BJU International最新文献

{"title":"The challenges of conducting a surgical trial—reflections on the en bloc resection of urothelium carcinoma of the bladder (EBRUC) II trial","authors":"Stephan Brönimann, Altug Tuncel, Rodolfo Hurle, David D'Andrea","doi":"10.1111/bju.16749","DOIUrl":"https://doi.org/10.1111/bju.16749","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"27 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, surveillance and natural history of high‐grade prostatic epithelial neoplasia in the era of multiparametric MRI and targeted biopsy","authors":"Nathalie Eid, Herbert Lepor","doi":"10.1111/bju.16748","DOIUrl":"https://doi.org/10.1111/bju.16748","url":null,"abstract":"ObjectivesTo determine the incidence of isolated high grade prostatic epithelial neoplasia (iHGPIN) following magnetic resonance imaging (MRI)–ultrasonography co‐registration fusion targeted biopsy (MRFTB) coupled with systematic biopsy (SB) and to assess the detection rates of clinically significant prostate cancer (csPCa).Patients and MethodsBeginning in June 2012, most patients at our institution underwent multiparametric MRI (mpMRI) before prostate biopsy. Biopsies were performed between June 2012 and October 2021. The surveillance protocol for iHGPIN included prostate‐specific antigen assessment every 6 months, digital rectal examinations annually, and multiparametric MRI (mpMRI) at 3 years. Repeat biopsies were recommended primarily for suspicious mpMRI, defined as a new Prostate Imaging‐Reporting and Data System (PI‐RADS) score >2 region of interest (ROI) or an increase in size of the pre‐existing ROI.ResultsOf the 628 biopsies, 230 (33.7%), 48 (7.0%), 404 (59.2%) were interpreted as benign, iHGPIN, or prostate cancer (PCa), respectively. Of these cancers 140 (34.7%) and 264 (65.3%) were low‐risk PCa and csPCa, respectively. iHGPIN was detected in MRRFTB only, SB only, and both MRFRB + SB in six (12.5%) 36 (75%), and six patients (12.5%), respectively. Of the 32 MRI scans performed at 3 years, a new PI‐RADS score >2 ROI or an increase in the size or PI‐RADS score of a pre‐existing ROI was observed in four and eight patients, respectively. Nine of these underwent biopsy. Three additional biopsies were performed on non‐suspicious mpMRI. csPCa was detected in two patients, both with an enlarging ROI.ConclusionTo our knowledge, this is the first study examining the incidence, natural history, and subsequent csPCa detection rates for iHGPIN in the era of mpMRI and MRI targeted biopsy. The lower prevalence of iHGPIN is attributed to the selection of biopsy candidates based on mpMRI and an increased likelihood of detecting pre‐existing csPCa. Our findings provide compelling evidence that biopsy strategies limited to MRI targets will almost eliminate iHGPIN detection while decreasing detection of csPCa. A 3‐year biopsy should be performed only in men with suspicious mpMRI.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"254 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percentage of free to total PSA as a biomarker of survival in metastatic castration-resistant prostate cancer","authors":"Andrew W. Silagy, Dixon T.S. Woon, Louise Kostos, Rui Bernardino, Ting W. Yiu, Marian S. Wettstein, Hanan Goldberg, Jaime O. Herrera-Cáceres, Hina Shiakh, Gregory Nason, Alexandre Zlotta, Eleftherios Diamantis, Damien Bolton, Neil Fleshner","doi":"10.1111/bju.16751","DOIUrl":"https://doi.org/10.1111/bju.16751","url":null,"abstract":"To analyse whether the percentage of free to total prostate-specific antigen (%fPSA) is a prognostic biomarker in metastatic castration-resistant prostate cancer (mCRPC), as novel studies suggest an elevated %fPSA is associated with adverse oncological outcomes for men with biochemical recurrence of prostate cancer.