BMC Psychiatry最新文献

{"title":"The association between age at menarche and depression: a cross-sectional analysis of the TABARI cohort at enrollment phase.","authors":"Mahmood Moosazadeh, Seyed Hamzeh Hosseini, Monirolsadate Hosseini Tabaghdehi, Masoomeh Shafiei, Erfan Ghadirzadeh","doi":"10.1186/s12888-025-06667-w","DOIUrl":"10.1186/s12888-025-06667-w","url":null,"abstract":"<p><strong>Background: </strong>Puberty, particularly menarche, involves hormonal changes that may influence depressive symptoms. However, research on the association between age at menarche (AAM) and depression yields contradictory results, possibly due to sample differences and differences in socioeconomic status, parenting style, and cultural factors within each studied population. Thus, this study aimed to investigate the association between AAM and depression in a large cohort of the Northern Iranian population.</p><p><strong>Methods: </strong>This cross-sectional study comprised 6103 female adults aged between 35 and 70 years from the Tabari cohort study. The association between depression and three different AAM subgroups (≤ 11 as early menarche, 12-13 as normal menarche, and ≥ 14 as late menarche) was compared using logestic regression models after adjusted sociodemographic factors.</p><p><strong>Results: </strong>The crude model showed that females with early AAM and normal AAM had higher odds of depression (OR: 1.27, 95% CI: 0.96-1.69, P = 0.09, and OR: 1.21, 95% CI: 1.03-1.43, P = 0.024, respectively) compared to the late AAM group (P for trend = 0.042). However, in the fully adjusted model, there were no significant associations (OR: 0.97, 95% CI: 0.73-1.29, P = 0.827 for early versus late AAM, and OR: 0.98, 95% CI: 0.82-1.17, P = 0.830 for normative versus late AAM).</p><p><strong>Conclusion: </strong>Our results indicated that, while no significant relationship was observed between different AAM subgroups and depression in the multivariable model, there was a notable trend suggesting an improvement in depression with later AAM.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"277"},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cognitive behavioral therapy on disease uncertainty, stressful life events, quality of life, anxiety, and depression in glioma patients undergoing chemotherapy: a quasi-experimental study.","authors":"Xiaonan Liu, Xiaolei Qi, Dandong Fang, Shubing Feng, Jing Chen, Xue Li, Jiajia Dang, Lin Wu","doi":"10.1186/s12888-025-06709-3","DOIUrl":"10.1186/s12888-025-06709-3","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of cognitive behavioral therapy on disease uncertainty and stressful life events in glioma patients undergoing chemotherapy.</p><p><strong>Methods: </strong>This quasi-experimental study enrolled 90 glioma patients from Sanmenxia Central Hospital between January and December 2021. Patients were divided into an intervention group (n = 45) or a control group (n = 45). The intervention group received cognitive behavioral therapy provided by nurses, while the control group received routine nursing care. Pre- and post-intervention assessments were conducted using the Mishel uncertainty in illness scale (MUIS), life events scale (LES), self-rating anxiety scale (SAS), self-rating depression scale (SDS), and quality of life scale (WHOQOL-BREF).</p><p><strong>Results: </strong>After four cycles of chemotherapy, the study group demonstrated a statistically significant decrease in MUIS and LES scores compared to the control group (p < 0.05). The study group showed significantly lower SAS and SDS scores than the control group (p < 0.05). Finally, the study group reported significantly higher WHOQOL-BREF scores than the control group (p < 0.05).</p><p><strong>Conclusion: </strong>The study revealed that the group that received CBT showed significant improvements in the psychological well-being of glioma patients undergoing chemotherapy. These findings suggest that incorporating CBT into standard nursing care can effectively improve the psychological well-being and quality of life of glioma patients during chemotherapy.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"272"},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the attitudes of mental health professionals toward recovery and peer support in Taiwan.","authors":"Yen-Ching Chang, Meng-Wen Huang, Tzu-Hsuan Chuang, Su-Ting Hsu","doi":"10.1186/s12888-025-06705-7","DOIUrl":"10.1186/s12888-025-06705-7","url":null,"abstract":"<p><strong>Background: </strong>While many Western countries have implemented mental health recovery-oriented and peer support services, they are still in the early stages of development in Taiwan, and the existing literature on professionals' perspectives regarding recovery-related issues in non-Western contexts remains limited. This study investigates the perspectives of professionals from well-established psychiatric rehabilitation organizations in Taiwan on the concept of recovery and peer support.