BMC Psychiatry最新文献

{"title":"Relationships between empathy, executive functions, and internalizing and externalizing symptoms in early adolescents.","authors":"Onat Yetim, Resul Çakır, Lut Tamam","doi":"10.1186/s12888-024-06324-8","DOIUrl":"10.1186/s12888-024-06324-8","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have shown associations between internalizing and externalizing symptoms, executive functions, and empathy. However, the mechanisms that affect this relationship remain unclear. This study employed regression analysis to explore the relationships between empathy, executive functions, and internalizing and externalizing symptoms.</p><p><strong>Method: </strong>Our study consisted of three consecutive stages. In the first stage, we assessed 2150 adolescents' parents aged 10-12 using the Strengths and Difficulties Questionnaire to determine which participants should be included in the subsequent stages. In the second stage, we conducted a pilot study with 50 participants to assess the validity of the assessment system and the six film scenes to be used in the following stage. Finally, in the third stage, we obtained 170 participants' state empathy, trait empathy, and executive functioning.</p><p><strong>Results: </strong>The regression analysis showed that working memory (β = 0.261) and externalizing symptoms (β = -0.157) predicted cognitive empathy, but only externalizing symptoms predicted affective empathy (β = -0.193). The regression analysis also showed that cognitive empathy (β = -0.513) and affective empathy (β = -0.535) predicted externalizing symptoms, but only inhibition predicted internalizing symptoms (β = 0.158).</p><p><strong>Conclusion: </strong>This population-based study highlights the reciprocal effects of externalizing symptoms on cognitive and affective empathy. No significant relationship was found between internalizing symptoms and empathy. This study also highlights the effect of working memory on cognitive empathy. These findings may inform psychological interventions to improve empathic abilities in early adolescence.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"858"},"PeriodicalIF":3.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in suicide: age group and summer effects in the United States (2015-2020).","authors":"Samantha To, Erick Messias, Laura Burch, John Chibnall","doi":"10.1186/s12888-024-06309-7","DOIUrl":"10.1186/s12888-024-06309-7","url":null,"abstract":"<p><strong>Background: </strong>Suicide is a global public health concern that affects more than 700,000 people globally every year. Seasonal variation in suicide rates is a phenomenon that has been well-documented, but recent data on the seasonality of suicide within specific age groups and sex in the United States remains less well understood.</p><p><strong>Methods: </strong>Publicly available data on monthly suicides was obtained from the Underlying Cause of Death database, CDC WONDER, from 2015-2020. The incidence of summer suicides, from June, July and August, for two groups, 15-24 and ages 25 + , was calculated and a two-sided test was performed. Seasonal Decomposition analysis was performed and time series created from 2015-2020 for every age group then converted into Trend, Seasonality, and Residual respectively.</p><p><strong>Results: </strong>For Americans ages 15-24, the highest spike in suicides was in autumn, September-October, with a trough in June. This is the only age group in which this occurred, differing from previous understanding of the seasonality of suicide in the literature. With all other age groups (25-34, 35-44, 45-54, 55-64, 65-74, 75 +) there was a consistent pattern of a peak in late spring/early summer, a small peak in fall, and a trough in late winter.</p><p><strong>Conclusions: </strong>There is a seasonal variation in suicide deaths in the United States with the youngest group, ages 15-24, presenting a different pattern compared to other ages. There were no significant differences in suicide seasonality by sex.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"856"},"PeriodicalIF":3.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and factors associated with tramadol use among university students in Ghana: a cross-sectional survey.","authors":"Joseph Lasong, Yula Salifu, Jonas Assani Wa Mwenda Kakungu","doi":"10.1186/s12888-024-06230-z","DOIUrl":"10.1186/s12888-024-06230-z","url":null,"abstract":"<p><strong>Background: </strong>There are progressively alarming rates of non-medical use, addiction and possible dependence on tramadol in low-middle-income countries. Tramadol is known to heighten negative consequences on social interactions, physical and cognitive abilities among adolescents, students and youth, particularly those with polysubstance use. However, literature on the use of tramadol in low-middle-income countries, especially among undergraduate university students in Ghana remains inadequate. Thus, this study sought to determine the prevalence and factors associated with tramadol use among undergraduate students in Ghana.