aims to reduce accident and emergency pressure and provide tailored care. However, it raises significant questions about the potential to exacerbate systemic fragmentation. Concerns highlight inadequate funding, the risk of resegregation of mental health from physical care and increased stigma if not properly integrated. This article argues that true holistic care requires seamless integration, advocating strongly for co-located mental health and medical emergency departments, which have shown improved outcomes. Ultimately, the success of these centres depends on addressing wider NHS issues, robust evaluation and a comprehensive vision prioritising the entire mental health pathway, from prevention to long-term recovery, to genuinely transform patient lives.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e187"},"PeriodicalIF":3.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking stigma, discrimination and promoting rights: global evaluation of the World Health Organization QualityRights e-training on mental health, recovery and community inclusion. 打破耻辱、歧视和促进权利:世界卫生组织关于心理健康、康复和社区包容的质量权利电子培训的全球评价。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-18 DOI: 10.1192/bjo.2025.10779
Michelle Funk, Natalie Drew Bold, Charity Muturi, Ledia Lazeri, Olga Kalina, Carmen Martinez-Viciana, Debra Machando, Mauro Giovanni Carta, Gemma F Parojinog, Simon Njuguna Kahonge, Sebnem Avşar Kurnaz, Melita Murko, Celline Cole, Layal Al Hanna, Emily McLoughlin, Magdalena Casamitjana Aguilà, Akwasi Osei, Jacob Shamuyarira, Alessandra Perra, Guadalupe Morales Cano, Zvjezdana Stjepanović, Simon Vasseur Bacle, Slađana Štrkalj-Ivezić, Ivana Svobodová, Gerli Sirk, Maria Francesca Moro
{"title":"Breaking stigma, discrimination and promoting rights: global evaluation of the World Health Organization QualityRights e-training on mental health, recovery and community inclusion.","authors":"Michelle Funk, Natalie Drew Bold, Charity Muturi, Ledia Lazeri, Olga Kalina, Carmen Martinez-Viciana, Debra Machando, Mauro Giovanni Carta, Gemma F Parojinog, Simon Njuguna Kahonge, Sebnem Avşar Kurnaz, Melita Murko, Celline Cole, Layal Al Hanna, Emily McLoughlin, Magdalena Casamitjana Aguilà, Akwasi Osei, Jacob Shamuyarira, Alessandra Perra, Guadalupe Morales Cano, Zvjezdana Stjepanović, Simon Vasseur Bacle, Slađana Štrkalj-Ivezić, Ivana Svobodová, Gerli Sirk, Maria Francesca Moro","doi":"10.1192/bjo.2025.10779","DOIUrl":"10.1192/bjo.2025.10779","url":null,"abstract":"<p><strong>Background: </strong>There is an urgent need to address the poor quality of mental healthcare and human rights violations within mental health systems and communities. To achieve this, efforts must focus on changing the attitudes that perpetuate stigma and discrimination against individuals with mental health conditions, as well as psychosocial, intellectual and cognitive disabilities. The World Health Organization (WHO) QualityRights e-training on mental health, recovery and community inclusion is tackling these issues in several countries; however, its global impact has yet to be evaluated.</p><p><strong>Aims: </strong>This study aims to assess the changes in attitudes following the completion of the WHO QualityRights e-training in countries worldwide.</p><p><strong>Method: </strong>Data from 3026 participants were analysed in this pre-post intervention study. Changes in scores on the WHO QualityRights Attitudes questionnaire were evaluated with the paired <i>t</i>-test and Wilcoxon signed-rank test.</p><p><strong>Results: </strong>The mean differences from baseline to post-training on the WHO QualityRights Attitudes questionnaire were 9.91 (95% CI 9.58-10.24, <i>d</i> = 1.07) for the total sample, 8.95 (95% CI 8.59-9.31, <i>d</i> = 0.99) for the high-income countries sample; and 12.75 (95% CI 12.03-13.47, <i>d</i> = 1.33) for the low- and middle-income countries sample. These findings indicate that participants, after completing the e-training, showed a decrease in negative attitudes toward individuals with mental health conditions and psychosocial, intellectual and cognitive disabilities.</p><p><strong>Conclusions: </strong>This study suggests that the WHO QualityRights e-training has a positive, large effect in reducing negative attitudes toward individuals with mental health conditions and psychosocial, intellectual and cognitive disabilities, and can contribute to reduced stigma and greater alignment with rights-based approaches. These findings support the scale-up of the WHO QualityRights e-training programme.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e185"},"PeriodicalIF":3.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of a good training placement in psychiatry: qualitative interview study of core trainees. 精神病学良好培训安排的特点:对核心学员的定性访谈研究。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-18 DOI: 10.1192/bjo.2025.10777
