BMC Psychiatry最新文献

{"title":"The impact of the COVID-19 pandemic on hospital admissions for psychiatric disorders: results from the multicentre study on the Italian population \"COVID-19 and Mental Health\" (CoMeH).","authors":"Massimiliano Aragona, Martina Ventura, Roberta Ciampichini, Anteo Di Napoli, Valeria Fano, Sara Leone, Martina Pacifici, Claudio Rosini, Caterina Silvestri, Fabio Voller, Alberto Zucchi, Christian Napoli, Alessio Petrelli","doi":"10.1186/s12888-025-07076-9","DOIUrl":"10.1186/s12888-025-07076-9","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"633"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The treatment characteristics of oral antipsychotics in treatment of adolescents with schizophrenia in China.","authors":"Huaning Wang, Yongjing Zhang, Tao Wu, Sijia Dong, Rui Chi, Kun Jiang, Hong Qiu, Wentian Dong, Tianmei Si","doi":"10.1186/s12888-025-07113-7","DOIUrl":"10.1186/s12888-025-07113-7","url":null,"abstract":"<p><strong>Background: </strong>Evidence on treatment for adolescent with schizophrenia in China is limited. Understanding the current practice of antipsychotics utilization is imperative to inform appropriate use in this population.</p><p><strong>Methods: </strong>This retrospective cohort study used electronic medical records (2018-2022) from two hospitals in China. Adolescents (12-17y) with schizophrenia (ICD-10: F20.x) who were prescribed oral antipsychotics during the study period were included. Index date was the date of the first antipsychotics prescription. Patients were followed up until the earliest of last antipsychotics prescription, 18y, or study end. Antipsychotic utilization was described by commonly prescribed antipsychotics, polypharmacy, dosage and medication adherence (indicated by proportion of days covered [PDC]). Dosage was converted using defined daily dose(DDD) for unified measurement.</p><p><strong>Results: </strong>Overall, 869 (mean age: 15.6y, male 50.6%) and 618 (mean age: 16.1y, male 50.7%) patients were included in PKU6H and XJH, respectively. Most patients (99.65% and 100.00%) had ever used second-generation antipsychotics (SGAs), while relatively few (4.14% and 4.21%) had ever used first-generation antipsychotics (FGAs). The top three ever-prescribed SGAs were aripiprazole (50.46%), olanzapine (38.45%), risperidone (34.41%) in PKU6H, and aripiprazole (35.76%), risperidone (28.96%), paliperidone (27.83%) in XJH, 32.34% and 11.49% patients had polypharmacy, respectively. The average daily dose was 0.77(SD 0.40) DDDs and 1.00(SD 0.52) DDDs, respectively, with most (81.59% and 63.27%) ≤ 1 DDD. Medication adherence was both around 0.8 and observed with a steady trend over long-term.</p><p><strong>Conclusions: </strong>In Chinese adolescent patients, SGA is the mainstream mostly prescribed as monotherapy. Polypharmacy is observed with a steady pattern. Antipsychotics were prescribed with equal or reduced dose compared to adults DDD, and good adherence observed.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"657"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Not so) voluntary hospitalization as part of Zolpidem-induced complex sleep behaviour: a case report.","authors":"Sriraksha R Nayak, Suman S Rao, Karthik K N, Harsha G T, Narayana Keertish","doi":"10.1186/s12888-025-06593-x","DOIUrl":"https://doi.org/10.1186/s12888-025-06593-x","url":null,"abstract":"<p><strong>Background: </strong>Since its approval 26 years ago, Zolpidem has been implicated in 61 cases of complex sleep behaviours (CSBs) reported to the US FDA. These cases typically describe activities such as eating, walking, cooking or driving while asleep after Zolpidem use. This report describes a unique presentation of Zolpidem-induced CSB.</p><p><strong>Case presentation: </strong>A 44-year-old male with recurrent depressive disorder presented with a history of waking up in a hospital with no recollection of how he was admitted. He subsequently discharged himself against medical advice. In addition to his regular treatment, he had been prescribed Zolpidem on an as-needed basis for persistent insomnia. A thorough review of his past medical history with corresponding prescriptions revealed two similar instances in which he sought discharge against medical advice after waking up in a hospital with no recollection of how he was admitted. Each instance was temporally correlated with the use of Zolpidem.