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study and a quota sampling technique were employed to gather data from January to March 2023 on 600 undergraduate students from the University for Development Studies, Tamale, Ghana and analyzed with SPSS (version 26.0). Multiple logistic regression model was used to identify factors associated with the use of tramadol (p-value ≤ 0.05).</p><p><strong>Results: </strong>The lifetime prevalence of tramadol use was 17.8%. Among those who used tramadol in their lifetime, 14.95% used tramadol alone whereas 85.05% used at least one substance alongside tramadol. The study recorded more females (67.8%) than males. Students aged 20-24 years (20.5%), those single/never married (18.7%), those renting/living alone (19.7%) and first year students (17.4%) accounted for the majority of groups at high risk of lifetime tramadol use. To improve academic performance was the primary reason for initiating tramadol use. Male sex (adjusted odds ratio [AOR] 2.673; 95% confidence interval [CI] 1.590-4.493; p < 0.0001) and those with lifetime cannabis use (AOR 2.137; 95%CI 1.267-3.604; p = 0.004) were significantly associated with lifetime tramadol use.</p><p><strong>Conclusions: </strong>This study revealed that lifetime tramadol use was high. Male sex and those with lifetime cannabis use were significantly related with lifetime tramadol use. The use of tramadol has become a public health threat and is important to limit its incidence and continuous use through extensive school and community health campaigns and strengthening of governmental policies against tramadol and other substance use since they increase the propensity of unwarranted cognitive, physical and social outcomes.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"853"},"PeriodicalIF":3.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote school instruction in Fall 2020 and psychiatric emergencies among adolescents in Los Angeles County.","authors":"Shutong Huo, Annie Ro, Senxi Du, Andrew Young, Tim A Bruckner","doi":"10.1186/s12888-024-06225-w","DOIUrl":"10.1186/s12888-024-06225-w","url":null,"abstract":"<p><strong>Objective: </strong>Schools play an essential role in providing mental health care for adolescents. School closures during COVID-19, as well as re-opening to remote-only instruction in Fall 2020, may indirectly affect the utilization of emergency psychiatric care. We examine COVID-19-related changes in emergency psychiatric care among youth during the school closure and after school reopening (with remote instruction).</p><p><strong>Methods: </strong>We use Box-Jenkins interrupted time series methods to analyze psychiatric emergency department (ED) visits among patients 10-19 years at LAC + USC Medical Center (LAC + USC) between January 5th, 2018, and December 31st, 2020. We control for the 1st societal shutdown in LA County (i.e., the nine weeks from March 13 to May 14, 2020) when analyzing the potential \"return to remote school\" shock.</p><p><strong>Results: </strong>Youth psychiatric ED visits fell by 15.3 per week during the Spring 2020 school closure (p < .05). The \"return to remote school\" coefficient (i.e., August 14th to September 10, 2020), by contrast, is positive but does not reach statistical detection above expected values (p = .11). However, the proportion of psychiatric ED visits rises 38% among youth during the \"return to remote school\" period (p = 0.006).</p><p><strong>Conclusion: </strong>The initiation of Fall 2020 remote instruction corresponded with a greater proportion of youth ED visits that are classified as psychiatric.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"854"},"PeriodicalIF":3.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating sex-related differences in brain structure and function in bipolar I disorder using multimodal MRI.","authors":"Ming-Yang Lee, Jun-Ding Zhu, Hsin-Jung Tsai, Shih-Jen Tsai, Albert C Yang","doi":"10.1186/s12888-024-06228-7","DOIUrl":"10.1186/s12888-024-06228-7","url":null,"abstract":"<p><strong>Background: </strong>Past research has highlighted that bipolar I disorder is associated with significant changes in brain structure and function. Notably, the manifestation and progression of bipolar I disorder have been known to differ between males and females. However, the relationship between sex-related differences and bipolar I disorder diagnosis affecting these changes was not fully understood. This study aimed to investigate the sex-by-diagnosis interactions concerning the structural and functional features of the brain in individuals with bipolar I disorder.