BMC Psychiatry最新文献

{"title":"Impaired neural activity and functional connectivity in the hippocampus of adolescents with non-suicidal self-injury addiction.","authors":"Xinbei Lin, Yongbing Sun, Yan Hu, Yangyang Chen, Yuang Gu, Keke Chen, Zhi Zou, Zhonglin Li, Xiaoling Wu, Tao Li, Xue Lv, Fengshan Yan, Shewei Dou, Zhiping Guo, Shuying Chang, Yongli Li","doi":"10.1186/s12888-025-07331-z","DOIUrl":"10.1186/s12888-025-07331-z","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) addiction is prevalent among adolescents, but its underlying neural mechanisms remain unclear. This study aims to investigate the neural activity and functional connectivity characteristics associated with NSSI addiction using resting-state functional magnetic resonance imaging (rs-fMRI).</p><p><strong>Methods: </strong>A prospective collection of 62 adolescents was completed for this study, including 33 adolescents with self-injury behaviors and 29 age-, gender-, and education-matched healthy controls. The addiction component of the Ottawa Self-Injury Inventory (OSI) was used to assess the degree of NSSI addiction. Amplitude of low-frequency fluctuation (ALFF) analysis was employed to detect changes in local neural activity. Differential brain regions were considered regions of interests (ROIs). Whole-brain functional connectivity (FC) analysis based on ALFF was used to further explore potential changes in functional connections between ROIs and other brain areas in the NSSI group, and to analyze the relationship between these neural changes and addiction characteristics.</p><p><strong>Results: </strong>ALFF analysis revealed decreased ALFF values in the bilateral hippocampus and increased ALFF values in the right supplementary motor area of NSSI adolescents compared to healthy controls. Significantly reduced FC values was observed between the left hippocampus and the left precuneus, right middle temporal gyrus, and right inferior temporal gyrus, and between the right hippocampus and the right middle temporal gyrus. Additionally, increased FC values was observed between the left hippocampus and the left thalamus. Furthermore, ALFF values in the bilateral hippocampus were negatively correlated with the total score of addiction characteristics in NSSI adolescents.</p><p><strong>Conclusions: </strong>This study highlights reduced local neural activity and functional connectivity in the bilateral hippocampus of NSSI adolescents, and demonstrates that these alterations are associated with heightened addictive features in self-injuring individuals.</p><p><strong>Trial registration: </strong>A study of positive psychological group interventions in adolescents with non-suicidal self-injury (registration date: 03/01/2024; registration number: ChiCTR2400079412).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"895"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of TPH2 DNA methylation and family functioning, parenting styles on OCD severity.","authors":"Lina Wang, Yu Chen, Shiqi Hu, Tiangui Yu, Zhenhua Liu, Dongdong Qiao","doi":"10.1186/s12888-025-07217-0","DOIUrl":"10.1186/s12888-025-07217-0","url":null,"abstract":"<p><strong>Objective: </strong>The etiology of obsessive-compulsive disorder (OCD) is multifactorial and remains incompletely understood. While both the Tryptophan hydroxylase 2 (TPH2) gene and the family environment have been implicated in OCD, few studies have examined their combined effects. This study aimed to investigate the association between TPH2 DNA methylation and family functioning and parenting styles in patients with OCD.</p><p><strong>Method: </strong>A total of 58 individuals with OCD and 89 age- and gender- matched healthy controls were recruited. DNA methylation levels at 12 CpG sites in the promoter region of TPH2 were quantified using the MassARRAY system. OCD symptom severity was assessed using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Parenting styles and family functioning were evaluated using the Egna Minnen Barndoms Uppfostran (EMBU) and Family Assessment Device (FAD), respectively.</p><p><strong>Results: </strong>(1) Methylation at CpG site 6 was significantly associated with OCD status in a binary logistic regression model and remained significant after Bonferroni correction. (2) In the OCD group, CpG sites 2 and 1/3/8 showed negative correlations with the 'general functioning' and 'roles' subscales of the FAD, respectively, while CpG site 7 was positively correlated with 'affective involvement'. Methylation levels at CpG sites 2, 4, 5, 9 and 10 significantly differed based on the presence or absence of specific parenting styles in EMBU. (3) Regarding symptom severity, methylation at CpG sites 6, 9 and 12, as well as FAD dimensions (problem-solving, communication, affective responsiveness, general functioning), father's punishment, and mother's preference, were significantly associated with Y-BOCS scores.