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The Evolution and Challenge of the Zika virus and its Uncharted Territory in the Neurological Realm. 寨卡病毒的演变和挑战及其在神经领域的未知领域。
Journal of neuroinfectious diseases Pub Date : 2016-06-01 Epub Date: 2016-05-16 DOI: 10.4172/2314-7326.1000215
Sneha Konda, Samantha Dayawansa, Jason H Huang
{"title":"The Evolution and Challenge of the <i>Zika virus</i> and its Uncharted Territory in the Neurological Realm.","authors":"Sneha Konda, Samantha Dayawansa, Jason H Huang","doi":"10.4172/2314-7326.1000215","DOIUrl":"10.4172/2314-7326.1000215","url":null,"abstract":"","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966672/pdf/nihms-804017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34611567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Texas Occurrence of Lyme Disease and Its Neurological Manifestations. 德克萨斯州莱姆病的发生及其神经学表现。
Journal of neuroinfectious diseases Pub Date : 2016-06-01 Epub Date: 2016-06-09 DOI: 10.4172/2314-7326.1000217
Jad A Dandashi, Damir Nizamutdinov, Samantha Dayawansa, Ekokobe Fonkem, Jason H Huang
{"title":"Texas Occurrence of Lyme Disease and Its Neurological Manifestations.","authors":"Jad A Dandashi,&nbsp;Damir Nizamutdinov,&nbsp;Samantha Dayawansa,&nbsp;Ekokobe Fonkem,&nbsp;Jason H Huang","doi":"10.4172/2314-7326.1000217","DOIUrl":"https://doi.org/10.4172/2314-7326.1000217","url":null,"abstract":"<p><p>Today, Lyme disease is the most commonly reported tick-borne disease in the United States and Europe. The culprits behind Lyme disease are the <i>Borrelia</i> species of bacteria. In the USA, <i>Borrelia burgdorferi</i> causes the majority of cases, while in Europe and Asia <i>Borrelia afzelii</i> and <i>Borrelia garinii</i> carry the greatest burden of disease. The clinical manifestations of Lyme disease have been identified as early localized, early disseminated, and late chronic. The neurological effects of Lyme disease include both peripheral and central nervous systems involvement, including focal nerve abnormalities, cranial neuropathies, painful radiculoneuritis, meningitis, and/or toxic metabolic encephalopathy, known as Lyme encephalopathy. Given the geographic predominance of Lyme disease in the Northeast and Midwest of the USA, no major studies have been conducted regarding Southern states. Between 2005 and 2014, the Center for Disease Control has reported 582 confirmed cases of Lyme disease in Texas. Because of the potential for increased incidence and prevalence in Texas, it has become essential for research and clinical efforts to be diverted to the region. The Texas A&M College of Veterinary Medicine and Biomedical Sciences Lyme Lab has been investigating the ecology of Lyme disease in Texas and developing a pan-specific serological test for Lyme diagnosis. This report aimed to exposure materials and raise awareness of Lyme disease to healthcare providers.</p>","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2314-7326.1000217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34611566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Idioventricular Rhythm in a Case of West Nile Encephalomyelitis 西尼罗河脑脊髓炎1例室性心律
Journal of neuroinfectious diseases Pub Date : 2016-05-02 DOI: 10.4172/2314-7326.1000214
R. Espinosa, Kimberly Schelb, Antonio Liu
{"title":"Idioventricular Rhythm in a Case of West Nile Encephalomyelitis","authors":"R. Espinosa, Kimberly Schelb, Antonio Liu","doi":"10.4172/2314-7326.1000214","DOIUrl":"https://doi.org/10.4172/2314-7326.1000214","url":null,"abstract":"Background: West nile virus (WNV), since its first appearance in the USA in 1999 has been a leading cause of viral encephalitis. There is one case report of associated fatal arrhythmia. Case: Presented is a 65 year old Hispanic male without significant past medical history presenting with West Nile Encephalomyelitis with subsequent quadriplegia and developed recurrent idioventricular rhythm requiring a permanent pacemaker. Conclusion: In the setting of West Nile Encephalomyelitis, cardiac monitoring for idioventricular rhythms and cardiac intervention should be considered.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79025462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Presumed Infectious Event in England and Wales during 2014 and 2015 Leading to Higher Deaths in those with Neurological and Other Disorders 2014年和2015年英格兰和威尔士推定的传染性事件导致神经和其他疾病患者的死亡率更高
Journal of neuroinfectious diseases Pub Date : 2016-04-30 DOI: 10.4172/2314-7326.1000213
Rodney P. Jones
