BJU International最新文献

{"title":"Robotic training in functional and reconstructive urology – current state and future directions","authors":"Arjun Nambiar, Arun Sahai, the Robotic Working Group, British Association of Urological Surgeons (BAUS) section of Female, Neurological and Urodynamic Urology (FNUU)","doi":"10.1111/bju.16679","DOIUrl":"10.1111/bju.16679","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 5","pages":"712-713"},"PeriodicalIF":3.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Position of the testes","authors":"Amr Gohar","doi":"10.1111/bju.16688","DOIUrl":"https://doi.org/10.1111/bju.16688","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"30 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryotherapy for posterior lesions of the prostate: the hydrogel technique","authors":"Chi Hang Yee, Peter Ka-Fung Chiu, Kae Jack Tay, Yu Guang Tan, Ho Fai Wong, Brian Siu, Rossella Nicoletti, Jeremy Yuen-Chun Teoh, Chi Fai Ng","doi":"10.1111/bju.16690","DOIUrl":"10.1111/bju.16690","url":null,"abstract":"<p>While radical prostatectomy and radiotherapy have robust long-term cancer control success for localised prostate cancer, the whole-gland treatment approaches carry a certain degree of negative impact on patients’ functional outcome [<span>1</span>]. Focal therapy targets only the cancerous foci within the prostate and thus minimises morbidity and complications. Cryotherapy as one of the most established focal therapy tools has demonstrated satisfactory oncological and functional results [<span>2</span>]. However, posterior lesions have been a concern for cryotherapy due to proximity to the rectum. It has been shown that while the temperature of −20°C is the threshold required to result in coagulative necrosis of tumour cells and often cryotherapy achieve a targeted temperature of −40°C, damage to surrounding healthy tissue can occur in normal tissue at −15°C [<span>3</span>]. Hydrogels are injectable viscous semi-liquid compounds comprised mostly of water with a hydrophilic polymer matrix giving structure to the substance. They can be polyethylene glycol (PEG) or hyaluronic acid-based products. De Castro Abreu et al. [<span>4</span>] have demonstrated the feasibility of adopting hydrogel into cryotherapy in a cadaver model by expansion of the Denonvilliers’ space. In a porcine model, Lam and Ng [<span>5</span>] have verified the temperature insulation ability of hydrogel. In the present clinical study, we illustrate and guide the usage of the hydrogel technique in cryotherapy for posterior lesions of the prostate. We aimed to assess the feasibility of such a technique in expanding the use of cryotherapy for posterior lesions.</p><p>Cryoablation is performed with fusion software platform (Trinity® system: KOELIS, La Tronche, France). Preoperatively, the patient's MRI images are registered for subsequent fusion and ablation planning. After general anaesthesia, the patient is positioned in the Lloyd-Davies position. The perineum is shaved and prepared with antiseptic solution to facilitate subsequent hydrogel injection and cryoablation (Video S1).</p><p>Between June 2023 to May 2024, 10 patients with middle or posterior lesions in their prostate going for cryotherapy were recruited for hydrogel injection in two academic units (Table S1). All patients were consented to the procedure and to the prospective focal therapy registry approved by our local institutes. The mean (SD) prostate size was 46.5 (24.2) mL and median (interquartile range) patient age was 72 (67.0–74.3) years. No patient was found to have any complication related to hydrogel injection or cryoablation. One patient developed Clavien–Dindo Grade IIIb complication related to his auxiliary procedure of TURP. The patient had a right posterior lesion in a 107 mL prostate gland. Due to concomitant LUTS, TURP was performed in the same session after cryoablation. The patient developed clot retention after the procedure; clot evacuation and haemostasis was performed on postoperative Day 1. T","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 5","pages":"869-873"},"PeriodicalIF":3.