</p><p><strong>Conclusions: </strong>This case illustrates a rare presentation of Zolpidem-induced CSB, where the patient hired a cab to a psychiatric hospital, admitted himself and cooperated with inpatient management until regaining awareness the following morning. The patient experienced three similar episodes of Zolpidem-induced CSB, each resulting in voluntary psychiatric admission. Practitioners prescribing Z-drugs, either alone or in combination with other psychotropic medications, should be aware of these rare yet potentially serious adverse events and their forensic implications.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"613"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A framework for parsing psychopathological heterogeneity: initial application in a large-scale unselected community sample.","authors":"Chaoyi Wu, Chenyu Yuan, Yinqing Fan, Ang Hong, Zhiling Wu, Zhen Wang","doi":"10.1186/s12888-025-06960-8","DOIUrl":"https://doi.org/10.1186/s12888-025-06960-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Traditional descriptive nosology arbitrarily distinguishes between mental illness and health, hindering the progress of scientific research and clinical practice. Building on recent advancements in psychiatric conceptualization, this study proposes an innovative phased framework for deconstructing psychopathological heterogeneity. The framework involves four key steps: extraction of symptom dimensions, identification of psychopathological subtypes, characterization of symptom interaction patterns using a network approach, and validation of their incremental validity through links to neurobehavioral functions. This framework is preliminarily applied to a large, non-selective community sample (N = 4102) to explore its utility and potential for deconstructing psychopathological heterogeneity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data on comprehensive psychopathology and RDoC negative valence constructs were collected from the sample. Factor analysis and exploratory graph analysis were used to extract symptom dimensions. Latent profile analysis based on these dimensions was applied to identify psychopathological profiles. Partial correlation networks were estimated for each profile, and symptom network characteristics were compared across profiles. Finally, hierarchical multiple regression was applied to assess incremental validity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The first step of the phased framework involves extracting homogeneous dimensions based on symptom co-occurrence patterns, yielding seven distinct dimensions: Obsessive-Compulsive, Emotional Distress, Eating-Related, Substance-Related, Aggressive, Psychotic, and Somatoform dimensions. The second step involves applying a person-centered approach to identify latent subgroups based on these symptom dimensions. Four profiles were identified, namely Substance Use Group, Moderate Symptomatology Group, Disengaged from Symptomatology Group, and Severe Symptomatology Group. The third step involves characterizing symptom interaction patterns across subgroups. Using a network approach, the Severe Symptomatology Group exhibited the densest interconnections and the highest global network strength, with Aggressive and Psychotic dimensions serving as core issues compared to other profiles. Finally, incremental validity was assessed through associations with self-reported neurobehavioral functions. Results showed that these profiles provided unique predictive value for RDoC negative valence constructs beyond both dichotomous diagnostic status and purely dimensional approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study introduces a fine-grained framework for deconstructing psychopathological heterogeneity, providing a comprehensive approach to parsing psychopathology. While the framework is preliminarily applied to a large sample from the Chinese population, future studies should integrate multimodal neurobehavioral measures, employ intensive longitudinal designs to track sympt","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"619"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the efficacy of rumination-focused cognitive-behavioral therapy in alleviating depression, negative affect, and rumination among patients with recurrent major depressive disorder: a randomized, multicenter clinical trial.","authors":"Mohsen Hasani, Saeedeh Zenoozian, Reza Ahmadi, Sahel Khakpoor, Soleiman Saberi, Reza Pirzeh, Omid Saed","doi":"10.1186/s12888-025-07065-y","DOIUrl":"https://doi.org/10.1186/s12888-025-07065-y","url":null,"abstract":"<p><strong>Background: </strong>Rumination plays a pivotal role in the onset, recurrence, and persistence of residual symptoms in major depressive disorder (MDD), making it a critical therapeutic target in the development of novel interventions. Rumination-Focused Cognitive-Behavioral Therapy (RFCBT), an adapted form of cognitive-behavioral therapy specifically designed to address ruminative thinking patterns, has garnered increasing attention in clinical research. In light of these developments, the present study was conducted to evaluate the efficacy of RFCBT in reducing rumination severity, depressive symptoms, and negative affect among individuals with recurrent MDD.