Journal of neuroinfectious diseases最新文献

{"title":"Epidemiological and Evolutionary Aspects of Streptococcus pneumoniae Meningitis in Burkina Faso","authors":"Savadogo Mamoudou, Napon Christian, B. M. Boushab, Zaongo Abraham, Kyéleme Nicole","doi":"10.4172/2314-7326.1000206","DOIUrl":"https://doi.org/10.4172/2314-7326.1000206","url":null,"abstract":"Aim: Pneumococcal meningitis remains a public health problem in Burkina Faso. The aim of our study was to describe the epidemiological and evolutionary aspects of pneumococcal meningitis. Patients and Methods: It was about a retrospective and descriptive study of the records of patients hospitalized for pneumococcal meningitis in the department of infectious diseases at CHU-YO, Burkina Faso during the period going from January 1st 2000 to December 31st 2014. Results: In 15 years, 318 cases were collected, representing a proportional morbidity of 5%. The sex ratio M/F was 1.2 and the average age was 24 years [44 days-70 years]. The majority (91%) of patients were from suburban areas of the city of Ouagadougou. Housewives, farmers and students were the most affected with 23%, 10% and 9%. The annual peaks of meningitis cases were recorded between January and April, which corresponds to the dry season. The evolution was fatal in 39.62%. The frequency of pneumococcal meningitis at CHU-YO remains relatively high with a heavy lethality. Hence the need to promote pneumococcal vaccination and strengthen the technical platform for an appropriate treatment of cases.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88517703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of the Insect-Specific Flavivirus Chaoyang in Mosquitoes in the Jewish Autonomous Region of the Far East of Russia","authors":"N. M. Pukhovskaya, N. Vysochina, S. V. Bakhmetyeva, N. Zdanovskaya, N. B. Belozerova, L. Ivanov, O. Morozova","doi":"10.4172/2314-7326.1000205","DOIUrl":"https://doi.org/10.4172/2314-7326.1000205","url":null,"abstract":"Pukhovskaya NM1, Vysochina NP1, Bakhmetyeva SV1, Zdanovskaya NI1, Belozerova NB1, Ivanov LI1 and Morozova OV2,3* 1Khabarovsk Antiplague Station Rospotrebnadzor, Khabarovsk, Russia 2Federal Research Center of Epidemilogy and Microbiology of N.F. Gamaleya, D.I. Ivanovsky Institute of Virology, Russia 3Federal Research Clinical Center of Physico-Chemical Medicine of the Federal Medical and Biological Agency of the Russian Federation, Russia *Corresponding author: Dr. Olga V Morozova, Federal Research Center of Epidemilogy and Microbiology of N.F. Gamaleya, D.I. Ivanovsky Institute of Virology, 16 Gamaleya Street, Moscow, Russia, Tel: 79164212628; E-mail: omorozova2010@gmail.com","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81706693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creutzfeldt-Jakob Disease and Hashimotos Thyroiditis: A Case Report Illustrating Prion-Induced Encephalitis","authors":"Luis Dabul, Gerardo F. Ferrer, Su-Jun Oh, J. Oms, M. Sanchez-Gonzalez, Rhaisa Dumenigo","doi":"10.4172/2314-7326.1000204","DOIUrl":"https://doi.org/10.4172/2314-7326.1000204","url":null,"abstract":"Sporadic creutzfelt-Jakob disease (sCJD) is a rare neurodegenerative disorder and the most common type of the prion diseases that affects humans. Its clinical manifestations are progressive dementia, myoclonus, visual or cerebellar disturbances, pyramidal dysfunction, and akinetic mutism. Laboratory findings include high levels of the 14-3-3 protein in cerebrospinal fluid and Electroencephalogram with periodic spikes at ≈ 1 Hz. We present a 51- year-old Hispanic woman with Hashimoto’s thyroiditis and a 1-year history of depression who developed rapidly progressive dementia. She required extensive diagnostic examinations and eventually was diagnosed with sCJD based on the World Health Organization diagnostic criteria. Real-time quaking-induced conversion (RT-QuIC) was positive, and thyroid peroxidase antibodies (TPO-AB) (2391 IU/ml) and 14-3-3 protein (3.8 ng/ml) were elevated. Her key findings included rapidly progressive dementia, ataxia, akinetic mutism, myoclonus, rigidity, visual disturbance, EEG (Electroencephalogram) with periodic sharp wave complexes at 1 Hz, and normal head CT scans. She progressively worsened and died 3 months after the onset. In sum, patients with CJD and Hashimoto’s thyroiditis should be (i) evaluated for autoimmune encephalitis, (ii) screened for a rise in TPO antibodies, and (iii) steroids administration should be considered as adjuvant therapy. This case illustrates a prion disease mediated immune system modulation which we believe is a potential underlying mechanism by which the 14-3-3 protein induces a steroid non-responsive autoimmune encephalitis.