BMC Psychiatry最新文献

{"title":"Suicidality among people with mild cognitive impairment: a sustematic review.","authors":"Alba Sánchez-Gil, Jesús Pérez, Víctor Navarro-López, Juan Luis Sánchez-González","doi":"10.1186/s12888-025-07228-x","DOIUrl":"10.1186/s12888-025-07228-x","url":null,"abstract":"<p><strong>Background: </strong>Mild cognitive impairment (MCI) is a clinical stage between the expected cognitive decline of healthy ageing and dementia. People with MCI experience functional decline, social isolation and emotional symptoms that may increase suicidal thoughts and behaviours (STB). We aimed to explore the relationship between MCI and STB, as well as clinical and socioeconomic factors that may contribute to it.</p><p><strong>Methods: </strong>To achieve our aims we carried out a comprensive systematic review of the existing scientific literature. We searched the following electronic databases up to June 2024: PubMed, Scopus, Cochrane Library, Web Of Science (WOS) and EMBASE. We employed the Cochrane Risk of Bias In Non-randomized Studies - of Exposure (ROBINS-E) and the Newcastle-Ottawa Scale to assess the quality of the eligible studies.</p><p><strong>Results: </strong>An initial search retrieved 1,176 publications; however, only 11 studies met eligibility criteria to be included in the final analysis. The quality of these studies ranged from 3 to 8 out of a maximum score of 9 in the Newcastle-Ottawa Scale, with a median score of 6. People with a formal diagnosis of MCI showed a higher prevalence of STB than those without such condition or with a more severe cognitive impairment. Comorbid psychiatric disorders, such as depression, other health problems, such as cardiovascular diseases, and a low socioeconomic status and/or poor educational background seemed to contribute to suicide risk in people with MCI.</p><p><strong>Conclusion: </strong>Our systematic review suggests that people suffering MCI may be at an increased risk of presenting STB. Suicide prevention programmes for older populations with MCI should advocate for integrated health and social care models to tackle the clinical and social burden of suffering MCI.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"782"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nano-Selenium supplementation on the JAK/STAT signaling pathway in major depressive disorder: a Triple-Blind, randomized controlled trial.","authors":"Morvarid Noormohammadi, Farnaz Etesam, Ali Amini, Pegah Khosravian Dehkordi, Morteza Mohammadzadeh, Farzad Shidfar","doi":"10.1186/s12888-025-07213-4","DOIUrl":"10.1186/s12888-025-07213-4","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is a prevalent mental health condition, wherein the JAK/STAT signaling pathway serves as a potent cellular mechanism implicated in its pathophysiology. Increased expression of JAK2, STAT3, and subsequently IDO1 genes appears to be linked to depressive symptoms. With their antioxidant capabilities and improved absorption due to the nano formula, selenium nanoparticles could potentially modulate this molecular pathway. This study aimed to assess the impact of nano-selenium supplementation on the expression of JAK2, STAT3, and IDO1 genes in patients with MDD.</p><p><strong>Methods: </strong>A triple-blind, randomized, placebo-controlled trial was conducted at the Psychosomatic Clinic of Imam Khomeini Hospital Complex. A total of 50 participants, newly diagnosed with MDD were randomized to either a nano-selenium (55 µg/day) or placebo group for 12 weeks. All participants were receiving their standard treatment (sertraline 50 mg/day). Blood samples were collected at baseline and post-intervention to measure the gene expression using RT-qPCR.</p><p><strong>Results: </strong>At the end of the study, both groups showed reductions in JAK2 and STAT3 relative gene expression after 12 weeks (P < 0.05). Although the reduction was more in the nano-selenium group, the between-group differences were not statistically significant.</p><p><strong>Conclusions: </strong>This study is the first to examine nano-selenium as a novel potential adjunct treatment for MDD. Though the degree of reduction in JAK2 and STAT3 levels was greater within the nano-selenium group, it appears that additional investigations are needed to elucidate its effects.</p><p><strong>Trial registration: </strong>The research received approval from the Research Ethics Committees of Iran University of Medical Sciences (Approval ID: IR IUMS.REC.1402.206, dated 2023-06-13) and was duly registered with the Iranian Registry of Clinical Trials (IRCT; registration number: IRCT20091114002709N62, dated 2023-07-29).