BJU International最新文献

{"title":"Outcomes of prostate cancer treatments","authors":"","doi":"10.1111/bju.16633","DOIUrl":"10.1111/bju.16633","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 2","pages":"184-185"},"PeriodicalIF":3.7,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to neoadjuvant chemotherapy leads to better survival outcomes in upper tract urothelial carcinoma","authors":"Alice Yu, Patrick J. Hensley, Heather L. Huelster, Austin Martin, Aaron Potrezke, Jonathan Pham, Jay D. Raman, Maximilian Pallauf, Nirmish Singla, Andrew Katims, Jonathan Coleman, Vitaly Margulis, Surena F. Matin, Philippe E. Spiess","doi":"10.1111/bju.16655","DOIUrl":"https://doi.org/10.1111/bju.16655","url":null,"abstract":"ObjectivesTo evaluate the benefit of neoadjuvant chemotherapy (NAC) for patients with high‐risk upper tract urothelial carcinoma (UTUC) using a large, well‐curated multi‐institutional database.Patients and MethodsThis study was a multi‐institutional retrospective analysis conducted by the UTUC Collaborative Network (UCAN), combining data from 2276 patients with UTUC who underwent radical nephroureterectomy at seven high‐volume tertiary care centres in the United States. The UCAN data were analysed to evaluate the impact of response to NAC on survival outcomes in patients with UTUC.ResultsA total of 378 patients in the UCAN database underwent NAC. On final surgical pathology, 101 patients (26.8%) had ≤ypT1N0 disease and were defined as NAC treatment responders. Patients who responded to NAC had significantly longer overall survival (OS) and progression‐free survival (PFS) compared to non‐responders. At 5 years post‐surgery, 81.5% of responders were alive compared to 59.8% of non‐responders. The median OS and PFS times among non‐responders were 7.0 years (95% confidence interval [CI] 5.6–9.7) and 6.0 years (95% CI 4.6–9.3) respectively, while the median OS and PFS were not reached among responders. Limitations of this study include its retrospective design, heterogeneity in chemotherapy regimens, and the absence of clearly defined patient selection criteria for treatment.ConclusionThese data suggest that NAC can play a pivotal role in the treatment of well‐selected UTUC patients who respond positively. Non‐responders had clearly inferior outcomes. More work is needed to find predictors of response which can improve patient selection.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"253 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic surgery: turning proficiency to independence in modern times","authors":"Kamran Haq, Bhavan Prasad Rai","doi":"10.1111/bju.16656","DOIUrl":"10.1111/bju.16656","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 4","pages":"548-549"},"PeriodicalIF":3.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes after cystectomy in Australian rural and metropolitan hospitals by intensive care admissions","authors":"Jessica A. Paynter, Zakary Doherty, Kirby R. Qin, David Pilcher, Janelle Brennan","doi":"10.1111/bju.16642","DOIUrl":"https://doi.org/10.1111/bju.16642","url":null,"abstract":"ObjectivesTo examine demographics and in‐hospital outcomes for patients admitted to Australian intensive care units (ICUs) following cystectomy of the urinary bladder. Additionally, to compare outcomes between metropolitan and rural hospitals.Patients and MethodsA retrospective cohort analysis was undertaken of all adult patients admitted to participating Australian ICUs (Australian and New Zealand Intensive Care Society Adult Patient Database) following cystectomy/cystoprostatectomy between January 2011 and December 2021. The primary outcome was in‐hospital mortality. Secondary outcomes were ICU and hospital length of stay.ResultsOver the 10‐year period, 3376 adult patients were admitted to 135 Australian ICUs after cystectomy. Of these, 3083 patients (91.3%) were treated in 106 metropolitan ICUs and 293 patients (8.7%) were treated in 29 rural ICUs. There was no difference in adjusted mortality between metropolitan and rural hospitals admitted to an ICU after cystectomy (odds ratio 1.32, 95% confidence interval 0.44–3.48; <jats:italic>P</jats:italic> = 0.6).ConclusionThere was no difference in in‐hospital mortality for cystectomy patients requiring ICU admission between metropolitan and rural hospitals. These findings may be used to inform decisions about the rural provision of cystectomy services.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"30 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"String theory: placement of locking ligation clips in sliding renorrhaphy for partial nephrectomy","authors":"Victor Yu,&nbsp;Sarah Lorger,&nbsp;Mark Broe,&nbsp;Ruban Thanigasalam,&nbsp;Scott Leslie,&nbsp;Louie Tolentino,&nbsp;Nariman Ahmadi,&nbsp;George McClintock","doi":"10.1111/bju.16640","DOIUrl":"10.1111/bju.16640","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 4","pages":"593-595"},"PeriodicalIF":3.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-side performance metrics in robotic surgery: international Delphi-based consensus from the Junior European Association of Urology Robotic Section/Young Academic Urologists","authors":"Christoph Würnschimmel,&nbsp;Marco Paciotti,&nbsp;Mike Wenzel,&nbsp;Carlo Andrea Bravi,&nbsp;Ruben De Groote,&nbsp;Paolo Dell'Oglio,&nbsp;Fabrizio Di Maida,&nbsp;Marcio Covas Moschovas,&nbsp;Federico Piramide,&nbsp;Filippo Turri,&nbsp;Iulia Andras,&nbsp;Gabriele Sorce,&nbsp;Nikolaos Liakos,&nbsp;Anthony Gallagher,&nbsp;Domenico Veneziano,&nbsp;Ton Brouwers,&nbsp;Evangelos Liatsikos,&nbsp;Alberto Breda,&nbsp;Alessandro Larcher","doi":"10.1111/bju.16638","DOIUrl":"10.1111/bju.16638","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"366-368"},"PeriodicalIF":3.