</p><p><strong>Methods: </strong>Data were collected through semi-structured interviews involving 19 professionals from nine organizations, which were then recorded and transcribed verbatim. Subsequently, the data were coded using Atlas.ti 8.0, followed by thematic analysis.</p><p><strong>Results: </strong>The analyses identified three main themes. First, attitudes toward recovery encompassed six subthemes: (1) coexisting with illness while finding personal fulfillment, (2) exercising one's rights and taking personal responsibility, (3) maintaining hope throughout the recovery journey, (4) recognizing the non-linear nature of recovery, (5) acknowledging the individuality of each recovery path, and (6) affirming that recovery is achievable for all. Additionally, four types of peer support were identified: supportive peer, staff assistant, life assistant, and mental health workforce. Furthermore, perspectives on peer support workers included four subthemes: (1) attitudes toward people with mental illness, (2) the need for a robust career support system, (3) organizational and professional support, and (4) self-awareness of people with mental illness.</p><p><strong>Conclusions: </strong>This study is one of the few that explore the perspectives of professionals on recovery and peer support in non-Western contexts. Professionals from well-established psychiatric rehabilitation organizations in Taiwan embraced most mental health recovery principles, but inconsistencies were found regarding the applicability of recovery to different individuals. Peer support in Taiwan remains largely informal, with concerns primarily focused on environmental factors. However, one personal factor is also critical. People with mental illness in non-Western contexts may require more extensive preparation to serve as peer support workers.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"271"},"PeriodicalIF":3.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes of Australian patients receiving inpatient mental health care towards deprescribing: a cross-sectional survey.","authors":"Rachel Law, Neeraj Gupta, Aili V Langford, Emily Reeve","doi":"10.1186/s12888-025-06717-3","DOIUrl":"10.1186/s12888-025-06717-3","url":null,"abstract":"<p><strong>Background: </strong>Psychotropic polypharmacy is common, increasing, and associated with higher risks of adverse effects, hospitalisations and mortality. This study aimed to explore the attitudes and beliefs of people receiving inpatient mental health care toward deprescribing (discontinuing a medication when the current or potential risk outweighs the current or potential benefit) and determine any patient characteristics associated with these attitudes and beliefs.</p><p><strong>Methods: </strong>A cross-sectional survey of patients admitted to two open acute psychiatric inpatient units was conducted over a 6-month period in the Australian metropolitan city of Adelaide. Individuals were eligible to participate regardless of their reason for admission, if they were at least 18 years old and able to converse, read and write in English, and provide informed consent. Participant characteristics and responses to the validated revised Patients' Attitudes Towards Deprescribing (rPATD) questionnaire were collected. The rPATD includes questions grouped into four factors: (i) perceived burden of medications, (ii) involvement in medication management, (iii) belief in appropriateness of medications, and (iv) concerns about stopping, plus two global questions. Participants were encouraged to think about medications that they use for their mental health conditions when completing the questionnaire.</p><p><strong>Results: </strong>One hundred participants were recruited, with a mean age of 41.6 (SD = 13.7). 65% of participants agreed that they would be willing to stop one or more of their psychotropic medications if their doctor said it was possible. In a binary logistic regression model, willingness to have a medication deprescribed was mostly strongly predicted by Involvement factor score (odds ratio [OR] = 5.92, 95% confidence interval [CI] = 2.10-15-16.70, p < 0.001).</p><p><strong>Conclusions: </strong>A majority of participants were open to having one or more medication deprescribed. When medically justified, mental health professionals should feel comfortable initiating conversations about deprescribing to understand patient attitudes and preferences, fostering shared decision-making for psychotropic medication management.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"269"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health expert's perspective on risk and protective factors of suicide ideation in Patients with OCD and depression.","authors":"Roma Sarwar, Alia Asmat","doi":"10.1186/s12888-024-06404-9","DOIUrl":"10.1186/s12888-024-06404-9","url":null,"abstract":"<p><strong>Background: </strong>Suicidal ideation and behavior present profound challenges in mental health care, particularly among individuals contending with Depression and Obsessive-Compulsive Disorder (OCD). While existing research has elucidated the intricate pathways through which depression and OCD independently contribute to suicide risk, there remains a critical gap in understanding the interplay between these disorders in shaping suicidal tendencies.