</p><p><strong>Conclusion: </strong>DNA methylation at specific CpG sites in the TPH2 promoter region may play a critical role in the pathogenesis and symptom severity of OCD. Methylation patterns also correlated with family functioning and parenting styles. These findings suggest that TPH2 methylation may mediate the link between adverse family environments and OCD, possibly through reduced serotonin synthesis and impaired emotion regulation. Our results support a gene-environment interaction model contributing to OCD vulnerability.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"882"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution structural magnetic resonance examination of the Habenula in patients with first-episode depression: an exploratory radiomics diagnostic value analysis based on cluster analysis.","authors":"Lin Hou, BingYang Bian, ShuXin Luan, XingChen Pan, MingYang Li, Han Xue, HongChao Wang, HuiMao Zhang, Lei Zhang","doi":"10.1186/s12888-025-07259-4","DOIUrl":"10.1186/s12888-025-07259-4","url":null,"abstract":"<p><strong>Background: </strong>The habenula (Hb) is a vital hub for the monoaminergic pathway and plays a crucial role in depression pathophysiology. However, owing to its small size and heterogeneity between individuals, there is no consensus on imaging alterations in the Hb in depression. This study aimed to examine the differences in the Hb between healthy controls (HCs) and patients with first-episode depression (FED) who were not taking any antidepressants, and to assess the value of Hb voxel cluster radiomic features in discriminating patients with FED from HCs.</p><p><strong>Methods: </strong>This cross-sectional study included 94 participants (47 HCs and 47 patients with FED) who underwent 3-T magnetic resonance imaging. Differences in the Hb volume and T1 values between the two groups were examined. Correlations among volume, T1 value, depression severity, and age were also examined. Furthermore, a clustering-based radiomics model to differentiate patients with FED from HCs was developed and validated.</p><p><strong>Results: </strong>In HCs, the Hb T1 value was positively related to age, whereas that of patients with FED showed no significant correlation. The prediction performance was improved in the clustering-based radiomics model (area under the curve [AUC] = 0.844) compared with the traditional model (AUC = 0.708).</p><p><strong>Conclusions: </strong>Our findings imply that the Hb and its internal heterogeneity are imaging markers for depression studies.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"896"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk and protective factors associated with depressive symptoms among school-going adolescents in Malaysia: a cross‑sectional study.","authors":"Norhafizah Sahril, Hamizatul Akmal Abd Hamid, Mohamad Aznuddin Abd Razak, Sheikh Shafizal Sheikh Ilman, Filza Noor Ansari, Noor Ani Ahmad","doi":"10.1186/s12888-025-07319-9","DOIUrl":"10.1186/s12888-025-07319-9","url":null,"abstract":"<p><strong>Introduction: </strong>Depression is a growing global concern, particularly among Malaysian adolescents, where its prevalence is on the rise. This study investigates both risk and protective correlates of depressive symptoms in a representative sample of school-attending Malaysian adolescents.</p><p><strong>Methods: </strong>Data from the 2022 National Health and Morbidity Survey (NHMS): Adolescent Health Survey, a comprehensive nationwide study. A multistage stratified cluster sampling method was used, and it involved two stages. The survey included a representative sample of secondary school students. Depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9), where a score of 10 or above indicated have depressive symptoms. Descriptive and complex sample logistic regression analyses were conducted using SPSS version 26.0.</p><p><strong>Results: </strong>The study involved 33,523 school-going adolescents, revealing a depressive symptoms prevalence of 26.9%. Multiple logistic regression analysis uncovered that female adolescents and those in higher age were more susceptible to depressive symptoms. In contrast, Chinese and Indian adolescents showed lower susceptibility to depressive symptoms. Factors such as parental separation, widowhood, loneliness, lack of close friendships, unable to sleep due to worry, bullying, truancy, and deficient parental bonding or connectedness were associated with a higher likelihood of depressive symptoms.