Ocular Surface Evaluation in Patients Treated with Pharmacological Treatment for Presbyopia

Sonia Facal, J. Leiro, A. Gualtieri, Cristian Perez, G. Benozzi, B. Orman
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引用次数: 8

Abstract

Background: Presbyopia is the progressive deterioration of accommodation and can be treated with a non-invasive pharmacological treatment using eye drops.Objective: To evaluate the ocular surface integrity and the tear production in patients under pharmacological treatment for presbyopia using eye drops with the combination of pilocarpine and diclofenac during one year. Methods: A total of thirty eyes were included in this study. The evaluation of the influence of the pharmacological treatment of the ocular surface, Schirmer test and tear film break-up time, ocular surface staining and conjunctival impression cytology were performed at baseline (T0) and after one year (T1). Results: For Schirmer test measurements there were no significant differences in patients under the pharmacological treatment (T=-0.56; P=0.58; n=30). Values of tear film break-up time increased significantly on T1, (T=-3.53; P=0.0047; n=30) indicating amelioration of the lachrymal film. For all stains the values on T1 were diminished, pointing out the amelioration of the corneo conjunctival surface. For conjunctival impression cytology, on T1, 33.3% of the samples suffered no changes, 23.3% of the samples got worst and 43.3% ameliorated their condition. Conclusion: Our results suggest that the pharmacological treatment for presbyopia produced a corneo conjunctival surface amelioration and no changes in tear production after one year of chronically use.
老花眼药物治疗患者的眼表评价
背景:老花眼是调节能力的逐渐恶化,可以通过滴眼液进行非侵入性药物治疗。目的:评价毛果芸香碱和双氯芬酸联合滴眼液治疗老花眼一年的眼表完整性和泪液生成情况。方法:本研究共纳入30只眼睛。在基线(T0)和一年后(T1)进行眼表药物治疗、Schirmer试验和泪膜破裂时间、眼表染色和结膜印模细胞学的影响评估。结果:对于Schirmer试验测量,接受药物治疗的患者没有显著差异(T=-0.56;P=0.58;n=30)。泪膜破裂时间值在T1时显著增加(T=-3.53;P=0.0047;n=30),表明泪膜的改善。对于所有污渍,T1的值都降低了,这表明角膜-结膜表面得到了改善。结膜印模细胞学检查,在T1,33.3%的样本没有变化,23.3%的样本病情恶化,43.3%的样本病情好转。结论:我们的研究结果表明,长期使用药物治疗老花眼一年后,角膜结膜表面得到改善,泪液生成没有变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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