</p><p><strong>Aim: </strong>This qualitative study aims to address this gap by exploring expert's perspective about the risk and protective factors associated with suicidal ideation among individuals diagnosed with depression and OCD.</p><p><strong>Method: </strong>Through semi-structured interviews with mental health experts, thematic analysis was employed to uncover the cognitive, emotional, and environmental stressors influencing suicidal thoughts and behaviors in this clinical population.</p><p><strong>Results: </strong>Findings reveal multifaceted cognitive vulnerabilities, adverse childhood experiences, and familial factors as prominent risk factors, while coping skills, social support, and religious beliefs emerged as key protective factors.</p><p><strong>Conclusion: </strong>By illuminating the complex interplay of factors contributing to suicidal ideation in the context of comorbid depression and OCD, this study provides valuable insights for the development of targeted interventions aimed at mitigating suicide risk and improving outcomes for affected individuals.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"266"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the perceived expressed emotion scale for adolescents (pees-gap).","authors":"Morenikeji Fausiat Hamzat, Bushura Afolabi Aroyewun, Gbenusola Akinwale","doi":"10.1186/s12888-025-06695-6","DOIUrl":"10.1186/s12888-025-06695-6","url":null,"abstract":"<p><strong>Background: </strong>Current assessments of expressed emotions among the psychiatric population face significant limitations in reliability and validity, particularly for non-clinical adolescent populations. Existing scales are designed for clinical settings and lack applicability to broader contexts. This study addresses these gaps by developing and validating the Perceived Expressed Emotion Scale for the General Adolescent Population (PEES-GAP). Tailored specifically for adolescents outside clinical environments, PEES-GAP enhances utility and effectiveness, offering a robust, reliable, and valid tool to assess emotional dynamics in diverse settings, representing a significant advancement in expressed emotion research.</p><p><strong>Methods: </strong>The study adopted a descriptive cross-sectional survey design, using accidental sampling techniques to recruit participants. One thousand seven hundred forty-one students were selected from six secondary schools and three universities from three southwestern Nigeria states to complete the questionnaires. Instruments for data collection included the Perceived Expressed Emotion Scale (PEES-GAP), Index of Family Relation (IFR), and Drug Abuse Screening Test (DAST). Ethical clearance for this study was sought and obtained from the University of Lagos Ethical Review Committee.</p><p><strong>Results: </strong>The study showed that PEES-GAP's internal consistency was 0.800, while validity analyses proved that the Index of family Relation (IFR) and Drug Abuse Screening Test (DAST) converged and diverged, respectively, with the three subdomains of expressed emotion as measured by PEES-GAP.</p><p><strong>Conclusion: </strong>This study confirms the 20-item PEES-GAP as a reliable, valid tool for assessing expressed emotion in adolescents across clinical and non-clinical settings. Ensuring comparability and broad application offers a uniform measure, promotes holistic understanding, and enhances resource efficiency. Hence, it comprehensively addresses mental health issues from the client's perspective.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"268"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grey matter volume differences in pediatric obsessive-compulsive disorder: a meta-analysis of voxel-based morphometry studies.","authors":"Lei Li, Yihao Liu, Tingting Luo, Yujie Tao, Shengnan Zhao, Pei Liu, Zhaozhi Yang, Yuchu Jiang, Manxue Zhang, Xiaoxia Duan, Mingjing Situ, Yi Huang","doi":"10.1186/s12888-025-06711-9","DOIUrl":"10.1186/s12888-025-06711-9","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder (OCD) is one of the most commonly seen mental disorders onset from childhood. The neural mechanisms underlying OCD development and maintenance remain poorly understood. Various empirical evidence from structural magnetic resonance imaging (MRI) studies has reported structural differences in grey matter (GM) among pediatric OCD patients. However, some of the findings diverge from others, and the association between GM and individual differences in pediatric OCD remains inconclusive. To address this gap, we conducted a meta-analysis to synthesize findings quantitatively.</p><p><strong>Methods: </strong>The current research conducted a quantitative meta-analysis of voxel-based GM studies to elucidate existence of neural correlates in pediatric OCD. A whole brain-based d-mapping approach was utilized to explore GM changes and further analyze the relationship between GM and individual differences in pediatric OCD patients.