BJU International最新文献

{"title":"A 10-year analysis of MRI-driven prostate cancer diagnosis and active surveillance: trends and implications","authors":"Nikita Sushentsev, Rosita Comune, Kazim Ayberk Sinci, Oleg Blyuss, Iztok Caglič, Christof Kastner, Tristan Barrett","doi":"10.1111/bju.16743","DOIUrl":"https://doi.org/10.1111/bju.16743","url":null,"abstract":"<p>Since the 2012 publication of the Prostate Imaging-Reporting and Data System (PI-RADS) recommendations [<span>1</span>], pre-biopsy MRI has emerged as the first-line diagnostic test in patients with suspected clinically localised prostate cancer (PCa). Initially endorsed by European and British guidelines in 2019 [<span>2, 3</span>] and subsequently reflected in the major North American guidelines [<span>4, 5</span>], this approach is supported by Level-1 evidence showing MRI reduces unnecessary biopsies in patients without MRI-identified suspicious lesions, while maintaining acceptable detection rates for clinically significant PCa (csPCa). These guidelines also recommend MRI for eligibility assessment and subsequent follow-up of patients with PCa on active surveillance (AS), a management strategy with increasing global uptake [<span>6</span>].</p>\u0000<p>In October 2014, our centre was among the first to implement dedicated MRI-driven diagnostic and AS programmes. Here, we present their impact on csPCa detection and AS enrolment over a decade.</p>\u0000<p>The local ethics committee approved this retrospective analysis of the local database, with consent taken from patients undergoing diagnostic procedures at our institution (Cambridge University Hospitals NHS Foundation Trust; Integrated Research Application System identifier [IRAS ID]: 313163 for pre-biopsy MRI data, Cambridge University Hospitals [CUH]/18/3592 for AS data). Data were analysed from all patients undergoing pre-biopsy prostate MRI during a 10-year period (October 2014 to October 2024) (Fig. 1A). csPCa was defined as biopsy-confirmed Grade Group (GG) ≥2 disease. Patients who commenced AS in our centre over the same period and had ≥12 months of follow-up were also included (Fig. 1D). AS misclassification was recorded if a patient showed either radiological progression to ≥rT3 stage or histological progression to GG ≥3 disease within 12 months of AS enrolment. Considering the COVID-19 disruption to imaging services, two observation periods were defined: pre-pandemic (Years 1–5) and post-pandemic (Years 7–10), with the latter also reflecting the impact of the 2019 national guidance recommending the omission of biopsies in patients without MRI-visible disease [<span>3</span>]. A two-sample <i>z</i>-test for proportions was used to compare the relevant csPCa diagnosis and AS progression rates between these two independent periods.</p>\u0000<figure><picture>\u0000<source media=\"(min-width: 1650px)\" srcset=\"/cms/asset/cf9e1b78-6715-472e-82db-f8e07ab86c76/bju16743-fig-0001-m.jpg\"/><img alt=\"Details are in the caption following the image\" data-lg-src=\"/cms/asset/cf9e1b78-6715-472e-82db-f8e07ab86c76/bju16743-fig-0001-m.jpg\" loading=\"lazy\" src=\"/cms/asset/f6de0524-9867-4db5-8fcf-f364ff24e016/bju16743-fig-0001-m.png\" title=\"Details are in the caption following the image\"/></picture><figcaption>\u0000<div><strong>Fig. 1<span style=\"font-weight:normal\"></span></strong><div>Open in figure viewer<i aria-hidden=\"true","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"183 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of active surveillance for Grade Group 1 prostate cancer and the impact of the use of MRI on overtreatment","authors":"Ivo I. de Vos, Cristina Marenghi, Fabio Badenchini, Egbert R. Boevé, Francisco Lozano-Uruñuela, Markus Graefen, Antti S. Rannikko, Frederic Staerman, Mikio Sugimoto, Takuma Kato, Diederik M. Somford, Mark Frydenberg, Chris H. Bangma, Sebastiaan Remmers, Monique J. Roobol","doi":"10.1111/bju.16727","DOIUrl":"https://doi.org/10.1111/bju.16727","url":null,"abstract":"To present the long-term outcomes of men with Grade Group (GG) 1 prostate cancer (PCa), included in the Prostate Cancer Research International Active Surveillance (PRIAS) study, and to assess the effect of the inclusion of magnetic resonance imaging (MRI) within the active surveillance (AS) protocol.