Journal of neuroinfectious diseases最新文献

The Blood-Brain Barrier and Bioenergetics in Stroke 脑卒中的血脑屏障和生物能量学

Journal of neuroinfectious diseases Pub Date : 2021-07-01 DOI: 10.4172/2314-7326.1000298

Emily A. Hone, Sajad Sarvari

引用次数: 0

Nodding Syndrome – An Investment Case for Global Health? 点头综合症——全球健康的投资案例?

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000273

A. Winkler, E. Schmutzhard, C. Årdal, P. Spencer

{"title":"Nodding Syndrome – An Investment Case for Global Health?","authors":"A. Winkler, E. Schmutzhard, C. Årdal, P. Spencer","doi":"10.4172/2314-7326.1000273","DOIUrl":"https://doi.org/10.4172/2314-7326.1000273","url":null,"abstract":"Nodding syndrome represents a complex encephalopathy in previously healthy children and adolescents that occurs in hot spots of South Sudan, northern Uganda and southern Tanzania. The core feature of this neurological disorder is a repetitive forward bobbing of the head towards the chin of a variable length of time associated with other features such generalized epileptic seizures, psychiatric symptoms/signs, stunted growth, wasting and reduced sexual development, among others. The etiology of this neuropediatric disorder so far has remained obscure, but there seems to be some evidence in support of a post-measles disorder as well as an involvement of the parasite Onchocerca volvulus which can cause skin and eye disease (river blindness). While discussing potential etiology and pathogenesis of nodding syndrome, we also explore reasons while funding for research on nodding syndrome has been so scarce and compare it to other similarly neglected diseases. Furthermore, we discuss the inclusion of nodding syndrome in the WHO list of neglected tropical diseases with the aim of creating a disease specific lobby, thereby supporting financing and collaboration on research and development for nodding syndrome. In the last paragraph we examine a global health approach to nodding syndrome via the sustainable development goals and conclude that by investing in some of the goals concerning health, poverty alleviation and quality education, among others, individuals suffering from nodding syndrome and their families may derive clear benefits which eventually can lead to an overall reduction in morbidity and mortality. However, other diseases will also benefit from employment of the sustainable development goals and therefore awareness of nodding syndrome needs to be raised, so that it will not be forgotten.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"10 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87487010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Potential Pitfalls in the Diagnostic Criteria for Neurocysticercosis: Are Mimmicks Common? 神经囊虫病诊断标准的潜在缺陷:拟态是否常见?

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000279

Ildefonso Rodríguez-Leyva, F. Cortes-Enríquez, Juan Francisco Hernández-Gómez

引用次数: 0

Rare Presentations of CNS Melioidosis - An Institutional Experience 罕见的中枢神经系统类鼻疽的表现-一个机构的经验

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000278

S. Ganapathy, R. Nair, Vinod Kumar

引用次数: 2

Atypical Base of Skull Osteomyelitis Presenting as Bilateral Facial Palsy 不典型颅底骨髓炎表现为双侧面瘫

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000282

S. Ibrikji, Halabi Te, J. Salameh

引用次数: 0

Alzheimer’s Disease:Intracellular Beta Amyloid Completes the Irreversible Pathway from Spirochetes to Biofilms to Beta Amyloid to Hyperphosphorylated Tau Protein 阿尔茨海默病:细胞内β -淀粉样蛋白完成了从螺旋体到生物膜到β -淀粉样蛋白到过度磷酸化Tau蛋白的不可逆途径