</p><p><strong>Results: </strong>Thirteen studies were included with 288 patients and 273 controls. Compared with controls, pediatric OCD demonstrated significantly greater GM volume in the left insula (SDM value = 1.72, p < 0.005) and left superior frontal gyrus (SFG) (orbital part) (SDM value = 1.47, p < 0.005), whereas we showed lower GM volume in the right superior temporal gyrus (STG) (SDM value = -1.87, p < 0.005), left inferior parietal gyri (IPG) (SDM value = -1.60, p < 0.005), left middle occipital gyrus (MOG) (SDM value = -1.66, p < 0.005), and left inferior frontal gyrus (IFG) (SDM value = -1.69, p < 0.005). The increase in SFG (orbital part) and decrease IPG was commonly found in those without psychiatric comorbidities and treatment-naive subgroup. Meta-regression analysis revealed that longer OCD duration was associated with less GM volume in IPG (SDM value = -3.057, p < 0.005). Finally, the onset age and the OCD symptoms severity were positively associated with GM volume in the SFG (SDM z = 2.387, p < 0.005).</p><p><strong>Conclusions: </strong>Our findings confirmed the most consistent GM differences in pediatric OCD, particularly in the MOG, IPG and SFG (orbital part), suggesting they are potential markers in pediatric OCD. Larger SFG (orbital part) and smaller IPG volumes are specific to those without comorbidities and untreated patients. The duration of OCD, symptom severity and onset age also influence GM structure. This research provides evidence of the underlying neuroanatomical characteristics of pediatric OCD.</p><p><strong>Trial registration: </strong>PROSPERO CRD42024601906.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"267"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal bidirectional association between psychosocial function and depression in Chinese patients with clinically remitted depression: a cross-lagged panel model analysis.","authors":"Huang Wenyan, Hao Yang, Qiao Huifen, Yang Hua, Zhang Ning, Teng Changjun, Ma Hui","doi":"10.1186/s12888-025-06694-7","DOIUrl":"10.1186/s12888-025-06694-7","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) imposes serious effect on patient's psychosocial function, which hinders the full recovery from the disease and increases the risk of recurrence, although the participants had achieved clinical remission. To understand the relationship between psychosocial function and depressive symptoms could facilitate recurrence prevention. Therefore, the purpose of this study was to analyze the relation among psychosocial function and BDI score in Chinese patients with clinically cured depression within 1 year follow-up.</p><p><strong>Methods: </strong>One hundred nineteen valid participants were assessed at baseline(t1), months 6(t2) and months 12(t3). Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms and indicate the possibility of depression level. Generic Quality of Life Inventory (GQOLI) was used to assessed the participants' psychosocial function(F), including body function (BF), psychological function (PF) and social function (SF). The application of a cross-lagged panel model (CLPM) approach revealed an association between BDI and psychosocial function.</p><p><strong>Result: </strong>The CLPM results showed total average score of psychosocial function have reciprocal influence on BDI score. The model analyzed by structural equation modeling satisfied all indices of goodness-of-fit (chi-square = 10.306, TLI = 0.959, CFI = 0.988 RMSEA = 0.115). And body function, psychological function, social function and BDI score also affect each other. Depressive symptoms and psychosocial function could predict scores of each other 6 months later. By comparing standardized cross-lagged path, only social function has a more pronounced impact on depressive symptoms, since the absolute effect of SFt1 → BDIt2 is larger than that of BDIt1 → SFt2 (a1 vs. b1 = -.267, SE = .108, P < 0.05, 95%CI[-.485,-.063]) and the absolute effect of SFt2 → BDIt3 is larger than that of BDIt2 → SFt3 (a2 vs. b2 = -.317, SE = .096, P < 0.01,95%CI[-.508,-.129]).</p><p><strong>Conclusion: </strong>The current study showed a significant bidirectional association between depressive level and psychosocial function, and the social function exerted more effect on the depression.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"270"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends of depressive disorders among women of reproductive age from 1990 to 2021: a systematic analysis of burden, sociodemographic disparities, and health workforce correlations.","authors":"Fangyi Dai, Yuzhou Cai, Min Chen, Yong Dai","doi":"10.1186/s12888-025-06697-4","DOIUrl":"10.1186/s12888-025-06697-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Depressive disorders significantly impact women of reproductive age (15-49 years), who face unique biological and social pressures-such as hormonal changes and caregiving responsibilities-that elevate their mental health risks. Despite rising prevalence, regional disparities in burden remain poorly understood. Moreover, no studies to date have examined the relationship between depressive disorders in women of reproductive age and different categories of health workforce. This study examines global, regional, and national trends from 1990 to 2021, highlighting socio-demographic disparities and exploring correlations with health workforce distribution.