Ioana Varvari, Frances Debell, David Harrison, Gopinath Ranjith
{"title":"Characteristics of a good training placement in psychiatry: qualitative interview study of core trainees.","authors":"Ioana Varvari, Frances Debell, David Harrison, Gopinath Ranjith","doi":"10.1192/bjo.2025.10777","DOIUrl":"10.1192/bjo.2025.10777","url":null,"abstract":"<p><strong>Background: </strong>Clinical placements are essential in healthcare education, offering practical experience and skill development under experienced supervision. However, little research has explored the characteristics of effective psychiatry placements. Understanding the factors considered vital by psychiatry core trainees for a successful placement is crucial amid concerns about trainee attrition in psychiatry programmes.</p><p><strong>Aims: </strong>This study aims to identify key elements that contribute to a successful psychiatric placement, as perceived by final-year core trainees.</p><p><strong>Method: </strong>This qualitative study uses one-hour, semi-structured interviews with 15 core trainees in their final placement within the South London and Maudsley Training Programme. Interviews were guided by appreciative inquiry principles, and two independent researchers employed a classic thematic analysis method while maintaining appropriate reflexivity throughout.</p><p><strong>Results: </strong>A central theme emerges regarding the importance of a well-designed learning environment, which includes a robust training infrastructure, psychological safety, active learning opportunities, access to role models and structured feedback. The supervisor-supervisee relationship is emphasised, with the ideal supervisor being both knowledgeable and empathetic and offering mentorship and pastoral support. These factors are key to professional growth, well-being and job satisfaction, and they are strongly linked to retention in the field.</p><p><strong>Conclusion: </strong>Core trainees value placements that address foundational training needs and cultivate psychological safety while facilitating experiential learning. Addressing these aspects in training programmes enhances the educational experience and improves retention. Future research should explore supervisors' perspectives and examine how to balance ideal and practical supervisory roles.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e184"},"PeriodicalIF":3.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using individualised bowel care plans to improve clinical outcomes in specialist intellectual disability mental health units in England and Wales: quality improvement project. 在英格兰和威尔士使用个性化肠道护理计划来改善专业智力残疾精神卫生单位的临床结果:质量改进项目。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-18 DOI: 10.1192/bjo.2025.10814
Alexandra Gabrielsson, Richard Laugharne, Jon Painter, Harriet Slater, Catherine Bright, Andrew Dossett, Romanie Dekker, Alex Bordessa-Kelly, Kloe Edwards, Jarod Newbury, Salman Azfar, Paul Bassett, Samuel Tromans, Indermeet Sawhney, Phil Elliot, Mahesh Odiyoor, Kiran Purandare, Rohit Shankar
{"title":"Using individualised bowel care plans to improve clinical outcomes in specialist intellectual disability mental health units in England and Wales: quality improvement project.","authors":"Alexandra Gabrielsson, Richard Laugharne, Jon Painter, Harriet Slater, Catherine Bright, Andrew Dossett, Romanie Dekker, Alex Bordessa-Kelly, Kloe Edwards, Jarod Newbury, Salman Azfar, Paul Bassett, Samuel Tromans, Indermeet Sawhney, Phil Elliot, Mahesh Odiyoor, Kiran Purandare, Rohit Shankar","doi":"10.1192/bjo.2025.10814","DOIUrl":"10.1192/bjo.2025.10814","url":null,"abstract":"<p><strong>Background: </strong>Constipation is a significant problem for people with intellectual disabilities, with a prevalence of 33-50%, causing at least five deaths annually in England. Individualised bowel care plans (IBCP) are recommended in England and Wales.</p><p><strong>Aims: </strong>We evaluated the feasibility and impact of IBCPs for people with intellectual disabilities who are in in-patient psychiatric units, and the effect on clinical outcomes.</p><p><strong>Method: </strong>People with intellectual disabilities who were at risk of constipation were recruited from four specialist in-patient psychiatric units in England and Wales. A constipation questionnaire was used to capture relevant data to devise IBCPs. Baseline, 3- and 6-monthly Health of the Nation Scales - Learning Disability (HoNOS-LD) were completed after the intervention. Descriptive statistics, Wilcoxon signed-rank, Mann-Whitney <i>U</i>, repeated-measures analyses of variance, with Bonferroni adjustment and Mauchly's tests were conducted. Significance was taken at <i>P</i> < 0.05.