</p><p><strong>Conclusions: </strong>Depressive symptoms is a significant issue among Malaysian school-going adolescents, with a prevalence rate of one in four (26.9%). Female adolescents and older students were found to have significantly higher odds of experiencing depressive symptoms, while adolescents of Chinese and Indian ethnicity were less likely to be affected. Other notable correlates included parental separation or widowhood, loneliness, lack of close friends, difficulty sleeping due to worry, bullying, truancy, and poor parental bonding and connectedness. Thus, it is crucial to develop targeted prevention and intervention programs for at-risk adolescents to enhance their mental health and well-being. The multiple logistic regression analysis showed that.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"891"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of aripiprazole monotherapy in bipolar disorder with delayed sleep-wake phase syndrome.","authors":"Tong Li, Ting Yang, Yuchen Lin, Zhaoyu Gan","doi":"10.1186/s12888-025-07289-y","DOIUrl":"10.1186/s12888-025-07289-y","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with bipolar disorder (BD) who also experience delayed sleep-wake phase (DSWP) disorder/syndrome may tend to be younger, have a higher risk of relapse, and exhibit more severe impairments in social functioning. However, few studies have explored this area, and there are currently no established treatment guidelines, prompting us to investigate this further through a case series.</p><p><strong>Methods: </strong>We report on a chart review of 15 patients diagnosed with bipolar disorder (BD) and delayed sleep-wake phase (DSWP) syndrome, who received Aripiprazole (APZ) monotherapy for 12 to 135 weeks.</p><p><strong>Results: </strong>Efficacy was observed within the first two weeks, indicated by reductions in Clinical Global Impressions-Severity (CGI-S) scores and an advancement of the sleep-wake cycle. By the final visit, 93.3% (14/15) of participants had achieved clinical remission (defined as CGI-S < 3), with their social functioning returning to normal. The most common adverse events were extrapyramidal side effects and weight gain, but both were reversible.</p><p><strong>Conclusion: </strong>In summary, APZ monotherapy may be an effective and safe treatment option for BD patients with DSWP syndrome. Our chart review highlights the potential value of further systematic investigation through a clinical trial.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"899"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between COVID pandemic-related post-traumatic stress disorder symptoms and self-care behaviors, fear of hypoglycemia, and depressive symptoms among Chinese adults with type 2 diabetes in the post-pandemic era.","authors":"Dianjiang Li, Enchun Pan, Ming Su, Zhongming Sun, Jinbo Wen, Keke Liu, Jingya Han, Xin Wang, Hong Fan, Sijun Liu","doi":"10.1186/s12888-025-07324-y","DOIUrl":"10.1186/s12888-025-07324-y","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic significantly impacted individuals with type 2 diabetes (T2D), especially in China, where stringent public health measures disrupted healthcare access and heightened psychological stress. The long-term associations of pandemic-related post-traumatic stress disorder (PTSD) symptoms with self-care behaviors, fear of hypoglycemia (FoH), and depressive symptoms in T2D patients remain underexplored. This study examines these associations in Chinese adults with T2D in the post-pandemic period.</p><p><strong>Methods: </strong>We conducted a cross-sectional study with 242 adults with T2D at community health centers in Huai'an, China. Data on PTSD symptoms (Impact of Event Scale-Revised), self-care behaviors (Summary of Diabetes Self-Care Activities-6), FoH (Hypoglycemia Fear Survey II-Worry Scale), and depressive symptoms (Patient Health Questionnaire-9) were collected. Generalized linear models adjusted for demographic and clinical factors analyzed associations between PTSD symptoms and self-care, FoH, and depressive symptoms.</p><p><strong>Results: </strong>The prevalence of PTSD in the sample was 10.33% (n = 25). Higher PTSD scores were significantly associated with poorer dietary adherence (β = -0.0036, 95% CI: -0.0066 to -0.0005) and foot care (β = -0.0365, 95% CI: -0.0494 to -0.0235), as well as increased FoH (β = 0.0171, 95% CI: 0.0055 to 0.0287) and depressive symptoms (β = 0.0148, 95% CI: 0.0076 to 0.0220). No significant associations were found with physical activity, blood glucose testing, or medication adherence (all P > 0.05).