</p><p><strong>Methods: </strong>This randomized clinical trial enrolled 44 university students diagnosed with MDD. Participants were randomly assigned in equal proportions to either the group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) condition or a waitlist (WL) control group. The g-RFCBT received 10 weekly group therapy sessions supplemented by two individual sessions (the initial session and the 12th session), while participants in the WL group received no intervention until the conclusion of the study. Assessments were conducted at four time points; pre-treatment, post-treatment, 2-month follow-up, and 6-month follow-up. Outcome measures included the Beck Depression Inventory-II (BDI-II), the Repetitive Thinking Questionnaire-31 (RTQ-31), and the Negative Affect subscale of the Positive and Negative Affect Schedule (PANAS-NA).</p><p><strong>Results: </strong>Repeated measures ANOVA revealed statistically significant improvements in the g-RFCBT group compared to the WL group. Within-group analyses indicated that RFCBT led to a 65% reduction in depressive symptoms and a 30% reduction in both rumination and negative affect from baseline to post-treatment. Furthermore, the g-RFCBT exhibited significantly greater reduction in depression, rumination, and negative affect compared to the WL group, with treatment effects sustained through the 6-month follow-up period.</p><p><strong>Conclusions: </strong>Group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) demonstrated significant efficacy in reducing the severity of depressive symptoms, rumination, and negative affect among individuals with major depressive disorder (MDD). Moreover, these therapeutic benefits were maintained over a 6-month follow-up period, suggesting durable treatment effects.</p><p><strong>Trial registration: </strong>This randomized clinical trial, consisting of an intervention and a waitlist control condition, that was registered in the Iranian Registry of Clinical Trials (IRCT Id: IRCT20181117041676N1) (Registration Date: June 3, 2019).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"626"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of a relationship between circulating ghrelin and sleep quality in male alcohol-dependent patients after abstinence.","authors":"Xian He, Lina Gu, Yayun Xu, Yi Zhai, Rongrong Gu, Erhui Sheng, Biao Dai, Qingrong Xia, Yu Liu","doi":"10.1186/s12888-025-07123-5","DOIUrl":"https://doi.org/10.1186/s12888-025-07123-5","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"625"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between gamma-aminobutyric acid levels and suicidal behavior in depression.","authors":"Qiujing Shao, Mengjun Geng, Ziyang Ji, Jiao Dong, Hongyu Wang, Zhenzhen Yang, Changhong Wang","doi":"10.1186/s12888-025-07056-z","DOIUrl":"https://doi.org/10.1186/s12888-025-07056-z","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"623"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between symptoms of gender dysphoria and social anxiety in transgender young adults: a network analysis.","authors":"Jiaqi Li, Yi Feng, Wenbang Niu, Shicun Xu, Yajun Bu, Yuanyuan Wang","doi":"10.1186/s12888-025-06858-5","DOIUrl":"https://doi.org/10.1186/s12888-025-06858-5","url":null,"abstract":"<p><strong>Background: </strong>Gender dysphoria and social anxiety co-occur in transgender young adults,whereas their underlying influencing mechanism remains limitedly explored.</p><p><strong>Aims: </strong>This study attempted to investigate the symptomatic relationships between these two mental illnesses in transgender young adults and explore heterogeneous network connections in various transgender groups.</p><p><strong>Methods: </strong>This study was from a large-scale cross-sectional survey that recruited 117,769 Chinese college students. After screening gender identity, we divided 2,352 transgender participants into three groups: transgender men, transgender women, and non-binary identities. The Utrecht Gender Dysphoria Scale-Gender Spectrum measured gender dysphoria, and the Social Anxiety Subscale of the Self-Consciousness Scale measured social anxiety. Network analysis and directed acyclic graphs explored the relationships between symptoms of gender dysphoria and social anxiety among transgender young adults.