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86487282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Embolic Infarcts from Alcaligenes Faecalis Meningitis: A Case Report","authors":"A. Prasad, S. Anwer, C. Martínez","doi":"10.4172/2314-7326.1000203","DOIUrl":"https://doi.org/10.4172/2314-7326.1000203","url":null,"abstract":"A 44 y/o gentleman with past medical history of possible seizures not on any anti-epileptics came to the Emergency Department with headache, fever and confusion for the past two to three days. CT head did not reveal any acute intracranial process. The patient’s labs showed leukocytosis with count of 20.6 and left shift. Soon after presentation, he had a witnessed generalized tonic, clonic seizure lasting 30 seconds. The patient was intubated for airway protection, placed on ASV ventilation mode and sedated with propofol. The patient was loaded with 1 gm of Levatiracetam and admitted to the Neuro-ICU service for further management.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73843077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological Complications of Novel Influenza A (H1N1) pdm09 Infection: Report of Two Cases and a Systematic Review of the Literature","authors":"H. Algahtani, B. Shirah, S. Alkhashan, Raafat Ahmad","doi":"10.4172/2314-7326.1000201","DOIUrl":"https://doi.org/10.4172/2314-7326.1000201","url":null,"abstract":"Background: Neurological complications of Influenza A (H1N1) pdm09 in adults are rarely reported in the literature. The aim of this study is to report a case of Influenza A (H1N1) pdm09 acute necrotizing encephalitis (ANE) and another case of acute hemorrhagic leukoencephalopathy (AHLE) and to review the neurological complications of this disorder in adults. Methods: We conducted a search on Medline, Ovid, EMBASE, ProQuest and PubMed databases using the key words (neurological complications of H1N1 in adults). We also added to the search results those articles which were not found in the search but exist in the literature under different search words. Only papers written in English published from March 2009 to December 2015 were included. Demographic data and clinical diagnosis of neurological complications and outcomes in adults including death, neurological sequalea or recovery after influenza A (H1N1) pdm09 infection have been reviewed. Results: we included 37 articles presenting a total of 261 adult patients with neurologic complications following Influenza A (H1N1) pdm09 infection. In addition, a case of influenza A (H1N1) pdm09 acute necrotizing encephalitis (ANE) and another case of acute hemorrhagic leukoencephalopathy (AHLE) arising from our own neurological practice were also included. Conclusion: In conclusion, this study demonstrates that influenza A (H1N1) pdm09 is both a pandemic and a seasonal (sporadic) disease. We speculate that most of the neurological complications are immune mediated and calling for further studies to test for the potential benefits of early steroids use in the disease. We are calling for an international collaboration and registry for Influenza A (H1N1) pdm09 infection.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86975610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidative and Anti-Inflammatory Potentials of Ambroxol in Ameliorating Vincristine Induced Peripheral Neuropathic Pain in Rats","authors":"Bhardwaj Hc, A. Muthuraman, Hari Ksl, S. Navis","doi":"10.4172/2314-7326.1000202","DOIUrl":"https://doi.org/10.4172/2314-7326.1000202","url":null,"abstract":"The present study was designed to investigate the ameliorative potential of Ambroxol, a voltage gated sodium channel 1.8 (VGSC 1.8) inhibitor in Vincristine induced neuropathic pain in rats. Administration with Vincristine (75 μg/mg, intraperitoneal) for 10 consecutive days induces neuropathic pain. Hyperalgesia and allodynic symptoms were assessed with various behavioral models i.e., paw thermal-heat hyperalgesia, tail cold hyperalgesia and paw cold allodynia via hot-plate test, cold-water tail immersion test and acetone drop test at different time intervals of 0,1,7,14, and 21 days. Oxidative stress markers i.e., thio-barbituric acid reactive substances, superoxide anion content and inflammatory mediators like tumor necrosis factor-alpha and myeloperoxidase were biochemically assessed from sciatic nerve tissue and surrounding muscular tissue homogenates respectively. Pharmacological cotreatments with Ambroxol (1000 mg/kg, per oral), Carbamazepine (100 mg/kg, per oral) and combination of Ambroxol with Pregabalin (10 mg/kg, per oral) for 14 days, significantly ameliorate the Vincristine induced neuropathic pain in terms of attenuating paw thermal hyperalgesia, tail-cold hyperalgesia and paw cold allodynia along with decrease in oxidative stress markers and inflammatory mediators. Therefore, on the basis of data in hand from present study, it has been concluded that Ambroxol have neuroprotective potential in ameliorating Vincristine induced neuropathic pain in rats.