Journal of neuroinfectious diseases最新文献_第6页

Nitrergic Myenteric Neurons are Spared in Experimental Chagasic Megacolon 实验性查加斯巨结肠中氮性肌群神经元的存活

Journal of neuroinfectious diseases Pub Date : 2016-12-23 DOI: 10.4172/2314-7326.1000235

Mayra Fern, A. Ricci, C. F. Campos, C. T. Cartelle, S. Béla, S. D. Cangussú, H. Santiago, C. Almeida-Leite, R. Arantes

{"title":"Nitrergic Myenteric Neurons are Spared in Experimental Chagasic Megacolon","authors":"Mayra Fern, A. Ricci, C. F. Campos, C. T. Cartelle, S. Béla, S. D. Cangussú, H. Santiago, C. Almeida-Leite, R. Arantes","doi":"10.4172/2314-7326.1000235","DOIUrl":"https://doi.org/10.4172/2314-7326.1000235","url":null,"abstract":"Chagas disease is a chronic disorder caused by the Trypanosoma cruzi protozoan. The infection causes alterations to the enteric nervous system such as megaesophagus and megacolon. There is evidence of denervation of myenteric ganglia. The intense parasitism of acute phase affects neuronal integrity but contrasts with the absence of parasites and the discreet inflammatory process of chronic phase, indicating a progressive injury mechanism that needs to be better understood in the megacolons. The potential selectivity of enteric neurons classes affected by the progression of the disease is not yet clear. Nitrergic neurons which co-localize other neurotransmitters represent the most common inhibitory neuron of the ENS. Recently a chronic stage of the Chagas disease was reproduced experimentally in a suitable murine model of megacolon. Considering the limitation of studying human intestine and the controversy on the pattern of nNOS involvement in chagasic megacolon, we decided to assess the nitrergic neurons in the myenteric plexus of mice. We used antibodies against structural protein gene product 9.5 (PGP 9.5) and functional neuronal nitric oxide synthase (n-NOS) at the acute and chronic phase of the disease to quantify myenteric ganglionar neurons in the colon of infected and non-infected mice. We found a reduction in the ganglionar number of neurons detected by anti-protein gene product 9.5 antibodies in colon from mice at the chronic stage. However, the number of nitrergic neurons per ganglia remained unchanged along the acute to phase chronic of the disease. Our findings indicate a long-term preservation of nitregic neurons detrimental to other classes of enteric in our model of experimental Chagas disease. We propose that differential loss of enteric neurons is at least one of the structural substrate for the development of the longterm morphfunctional changes that lead to the megacolon.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87727067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Neurotoxocariais: A Rare or Neglected Disease? 神经弓形虫病:罕见还是被忽视的疾病?

Journal of neuroinfectious diseases Pub Date : 2016-12-14 DOI: 10.4172/2314-7326.1000234

Aless, R. Nicoletti

引用次数: 1

The Etiological Diagnosis and Outcome in Patients of Acute Viral Encephalitis: A Prospective Observational Study at Tertiary Care Centre of North India 急性病毒性脑炎患者的病因诊断和预后:印度北部三级保健中心的前瞻性观察研究

Journal of neuroinfectious diseases Pub Date : 2016-11-30 DOI: 10.4172/2314-7326.1000233

Deepak Bhagch, V. Atam, S. Thadani, K. Sawlani, I. Atam, A. Thadani

{"title":"The Etiological Diagnosis and Outcome in Patients of Acute Viral Encephalitis: A Prospective Observational Study at Tertiary Care Centre of North India","authors":"Deepak Bhagch, V. Atam, S. Thadani, K. Sawlani, I. Atam, A. Thadani","doi":"10.4172/2314-7326.1000233","DOIUrl":"https://doi.org/10.4172/2314-7326.1000233","url":null,"abstract":"Background: Encephalitis, despite being an uncommon entity, is of public health importance worldwide because \u0000of its high morbidity and mortality. Around 70% of the disease burden is in Uttar Pradesh itself. \u0000Purpose of study: To study the etiological prevalence and outcome of different viruses as causative agent of \u0000acute viral encephalitis in patients reporting to a tertiary health care center in North India. \u0000Methods: All the patients presenting with febrile encephalopathy attending the medicine outdoor patient \u0000 department or emergency of medicine department were enrolled in the study, of these a total of 92 patients fulfilling \u0000 the inclusion criteria were included in the study. An informed consent from the patients/their attendants was \u0000obtained. \u0000Results: Minimum age of patients was found to be 14 years while maximum age was 61 years. Around 65.22% \u0000 were males and majority of the patients were from Barabanki (22.83%). Magnetic Resonance Imaging findings were \u0000 found to be positive in 85.87%. Most common etiology was Japanese encephalitis (38.04%) with human \u0000 immunodeficiency Virus encephalitis (3.26%) being least common. After a follow up at 1 month, neurological \u0000 sequelae were found to be highest in Japanese encephalitis while 100% mortality in human immunodeficiency virus \u0000 encephalitis and recovery was highest in Dengue encephalitis (85.00%). Difference in outcome of different types of \u0000 encephalitis was found to be statistically significant. Recovery was highest in age group up to 20 years (57.69%). \u0000Difference in outcome and age of patients was found to be statistically significant. \u0000Conclusion: Early Reporting, appropriate workup and stabilization of the suspected acute viral encephalitis \u0000patients are important so as to reduce the morbidity and mortality.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91313694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Serologic Indicators for Laboratory Diagnosis of Asymptomatic Neurosyphilis 探讨无症状神经梅毒血清学指标的实验室诊断