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of a nomogram for unilateral pelvic lymph node dissection in prostate cancer","authors":"Gernot Ortner, Fabian Falkenbach, Mykyta Kachanov, Tim Inderhees, Tobias Maurer, Sophie Knipper, Markus Graefen, Lars Budäus","doi":"10.1111/bju.16687","DOIUrl":"https://doi.org/10.1111/bju.16687","url":null,"abstract":"ObjectivesTo explore the rationale of unilateral extended pelvic lymph node dissection (ePLND) during radical prostatectomy (RP) by external validation of a nomogram for unilateral ePLND (unilat‐NG) and comparison to the Briganti 2019 nomogram.Patients and methodsPatients with magnetic resonance imaging‐fusion biopsy and consecutive RP with bilateral ePLND were identified within an institutional database. The primary endpoint was the detection rate of lymph node invasion (LNI) contralateral to the prostatic lobe with adverse cancer characteristics. The performance of the unilat‐NG and the Briganti 2019 nomogram to detect contralateral LNI was assessed using descriptive analysis, the receiver operating characteristic curve–derived area under the curve (AUC), and multivariable logistic regression analyses.ResultsOf the overall 406 consecutive patients, 68/406 (16.7%) presented with pathological (p)N1 disease at RP. The AUC for the unilat‐NG with a 1%, 2% and 2.5% cut‐off was 0.58 (95% confidence interval [CI] 0.53–0.63), 0.67 (95% CI 0.59–0.75), and 0.69 (95% CI 0.60–0. 77), respectively; compared to an AUC of 0.72 (95% CI 0.66–0.78) for the Briganti 2019 nomogram with a 7% cut‐off. Applying the unilat‐NG with a 2.5% cut‐off, contralateral ePLND could be omitted in 303/406 (74.6%) patients, misclassifying 10/406 (2.5%) patients with pN0 disease.ConclusionThe Briganti 2019 nomogram outperformed the novel unilat‐NG in contralateral LNI prediction. Yet, a significant proportion of patients undergoing unilateral ePLND would be falsely classified with pN0 disease using any of the nomograms. Therefore, bilateral ePLND should remain the standard of care if PLND is indicated.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"2 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of invasive penile cancer after treatment of penile intraepithelial neoplasia","authors":"Inessa Bjartmar, Axel Gerdtsson, Christian Torbrand, Sinja Kristiansen","doi":"10.1111/bju.16674","DOIUrl":"https://doi.org/10.1111/bju.16674","url":null,"abstract":"ObjectivesTo examine the risk of progression and time to progression from penile intraepithelial neoplasia (PeIN) to invasive penile cancer in patients treated for PeIN with either surgery, laser ablation or topical treatment, and to examine recurrence risk after treatment of PeIN.Patients and MethodsData on patients diagnosed with PeIN (<jats:italic>n</jats:italic> = 1122) between 2000 and 2020 were extracted from the Swedish National Penile Cancer Registry (NPECR). Progression was defined as a second registration of invasive penile cancer in this registry. Additionally, patient charts from the three largest cities in Sweden (Stockholm, Gothenburg and Malmö) were analysed with regard to both progression of PeIN to invasive cancer and recurrence risk after treatment.ResultsThe NPECR included 1122 patients with PeIN, of whom 23 were re‐registered as having invasive penile cancer. In the 927 PeIN patients for whom data on treatment were available, re‐registration of invasive cancer was seen in 13 patients after surgery, six after laser ablation, and one after topical treatment. The progression‐free probabilities at 24 months in these treatment groups were 99.3% (95% confidence interval [CI] 0.987; 0.999), 100% (95% CI 1.000; 1.000) and 98.8% (95% CI 0.965; 1.000), respectively (log‐rank test <jats:italic>P</jats:italic> = 0.192). In the Stockholm, Gothenburg and Malmö cohort, 253 patients with PeIN were followed and 14 developed invasive penile cancer. Of the 247 PeIN cases with data on treatment, four progressed after surgery, eight after laser ablation, and one after topical treatment. The progression‐free probabilities at 24 months in these treatment groups were 98.2% (95% CI 0.956; 1.000), 86.2% (95% CI 0.744; 0.997) and 100% (95% CI 1.000; 1.000), respectively (log‐rank test <jats:italic>P</jats:italic> &lt; 0.001).ConclusionWe found that PeIN has a low risk of progressing into invasive penile cancer regardless of treatment modality. However, laser ablation therapy is not recommended due to a higher risk of progression after such treatment compared to surgical and topical treatment. We recommend individualised follow‐up protocols of PeIN based on treatment and lesion location.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"15 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of high-risk localised muscle invasive bladder cancer","authors":"","doi":"10.1111/bju.16672","DOIUrl":"https://doi.org/10.1111/bju.16672","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"364-365"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term multicentre analysis of robot-assisted radical cystectomy for non-muscle-invasive bladder cancer","authors":"Neeraja Tillu, Reuben Ben-David, Viktor Skokic, Jordan M. Rich, Kaushik P. Kolanukuduru, Linda Dey, Juhana Rautiola, Johan Björklund, Mohammed Almoflihi, Ahmed Eraky, Gus Miranda, Giovanni Cacciamani, Mihir Desai, Reza Mehrazin, John P. Sfakianos, Peter Wiklund","doi":"10.1111/bju.16686","DOIUrl":"https://doi.org/10.1111/bju.16686","url":null,"abstract":"To evaluate the 12-year survival outcomes of patients with non-muscle-invasive bladder cancer (NMIBC) who underwent robot-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD), focusing on those upstaged to ≥pT2 or with node-positive disease.