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74922020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke in a Young Patient: A Sentinel Presentation of Neurosyphilis and Human Immunodeficiency Virus (HIV)","authors":"S. Cutting, E. Flaherty","doi":"10.4172/2314-7326.1000197","DOIUrl":"https://doi.org/10.4172/2314-7326.1000197","url":null,"abstract":"Objective: To describe a case of ischemic stroke in a young patient leading to diagnosis of concomitant neurosyphilis and HIV infections. Background: Meningovascular syphilis is an early manifestation of neurosyphilis which can lead to an infectious endarteritis (Heubner’s arteritis) and subsequent ischemic stroke. In the present era, early neurosyphilis is most frequently seen in patients with concomitant HIV infection and previous series have demonstrated that neurosyphilis a common sentinel presentation of HIV. However, clinicians may fail to inquire about at-risk behaviors and test for these infections in young stroke patients. Methods: Case report of a young patient with multifocal ischemic stroke admitted to our institution. Results: A 19 year-old male with a history of migraine headaches, worsened over several months, presented to a community hospital after awakening with left sided hemiplegia, numbness, and slurred speech. MRI brain revealed multifocal ischemic stroke in the middle cerebral artery territory and right cerebellum. After an unrevealing initial workup, he was transferred to our academic facility for further investigation. Cerebral angiogram revealed focal areas of high-grade stenosis affecting multiple vessels, and delayed filling of the intracranial circulation suggestive of vasculitis. Serum RPR was reactive, and the cerebrospinal fluid (CSF) profile showed a neutrophilic pleocytosis, with reactive CSF VDRL. HIV testing sent on admission was positive. The patient disclosed a history of unprotected sexual relationships with multiple male partners. He did not have a personal history of sexually transmitted infections, nor was he aware of previous infected partners. Conclusions: Neurosyphilis should be a diagnostic consideration in young patients with ischemic stroke. Clinicians should also be aware of the high incidence of concomitant syphilis and HIV in at-risk populations. Effort should be made to inquire about high-risk behaviors and initiate testing for these infections early in the diagnostic workup to avoid missing these crucial diagnoses.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76665376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Management in Dentistry: A Review and Update","authors":"S. Patil","doi":"10.4172/2314-7326.1000199","DOIUrl":"https://doi.org/10.4172/2314-7326.1000199","url":null,"abstract":"Pain management has progressed a great deal scientifically throughout the last century, in large part as a result of the introduction of the more effective pharmacologic agents and the developmental of a better understanding of the molecular principles that govern their use. There is still a great deal for researches and practitioners to learn about the mechanism and treatments for pain. This review article will discuss regarding the important aspects of the pain control in dentistry.","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74900103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 20-Year-Old Woman with Stenosis and Dilations of the Biliary Tree","authors":"I. Franceschet, N. Cazzagon, R. Motta, A. Floreani","doi":"10.4172/2314-7326.1000196","DOIUrl":"https://doi.org/10.4172/2314-7326.1000196","url":null,"abstract":"Copyright: © 2016 Franceschet I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. A 20-Year-Old Woman with Stenosis and Dilations of the Biliary Tree Irene Franceschet1, Nora Cazzagon1, Raffaella Motta2 and Annarosa Floreani1* 1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy 2Department of Medicine, University of Padova, Padova, Italy","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88890246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic Meningits: A Review","authors":"Saumya H Mittal, S. Mittal, Tuhina Govil","doi":"10.4172/2314-7326.1000198","DOIUrl":"https://doi.org/10.4172/2314-7326.1000198","url":null,"abstract":"Copyright: © 2016 Mittal S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Eosinophilic Meningits: A Review Saumya Mittal1*, Salony Mittal2 and Tuhina Govil3 1Department of Neurology, KMC Hospital, Mangalore, India 2Department of Pathology, KMC University, Mangalore, India 3Children’s Hospital of Michigan, Detroit Medical Centre, Detroit, USA","PeriodicalId":89982,"journal":{"name":"Journal of neuroinfectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73065111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}