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"785"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative study of the experience of parents whose adolescent has been hospitalized for a suicidal episode: reshaping, mobilizing, and adapting.","authors":"Amélie Carquet, Emilie Carretier, Jonathan Lachal, Rahmeth Radjack, Sevan Minassian, Marie Rose Moro","doi":"10.1186/s12888-025-07216-1","DOIUrl":"10.1186/s12888-025-07216-1","url":null,"abstract":"<p><strong>Background: </strong>A suicidal crisis is a set of symptoms that can occur frequently during adolescence. It can require hospitalization, a form of care that often also facilitates work with the adolescent's parents, whose inclusion has proven beneficial. The objective of this work is to analyze parents' experience of their adolescent's suicidal crisis and hospitalization.</p><p><strong>Methods: </strong>This is a qualitative study with data collected from semi-structured interviews of 13 parents of teens who had been hospitalized in an adolescent psychiatry ward for a suicidal crisis. The data were analyzed with Interpretative Phenomenological Analysis.</p><p><strong>Results: </strong>Parents described how the adolescent's suicidal crisis drastically disrupted their relationships both with the youth and within the family, as well as strongly affecting their own well-being. Hospitalization was often perceived as a relief by protecting the adolescent. Separation from the teen and the care offered, including family sessions, led simultaneously to reorganization and support of the family. The construction of a new family and personal equilibrium continued after hospitalization with the search for strategies to prevent acute recurrence.</p><p><strong>Conclusions: </strong>Parents faced with their adolescent's suicidal crisis are immediately affected and mobilized. The youth's hospital admission supports the family's mobilization while inducing its reshaping but does not appear entirely sufficient. It is crucial to provide interventions that enhance parents' skills in supporting their suicidal teen and to promote parental empowerment and family recovery. Specifically, approaches combining psychoeducation, family-based work and peer support with other parents hold promise in addressing parental needs in this context.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"781"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between depression and asthma: insight from observational and genetic evidence.","authors":"Tanao Ji, Yue Lv, Jianan Yang, Xianping Diao, Jun Gu","doi":"10.1186/s12888-025-07245-w","DOIUrl":"10.1186/s12888-025-07245-w","url":null,"abstract":"<p><strong>Background: </strong>Depression and asthma share several pathophysiologic risk factors, and their precise connection remains unclear. Our research seeks to assess the relationship between depression and asthma.</p><p><strong>Methods: </strong>The association between depression and asthma was assessed through a multivariable logistic regression analysis, with data sourced from The National Health and Nutrition Examination Survey (NHANES) 2007-2018 and the English Longitudinal Study of Ageing (ELSA) 2004-2019. Subsequently, a linkage disequilibrium score regression (LDSC) analysis was conducted to evaluate the genetic correlation between depression and asthma. Moreover, a two-sample Mendelian randomization (MR) analysis was conducted by employing genome-wide association study (GWAS) summary statistics by means of both univariable MR (UVMR) and multivariable MR (MVMR).</p><p><strong>Results: </strong>This study included 31,434 participants from NHANES and 17,021 participants from ELSA for observational research. In the unadjusted model, participants with depression had a significantly increased risk of asthma in comparison to participants without depression, both in NHANES (OR = 2.002, 95%CI: 1.827-2.193, P < 0.001) and in ELSA (OR = 1.753, 95%CI: 1.581-1.943, P < 0.001). After adjusting potential confounders, the results remain significant. The LDSC result revealed a significant positive genetic correlation between depression and asthma (rg = 0.352, P < 0.001).The UVMR results further substantiated a genetically predicted causality of depression on asthma (OR = 1.291, 95%CI: 1.157-1.442, P < 0.001), while the reverse causality does not stand. Similar findings from MVMR were obtained for the causality investigation after adjusting smoking (OR = 1.326, 95%CI: 1.156-1.520, P < 0.001), drinking (OR = 1.375, 95%CI: 1.186-1.593, P < 0.001), and education (OR = 1.425, 95%CI: 1.253-1.621, P < 0.001).