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"209 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"March's reviewers of the month","authors":"","doi":"10.1111/bju.16673","DOIUrl":"https://doi.org/10.1111/bju.16673","url":null,"abstract":"&lt;p&gt;Like most journals, BJUI relies on the hard work and dedication of its peer reviewers and we are grateful to them all. Each month the Editorial Team nominates peer reviewers whose reviews have stood out for their quality and timeliness and those selected as the best are highlighted on this page in recognition of their exceptional work.&lt;/p&gt;&lt;p&gt;Dr Hemal has done pioneering work in the field of laparoscopic urology venturing in the field since 1992 and has been associated with initial development of robotic urologic surgery since 2001 developing several techniques. His unique contribution has been in training of Fellows, residents, urologists (worldwide) in addition performing live demonstration of endourological, laparoscopic and Robotic Urologic Surgical procedures in over 350 scientific conferences all across the world for educational purposes and disseminating the knowledge, Proctoring, Mentoring and Preceptorship in Laparoscopic, Endourology and Robotic Urologic Surgery during entire career spanning over 35 years. He helped developing robotic program and Team at several centres all across the world since 2001. Dr Hemal has seven books and over 450 scientific papers in peer-reviewed journals and another 200 papers and book chapters to his credit. He has been the recipient of many academic distinctions and awards to name a few prestigious BC Roy Award, UGC Hari Om Ashram award and “Padma-Shree” by the president of India. He is also recipient of several other prestigious award such as Urologist of the Decade award, Guest Scholar of the American College of Surgeons, SIU- scholar, Fulbright scholar, and Health Hero award given by Business Journal of USA. He has also received Sushruta award by Indian, American Urology association. He has been nominated as Best Doctor of America, Top Doctor of America and Top Prostate Cancer doctor since 2008 every year till the date. He was also featured as Top Prostate Cancer doctor of USA in New York Times, USA.&lt;/p&gt;&lt;p&gt;Dr Usher-Smith is a GP and Associate Professor of General Practice at the University of Cambridge. Her main research interest focuses on optimising the implementation of risk-stratified medicine to promote prevention and early detection of cancer and cardiovascular disease. This includes quantitative and qualitative research covering the development and validation of risk models, evaluation of the societal, psychological, behavioural and system-level aspects associated with implementation, and conducting feasibility and pilot studies within clinical practice. Alongside research on breast cancer risk assessment and risk-stratified bowel cancer screening, she co-led the Yorkshire Kidney Screening Trial, the first study to assess the feasibility of incorporating an additional abdominal CT-scan within risk-based lung cancer screening programmes, and is currently leading a feasibility study of incorporating a newly developed PREDICT Kidney risk communication tool into clinical care for patients who have ","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"363"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16673","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistics in clinical urology research: fundamental concepts in comparative research","authors":"Melissa Assel,&nbsp;Sigrid V. Carlsson","doi":"10.1111/bju.16685","DOIUrl":"10.1111/bju.16685","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 5","pages":"714-716"},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urology residency – a demographic cross-sectional study by the Swiss Society of Residents in Urology","authors":"Silvan Sigg,&nbsp;Luca Afferi,&nbsp;Fabienne Lehner,&nbsp;Sarah Dugas,&nbsp;Madlen Kasten,&nbsp;Julien Blanc,&nbsp;Andres Affentranger,&nbsp;Fabian Aschwanden,&nbsp;the Swiss Society of Residents in Urology (SRU)","doi":"10.1111/bju.16684","DOIUrl":"10.1111/bju.16684","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 6","pages":"884-886"},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}