BJU International最新文献

{"title":"Outcomes after cystectomy in Australian rural and metropolitan hospitals by intensive care admissions","authors":"Jessica A. Paynter, Zakary Doherty, Kirby R. Qin, David Pilcher, Janelle Brennan","doi":"10.1111/bju.16642","DOIUrl":"https://doi.org/10.1111/bju.16642","url":null,"abstract":"ObjectivesTo examine demographics and in‐hospital outcomes for patients admitted to Australian intensive care units (ICUs) following cystectomy of the urinary bladder. Additionally, to compare outcomes between metropolitan and rural hospitals.Patients and MethodsA retrospective cohort analysis was undertaken of all adult patients admitted to participating Australian ICUs (Australian and New Zealand Intensive Care Society Adult Patient Database) following cystectomy/cystoprostatectomy between January 2011 and December 2021. The primary outcome was in‐hospital mortality. Secondary outcomes were ICU and hospital length of stay.ResultsOver the 10‐year period, 3376 adult patients were admitted to 135 Australian ICUs after cystectomy. Of these, 3083 patients (91.3%) were treated in 106 metropolitan ICUs and 293 patients (8.7%) were treated in 29 rural ICUs. There was no difference in adjusted mortality between metropolitan and rural hospitals admitted to an ICU after cystectomy (odds ratio 1.32, 95% confidence interval 0.44–3.48; <jats:italic>P</jats:italic> = 0.6).ConclusionThere was no difference in in‐hospital mortality for cystectomy patients requiring ICU admission between metropolitan and rural hospitals. These findings may be used to inform decisions about the rural provision of cystectomy services.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"30 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"String theory: placement of locking ligation clips in sliding renorrhaphy for partial nephrectomy","authors":"Victor Yu,&nbsp;Sarah Lorger,&nbsp;Mark Broe,&nbsp;Ruban Thanigasalam,&nbsp;Scott Leslie,&nbsp;Louie Tolentino,&nbsp;Nariman Ahmadi,&nbsp;George McClintock","doi":"10.1111/bju.16640","DOIUrl":"10.1111/bju.16640","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 4","pages":"593-595"},"PeriodicalIF":3.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-side performance metrics in robotic surgery: international Delphi-based consensus from the Junior European Association of Urology Robotic Section/Young Academic Urologists","authors":"Christoph Würnschimmel,&nbsp;Marco Paciotti,&nbsp;Mike Wenzel,&nbsp;Carlo Andrea Bravi,&nbsp;Ruben De Groote,&nbsp;Paolo Dell'Oglio,&nbsp;Fabrizio Di Maida,&nbsp;Marcio Covas Moschovas,&nbsp;Federico Piramide,&nbsp;Filippo Turri,&nbsp;Iulia Andras,&nbsp;Gabriele Sorce,&nbsp;Nikolaos Liakos,&nbsp;Anthony Gallagher,&nbsp;Domenico Veneziano,&nbsp;Ton Brouwers,&nbsp;Evangelos Liatsikos,&nbsp;Alberto Breda,&nbsp;Alessandro Larcher","doi":"10.1111/bju.16638","DOIUrl":"10.1111/bju.16638","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"366-368"},"PeriodicalIF":3.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142975235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoos as a risk factor for bladder cancer: a call for cohort studies","authors":"Nicolas Kluger,&nbsp;Sebastiaan A.S. van der van der Bent","doi":"10.1111/bju.16648","DOIUrl":"10.1111/bju.16648","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 4","pages":"584-585"},"PeriodicalIF":3.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urologists and social media: pitfalls and perils and what to think about before hitting ‘send’","authors":"Helen W Cui,&nbsp;John Reynard","doi":"10.1111/bju.16636","DOIUrl":"10.1111/bju.16636","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To summarise current guidelines from professional bodies relevant to urologists on social media, and to discusses a range of risks associated with social media use. These include the risk of a fitness to practise investigation, breaking the law, loss of employment, and personal risk in the form of harassment and doxxing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Review of guidelines and recommendations published by professional bodies revelant to urologists and review of relevant case examples in the medical profession and other relevant professions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This article finds whereas most doctors will be aware of the risks of posting on public social media platforms, the recent case studies in medical and other contexts have highlighted the risks of disciplinary action from regulators and even criminal investigation in the use of private social media.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although the majority of urologists are unlikely to violate ethical and good medical practice principles in their use of social media, this article serves as a reminder of the potential consequences based on real-life case examples.</p>\u0000 </section>\u0000 </div>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"390-398"},"PeriodicalIF":3.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial distribution and subtype‐specific expression patterns of Nectin‐4 in muscle‐invasive bladder cancer","authors":"Csilla Olah, Lara Sichward, Boris Hadaschik, Christopher Darr, Viktor Grünwald, Ulrich Krafft, Barbara T. Grünwald, Osama Mahmoud, Mulham Al‐Nader, Peter Nyirady, Henning Reis, Tibor Szarvas","doi":"10.1111/bju.16643","DOIUrl":"https://doi.org/10.1111/bju.16643","url":null,"abstract":"ObjectiveTo investigate the expression patterns of Nectin‐4, the target molecule of the antibody‐drug conjugate enfortumab vedotin (EV), in relation to histological and molecular subtypes of urothelial bladder cancer (UBC).Patients and MethodsWe assessed the protein expression patterns of Nectin‐4 in a spatially organised tissue microarray containing 1386 tissue cores from 314 consecutive patients with UBC who underwent radical cystectomy (2005–2018). Results were correlated with clinicopathological and follow‐up data, as well as with different spatial locations (tumour central vs tumour‐normal interface and primary tumour vs lymph node [LN] metastases). Additionally, we