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoos as a risk factor for bladder cancer: a call for cohort studies","authors":"Nicolas Kluger,&nbsp;Sebastiaan A.S. van der van der Bent","doi":"10.1111/bju.16648","DOIUrl":"10.1111/bju.16648","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 4","pages":"584-585"},"PeriodicalIF":3.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urologists and social media: pitfalls and perils and what to think about before hitting ‘send’","authors":"Helen W Cui,&nbsp;John Reynard","doi":"10.1111/bju.16636","DOIUrl":"10.1111/bju.16636","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To summarise current guidelines from professional bodies relevant to urologists on social media, and to discusses a range of risks associated with social media use. These include the risk of a fitness to practise investigation, breaking the law, loss of employment, and personal risk in the form of harassment and doxxing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Review of guidelines and recommendations published by professional bodies revelant to urologists and review of relevant case examples in the medical profession and other relevant professions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This article finds whereas most doctors will be aware of the risks of posting on public social media platforms, the recent case studies in medical and other contexts have highlighted the risks of disciplinary action from regulators and even criminal investigation in the use of private social media.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although the majority of urologists are unlikely to violate ethical and good medical practice principles in their use of social media, this article serves as a reminder of the potential consequences based on real-life case examples.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"390-398"},"PeriodicalIF":3.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution and subtype‐specific expression patterns of Nectin‐4 in muscle‐invasive bladder cancer","authors":"Csilla Olah, Lara Sichward, Boris Hadaschik, Christopher Darr, Viktor Grünwald, Ulrich Krafft, Barbara T. Grünwald, Osama Mahmoud, Mulham Al‐Nader, Peter Nyirady, Henning Reis, Tibor Szarvas","doi":"10.1111/bju.16643","DOIUrl":"https://doi.org/10.1111/bju.16643","url":null,"abstract":"ObjectiveTo investigate the expression patterns of Nectin‐4, the target molecule of the antibody‐drug conjugate enfortumab vedotin (EV), in relation to histological and molecular subtypes of urothelial bladder cancer (UBC).Patients and MethodsWe assessed the protein expression patterns of Nectin‐4 in a spatially organised tissue microarray containing 1386 tissue cores from 314 consecutive patients with UBC who underwent radical cystectomy (2005–2018). Results were correlated with clinicopathological and follow‐up data, as well as with different spatial locations (tumour central vs tumour‐normal interface and primary tumour vs lymph node [LN] metastases). Additionally, we correlated Nectin‐4 expression levels with histological and molecular subtypes. Finally, we assessed the value of Nectin‐4 expression for predicting the efficacy of platinum therapy in the peri‐operative setting.ResultsNectin‐4 expression was observed in 63% of primary tumours and 87% of LN metastases, with significantly higher levels in LNs. Of the histological subtypes, the micropapillary (58%) and pure urothelial histologies (30%) were associated with the highest Nectin‐4 positivity, while the sarcomatoid (17%), squamous (15%) and small/cell‐neuroendocrine (0%) subtypes exhibited the lowest. Nectin‐4 immunopositivity rates were significantly higher in luminal (urothelial‐like [42%] and genomically unstable [34%] Lund subtypes) compared to the basal (5%) or mesenchymal (0%) molecular subtypes. Higher Nectin‐4 expression levels were associated with lower tumour stage but showed no association with overall survival. Finally, patients with low Nectin‐4 expression tended to derive more benefit from platinum‐based chemotherapy in both adjuvant and neoadjuvant settings (<jats:italic>P</jats:italic> &lt; 0.001, <jats:italic>P</jats:italic> = 0.067).ConclusionOur results revealed a low spatial heterogeneity of Nectin‐4 expression within the primary tumour. In contrast, differential Nectin‐4 expression was found in the context of histological and molecular subtypes. Nectin‐4‐expressing tumours may show varying sensitivity to both EV and platinum‐based chemotherapy.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"2 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gemcitabine and docetaxel for high-risk non-muscle-invasive bladder cancer: EuroGemDoce group results","authors":"Pietro Scilipoti, Mattia Longoni, Mario de Angelis, Paolo Zaurito, Albane Massiet, Daniele Dutto, Francesco Soria, Mario Álvarez-Maestro, Alfredo Aguilera Bazán, Benjamin Pradere, Tobias Klatte, Roberto Contieri, Rodolfo Hurle, Wojciech Krajewski, José Daniel Subiela, Renate Pichler, Aleksandra Szostek, Gautier Marcq, José Luis Rodríguez Elena, Javier Aranda, Paolo Gontero, Morgan Rouprêt, Shahrokh F. Shariat, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Evanguelos Xylinas, Marco Moschini, , ","doi":"10.1111/bju.16645","DOIUrl":"https://doi.org/10.1111/bju.16645","url":null,"abstract":"To evaluate the oncological efficacy and safety of sequential intravesical gemcitabine/docetaxel (Gem/Doce) therapy in a European cohort of patients with high-risk and very-high-risk non-muscle-invasive bladder cancer (NMIBC) after previous Bacillus Calmette–Guérin (BCG) treatment.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"26 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}