</p><p><strong>Results: </strong>Of 24 people with intellectual disabilities recruited from four units, all three data points were available for 18 patients. Constipation rates showed no statistically significant decline. The total HoNOS-LD score (18 items) did not decline. HoNOS-LD item 12 for physical functioning showed significant improvement for PwID with constipation compared with those without, between baseline and 6 months.</p><p><strong>Conclusions: </strong>This quality improvement project suggests that a bigger study of IBCPs is feasible. Most outcomes examined via the HoNOS-LD, particularly those linked with mental illness, challenging behaviour and quality of life, did not show significant change, possibly because of the small sample size. However, people with intellectual disabilities and constipation showed positive changes in their physical functioning outcomes compared with those without constipation. Further in-depth evaluation of this intervention is needed.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e186"},"PeriodicalIF":3.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Positive symptoms and their associations with life and trauma events among young adults in a first-episode psychosis clinic: qualitative analysis. 在一个首发精神病诊所的年轻人中,阳性症状及其与生活和创伤事件的关系:定性分析
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-15 DOI: 10.1192/bjo.2025.10802
Alix-Anne Ternamian, Mathilde Marchal, Julie Haesebaert, Frédéric Haesebaert
{"title":"Positive symptoms and their associations with life and trauma events among young adults in a first-episode psychosis clinic: qualitative analysis.","authors":"Alix-Anne Ternamian, Mathilde Marchal, Julie Haesebaert, Frédéric Haesebaert","doi":"10.1192/bjo.2025.10802","DOIUrl":"10.1192/bjo.2025.10802","url":null,"abstract":"<p><strong>Background: </strong>Trauma plays a critical role in psychosis, but the nature of the relationship between specific symptoms and trauma history remains unclear.</p><p><strong>Aims: </strong>The aim of the study was to explore the experience of positive symptoms and their association with trauma and life events from the perspective of patients with first-episode psychosis (FEP).</p><p><strong>Method: </strong>Seventeen participants who were enrolled in an FEP programme participated in a qualitative interview examining their life and trauma events, the onset of their symptoms, their experience of positive symptoms and their perceived associations between symptoms and life and trauma events. The interview was based on a semi-structured interview of six main questions and follow-up questions. Participants also completed the Trauma and Life Experiences Checklist (TALE), and were asked about the relevance of the whole interview. Thematic content analysis, exploratory cluster analysis and matrix queries coding were performed.</p><p><strong>Results: </strong>Fifteen participants described the experience of psychotic symptoms as distressing or traumatic. Eleven participants attributed the onset of positive psychotic symptoms to trauma and life events. Ten participants described explicit thematic associations between their symptoms and trauma and life events. Twelve participants evaluated the interview as relevant and helpful.</p><p><strong>Conclusions: </strong>Our findings give insight into the lived experience of positive symptoms and potential psychological interventions valuing causal theories of participants and the association with life and trauma events.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e178"},"PeriodicalIF":3.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology. 研究炎症是否介导遗传风险和创伤对精神病理的影响。
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-15 DOI: 10.1192/bjo.2025.10054
Philippa Lilford, Gemma Hammerton, Golam M Khandaker, Jeremy Hall, Stan Zammit, Hannah J Jones