correlated Nectin‐4 expression levels with histological and molecular subtypes. Finally, we assessed the value of Nectin‐4 expression for predicting the efficacy of platinum therapy in the peri‐operative setting.ResultsNectin‐4 expression was observed in 63% of primary tumours and 87% of LN metastases, with significantly higher levels in LNs. Of the histological subtypes, the micropapillary (58%) and pure urothelial histologies (30%) were associated with the highest Nectin‐4 positivity, while the sarcomatoid (17%), squamous (15%) and small/cell‐neuroendocrine (0%) subtypes exhibited the lowest. Nectin‐4 immunopositivity rates were significantly higher in luminal (urothelial‐like [42%] and genomically unstable [34%] Lund subtypes) compared to the basal (5%) or mesenchymal (0%) molecular subtypes. Higher Nectin‐4 expression levels were associated with lower tumour stage but showed no association with overall survival. Finally, patients with low Nectin‐4 expression tended to derive more benefit from platinum‐based chemotherapy in both adjuvant and neoadjuvant settings (<jats:italic>P</jats:italic> &lt; 0.001, <jats:italic>P</jats:italic> = 0.067).ConclusionOur results revealed a low spatial heterogeneity of Nectin‐4 expression within the primary tumour. In contrast, differential Nectin‐4 expression was found in the context of histological and molecular subtypes. Nectin‐4‐expressing tumours may show varying sensitivity to both EV and platinum‐based chemotherapy.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"2 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gemcitabine and docetaxel for high-risk non-muscle-invasive bladder cancer: EuroGemDoce group results","authors":"Pietro Scilipoti, Mattia Longoni, Mario de Angelis, Paolo Zaurito, Albane Massiet, Daniele Dutto, Francesco Soria, Mario Álvarez-Maestro, Alfredo Aguilera Bazán, Benjamin Pradere, Tobias Klatte, Roberto Contieri, Rodolfo Hurle, Wojciech Krajewski, José Daniel Subiela, Renate Pichler, Aleksandra Szostek, Gautier Marcq, José Luis Rodríguez Elena, Javier Aranda, Paolo Gontero, Morgan Rouprêt, Shahrokh F. Shariat, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Evanguelos Xylinas, Marco Moschini, , ","doi":"10.1111/bju.16645","DOIUrl":"https://doi.org/10.1111/bju.16645","url":null,"abstract":"To evaluate the oncological efficacy and safety of sequential intravesical gemcitabine/docetaxel (Gem/Doce) therapy in a European cohort of patients with high-risk and very-high-risk non-muscle-invasive bladder cancer (NMIBC) after previous Bacillus Calmette–Guérin (BCG) treatment.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"26 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial","authors":"Meryam El Issaoui,&nbsp;Marlene Elmelund,&nbsp;Niels Klarskov","doi":"10.1111/bju.16647","DOIUrl":"10.1111/bju.16647","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX-A) injections for overactive bladder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>This single-centre, randomised, double-blind, placebo-controlled two period crossover trial was conducted on women scheduled for BTX-A injections at our outpatient urogynaecology clinic between September 2022 and May 2024. Patients were randomly assigned (1:1) to receive either alkalinised lidocaine or placebo during the first treatment period. Alkalinised lidocaine solution comprised lidocaine hydrochloride (20 mg/mL, 20 mL), sodium hydrogen carbonate (1 mmoL/mL, 10 mL), and sodium chloride (9 g/L, 10 mL). The matching placebo was sodium chloride (9 g/L, 40 mL). The primary outcome measure was procedural pain rated on a 100-mm visual analogue scale (VAS). Secondary outcomes included adverse effects such as post-void residual urine volumes requiring catheterisation, urinary tract infection, haematuria 1 week after treatment, and patient satisfaction measured on a 5-point scale. During the second treatment period, patients received the alternative intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We enrolled 50 patients, of which 41 were eligible for per-protocol analyses. The mean VAS score was significantly lower following intravesical alkalinised lidocaine (mean 21.3 mm, 95% confidence interval [CI] 14.7–27.8 mm) compared to placebo (mean 41.6 mm, 95% CI 35.0–48.1 mm) with a mean difference of −20.3 mm (95% CI −29.2 to −11.5 mm; <i>P</i> &lt; 0.001). Adverse events and patient satisfaction did not significantly differ between the alkalinised lidocaine and placebo treatments (<i>P</i> = 0.825 and <i>P</i> = 0.138, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Intravesical instillation of alkalinised lidocaine before BTX-A injections significantly reduced VAS pain scores compared to placebo (ClinicalTrials.gov identifier: NCT05415865).</p>\u0000 </section>\u0000 </div>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 4","pages":"638-647"},"PeriodicalIF":3.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16647","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of serum and plasma microRNA expression levels in patients with germ cell tumours","authors":"Fady Baky, Richard S. Matulewicz, Andrea Knezevic, Jahwa Hossain, Brandon Williams, Anna Lee, Joel Sheinfeld, Nicole Liso, Rachel So, Alisa Valentino, Fei Ye, Samuel A. Funt, Darren R. Feldman","doi":"10.1111/bju.16644","DOIUrl":"https://doi.org/10.1111/bju.16644","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"14 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142940341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating choices: understanding the decision-making journey of patients with localised kidney cancer","authors":"Katharina Beyer, Lionne D.F. Venderbos, Monique J. Roobol, Rachel H. Giles, Paul Verhagen, Ravi Barod, Lisa M. Wintner, Michael A.S. Jewett, Mieke Van Hemelrijck, Netty Kinsella","doi":"10.1111/bju.16635","DOIUrl":"https://doi.org/10.1111/bju.16635","url":null,"abstract":"To explore patients’ experience of decision making regarding treatment of localised kidney cancer.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"14 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}