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"6 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why prompting matters: achieving clinically accurate and consistent responses with Chat GPT","authors":"Nethusan Sivanesan, Gabriela M. Diaz, Keervani Kandala, Wei Shen Tan, Preston C. Sprenkle","doi":"10.1111/bju.16738","DOIUrl":"https://doi.org/10.1111/bju.16738","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"42 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical cystectomy mortality in older patients: a systematic review and meta-analysis","authors":"Jake Tempo, Sulleyman Felemban, Kirby R. Qin, Marlon Perera, Joseph Ischia, Damien Bolton, Declan G. Murphy, Brian Kelly, David I. Watson, Michael O’Callaghan","doi":"10.1111/bju.16733","DOIUrl":"https://doi.org/10.1111/bju.16733","url":null,"abstract":"To perform a systematic review and meta-analysis of post-radical cystectomy (RC) mortality and complications in older people to aid decision-making pertinent to RC, as bladder cancer is typically a disease of older people, yet older people are less likely than their younger peers to undergo RC, predominantly due to concerns about morbidity and mortality of surgery.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"183 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143814112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent key papers in prostate cancer","authors":"","doi":"10.1111/bju.16718","DOIUrl":"10.1111/bju.16718","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 5","pages":"710-711"},"PeriodicalIF":3.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May's reviewers of the month","authors":"","doi":"10.1111/bju.16719","DOIUrl":"10.1111/bju.16719","url":null,"abstract":"<p>Like most journals, BJUI relies on the hard work and dedication of its peer reviewers and we are grateful to them all. Each month the Editorial Team nominates peer reviewers whose reviews have stood out for their quality and timeliness and those selected as the best are highlighted on this page in recognition of their exceptional work.</p><p>Dr Teele Kuusk, MD, PhD, is a highly accomplished urologist with a dedicated focus on kidney cancer. She graduated from the University of Tartu and has been a Consultant Urologist since 2016. She further developed her expertise in uro-oncology, particularly in renal cancer, during her fellowship at the Netherlands Cancer Institute. Additionally, she honed her surgical and clinical skills in London.</p><p>Dr Kuusk was awarded a PhD from Utrecht University for her research on lymphatic drainage in renal tumours. She is actively involved in shaping the future of kidney cancer management as an associate editor for the UROONCO platform on kidney cancer and as a member of the European Association of Urology (EAU) Kidney Cancer Guidelines Panel.</p>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 5","pages":"709"},"PeriodicalIF":3.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Men's experiences of the Swedish Organised Prostate Cancer Testing programme: a qualitative study","authors":"Karin Olsson, Sara Delilovic, Moa Backman Enelius, Anna Hägglund, Anna Lantz, Anne Richter","doi":"10.1111/bju.16735","DOIUrl":"https://doi.org/10.1111/bju.16735","url":null,"abstract":"To investigate men's experiences of undergoing the diagnostic pathway within the Swedish Organised Prostate Cancer Testing (OPT) programme in Stockholm County.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"183 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Prostate cancer in transgender women: what does a urologist need to know?”","authors":"","doi":"10.1111/bju.16723","DOIUrl":"https://doi.org/10.1111/bju.16723","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"33 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transperineal prostate biopsy under local vs general anaesthesia: a cost-effectiveness analysis","authors":"Matthew J. Roberts, Shiksha Arora, Henry H. Yao, Donnacha Hogan, Brendan Dias, Helen E. O'Connell, David Wetherell, Homayoun Zargar, Michael Kwok, Stephen P. McGeorge, Adam Pearce, John Yaxley, Haitham Tuffaha","doi":"10.1111/bju.16722","DOIUrl":"https://doi.org/10.1111/bju.16722","url":null,"abstract":"To estimate the cost effectiveness of local anaesthetic (LA) transperineal prostate biopsy (TPB) compared to general anaesthetic (GA) TPB, considering both hospital/health system and societal perspectives.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"23 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of MRI for persistent prostate cancer following irreversible electroporation focal therapy","authors":"Kai Zhang, Jeremy Teoh, Pilar Laguna, Jose Dominguez-Escrig, Eric Barret, Juan Casanova Ramon-Borja, Gordon Muir, Julia Bohr, Paula Pelechano Gomez, Theo M. de Reijke, Chi-Fai Ng, Chi-Ho Leung, Rafael Sanchez-Salas, Jean de la Rosette","doi":"10.1111/bju.16720","DOIUrl":"https://doi.org/10.1111/bju.16720","url":null,"abstract":"To investigate the diagnostic value of magnetic resonance imaging (MRI) for persistent prostate cancer after irreversible electroporation (IRE) therapy.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"22 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}