{"title":"Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology.","authors":"Philippa Lilford, Gemma Hammerton, Golam M Khandaker, Jeremy Hall, Stan Zammit, Hannah J Jones","doi":"10.1192/bjo.2025.10054","DOIUrl":"10.1192/bjo.2025.10054","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal studies have revealed that raised levels of inflammatory markers and trauma in childhood are associated with psychopathology in adulthood.</p><p><strong>Aims: </strong>To examine whether inflammation in childhood mediates the effects of genetic risk and trauma on psychopathology in early adulthood.</p><p><strong>Method: </strong>Measures of trauma exposure, inflammation and psychopathology were collected from the Avon Longitudinal Study of Parents and Children. Exposure to trauma was measured from 5 to 11 years of age; C-reactive protein and interleukin-6 levels were measured at 9 years; and depression, anxiety disorders, negative symptoms and psychotic experiences were assessed at 24 years. Polygenic risk scores (PRSs) were created for schizophrenia, depression, anxiety and psychotic experiences. Mediation analyses were conducted using imputed data (<i>N</i>: 7859 to 8700) to investigate whether inflammation mediated the associations of genetic risk and childhood trauma with psychopathology.</p><p><strong>Results: </strong>Most psychiatric PRSs were associated with multiple psychopathological outcomes in adulthood, with the exception of the PRS for psychotic experiences. Childhood trauma was associated with all psychopathology. However, there was no strong evidence that inflammatory markers in childhood mediated associations among PRSs, trauma and psychopathology. Sensitivity analyses using outcomes from age 18 and PRSs based on single-nucleotide polymorphisms that met more stringent standards of evidence of association gave results consistent with those of our primary analyses.</p><p><strong>Conclusions: </strong>We found little evidence that interleukin-6 or C-reactive protein mediated the pathway between genetic liability for psychiatric phenotypes or trauma and subsequent psychopathology. Longitudinal investigation of other inflammatory and non-inflammatory pathways is required to identify modifiable targets and inform novel treatment strategies for individuals at genetic or trauma-related risk of psychiatric illness.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e181"},"PeriodicalIF":3.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in mental health of adolescents during three months of the COVID-19 pandemic: longitudinal study. COVID-19大流行三个月期间青少年心理健康的变化:纵向研究
IF 3.5 3区 医学
BJPsych Open Pub Date : 2025-08-15 DOI: 10.1192/bjo.2025.10801
Matthias Pierce, Emily Banwell, Stephanie Gillibrand, Margarita Panayiotou, Pamela Qualter, Luke Munford, Ola Demkowicz
{"title":"Changes in mental health of adolescents during three months of the COVID-19 pandemic: longitudinal study.","authors":"Matthias Pierce, Emily Banwell, Stephanie Gillibrand, Margarita Panayiotou, Pamela Qualter, Luke Munford, Ola Demkowicz","doi":"10.1192/bjo.2025.10801","DOIUrl":"10.1192/bjo.2025.10801","url":null,"abstract":"<p><strong>Background: </strong>Understanding the effect(s) of the COVID-19 pandemic is key for planning for future pandemics.</p><p><strong>Aims: </strong>This study examines change in self-reported mental health difficulties during three months of the pandemic among adolescent (10- to 15-year-olds) participants from the UK Household Longitudinal Study (waves 7, 9 and 11 of the main survey and waves 4, 5 and 8 of the COVID-19 surveys).</p><p><strong>Method: </strong>We focused on mental health difficulties using the Strengths and Difficulties Questionnaire (SDQ), using repeated cross-sectional and longitudinal analyses to examine data among 6471 adolescents who responded to at least one survey since 2015, and 2,300 who responded to at least one COVID-19 survey during July 2020, November 2020 or March 2021.</p><p><strong>Results: </strong>Repeated cross-sectional data showed similar mean total SDQ across surveys before and during the pandemic (range during pandemic 11.4 to 11.9; range pre-pandemic 11.1 to 11.8). Longitudinal analyses provided no evidence of mental health change compared with pre-pandemic trends (estimated change mean SDQ (β) = 0.05, 95% CI -0.42 to 0.51; <i>p</i> = 0.85), or differential sociodemographic effects, except greater effects in rural households (β = 0.67, 95% CI -0.08 to 1.41) than urban environments (β = -0.18, 95% CI -0.69 to 0.33). Though subscales generally saw higher scores during the pandemic than before, these were consistent with pre-pandemic trends, excepting a slight improvement in conduct problems (β = -0.26, 95% CI 0.12 to 0.40).</p><p><strong>Conclusions: </strong>The study offers evidence among a representative sample that mental health difficulties did not, on average, deteriorate for adolescents during three months of the pandemic.</p>","PeriodicalId":9038,"journal":{"name":"BJPsych Open","volume":"11 5","pages":"e177"},"PeriodicalIF":3.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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