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000276

H. Allen, R. Allawh, C. Cusack, S. Joshi

{"title":"Alzheimer’s Disease:Intracellular Beta Amyloid Completes the Irreversible Pathway from Spirochetes to Biofilms to Beta Amyloid to Hyperphosphorylated Tau Protein","authors":"H. Allen, R. Allawh, C. Cusack, S. Joshi","doi":"10.4172/2314-7326.1000276","DOIUrl":"https://doi.org/10.4172/2314-7326.1000276","url":null,"abstract":"In this histopathological study, we have identified beta amyloid (Aβ) intracellularly in hippocampal specimens of Alzheimer’s disease (AD) patients. This is a continuation of the same histopathological project in which we observed biofilms intracellularly in the same neuronal cells in the same brain samples. To demonstrate that these were intracellular biofilms, we utilized the same techniques that showed biofilms in senile plaques in AD, in occluded eccrine ducts in atopic dermatitis, and in tonsils of psoriasis patients. Lyme spirochetes have recently been cultured from AD brains, and those same cultivated organisms have been shown in vitro to make biofilms, beta amyloid precursor protein (AβPP), and Aβ. We believe these spirochetes (and others) make the in vivo biofilms, and we believe our finding of intracellular Aβ helps confirm the in vitro observations. The Aβ, in turn, has previously been shown to stimulate the production and accumulation of hyperphosphorylated tau protein which has been shown to result in axonal and dendritic disintegration. With neuronal cell deterioration, the biofilms, AβPP, Aβ, and neurofibrillary tangles that were once inside are now present outside the cells. Once in the tissue, biofilms lead to upregulation of Toll-like receptor 2 (TLR2) which by known pathways leads to further production of Aβ. Thus, the Aβ can be derived from two sources: one is the spirochetes themselves and the other is from the activation of the innate immune system. The two major components of AD (tau protein and Aβ) have consequently been shown to be created by the pathogenic spirochetes. The spirochetes themselves have been shown to be of Lyme disease and dental origin.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"29 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72947019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Follow-Up MR and MRS Studies in Herpes Simplex Encephalitis 单纯疱疹脑炎的MR和MRS随访研究

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000281

Z. Tyrakowska-Dadełło, E. Tarasów, Anna M. Moniuszko-Malinowska, Sawomir Pancewicz, J. Zajkowska

引用次数: 0

Neurocysticercosis and Epilepsy: A Review 神经囊虫病与癫痫:综述

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000280

L. M. Machado, F. M. Oliveira, A. P. Oliveira

引用次数: 0

Tetanus Presented as Hemiparesis and Facial Dystonia 破伤风表现为偏瘫和面部肌张力障碍

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000272

J. Dulski, M. Schinwelski, M. Dubaniewicz, J. Sławek

{"title":"Tetanus Presented as Hemiparesis and Facial Dystonia","authors":"J. Dulski, M. Schinwelski, M. Dubaniewicz, J. Sławek","doi":"10.4172/2314-7326.1000272","DOIUrl":"https://doi.org/10.4172/2314-7326.1000272","url":null,"abstract":"We report a case of tetanus presenting as the facial dystonia and hemiparesis with complete recovery and video accompanied follow-up. A 78-year-old male, who sustained an abrasion to his right forearm, presented with dysarthria, dysphagia, prominent involuntary painful muscle spasms in the face, blepharospasm, risus sardonicus, trismus (lockjaw), neck muscle rigidity and mild weakness of the distal right upper extremity. The combined treatment of human antitetanus immunoglobulin, tetanus vaccine, penicillin, metronidazole and diazepam were given with no effect. He continued to worsen and due to the risk of the respiratory failure (finally not developed) he was sent to the Intensive Care Unit. The combined treatment was continued, and his symptoms started to improve within 2 weeks. As the muscle rigidity has been improving, the patient developed significant right hemiparesis. The imaging of the brain and cervical spine found no significant pathology. At the follow-up visits the patient presented only slightly impaired dexterity of the right hand that gradually resolved. There are many reports of unusual presentations of tetanus, however, hemiparesis is uncommon, and to our knowledge, only one case was reported in the literature. We highlight the variability of clinical presentation of tetanus, the need to consider tetanus in cases of rapidly evolving muscle spasms following peripheral injuries and provide the guidelines on tetanus prophylaxis.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"113 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79400679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Intraoperative Use of Vancomycin Powder Increase the Risk of Gram-Negative Infections? 术中使用万古霉素粉剂会增加革兰氏阴性感染的风险吗?

Journal of neuroinfectious diseases Pub Date : 2018-01-01 DOI: 10.4172/2314-7326.1000274

H. Aliabadi, A. Nikpour, B. BarryChehrazi

引用次数: 0