Journal of neuroinfectious diseases Pub Date : 2016-11-09 DOI: 10.4172/2314-7326.1000232

Weiming Gu, Yue Chen, Lei Wu, Yang Yang

{"title":"Exploring Serologic Indicators for Laboratory Diagnosis of Asymptomatic Neurosyphilis","authors":"Weiming Gu, Yue Chen, Lei Wu, Yang Yang","doi":"10.4172/2314-7326.1000232","DOIUrl":"https://doi.org/10.4172/2314-7326.1000232","url":null,"abstract":"Background: Diagnosis of asymptomatic neurosyphilis (NS) has been challenging. The gold standard for NS diagnosis relies on venereal disease research laboratory (VDRL) test of cerebrospinal fluids (CSF). The aim of this study was to examine criteria for lumbar puncture and CSF examinations in asymptomatic NS patients. \u0000Methods: One hundred and twenty-three syphilis inpatients were recruited, including 24 NS and 99 non-NS cases. NS diagnosis was based on hospital discharge. Clinical data were collected. Serological tests included Treponema pallidum particle agglutination assay (TPPA), the toluidine red unheated serum test (TRUST), and concentrations of serum IgG, IgA, IgM and albumin. Parameters of CSF examinations included reactivity of VDRL test and TPPA, white blood cell counts (WBC), levels of CSF IgA, IgG and IgM, levels of CSF albumin, total protein and glucose. \u0000Results: Neurologic manifestations were significantly associated with NS. The titres and reactivity of serum TRUST and TPPA, and the concentrations of serum IgG, IgA, IgM and albumin were not significantly different between NS and non-NS patients. In CSF, 95.8% NS patients were VDRL reactive, and all non-NS patients were VDRL non-reactive. Levels of CSF WBC, IgG, IgA, IgM, albumin and total protein were significantly higher in NS than non-NS patients. Levels of CSF glucose and chloride were not different between NS and non-NS patients. The indexes of IgG and IgM and the quotient of albumin were significantly higher in NS than in non-NS patients. Multiple logistic regression analysis revealed that among the CSF and non-CSF indicators only neurologic manifestations were significantly associated with NS. \u0000Conclusions: Neurologic manifestation was the only indicator significantly associated with NS. Serologic parameters seem not sensitive laboratory indicators for diagnosis of NS.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76129718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Transcranial Magnetic Stimulation Therapy in Spastic Cerebral Palsy Children Improves Motor Activity 经颅磁刺激治疗痉挛性脑瘫儿童改善运动活动

Journal of neuroinfectious diseases Pub Date : 2016-11-05 DOI: 10.4172/2314-7326.1000231

Meena Gupta, B. Rajak, D. Bhatia, A. Mukherjee

{"title":"Transcranial Magnetic Stimulation Therapy in Spastic Cerebral Palsy Children Improves Motor Activity","authors":"Meena Gupta, B. Rajak, D. Bhatia, A. Mukherjee","doi":"10.4172/2314-7326.1000231","DOIUrl":"https://doi.org/10.4172/2314-7326.1000231","url":null,"abstract":"Transcranial magnetic stimulation (TMS) is a new interventional tool used in the study of neuronal activity and treatment of psychiatric disorders. Repetitive TMS (rTMS) is a non-invasive technique of stimulating the brain employing magnetic pulses. Recent research has demonstrated the efficacy of rTMS in facilitating motor functions. Using these evidences, we studied the effectiveness of rTMS in improving motor activity in spastic cerebral palsy (CP) children. CP is a neuro-developmental disorder of movement and posture that is caused by injury to the developing brain that restrict activities of daily living. In the quest to treat CP, several interventions are used among which physical therapy is the mainstay therapy. In this study, we selected 45 spastic CP children and divided them randomly into three groups-the reference group (RG) that was provided only physical therapy (PT) for 30 minutes daily for 20 days; the interventional group (IG) that was administered rTMS frequency of 5Hz (IG-A) and 10Hz (IG-B) for 15 minutes (1500 pulses) daily followed by PT as in RG. Gross motor function measure (GMFM) was used as assessment tool to evaluate the motor performance. Prior to start of therapy, pre-assessment of GMFM was performed on all participants and post assessment after completion of 20 sessions. The result was statistically significant in all three groups (p<0.001) and the mean change demonstrated 0.64%, 1.75% and 2.59% improvement in motor activity among participants in RG, IG-A and IG-B respectively. The study demonstrated positive effect of rTMS in improving motor activity when combined with PT.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74335913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