{"title":"A Presumed Infectious Event in England and Wales during 2014 and 2015 Leading to Higher Deaths in those with Neurological and Other Disorders","authors":"Rodney P. Jones","doi":"10.4172/2314-7326.1000213","DOIUrl":"https://doi.org/10.4172/2314-7326.1000213","url":null,"abstract":"A recurring series of periods of unexplained higher deaths in those suffering from neurological conditions (Alzheimer’s, Dementia, Parkinson’s etc.) has been previously identified, and the effect of the 2012 event was investigated in some detail. Since that time, a seemingly similar event occurred in 2014, which exhibited all the characteristics of the previous events, namely, spatial spread of both deaths and medical admissions throughout the UK, deaths and admissions limited to a particular range of conditions, all of which endure for approximately 12 months before abating, and a parallel increase in NHS staff sickness absence - all of which are suggestive of an infectious aetiology. The trend observed at national level is greatly attenuated due to the unique kinetics of sub-national spread and duration of the event; however, despite this limitation a specific increase in neurological and other deaths can likewise be seen during the 2014 event. The 2014 event mainly initiated during the last half of 2014, and as such, the increased deaths only reflected half of the potential increase, although they were highly statistically significant. As before, the increase in deaths is condition, gender and age specific. In addition to those with existing neurological deaths, increased deaths were observed in those with cancer, congenital and perinatal conditions. A potential interaction between this agent and an influenza outbreak in January of 2015 appears to have led to additional effects against those with Alzheimer’s and dementia and a period of higher deaths inconsistent with the effects of influenza alone. The pattern of conditions most affected shows some evidence for common immune function aetiology, and the immune modifying virus cytomegalovirus may be in some way involved in these events, either as cause or via opportunistic reactivation.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75640879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Spinal Hansens with Pseudo Syringomyelitic Form 假性脊髓脊髓炎样脊髓hansen
Journal of neuroinfectious diseases Pub Date : 2016-04-30 DOI: 10.4172/2314-7326.1000212
S. Natuva, T. Sunanda, Venugopal Basam, Ganesh Vallampalli
{"title":"Spinal Hansens with Pseudo Syringomyelitic Form","authors":"S. Natuva, T. Sunanda, Venugopal Basam, Ganesh Vallampalli","doi":"10.4172/2314-7326.1000212","DOIUrl":"https://doi.org/10.4172/2314-7326.1000212","url":null,"abstract":"Spinal cord involvement is rare in leprosy but not unknown. We document an interesting case of a 56 year old male presented with progressive weakness of all four limbs with gross wasting of limb muscles and multiple painless trophic ulcers over the hands and legs. Examination revealed pan sensory loss in glove and stock distribution with suspended sensory loss for pain and temperature over the chest. Areflexia was noted in the upper limbs and brisk reflexes were present in the lower limbs. Generalized peripheral nerve thickening was noted. Leprosy was diagnosed and confirmed by nerve biopsy. Other causes of intra spinal lesions were excluded. This pseudo syringomyelitic from of leprosy is difficult to diagnose as it often mimics intra medullary spinal lesions.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82986373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Alzheimer's disease: a novel hypothesis for the development and the subsequent role of beta amyloid 阿尔茨海默病:β -淀粉样蛋白发展及其后续作用的新假设
Journal of neuroinfectious diseases Pub Date : 2016-04-25 DOI: 10.4172/2314-7326.1000211
H. Allen
{"title":"Alzheimer's disease: a novel hypothesis for the development and the subsequent role of beta amyloid","authors":"H. Allen","doi":"10.4172/2314-7326.1000211","DOIUrl":"https://doi.org/10.4172/2314-7326.1000211","url":null,"abstract":"Spirochetes, biofilms, innate immune system activity have all been recently found in the brains of Alzheimer's disease patients. The mechanism and actions of those entities in producing the disease were postulated in those studies. The production and role of beta amyloid were not included in the discussion; we hypothesize herein how the development of that molecule occurs as a result of the Toll-like receptor 2 activation leading not only to TNFα, but also NFκB which themselves have been previously shown to induce the secretases necessary to cleave the amyloid precursor protein. This leads directly to beta amyloid. The beta amyloid (Aβ) has been shown to be antimicrobial, and its presence on and around the hippocampal plaques (the pathological hallmark of Alzheimer's disease) has been demonstrated. It becomes apparent that the Aβ tries to kill the spirochetes but cannot penetrate the biofilm. Its buildup then interrupts and destroys the neurocircuitry of the brains.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82607056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Differences in IPS-1-Mediated Innate Immune Responses between Neurotrophic Flavivirus Infection 神经营养性黄病毒感染间ips -1介导的先天免疫应答差异