</p><p><strong>Conclusion: </strong>Our findings indicate that depression may play a contributory role in the development of asthma, underscoring the potential benefit of implementing prevention strategies aimed at managing depression to mitigate asthma risk.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"786"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear of progression profiles and their association with quality of life and depression in ischemic stroke survivors: a latent profile analysis.","authors":"Jia Li, Yi He, Fei Xie, Zhiming Kang, Jing Mei, Bin Mei","doi":"10.1186/s12888-025-07242-z","DOIUrl":"10.1186/s12888-025-07242-z","url":null,"abstract":"<p><strong>Background: </strong>Fear of progression (FoP) has been well-documented in patients with cancer and chronic disease. However, there is little information in stroke patients. The purpose of this study was to explore the profiles and associated factors of FoP among ischemic stroke survivors, and to examine the association of FoP profiles with quality of life (QoL) and depression.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from July 2023 to June 2024. Two hundred ischemic stroke survivors were recruited. Data collection included a self-designed sociodemographic and clinical information questionnaire, the Fear of Progression Questionnaire-Short Form, the Stroke Specific Quality of Life Scale, and the Self-Rating Depression Scale. Latent profile analysis (LPA), univariate analysis, multinomial logistic regression analysis, and multiple hierarchical regression analysis were adopted in this study.</p><p><strong>Results: </strong>LPA identified three subgroups of FoP: Group 1-the low FoP (23%), Group 2-the moderate FoP with family-related concerns (45%), and Group 3-the high FoP with work-related concerns (32%). Older age (OR = 0.245, p = 0.003) and lower functional independence (Barthel index, BI) (OR = 0.976, p = 0.034) were associated with Group 2, while younger age (OR = 8.771, p = 0.018) and lower monthly family income (OR = 9.960, p = 0.004) were associated with Group 3. FoP profiles explained 3.0% variance in QoL and 3.3% variance in depression (p < 0.05). Group 2 and 3 showed significantly lower QoL than Group 1 (p < 0.05), while Group 2 and Group 3 had higher depression than Group 1 (p < 0.05).</p><p><strong>Conclusion: </strong>Three heterogeneous subgroups of FoP were identified in ischemic stroke survivors. Age, household monthly income, and functional independence were associated with different latent profiles of FoP. Healthcare providers should categorize patients with FoP into subgroups and provide targeted interventions based on each profile's characteristics and associated factors. This could contribute to promoting their QoL and lowering their depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"780"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of cyberbullying with major depressive disorders among Bangladeshi female adolescents: findings from the Bangladesh adolescent health and wellbeing survey 2019-20.","authors":"Syed Toukir Ahmed Noor, Md Fakrul Islam, Md Sabbir Hossain, Raisha Binte Islam, Rajon Banik, Shafayatul Islam Shiblee, Sarker Mohammad Nasrullah, Sahar Raza","doi":"10.1186/s12888-025-07234-z","DOIUrl":"10.1186/s12888-025-07234-z","url":null,"abstract":"","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"783"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of theta burst stimulation on cognitive function and characteristics of blood oxygen alterations based on near-infrared spectroscopy in chronic schizophrenia.","authors":"Chunying Gao, Guangjian Li, Xiangrong Zhang, Tongbo Lu, Zhou Wang, Chenzhi Zhou, Gang Chen, Di Ma, Wenjie Wang, Xinyu Fang, Suwan Guo, Chengbao Huang, Chao Zhou","doi":"10.1186/s12888-025-07240-1","DOIUrl":"10.1186/s12888-025-07240-1","url":null,"abstract":"<p><strong>Background: </strong>To explore the efficacy of theta burst stimulation (TBS) on the cognitive function of chronic schizophrenia, and to analyze the effect of TBS on brain function using functional near-infrared spectroscopy (fNIRS).