</p><p><strong>Methods: </strong>Both structural and functional MRI data were obtained from 105 individuals with bipolar I disorder (36 males and 69 females) and 210 healthy controls (72 males and 138 females). Voxel-wise analyses of gray matter volume and functional connectivity were conducted using a general linear regression model. This model included age, sex, diagnosis, and a sex-by-diagnosis interaction as predictors to explore potential sex-related differences in the brain features of participants with bipolar I disorder.</p><p><strong>Results: </strong>The gray matter volume analysis revealed significant sex-by-diagnosis interactions in six brain regions: the left caudate (p < 0.001), left thalamus (p < 0.001), right caudate (p = 0.003), right thalamus (p < 0.001), left anterior cingulate gyrus (p = 0.022), and left middle/posterior cingulate gyrus (p = 0.015). Using these regions as seeds, we detected a significant sex-by-diagnosis interaction in the functional connectivity alteration between the left thalamus and right angular gyrus (p = 0.019).</p><p><strong>Conclusions: </strong>Our findings revealed a noteworthy sex-by-diagnosis interaction, with male individuals with bipolar I disorder displaying larger gray matter volume and altered functional connectivity in the limbic system compared to female individuals with bipolar I disorder and healthy participants. These results hint at potential sex-related differences in the pathophysiology of the limbic system in bipolar I disorder, which may have significant implications for understanding the underlying mechanisms in bipolar I disorder. Our findings could contribute to developing more personalized treatment approaches for individuals with bipolar I disorder.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"855"},"PeriodicalIF":3.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the connectivity of dorsolateral prefrontal cortex and the modulatory impact of transcranial magnetic stimulation in adolescents with depression: a focus on pain-related cognitive processing.","authors":"Dan Qiao, Yiran Li, Xiaoyu Zhang, Yujiao Wen, Xuemin Zhang, Lu Ma, Gaizhi Li, Chunxia Yang, Zhifen Liu","doi":"10.1186/s12888-024-06321-x","DOIUrl":"10.1186/s12888-024-06321-x","url":null,"abstract":"<p><strong>Background: </strong>Abnormal cognitive response to pain is consistently associated with deleterious outcomes among adolescents with depression. Highly relevant to both pain and cognition, dorsolateral prefrontal cortex (DLPFC) is important to understanding pain cognition. Our study aimed to characterize the circuit of DLPFC and the efficacy of transcranial magnetic stimulation (TMS) over DLPFC on pain cognition in adolescents with depression.</p><p><strong>Methods: </strong>Using neuroimaging data, we first compared functional connectivity (FC) of DLPFC between 60 adolescents with depression and 65 controls. The patients were then divided into add-on TMS group (N = 30) and Sertraline group (N = 30). Clinical outcome was determined using Pain Vigilance and Awareness Questionnaire (PVAQ) and Pain Catastrophizing Scale (PCS). Finally, we conducted regression analysis to assess the effect that FC of DLPFC contributes to in predicting clinical outcome.</p><p><strong>Results: </strong>FC analysis showed that compared to controls, patients displayed hyperconnection of left DLPFC - left triangular part of inferior frontal gyrus (IFG), which was significantly correlated with higher PCS total-, magnification- and helplessness-scores. Patients also showed hyperconnection of right DLPFC - right supramarginal gyrus (SMG), which was correlated with lower PCS total- and rumination- scores. After intervention, the add-on TMS group displayed significantly decreased score on PVAQ, PCS total and rumination. FC of left DLPFC - bilateral triangular part of IFG, - right SMG, as well as right DLPFC - left putamen, could predict the improvement of pain vigilance and magnification.</p><p><strong>Conclusion: </strong>Our results point to a key role of DLPFC acting as a connection linking cognitive control and pain processing in adolescents with depression.</p><p><strong>Trial registration: </strong>The study is registered in https://www.chictr.org.cn/ with a registration number ChiCTR2000039503 (date: 10.30.2020).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"852"},"PeriodicalIF":3.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between academic procrastination and anxiety symptoms among medical students during the COVID-19 pandemic: exploring the moderated mediation effects of resilience and social support.","authors":"Xinru Li, Yanyan Xu, Gen Li, Lingfang Ning, Xinyue Xie, Chunyu Shao, Chong Liu, Xiaoshi Yang","doi":"10.1186/s12888-024-06202-3","DOIUrl":"10.1186/s12888-024-06202-3","url":null,"abstract":"<p><strong>Background: </strong>Medical students have experienced increased anxiety symptoms during the pandemic of COVID-19. However, there is a paucity of investigation on the effect of academic procrastination, and personal resources (such as social support and resilience) on anxiety symptoms among this population.