</p><p><strong>Results: </strong>Transgender young adults in this study consist of 1,223 transgender men, 538 transgender women, and 591 non-binary identities. \"Unhappy in physical characteristics\" and \"Hopeless\" were the most crucial central symptoms; \"Distressing body functions\" and \"Hard time working\" were the main bridge symptoms in network structures of gender dysphoria and social anxiety. In transgender women's network structure, \"Distressing bodily functions\" was positively connected to \"Hard time working,\" while it was positively linked to \"Nervous speaking\" in that of the non-binary group.</p><p><strong>Discussion: </strong>Feeling unhappy with physical characteristics and hopelessness are crucial influencing factors in transgender young adults' co-occurring symptoms of gender dysphoria and social anxiety. Since symptomatic connections were heterogeneous across the three transgender groups, diverse tailoring interventions combined with social efforts are required to buffer against the co-occurrence of gender dysphoria and social anxiety.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"614"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapy in the digital age: exploring in-person and virtual cognitive behavioural therapy.","authors":"Julie Vizza, Sanaz Riahi, Olivia Jackson, Christen Potvin, David Rudoler","doi":"10.1186/s12888-025-07063-0","DOIUrl":"https://doi.org/10.1186/s12888-025-07063-0","url":null,"abstract":"<p><strong>Introduction: </strong>The adoption of client-centred care has become a foundational principle in mental health treatment, prioritising interventions tailored to the unique needs and preferences of clients across settings. Virtual or internet-based cognitive behavioural therapy (eCBT) has emerged as an effective, cost-efficient alternative to traditional, in-person CBT for a variety of mental health conditions, including anxiety and depression. Initially explored in experimental settings, eCBT gained substantial use during COVID-19, when the demand for accessible, remote mental health services were needed. Despite its broad implementation, limited research exists on the real-world experiences of clients who have participated in eCBT, particularly regarding its strengths and challenges compared to in-person therapy.</p><p><strong>Objectives: </strong>This study aimed to (1) explore the experiences of clients who have participated in both in-person CBT and eCBT, and (2) identify strengths and challenges associated with each modality from the client's perspective.</p><p><strong>Methods: </strong>Clients were recruited from three outpatient clinics at Ontario Shores Centre for Mental Health Sciences in Whitby, Ontario. In-depth interviews were conducted with twelve clients between June and December 2023. Transcripts were analysed using Braun and Clarke's six-step approach to thematic analysis.</p><p><strong>Results: </strong>Five main themes emerged from the data: (1) accessing therapy in a new way; (2) building a foundation for care: the client-provider relationship; (3) satisfaction with care; (4) addressing clients' needs in the environment; and (5) client empowerment. Many clients expressed high satisfaction with eCBT, citing factors such as ease of access, flexibility, and the perceived effectiveness of virtual sessions in fostering mental health support. However, clients also noted challenges with technology, which could impact therapeutic engagement and the quality of the client-provider relationship.</p><p><strong>Discussion: </strong>The strengths and challenges identified in eCBT parallel those encountered in in-person settings, though eCBT was particularly appreciated by clients comfortable with digital environments. These findings emphasise the importance of client-centred care in virtual contexts, including the need for provider training in digital rapport-building and consideration of technological barriers. Ultimately, insights from this study can inform the refinement of eCBT delivery and support tailored approaches that align with the diverse needs of mental health service users in post-pandemic healthcare landscapes.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"615"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Understanding adolescent self-harm attempts in Ghana: a qualitative analysis of family and social risk factors.","authors":"Wisdom Kudzo Axame, Lebene Kpodo, James Kofi Bilabam, Rebecca Assiam, Nuworza Kugbey, Sitsofe Gbogbo","doi":"10.1186/s12888-025-06870-9","DOIUrl":"10.1186/s12888-025-06870-9","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"596"},"PeriodicalIF":3.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144494539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}