</p><p><strong>Methods: </strong>One hundred stable chronic schizophrenia patients were selected and divided randomly into the experimental group (50 cases) and control group (50 cases). The experimental group received real TBS stimulation to the left dorsolateral prefrontal cortex (DLPFC) for 4 weeks, while the control group received sham stimulation to the same site. The Mini-mental State Examination (MMSE) and Mattis-dementia Rating Scale Second Edition (MDRS-2) were used to assess cognitive function. fNIRS was used to detect the changes in hemoglobin signal values during the verbal fluency task (VFT) before and after TBS intervention.</p><p><strong>Results: </strong>Repeated measures analysis of variance showed that the interaction effect of group-by-time had a significant impact on MMSE, MDRS-2 total scores, MDRS-2 attention, MDRS-2 initiation/sustain, MDRS-2 concept formation, and MDRS-2 memory subscale scores for both groups of patients. Tests of within-subjects effects showed that significant improvements in MMSE, MDRS-2 total scores, MDRS-2 attention and memory subscale scores were found between the experimental group and control group after TBS, as well as in the experimental group before and after TBS. Multiple factor stepwise regression analyses found that the improvement of MDRS-2 total scores after the intervention was positively correlated with age in the experimental group. Based on fNIRS-VFT, the experimental group showed significant decrease in deoxyhemoglobin signal values in channel 47 (left dorsolateral prefrontal cortex) before and after the intervention.</p><p><strong>Conclusions: </strong>TBS may have the potential to improve brain activity by enhancing the blood oxygen consumption of the stimulation target, as indicated by the fNIRS findings. Then, it may contribute to improvements in cognitive function of patients with chronic schizophrenia. However, the age of the patients may be an independent factor influencing the prediction of the treatment effect.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"784"},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of delusional parasitosis by proxy: a rare entity.","authors":"Caroline Chivily, Brianna Glover","doi":"10.1186/s12888-025-07236-x","DOIUrl":"10.1186/s12888-025-07236-x","url":null,"abstract":"<p><strong>Background: </strong>Delusional parasitosis is a rare, fixed, false belief that an individual is infested with parasites or other living organisms despite no laboratory evidence to confirm this belief. It can manifest as a shared belief, folie à deux, or by proxy.</p><p><strong>Case presentation: </strong>This case report describes an 8-year-old patient with Trisomy 21 with delusional parasitosis by proxy. The patient's mother remained fixated on the patient having a parasitic infection despite extensive reassuring evaluations. There were multiple normal-appearing pictures and videos of the patient's urine, stool, skin and throat shown to the medical team, consistent with the \"specimen sign\" described in the literature.</p><p><strong>Conclusions: </strong>Delusional parasitosis is rare and can be difficult to diagnose and treat. It has even more complexity and implications in pediatric or other vulnerable populations. A multidisciplinary treatment approach is important to build trust and prevent harm.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"777"},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subgroups of suicidal ideation and simulated intervention responses among left-behind children with depression risk: an Ising computational network model.","authors":"Xiaofan Yu, Ling Li, Chang Liu, Lei Ren, Xiewan Chen, Kuiliang Li","doi":"10.1186/s12888-025-07207-2","DOIUrl":"10.1186/s12888-025-07207-2","url":null,"abstract":"<p><strong>Background: </strong>Left-behind children (LBC) with depression risk exhibit a higher suicide risk than their peers. To better understand the psychological mechanisms contributing to elevated suicide risk, this study employed a person-centered approach to systematically identify latent subgroups of suicidal ideation, with a particular focus on the roles of positive and negative suicidal ideation, and to investigated their differential responses to simulated interventions.</p><p><strong>Methods: </strong>From the Psychological Healthcare Guard Children and Adolescents Project of China cohort, 10,852 left-behind children with depression risk were selected. Using self-reported demographic data, depressive symptoms, and positive and negative suicidal ideation, we conducted latent profile analysis, network analysis, and computational simulation to evaluate the effects of key intervention targets.