</p><p><strong>Conclusions: </strong>COVID pandemic-related PTSD symptoms may be associated with certain worsened self-care behaviors, heightened FoH, and increased depressive symptoms among patients with T2D. These findings suggest that addressing mental health by integrating psychological support into chronic-care models could help improve diabetes outcomes, particularly for vulnerable groups facing future public health challenges.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"892"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive and mobile phone addiction symptoms in Chinese adolescents with major depressive disorder: the mediating effect of alexithymia.","authors":"Yinghan Tian, Yingao Cui, Lewei Liu, Changhao Chen, Zhiwei Liu, Wenzheng Li, Jiawei Wang, Xiangfen Luo, Xiangwang Wen, Cheng Yang, Lei Xia, Huanzhong Liu","doi":"10.1186/s12888-025-07271-8","DOIUrl":"10.1186/s12888-025-07271-8","url":null,"abstract":"<p><strong>Background: </strong>Mobile phone addiction (MPA) is associated with depression, yet the underlying mechanisms are not clear. This study aimed to explore the socio-demographic and clinical correlates of MPA symptoms, the associations between depressive and MPA symptoms, and whether the associations are mediated by alexithymia among adolescents with major depressive disorder (MDD).</p><p><strong>Methods: </strong>This cross-sectional study was conducted from January to July 2021 in seven hospitals across the northern, central, and southern regions of Anhui Province, China. MPA symptoms, depressive symptoms, and alexithymia were assessed using the Mobile Phone Addiction Scale (MPAS), the Center for Epidemiologic Studies of Depression Symptom Scale (CES-D) and the 20-item Toronto Alexithymia Scale (TAS-20), respectively.</p><p><strong>Results: </strong>A total of 286 adolescents with MDD were included. Univariate analyses revealed that adolescents with abnormal parental marriage, poorer academic performance, higher total scores of CES-D and TAS-20, and higher subscale scores of difficulty identifying feeling (DIF) and externally oriented thinking (EOT) were likely to have more severe MPA symptoms (all P < 0.05). Multivariate linear regression analyses showed that depressive symptoms were positively correlated with the severity of MPA symptoms in adolescents with MDD (all P < 0.05). Alexithymia and EOT partially mediated the associations between depressive and MPA symptoms.</p><p><strong>Conclusion: </strong>MPA symptoms are common in adolescents with MDD, and the effect of depressive symptoms on the severity of MPA symptoms is mediated partially through alexithymia. Therefore, effective identification and intervention for alexithymia may be important strategies to help clinical staff reduce the risk of MPA among adolescents with MDD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"898"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between career adaptability, decent work, job satisfaction and burnout among psychiatrists: a cross-sectional study.","authors":"Huaineng Wu, Simin Zhu, Luoyan Wang, Huibo Yuan, Bowen Xue, Hong Luo","doi":"10.1186/s12888-025-07343-9","DOIUrl":"10.1186/s12888-025-07343-9","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has led to a global increase in demand for mental health services, worsening the shortage of psychiatrists. As a result, psychiatrists have experienced decreased job satisfaction, diminished perceptions of decent work, and increased burnout. Understanding psychiatrists' career adaptability is crucial for addressing these challenges.</p><p><strong>Methods: </strong>This cross-sectional study employed convenience sampling in February 2024. A total of 516 psychiatrists working in public hospitals in Zhejiang Province and the Xinjiang Uygur Autonomous Region were assessed using demographic characteristics, the Career Adapt-Abilities Scale (CAAS), the Decent Work Perceptions Scale (DWPS), the Minnesota Satisfaction Questionnaire (MSQ), and the Maslach Burnout Inventory-General Survey (MBI-GS).</p><p><strong>Results: </strong>The study revealed that career adaptability significantly impacts burnout, job satisfaction, and perceptions of decent work. Job satisfaction and perceptions of decent work negatively affect burnout, while decent work positively influences job satisfaction. Mediation analysis further revealed that decent work mediates the relationship between career adaptability and burnout.</p><p><strong>Conclusions: </strong>This study emphasizes the importance of career adaptability among psychiatrists and the mediating role of decent work and job satisfaction. Therefore, psychiatric hospital management should implement strategies to enhance physicians' career adaptability, promote decent work, improve job satisfaction, reduce burnout, and protect physicians' professional well-being.