International Journal of Ophthalmic Pathology最新文献

{"title":"Xeroderma Pigmentosum- Diagnosis and Treatment of Two Different Ocular Tumors in Eyelid and Conjunctiva","authors":"Hoehr Gc, Vesanterä Fr, Biselli Lg, Selegatto Lt, Batalha Cp, Alves Lp, Sobrinho Mva, Pereira Ic","doi":"10.4172/2324-8599.1000220","DOIUrl":"https://doi.org/10.4172/2324-8599.1000220","url":null,"abstract":"Xeroderma Pigmentosum is an autosomal recessive disease caused by alterations in the DNA repairing gene. The clinical manifestation involves extreme sensitivity to ultraviolet radiation and progressive effects in sun exposed areas (skin, mucosa and ocular surface) such as inflammation, sunburn, pigment changes and neoplasia. This disease may be associated with ocular findings such as dry eye syndrome, photophobia, blepharospasm and a number of corneal diseases such as ulceration, perforation and tumors. In this paper, we report the case of a patient with Xeroderma Pigmentosum, accompanied by ocular manifestations and treatment.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapsing Optic Neuropathy Followed by Optic Nerve Injury after Peribulbar Anesthesia – A Case Report","authors":"L. Ian, H. Wei-Cherng","doi":"10.4172/2324-8599.1000219","DOIUrl":"https://doi.org/10.4172/2324-8599.1000219","url":null,"abstract":"Purpose: To present a case with adrenal insufficiency with relapsing visual deterioration due to optic nerve Injury after peribulbar anesthesia. Methods: A case report. Results: A 74-year-old man with adrenal insufficiency underwent cataract surgery of his left eye under peribulbar anesthesia. The best-corrected visual acuity (BCVA) of his left eye before the surgery was 20/125. During anesthesia, optic nerve injury by needle was noted. His bare visual was 20/125 with normal intraocular findings on the first postoperative day. However, BCVA of his left eye decreased to hand motion at 15cm of his left eye on the postoperative day 3 without obvious relative afferent pupillary defect. He was admitted for methylprednisolone intravenous injection therapy for 3 days. BCVA of his left eye recovered to 20/400 after the therapy. However, 2 days later, his visual acuity was downhill below 20/400 and he was admitted for steroids therapy again. BCVA of his left eye was stable around 20/30 after 4 months followup. Conclusion: The prognosis of partial optic nerve injury is relatively good. Steroids therapy or replacement treatment for patient with adrenal insufficiency for ophthalmic surgery under local anesthesia could be considered under some condition (such as after an eventful surgery) or we should discuss with his/her internist before starting the treatment.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":"2018 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44486650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Surface Evaluation in Patients Treated with Pharmacological Treatment for Presbyopia","authors":"Sonia Facal, J. Leiro, A. Gualtieri, Cristian Perez, G. Benozzi, B. Orman","doi":"10.4172/2324-8599.1000218","DOIUrl":"https://doi.org/10.4172/2324-8599.1000218","url":null,"abstract":"Background: Presbyopia is the progressive deterioration of accommodation and can be treated with a non-invasive pharmacological treatment using eye drops.Objective: To evaluate the ocular surface integrity and the tear production in patients under pharmacological treatment for presbyopia using eye drops with the combination of pilocarpine and diclofenac during one year. Methods: A total of thirty eyes were included in this study. The evaluation of the influence of the pharmacological treatment of the ocular surface, Schirmer test and tear film break-up time, ocular surface staining and conjunctival impression cytology were performed at baseline (T0) and after one year (T1). Results: For Schirmer test measurements there were no significant differences in patients under the pharmacological treatment (T=-0.56; P=0.58; n=30). Values of tear film break-up time increased significantly on T1, (T=-3.53; P=0.0047; n=30) indicating amelioration of the lachrymal film. For all stains the values on T1 were diminished, pointing out the amelioration of the corneo conjunctival surface. For conjunctival impression cytology, on T1, 33.3% of the samples suffered no changes, 23.3% of the samples got worst and 43.3% ameliorated their condition. Conclusion: Our results suggest that the pharmacological treatment for presbyopia produced a corneo conjunctival surface amelioration and no changes in tear production after one year of chronically use.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":"2018 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41865231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Findings and Signs of Visual Impairment in Baby and Child","authors":"B. Turgut, O. Çatak, T. Demir","doi":"10.4172/2324-8599.1000221","DOIUrl":"https://doi.org/10.4172/2324-8599.1000221","url":null,"abstract":"Severe visual impairment can cause behavioral and developmental disorders and disabilities in the learning, hearing, walking and speaking in children. The disorders causing to low vision or blindness in children usually occur in the first month of the life. It is possible that baby and infants cannot express the visual complaints. The education of the parents on the clinical signs of visual impairment in children is critical because it has been considered that a half of the childhood blindness is preventable. Additionally, all children should be examined by an ophthalmologist first and 6th month after the birth, in 18-24th months, 3 years old and 5-6 years old of age.