</p><p><strong>Results: </strong>Latent profile analysis identified three suicidal ideation subgroups-low, moderate, and high (40%, 39%, and 21%, respectively)-with significant differences in depression levels across groups. The Ising network model revealed that the most influential node in the overall sample was the negative suicidal ideation (SN08: Frustrated in life), whereas positive suicidal ideation nodes (SP03: Satisfied with life and SP06: Confident about the future) dominated in all subgroups. Simulated interventions showed that positive ideation nodes had the greatest impact on suicidal ideation risk, particularly in the high-risk group, where risk scores increased by 1.9 points under the aggravation intervention, highlighting the pivotal role of positive emotion-focused interventions.</p><p><strong>Conclusions: </strong>This study offers novel insights into suicidal ideation among left-behind children with depression risk, from an individual-centered level, demonstrating that positive suicidal ideation plays a more important role than negative ideation in both aggravation and alleviation intervention effects, with key targets varying across subgroups. Targeted interventions prioritizing positive ideation in high-risk groups are recommended to optimize prevention and treatment strategies.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"774"},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health care seeking behavior in Bangladesh: determinants and treatment gaps.","authors":"Rumana Huque, Abul Kalam Azad, Khaleda Islam, Helal Uddin Ahmed, Mohammad Robed Amin","doi":"10.1186/s12888-025-06813-4","DOIUrl":"10.1186/s12888-025-06813-4","url":null,"abstract":"<p><strong>Background: </strong>The study provides evidence of the existing pattern of mental healthcare-seeking behavior and treatment gaps among the adult population in Bangladesh and identifies the factors associated with mental healthcare-seeking behavior in the country.</p><p><strong>Methods: </strong>We used the National Mental Health Survey Bangladesh 2019 dataset with 7270 households to identify the patterns of and facilitators for seeking mental health care in Bangladesh. A Probit model using a standard normal cumulative distribution function (CDF) with three specifications has been applied to identify the factors influencing mental healthcare-seeking behavior and the probability of seeking mental healthcare services in Bangladesh. We also compared the probit model results with the logit model (a similar method) to examine the consistency of the findings.</p><p><strong>Results: </strong>The study finds a large treatment gap for mental health care seeking in Bangladesh. We found that about 90% of mental health patients do not seek mental healthcare services in the country. Among the different mental health disorders, addictive disorder is found with the highest treatment gap (95.24%), while bipolar disorder is observed with the lowest treatment gap (65.63%). Both the logit and probit model shows that the existence of a mentally disordered patient in a family is the only statistically significant determinant that increases the probability of seeking mental health care for other family members among the socio-economic factors, such as gender, age, marital status, religion, education level, household size, and residential status. The marginal effects analysis shows that the existence of a mentally disordered family member increases the probability of seeking mental health care services by around 6% both in logit and probit models. By disaggregating the sample observations into women and men, we also found that marital status and household size are significant determinants. The other socio-economic variables considered in the study are found statistically insignificant. The lesser tendency to seek mental health treatment in the country requires policy intervention by government and non-government organizations.</p><p><strong>Conclusion: </strong>Though mental health conditions are major public health concerns in Bangladesh, the treatment-seeking behavior among people with mental health disorders is very low, implying a large treatment gap for mental health conditions. The findings indicate the urgent need to increase mental health service coverage among mental health patients.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"779"},"PeriodicalIF":3.4,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}