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"888"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription drug misuse and risk factors among Somali adolescents: a qualitative study exploring peer influence, stress, and academic pressure.","authors":"Mohamed Jayte, Abdifitah Abdullahi Mohamed, Abdifatah Hersi Karshe, Hassan Omar Ali, Abdullahi Hussein Ahmed","doi":"10.1186/s12888-025-07336-8","DOIUrl":"10.1186/s12888-025-07336-8","url":null,"abstract":"<p><strong>Background: </strong>Drug misuse among adolescents is a growing public health concern in Somalia, with prescription drug abuse emerging as a significant issue. This behavior is influenced by a complex interplay of psychological, social, and environmental factors, including peer pressure, academic stress, and community dynamics. Understanding these factors is essential for designing effective interventions to mitigate the rising trend of substance abuse among Somali youth.</p><p><strong>Methods: </strong>This qualitative study employed in-depth interviews (IDIs) and key informant interviews (KIIs) to explore the motivations and risk factors associated with drug misuse among Somali adolescents. A purposive sampling technique was used to recruit 20 participants, including 15 adolescents and 5 key informants (parents, teachers, and community leaders). Data were analyzed using NVivo software, with thematic analysis conducted to identify emerging themes.</p><p><strong>Results: </strong>The study identified multiple risk factors contributing to adolescent drug misuse. Psychological stressors, such as anxiety and academic pressure, were key motivations for drug use. Social influences, particularly peer pressure and digital platforms, played a significant role in drug initiation. Family dynamics, including parental neglect and socioeconomic challenges, further exacerbated the problem.</p><p><strong>Conclusion: </strong>Addressing adolescent drug misuse in Somalia requires multi-level interventions, including family support, school-based awareness programs, and policy enforcement. Community engagement is crucial in preventing substance abuse among Somali youth.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"893"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing temporal patterns in patient-reported wish to live and wish to die signal the imminent emergence and aftermath of suicide attempts: a dynamical systems analysis.","authors":"Craig J Bryan, Melanie L Bozzay, Jarrod Hay, Austin Starkey, Jeffrey V Tabares, Justin C Baker","doi":"10.1186/s12888-025-07295-0","DOIUrl":"10.1186/s12888-025-07295-0","url":null,"abstract":"<p><strong>Background: </strong>Existing suicide risk screening and detection methods are unable to reliably identify who will engage in suicidal behavior (SB), and when. Modeling the \"push-pull\" among risk and protective processes could be useful for understanding when patients may be at increased risk for transitioning from lower to higher risk states. This study examines if changing temporal dynamics in wish to live (WTL) and wish to die (WTD) ratings, assessed during consecutively scheduled psychiatric outpatient visits, can differentiate patients who will attempt suicide and signal when suicidal behavior is about to occur.</p><p><strong>Methods: </strong>78 adults with past-month suicidal ideation and/or suicidal behaviors who enrolled in a randomized clinical trial comparing two outpatient psychotherapies provided weekly WTL and WTD ratings assessed with the first two items of the Scale for Suicide Ideation and weekly occurrence of suicide attempts assessed with items from the Self-Injurious Thoughts and Behaviors Interview-Revised.</p><p><strong>Results: </strong>Session-to-session changes in WTL and WTD were examined using multilevel regression modeling supplemented by eigenvalue decomposition analysis. Temporal patterns significantly differed over time between patients who attempted suicide versus patients who did not. Temporal patterns remained consistent over time among patients who did not attempt suicide. Among patients who attempted, temporal patterns changed from pre- to post-attempt, consistent with a state transition.</p><p><strong>Conclusions: </strong>Suicidal behaviors represent a state transition that is foreshadowed by unique temporal patterns in self-reported WTL and WTD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"884"},"PeriodicalIF":3.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}