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45024602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of the modified method of surgical treatment of terminal glaucoma","authors":"pShlomo Dotanp","doi":"10.4172/2155-9570-C10-105","DOIUrl":"https://doi.org/10.4172/2155-9570-C10-105","url":null,"abstract":"","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70300220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year Outcomes of a Treat-and-Extend Regimen of Intravitreal Aflibercept for Wet ARMD at the Western Eye Hospital","authors":"A. Hamoud, G. Almeida, M. Kurumthottical, A. Goodluck, E. Yang, R. Pasu, C. Quijano, S. Younis","doi":"10.4172/2324-8599.1000215","DOIUrl":"https://doi.org/10.4172/2324-8599.1000215","url":null,"abstract":"Wet age-related macular degeneration wARMD is the leading cause of central visual loss in elderly patients in the developed countries. Overexpression of vascular endothelial grown factor (VEGF) is known to play a major role in the pathogenesis of choroidal neovascularization. Aflibercept is a fully human, recombinant fusion protein that inhibits VEGF. It has a higher tendency to combine with VEGF-A and it blocks other factors such as VEGF-B and placental growth.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":"7 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44994807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression and Incidence of Geographic Atrophy in Patients with Wet Age-Related Macular Degeneration undergoing Anti- VEGF Therapy","authors":"A. Hamoud, G. Almeida, M. Kurumthottical, A. Goodluck, E. Yang, R. Pasu, C. Quijano, S. Younis","doi":"10.4172/2324-8599.1000216","DOIUrl":"https://doi.org/10.4172/2324-8599.1000216","url":null,"abstract":"Importance: Age Related Macular Degeneration (AMD) is one of the leading causes of blindness in the developed world. There are two phenotypes of AMD as defined by the United Kingdom Department of Health: neovascular AMD (nAMD) and geographic atrophy (GA). GA can develop after nAMD as well. There is recent evidence of the development of GA after anti-vascular endothelial growth factor (anti-VEGF) treatment. Our study aims to assess the percentage, risk factors and characteristics of patients developing GA after the different anti-VEGF medications for nAMD. \u0000Observations: We retrospectively reviewed case records of 1415 eyes diagnosed with nAMD treated with anti-VEGF for a period of 60 months. Pre and post anti-VEGF treatment characteristics were recorded. Main outcome measures were the number of patients that developed GA after treated for nAMD with aflibercept, ranibizumab and bevaciumab. Secondary outcome measures included the following: number of injections per type, mean change in the best corrected visual acuity (BCVA), area of GA, central macular thickness (CMT), and the proportion of patients showing change in intra- retinal fluid (IRF), sub-retinal fluid (SRF) and pigment epithelial detachment (PED). 109 eyes (7.7%) developed GA after the last assessment. The number of injections was significantly related to the development of GA, R2=0.000246358, P<0.01. Other studied variables could not significantly predict development or progression of GA. \u0000Conclusion and relevance: In the era of antiVEGF for nAMD treatment, we need to take into account the risk of excessive treatment. Considering GA treatment is still under research the perfect balance between treatment and withholding still needs to be found. In addition other associations or risk factors for GA development after anti-VEGF need to be researched.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":"2018 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49077753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocapsular Ring Implantation for Traumatic Subluxated Cataract: Modified Techniques","authors":"Satyaprakash Singh, R. Oli, A. Singh, Santosh Kumar","doi":"10.4172/2324-8599.1000217","DOIUrl":"https://doi.org/10.4172/2324-8599.1000217","url":null,"abstract":"Purpose: To establish the modifications in techniques for endocapsular ring insertion and its scleral fixation in subluxated cataract that causes minimal stress to capsulo-zonular complex. To assess the intraoperative performance and post-operative outcomes with our modified techniques. Design: Prospective, interventional, non-comparative case series. Methods: The study population consisted of 29 eyes with various degree of subluxated cataract that underwent endocapsular ring implantation with techniques modified by us followed by phacoemulsification and implantation of intraocular lens (IOL) in the capsular bag. Main outcome measures were success rate of endocapsular ring