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Using data from the Global Burden of Disease Study, we examined the prevalence, incidence, and disability-adjusted life years (DALYs) of depression in women of childbearing age (15-49 years) across 204 countries and territories from 1990 to 2021. Long-term trends were assessed through estimated annual percentage change (EAPC), while decomposition analyses identified drivers of disease burden changes. We also analyzed correlations between depressive disorder burden and various health workforce categories using data from the GBD 2019 Health Workforce Collaborators.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From 1990 to 2021, the global prevalence of depression in women of reproductive age rose by 67.58%, incidence by 71.44%, and DALYs by 69.08%. Notably, this burden increased dramatically during the COVID-19 pandemic, with prevalence rising by 17.86%, incidence by 24.51%, and DALYs by 20.80% between 2019-2021 alone. Regions with low sociodemographic index (SDI) saw the largest increase in absolute cases (157.80% for prevalence), while high SDI regions experienced the fastest rise in age-standardized rates (32.45% for prevalence). Among all SDI levels, the 15-19 age group exhibited the greatest increase. Decomposition analyses indicated that population growth primarily drove the increased disease burden, though epidemiological changes played a larger role in high SDI regions. Our analysis revealed significant correlations between depressive disorder burden and health workforce distribution. Notably, countries with high depressive disorder burden, such as Georgia, might benefit from increasing the number of Audiologists and Counsellors while optimizing the role of Medical Assistants and Community Health Workers in detection and referral.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The global burden of depression among women of childbearing age is increasing significantly, with a marked acceleration during the COVID-19 pandemic period. Notable disparities exist across regions and age groups, with differential impacts in pre-pandemic versus pandemic timeframes. The correlations between health workforce categories and depressive disorder burden underscore the need for targeted interventions and resource allocation. These findings highlight the urgent need for str","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"263"},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between schizophrenia and psoriasis: a two-sample Mendelian randomization study.","authors":"Lusheng Miao, Taosheng Miao, Ying Zhang, Jin Hao","doi":"10.1186/s12888-025-06687-6","DOIUrl":"10.1186/s12888-025-06687-6","url":null,"abstract":"<p><strong>Background: </strong>Numerous clinical studies have investigated the association between schizophrenia and psoriasis, but the findings remain inconsistent.</p><p><strong>Methods: </strong>We employed Mendelian randomization (MR) methods to evaluate the causal relationship between schizophrenia and psoriasis and its subtypes. Inverse variance weighting was used as the primary approach for MR analysis, complemented by inverse magnetic resonance analysis and sensitivity testing. To identify potential mediators, we applied a two-step MR approach. Additionally, pathway and functional enrichment analyses were conducted to uncover possible mechanisms linking schizophrenia and psoriasis.</p><p><strong>Results: </strong>MR analysis indicated an association between schizophrenia and psoriasis (OR: 1.0010; p = 0.008). Subtype analyses revealed that genetic susceptibility increased the risk of developing psoriasis vulgaris (OR: 1.18; 95% CI: 1.03-1.34; p = 0.016) but was not significantly associated with arthropathy (OR: 1.04; 95% CI: 0.97-1.12; p = 0.292). Emotional states such as tenseness, tiredness, and misery fulfil the criteria of the MR two-step approach and can be considered as potential mediators of the association between schizophrenia and psoriasis vulgaris. Pathway and functional enrichment analyses suggested the involvement of oxidative stress-driven hypothalamic-pituitary-adrenal (HPA) axis pathways in the link between schizophrenia and psoriasis.</p><p><strong>Conclusion: </strong>Our MR study established a significant association between schizophrenia and psoriasis vulgaris, identifying tenseness, tiredness, and misery as potential mediators. Pathway and functional enrichment analyses indicated that oxidative stress in the HPA axis may represent a shared mechanism underlying schizophrenia and psoriasis.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"25 1","pages":"264"},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}