</p><p><strong>Objective: </strong>The main objective of this research was to evaluate the link between academic procrastination and anxiety symptoms among medical students during the pandemic of COVID-19 and clarify how resilience and social support mediate or moderate the relations between academic procrastination and anxiety symptoms.</p><p><strong>Methods: </strong>With a cross-sectional stratified sampling, 595 participants completed a self-administered questionnaire to assess anxiety symptoms and associated factors. The study used the Generalized Anxiety Disorder 7-item Scale (GAD-7 cutoff ≥ 10), the Academic Procrastination Scale (PASS), Connor Davidson Resilience Scale (CD-RISC),and Perception Social Support Scale for measurements.</p><p><strong>Results: </strong>The results of the study showed that 26.4% (157/595) of medical students exhibited symptoms of anxiety. Regression analysis revealed an inverse relationship between resilience, social support, and anxiety symptoms (β = -0.058, P < 0.05). As revealed by the analysis results, the study found a total effect of 0.338, a direct effect of 0.270, and resilience exhibited a mediating effect of 0.068. The direct effect (0.270) accounted for 79.59% of the total effect (0.338), while the mediating effect (0.068) contributed to 20.12% of the total effect (0.338). This further supports the role of psychological resilience in mediating the link between academic procrastination and anxiety symptoms.</p><p><strong>Conclusion: </strong>The study implies that promoting resilience may be an effective intervention to lessen the detrimental consequences of academic procrastination on anxiety symptoms, and social support might provide a defense against the negative influence of academic procrastination on anxiety symptoms.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"850"},"PeriodicalIF":3.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal stability of dynamic functional architecture in drug-naïve children with attention-deficit/hyperactivity disorder.","authors":"Shuangli Chen, Beihui Xue, Ronghui Zhou, Andan Qian, Jiejie Tao, Chuang Yang, Xiaoqi Huang, Meihao Wang","doi":"10.1186/s12888-024-06310-0","DOIUrl":"10.1186/s12888-024-06310-0","url":null,"abstract":"<p><strong>Background and aims: </strong>Attention-deficit/hyperactivity disorder (ADHD) is most commonly diagnosed neurodevelopmental disorder in childhood, characterized by developmentally inappropriate inattention and/or hyperactivity/impulsivity symptoms. Static and dynamic functional connectivity (FC) studies have revealed brain dysfunction in ADHD. However, few studies have estimated the stability of dynamic functional architecture of children with ADHD. The present study attempted to identify the functional stability (FS) abnormalities associated with ADHD in drug-naïve children.</p><p><strong>Materials and methods: </strong>The resting-state fMRI of 42 children with ADHD and 30 healthy controls (HCs) were collected. Using the sliding window approach, FS of each voxel was obtained by measuring the concordance of dynamic FC over time. Further, the seed based dynamic FC (dFC) was conducted to explore the specific brain regions with dFC alteration related to these brain regions with altered FS. Then, the inter-group comparison and correlation analysis were performed.</p><p><strong>Results: </strong>We found that children with ADHD exhibited (1) decreased FS in the bilateral superior frontal gyrus (SFG) and increased FS in the right middle temporal gyrus (MTG), which both belong to the default mode network (DMN); (2) increased dFC between the bilateral SFG of DMN and the left insula of salience networks (SN) (GRF, voxel-wise p < 0.001, cluster-wise p < 0.05); (3) decreased dFC between the right MTG and the left cerebellum posterior lobe, and (3) worse performance in the Stroop test that significantly correlate with decreased FS in the bilateral SFG (p = 0.043, FDR corrected).</p><p><strong>Conclusions: </strong>Our findings showed that the abnormal functional architecture involved the DMN (the bilateral SFG and right MTG) and SN (left insula) regions in children with ADHD. This preliminary study provides novel insight into the dynamic brain functional networks in ADHD.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"851"},"PeriodicalIF":3.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of undiagnosed attention-deficit/hyperactivity disorder among undergraduate medical students: a survey from Pakistan.","authors":"Hafsa Sabir, Misha Khan, Komal Imran, Zaib-Un Nisa, Samar A Amer","doi":"10.1186/s12888-024-06182-4","DOIUrl":"10.1186/s12888-024-06182-4","url":null,"abstract":"<p><strong>Background: </strong>Attention-deficit/hyperactivity disorder (ADHD) is now acknowledged as a significant public health concern, a persistent neurodevelopmental disorder. It poses challenges across various life domains, persisting into adulthood, and is often undiagnosed. From July 2023 to December 2023, this study investigated the prevalence, types, participants' knowledge and perceptions, and demographic determinants of undiagnosed adult ADHD among undergraduate medical students in Pakistan.