Journal of neuroinfectious diseases最新文献_第7页

The Cognitive Impairment of Elderly Living with Human Immunodeficiency Virus (HIV): A Cross-Sectional Study about the Role of Viral Neurotoxicity 老年人类免疫缺陷病毒(HIV)患者的认知障碍:病毒神经毒性作用的横断面研究

Journal of neuroinfectious diseases Pub Date : 2016-10-02 DOI: 10.4172/2314-7326.1000224

J. P. C. Diniz, U. Tupinambás, Ludimila Labanca, Sheila Melo Barbara, Oliveira Souza, Denise Utsch-Gonçalves

{"title":"The Cognitive Impairment of Elderly Living with Human Immunodeficiency Virus (HIV): A Cross-Sectional Study about the Role of Viral Neurotoxicity","authors":"J. P. C. Diniz, U. Tupinambás, Ludimila Labanca, Sheila Melo Barbara, Oliveira Souza, Denise Utsch-Gonçalves","doi":"10.4172/2314-7326.1000224","DOIUrl":"https://doi.org/10.4172/2314-7326.1000224","url":null,"abstract":"Aging with HIV has been associated with a higher frequency of neurocognitive disorders. The auditory evoked potentials P300 evaluate cognitive function. In a cross-sectional study, we analyzed the auditory cognition of elderly living with HIV through P300. We compared 34 HIV-infected elderly undergoing regular treatment to 76 HIV-negative elderly (controls) according to P300 latency and the scores of neuropsychological tests. The groups were stratified into age subgroups: 50 ≥ 59, 60 ≥ 69 and ≥70 years. Each age subgroup infected with HIV was compared to the age subgroup of controls immediately older. HIV group consisted of 20 (61%) men, mean age 61 ± 7 years and controls of 24 (32%) men, mean age 67 ± 4 years. Years of schooling were seven (interquartile range 4/8) in HIV group against four (4/11) in controls (p=0.044). P300 latency was similar between genders in the groups. P300 latency was 353 ± 35 ms in HIV group and 331 ± 29 ms in controls (p=0.006). In within-analysis, P300 latency augmented with the increase of age in HIV group (p=0.001) and remained stable in controls (p=0.252). In between-analysis, P300 latency was delayed in HIV subgroup 60 ≥ 69 as compared to controls ≥70 years (p=0.033) and delayed in HIV subgroup ≥70 years as compared to controls ≥70 years (p<0.001). In neuropsychological tests, HIV group presented poor performance in Nine Hole test (p=0.029) and correlation was found between an altered P300 and poor performance to execute the task with the dominant hand (p=0.043). We concluded that even under regular treatment, HIV infection may accelerate the cognitive impairment in the aging.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"32 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89534558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

How Do Viruses Really Cause Neuropathology?: Is There More to the Story 病毒是如何真正引起神经病理学的?:还有更多的故事吗

Journal of neuroinfectious diseases Pub Date : 2016-09-29 DOI: 10.4172/2314-7326.1000228

J. A. Hobbs, Hena Waseem

引用次数: 2

Cryptococcal Meningitis with Cerebral Herniation 隐球菌性脑膜炎伴脑疝

Journal of neuroinfectious diseases Pub Date : 2016-08-17 DOI: 10.4172/2314-7326.1000222

Wen-Liang Yu

引用次数: 1

HMGB1-TLR Signaling in Rasmussens Encephalitis HMGB1-TLR信号在拉斯穆森脑炎中的作用

Journal of neuroinfectious diseases Pub Date : 2016-08-12 DOI: 10.4172/2314-7326.1000223

Tianfu Li, Qing Gao, G. Luan

引用次数: 5

Natural Medicine for Management of Neuroinfectious Disease: An Interesting Topic 神经传染病管理的天然药物:一个有趣的话题

Journal of neuroinfectious diseases Pub Date : 2016-07-12 DOI: 10.4172/2314-7326.1000E106

V. Wiwanitkit

引用次数: 1

A Different Role of Metallothionein-3 (Mt3) in Oxidative Stress and Neurodegeneration of Brain 金属硫蛋白-3 (Mt3)在脑氧化应激和神经变性中的不同作用

Journal of neuroinfectious diseases Pub Date : 2016-06-30 DOI: 10.4172/2314-7326.1000221

Sook-Jeong Lee

引用次数: 6

Outbreak of Neuro-Chikungunya in Northeastern Brazil 巴西东北部神经基孔肯雅热暴发

Journal of neuroinfectious diseases Pub Date : 2016-06-11 DOI: 10.4172/2314-7326.1000218

H. A. Martins, S. N. Bernardino, K. Ribas, Camila Cordeiro dos Santos, Taciana Antunes, Valdenilson Ribeiro Ribas, M. Valença

引用次数: 12

Can Postcontrast-T2FLAIR be a Boon over Postcontrast-T1GRE Images in MR Brain Imaging? 磁共振脑成像中，t2flair造影优于t1gre造影吗?

Journal of neuroinfectious diseases Pub Date : 2016-06-06 DOI: 10.4172/2314-7326.1000219

R. Rastogi, S. Jain, Y. Gupta, P. Joon, A. Wani, Vijai Pratap

引用次数: 7

Novel Insights into the Role of Defensins in Virus-Induced Autoimmunity in the Central Nervous System 防御素在病毒诱导的中枢神经系统自身免疫中的作用的新见解

Journal of neuroinfectious diseases Pub Date : 2016-06-03 DOI: 10.4172/2314-7326.1000216

E. Kazakos, J. Kountouras, G. Deretzi

引用次数: 1

Neuropathology of Zika Virus Infection. 寨卡病毒感染的神经病理学。

Journal of neuroinfectious diseases Pub Date : 2016-06-01 Epub Date: 2016-06-23 DOI: 10.4172/2314-7326.1000220

Isaac H Solomon, Danny A Milner, Rebecca D Folkerth

{"title":"Neuropathology of Zika Virus Infection.","authors":"Isaac H Solomon, Danny A Milner, Rebecca D Folkerth","doi":"10.4172/2314-7326.1000220","DOIUrl":"10.4172/2314-7326.1000220","url":null,"abstract":"<p><p>Zika virus (ZIKV) is a member of the Flaviviridae family that had been associated only with mild disease prior to the 2015 outbreak in Brazil. A dramatic increase in reported cases of microcephaly and Guillain-Barré syndrome during this time prompted significant research into possible associations with ZIKV and its neurotropic properties. Infection of neural progenitor cells and organoids have been shown to induce apoptosis and dysregulation of growth, and mouse studies have demonstrated viral replication in brain tissue in adults, as well as vertical transmission resulting in embryonic brain abnormalities. Large case series of clinical and radiological findings of congenital ZIKV infection have begun to be published; however, pathology reports have been limited to two case reports and two small case series. Thus far, the findings have largely been restricted to the brain and include diffuse grey and white matter involvement consisting of dystrophic calcifications, gliosis, microglial nodules, neuronophagia, and scattered lymphocytes. Mild chronic villitis was observed in the placental tissue in some cases, and the remaining organs were essentially uninvolved. Larger, systematic studies, including correlation of histological findings with gestational age at the time of maternal infection, will be required to determine the full range of Zika virus-induced abnormalities and to help guide future clinical decision making.</p>","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34651687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0