Journal of neuroinfectious diseases Pub Date : 2016-03-21 DOI: 10.4172/2314-7326.1000210
Loreen Zegenhagen, Chaitanya Kurhade, Andrea Kröger, Anna K Ãverby
{"title":"Differences in IPS-1-Mediated Innate Immune Responses between Neurotrophic Flavivirus Infection","authors":"Loreen Zegenhagen, Chaitanya Kurhade, Andrea Kröger, Anna K Ãverby","doi":"10.4172/2314-7326.1000210","DOIUrl":"https://doi.org/10.4172/2314-7326.1000210","url":null,"abstract":"Loreen Zegenhagen1,2*, Chaitanya Kurhade3, Andrea Kroger1,2 and Anna K Overby3 1Institute of Medical Microbiology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany 2Innate Immunity and Infection, Helmholtz Centre for Infection Research, Braunschweig, Germany 3Department of Clinical Microbiology, Virology, Umea University, Umea, Sweden *Corresponding author: Loreen Zegenhagen, Institute of Medical Microbiology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, Tel: 4953161815062; Fax: 0144380243; E-mail: Loreen.Zegenhagen@helmholtz-hzi.de","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85880577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Uncommon Strain for an Intracranial Infection: Bacillus Simplex as Suspected Cause of Brain Abscess 颅内感染的罕见菌株:单纯芽孢杆菌疑似引起脑脓肿
Journal of neuroinfectious diseases Pub Date : 2016-03-19 DOI: 10.4172/2314-7326.1000209
Aless, R. Pesce, G. Toccaceli, Giancarlo D Andrea
{"title":"Uncommon Strain for an Intracranial Infection: Bacillus Simplex as Suspected Cause of Brain Abscess","authors":"Aless, R. Pesce, G. Toccaceli, Giancarlo D Andrea","doi":"10.4172/2314-7326.1000209","DOIUrl":"https://doi.org/10.4172/2314-7326.1000209","url":null,"abstract":"Brain abscess is a serious life threatening condition. Leading causes include open head injury, history of neurosurgical procedure, dissemination from distant abscessual foci, sepsis, continuity spreading. Most common pathogens involved in genesis of brain abscesses are Streptococcus and Staphylococcus spp. depending on the pathogenetic mechanism. The aim of this study is to report a brain abscess sustained by Bacillus Simplex, a microorganism thought to be responsible of food-borne diseases, whose marginal role is recognized in human pathology, but in this case, for the first time in literature, described as suspected as cause of brain abscess.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91253429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Paralytic Rabies Misdiagnosed as Guillain-Barre Syndrome in a Guest Worker: A Case Report 外来工误诊为格林-巴利综合征的麻痹性狂犬病1例报告
Journal of neuroinfectious diseases Pub Date : 2016-03-19 DOI: 10.4172/2314-7326.1000208
R. Cohen, Frida Babushkin, Maurice Shapiro, Martina Uda, R. Willoughby, D. David
{"title":"Paralytic Rabies Misdiagnosed as Guillain-Barre Syndrome in a Guest Worker: A Case Report","authors":"R. Cohen, Frida Babushkin, Maurice Shapiro, Martina Uda, R. Willoughby, D. David","doi":"10.4172/2314-7326.1000208","DOIUrl":"https://doi.org/10.4172/2314-7326.1000208","url":null,"abstract":"Regev Cohen1,2*, Frida Babushkin1, Maurice Shapiro3, Martina Uda3, Rodney E Willoughby4 and Dan David5 1Infectious Diseases Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel 2Technion Israel Institute of Technology, Haifa, Israel 3Intensive Care Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel 4Medical College of Wisconsin, Milwaukee, WI, USA 5Rabies Laboratory, Kimron Veterinary Institute, Bet Dagan, Israel *Corresponding author: Regev Cohen, Infectious Diseases Unit, Sanz Medical Center, Laniado Hospital, Netanya, Israel, Tel: 9728609133; E-mail: regevco@gmail.com","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88136687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Safety of Prolonged Intraventricular Administration of Olistin Methanesulphonate 长时间脑室内给药奥利斯汀的安全性
Journal of neuroinfectious diseases Pub Date : 2016-03-18 DOI: 10.4172/2314-7326.1000207
Mairi Ziaka, D. Makris, S. Markantonis, E. Zakynthinos
{"title":"Safety of Prolonged Intraventricular Administration of Olistin Methanesulphonate","authors":"Mairi Ziaka, D. Makris, S. Markantonis, E. Zakynthinos","doi":"10.4172/2314-7326.1000207","DOIUrl":"https://doi.org/10.4172/2314-7326.1000207","url":null,"abstract":"Mairi Ziaka1, Demosthenes Makris1*, Sophia Markantonis2 and Epaminondas Zakynthinos1 1Critical Care Department, University Hospital of Larissa, Larissa, Greece 2Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Athens, Greece *Corresponding author: Demosthenes Makris, Department of Critical Care Medicine, University Hospital of Larissa,University of Thessaly School of Medicine, Biopolis, Larisa 41000, Greece, Tel: 302413502960; E-mail: dimomakris@med.uth.gr","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74547200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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