West Nile Virus Infections in (European) Birds (欧洲)鸟类中的西尼罗河病毒感染

Journal of neuroinfectious diseases Pub Date : 2016-10-24 DOI: 10.4172/2314-7326.1000226

P. Koraka, L. Barzon, B. Martina

引用次数: 4

Risk of Reactivation of Latent HBV Hepatitis in Patients Under Neurosurgical Treatment 神经外科治疗患者潜伏性HBV肝炎再激活的风险

Journal of neuroinfectious diseases Pub Date : 2016-10-20 DOI: 10.4172/2314-7326.1000230

Y. Ogawa, T. Tominaga

引用次数: 1

Triptolide Protects Neurons from Endoplasmic Reticulum Stress-Mediated Apoptosis in Cerebral Ischemic Injury Rats 雷公藤甲素保护脑缺血损伤大鼠内质网应激介导的神经元凋亡

Journal of neuroinfectious diseases Pub Date : 2016-10-17 DOI: 10.4172/2314-7326.1000229

Yingchao Su, Zhang Benping, M. Yihong, San Yongzhi, Q. Jun, Chunhua Liu, Senlin Mao, Mingjie Li, Pengwei Wang, Li Feng

{"title":"Triptolide Protects Neurons from Endoplasmic Reticulum Stress-Mediated Apoptosis in Cerebral Ischemic Injury Rats","authors":"Yingchao Su, Zhang Benping, M. Yihong, San Yongzhi, Q. Jun, Chunhua Liu, Senlin Mao, Mingjie Li, Pengwei Wang, Li Feng","doi":"10.4172/2314-7326.1000229","DOIUrl":"https://doi.org/10.4172/2314-7326.1000229","url":null,"abstract":"This study aimed to investigate the neuroprotective effect of Triptolide (T10) on cerebral ischemia/reperfusion \u0000 (I/R) injury and explore the underlying mechanisms. Adult male Sprague-Dawley rats were treated with T10 and \u0000 subjected to middle cerebral artery occlusion (MCAO) for 90 min. Neurological deficits and infarct volume were \u0000 measured 24 h after reperfusion. ER stress-mediated proteins, ryanodine receptors (RyRs), cysteinyl aspartate \u0000 specific proteinase 8 (Caspase-8), Fas-associated death domain (FADD) and C/EBP homologous protein (CHOP) \u0000 were evaluated 1, 4, and 24 h after reperfusion. Pretreatment with 1 mg/kg of T10 significantly reduced infarct \u0000 volume and neurological deficits. Further, TUNEL staining demonstrated T10 significantly decreased neuronal \u0000 apoptosis in the peri-infarct area after reperfusion. More importantly, T10 prevented ER stress-mediated expression \u0000 of RyR, FADD, caspase-8 and CHOP in the peri-infarct area of rats. These results indicate that T10 attenuates the \u0000 ER stress-induced apoptosis in cerebral I/R injury and suggest that T10 is a promising agent for the treatment of \u0000 ischemic stroke.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"32 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2016-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83959768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primate Erythroparvovirus 1 (Parvovirus B19): An Etiologic Agent of Ataxia and Cerebellar Disease? 灵长类红细小病毒1(细小病毒B19):共济失调和小脑疾病的病原?

Journal of neuroinfectious diseases Pub Date : 2016-10-03 DOI: 10.4172/2314-7326.1000227

J. A. Hobbs, Hena Waseem

引用次数: 0

Unusual Pyogenic Meningitis Masquerading as Leukodystrophy 伪装成脑白质营养不良的异常化脓性脑膜炎

Journal of neuroinfectious diseases Pub Date : 2016-10-02 DOI: 10.4172/2314-7326.1000225

R. Rastogi, S. Jain, Y. Gupta, P. Joon, A. Wani, Vijai Pratap

引用次数: 0