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 342 undergraduate medical students who fulfilled the selection criteria. The data was collected using an online self-administered survey consisting of three main parts using the WHO 18-question Adult ADHD Self-Report Scale, Version 1.1 (ASRS-v1.1), to assess adult ADHD symptoms. Data analysis was conducted using SPSS (version 26.0).</p><p><strong>Results: </strong>119 medical students, or 34.8%, had adult ADHD. Inattentive dominance was the most prevalent presentation at (86, 72.3%), followed by mixed dominance at (20, 16.8%), and hyperactive dominance at (13, 10.9%). There was a statistically significant (p < 0.05) association between individuals who screened positive for adult ADHD and had co-occurring psychological disorders (e.g., anxiety, depression) and a family history of psychiatric disorders (e.g., ADHD, generalized anxiety disorder, bipolar disorder). Additionally, these individuals perceived that individuals with adult ADHD could live a normal life despite their condition. While the type of ADHD was significantly associated with the use of medications for psychological disorders, it was significantly higher among hyperactive dominants (5,71.4%), and the family history of GAD was significantly higher (2,10.0%) among mixed dominants.</p><p><strong>Conclusion: </strong>This study reveals a significant prevalence of undiagnosed adult ADHD and an inattentive dominance among medical students in Pakistan, highlighting gaps in awareness and screening. These findings emphasize the crucial need for implementing ADHD screening programs.</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"845"},"PeriodicalIF":3.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Neurocognitive Adaptive Training for Depression combined with SSRIs for treating cognitive impairment among patients with late-life depression: a 12-week, randomized controlled study.","authors":"Xiao Wang, Jiaojiao Zhou, Kemeng Zhu, Yida Wang, Xianglin Ma, Li Ren, Chengwei Guo, Zhanjun Zhang, Peng Lu, Qinge Zhang","doi":"10.1186/s12888-024-06276-z","DOIUrl":"10.1186/s12888-024-06276-z","url":null,"abstract":"<p><strong>Background: </strong>This randomized, open-label study examined the therapeutic effects of Neurocognitive Adaptive Training for Depression (NCAT-D) combined with selective serotonin reuptake inhibitors (SSRIs) on cognitive impairment among patients with late-life depression (LLD).</p><p><strong>Method: </strong>Study data were collected from May 5, 2021, to April 21, 2023. Outpatients who met the diagnostic criteria for major depressive disorder according to the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (i.e., a total score on the 17-item Hamilton Depression Rating Scale (HAMD-17) ≥ 18 and a total score on the Montreal Cognitive Assessment scale (MOCA) < 26) were recruited at Beijing Anding Hospital. These participants were randomly assigned to receive up to 12 weeks of NCAT-D and SSRIs treatment (n = 57) or SSRIs with a control treatment (n = 61). Primary outcomes included changes in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores from baseline to week 12 between the two groups. Assessments were conducted at baseline, after 2 weeks, 4 weeks, 8 weeks, and at 12 weeks. Mixed model repeated measures (MMRM) analysis was performed on modified intention-to-treat (mITT) and completer populations.</p><p><strong>Results: </strong>The full analysis set (FAS) included 118 patients (NCAT-D and SSRIs group, n = 57; SSRIs and Control group, n = 61). During the 12-week study period, MMRM analysis revealed a significantly greater reduction in cognitive function (as indicated by ADAS-cog total scores) from baseline to post-treatment in the NCAT-D and SSRIs group compared to the SSRIs and Control groups [(F (1,115) = 13.65, least-squares mean difference [95% CI]: -2.77 [- 3.73, - 1.81], p < 0.001)]. The intervention group showed a significantly greater reduction in HAMD-17 scores compared to the control group [MMRM, estimated mean difference (SE) between groups: -3.59 [- 5.02, - 2.15], p < 0.001]. There was no significant difference in the incidence of adverse events between the two groups.</p><p><strong>Conclusions: </strong>NCAT-D combined with SSRIs was efficacious and well tolerated in LLD patients with cognitive impairment.</p><p><strong>Trial registration: </strong>Registered on October 18, 2022, at ClinicalTrials.gov Identifier: (#NCT05588102).</p>","PeriodicalId":9029,"journal":{"name":"BMC Psychiatry","volume":"24 1","pages":"848"},"PeriodicalIF":3.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}