implantation, intraoperative performance, IOL centration and best corrected visual acuity (BCVA) at last visit. Secondary outcome measures included posterior capsular opacification (PCO) and other postoperative complications. Result: The mean age was 37.03 ± 12.37years. Mean degree of subluxation was 140 ± 66 degree. Preoperatively vitreous detected in anterior chamber of 6 eyes (20.69%). Two port anterior vitrectomy was performed in 6 eyes (20.69%). We could implant the intended endocapsular ring in 28 out of 29 eyes (96.55%). In one eye we could not implant the endocapsular ring because of extension of zonular dialysis due to weak zonules. Mean follow-up was 22.42 ± 2.31 months. Mean preoperative BCVA was + 0.68 ± 0.22 log MAR (24 eyes). Mean postoperative BCVA at final follow-up was +0.27 ± 0.16 log MAR (28 eyes).BCVA 20/40 or better was seen in 26 eyes (92.86%) at final followup. In 2 eyes (7.14%) mild IOL decentration was noted but none were symptomatic and required no intervention.PCO developed in 5 eyes (17.85%); 3 eyes (10.71%) required Nd:YAG capsulotomy. Other complications included cystoid macular edema in 1 eye (3.57%), and mild uveitis in 3 eyes (10.71%). Conclusion: With our modified techniques for endocapsular ring insertion and its scleral fixation, we could smoothy and safely implant the endocapsular rings in subluxated cataract with higher success rate, minimal intraoperative complications and good postoperative outcome.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42088138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital Solitary Fibrous Tumour: A Report of Two Cases and Review of the Literature","authors":"M. Albert-Fort, Gonzalez-C., M. IaL","doi":"10.4172/2324-8599.1000213","DOIUrl":"https://doi.org/10.4172/2324-8599.1000213","url":null,"abstract":"We present two clinical cases of patients aged 36 and 74 with an orbital solitary fibrous tumour (SFT). The diagnosis was confirmed by immunohistochemistry being positive for CD34, BCL-2, CD99 and STAT6. The first case was satisfactorily removed during the biopsy and in the second case partial resection was achieved. The patient was referred to neurosurgery after confirming the diagnosis and because of intracranial invasion of the tumour. Discussion Orbital SFT is a generally benign neoplasm originating from the mesenchyme, uncommon in the orbit. It is diagnosed using immunohistochemical technique and the treatment of choice is surgical resection of the tumour in order to prevent recurrences. Usually, local resection of the tumour is sufficient. However, in some situations, infiltration of the tumour requires more extensive resection of adjacent tissues. Radiation therapy does not appear to be beneficial and the efficacy of chemotherapy has not been demonstrated in this type of tumour.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":"2018 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45668667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Characteristics, Treatment, and Outcomes of Giant Cell Arteritis are Dependent on Histological Subtype","authors":"M. Salter, J. Chacko, J. Stanley, W. Henry, H. Brown","doi":"10.4172/2324-8599.1000214","DOIUrl":"https://doi.org/10.4172/2324-8599.1000214","url":null,"abstract":"Objective: To determine the clinical outcomes of the two histopathological patterns considered positive for giant cell arteritis (GCA): active arteritis and healed arteritis. Methods: A retrospective chart review was performed of 22 patients with biopsy-proven GCA. Eleven patients had active arteritis and eleven patients had post-inflammatory alterations consistent with healed arteritis. We sought to compare presenting symptoms, ischemic ocular events, inflammatory markers (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], and platelet count), relapses, and dosage requirements of long-term steroids between the two groups. Results: 7 of 11 patients with active arteritis had an initial ocular ischemic event while 3 of the 11 patients with healed arteritis had an initial ischemic event to the eye. There was no statistical difference in initial ESR between the two groups, but CRP and platelet counts on initial presentation were statistically higher in the active group (p = 0.0002 and p <0.0001 respectively). Patients with active arteritis on biopsy required higher doses of steroids over a 2-year follow-up compared to the healed group: on average 11 mg/day to 1 mg/day at 1 year (p = 0.0008), and 7 mg/day to 0.5 mg/day at 2 years (p = 0.0208), respectively. During the follow-up period, 2 of the 11 patients in the active group demonstrated a recurrent ischemic event to the eye same or fellow eye while in the healed group there were no recurrent ischemic events. Conclusions: Patients with healed arteritis on pathological examination of temporal artery biopsy appear to have better prognoses and may require less aggressive treatment than those with active inflammation.","PeriodicalId":89944,"journal":{"name":"International Journal of Ophthalmic Pathology","volume":" ","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47015299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}