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"28 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in assessing long-term urinary and fecal outcomes following bladder exstrophy repair: Response to Liao et al.","authors":"Abdellaoui Sarah, Cazzorla Fabiana, Morel-Journel Nicolas, Bidault Valeska, Neuville Paul, Ruffion Alain, Pierre D.E. Mouriquand, Demède Delphine","doi":"10.1111/bju.16753","DOIUrl":"https://doi.org/10.1111/bju.16753","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"1 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive surgical margin and oncological outcomes after robot‐assisted radical prostatectomy in different Cancer of the Prostate Risk Assessment risk groups","authors":"Anna Hagman, Anna Lantz, David Grannas, Stefan Carlsson, Olof Akre, Mats Olsson, Lars Egevad, Jonas Höijer, Peter Wiklund","doi":"10.1111/bju.16732","DOIUrl":"https://doi.org/10.1111/bju.16732","url":null,"abstract":"ObjectiveTo evaluate the impact of a positive surgical margin (PSM) in relation to the risk of biochemical recurrence (BCR) and additional treatment in different preoperative Cancer of the Prostate Risk Assessment (CAPRA) risk groups after robot‐assisted radical prostatectomy (RARP).Patients and methodsRetrospective cohort study of 1039 patients subjected to RARP for prostate cancer at a single European institution. PSM was stratified by extent (focal extensive). The CAPRA score was used for risk group stratification. BCR was defined as a prostate‐specific antigen level &gt;0.2 ng/mL. Additional treatment was defined as salvage radiotherapy (sRT) and/or androgen‐deprivation therapy (ADT).ResultsIn total 227 patients had a PSM (21.8%). When compared to a negative surgical margin, an extensive PSM was associated with an increased risk of BCR (hazard ratio [HR] 2.16, 95% confidence interval [CI] 2.09–8.29; HR 3.76, 95% CI 2.33–6.06; HR 2.35, 95% CI 1.03–5.38) and sRT (HR 3.75, 95% CI 1.45–9.7; HR 4.57, 95% CI 2.47–8.43; HR 9.32, 95% CI 1.06–14.82) in the low‐, intermediate‐ and high‐risk groups, respectively. In high‐risk patients a focal PSM was associated with an increased risk of BCR (HR 5.79, 95% CI 1.62–20.65), sRT (HR 9.32, 95% CI 1.7–50.95) and ADT (HR 4.11, 95% CI 1.08–15.57) whereas in low‐ and intermediate‐risk patients a modest effect on BCR but no significant effect on sRT or ADT was found. We found no significant interaction between CAPRA risk group and PSM (<jats:italic>P =</jats:italic> 0.25).ConclusionsWhile an extensive PSM was associated with an increased risk of recurrence in all risk groups, a focal PSM was associated with additional treatment only among men with high‐risk tumours.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"9 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 360° multidisciplinary appraisal of novel surgical technologies – is this a new standard?","authors":"Anthony Emmanuel, Sachin Malde, Prokar Dasgupta, Majed Shabbir","doi":"10.1111/bju.16756","DOIUrl":"https://doi.org/10.1111/bju.16756","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"33 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matched‐pair analysis of peri‐operative and oncological outcomes of robot‐assisted vs open retroperitoneal lymph node dissection","authors":"Pailin Pongratanakul, Marieke Vermeulen‐Spohn, Carolin Wöltjen, Sophia Thy, Andreas Hiester, Peter Albers, Yue Che","doi":"10.1111/bju.16747","DOIUrl":"https://doi.org/10.1111/bju.16747","url":null,"abstract":"ObjectiveTo analyse a comparatively large cohort of patients who underwent robot‐assisted retroperitoneal lymph node dissection (R‐RPLND) in a single centre, assessing the peri‐operative and oncological safety of this procedure compared to that in a matched‐pair cohort of patients who underwent open retroperitoneal lymph node dissection (O‐RPLND).MethodsWe retrospectively identified 100 patients who underwent R‐RPLND between October 2010 and January 2024. A matched‐pair analysis of R‐RPLNDs and O‐RPLNDs was conducted based on the following criteria: surgical indication, histology, clinical stage (CS), and tumour size. The primary endpoint of this analysis was progression‐free survival (PFS). Secondary endpoints were peri‐operative parameters.ResultsBased on surgical indication, the R‐RPLND cohort was divided into four groups: CS II seminoma (Group 1, 42 patients); marker‐negative CS II non‐seminoma (Group 2, 15 patients); CS I non‐seminoma with high‐risk factors (Group 3, seven patients), and post‐chemotherapy patients (Group 4, 34 patients). Two patients were excluded due to uncommon testicular histology. With a mean follow‐up of 32, 31, 32 and 28 months in the four groups, respectively, relapses occurred in 10/42 of Group 1, 3/15 of Group 2, and 1/7 of Group 3, while all patients remained relapse‐free in Group 4. The matched‐pair analysis revealed that histological retroperitoneal lymph node dissection specimens, relapse rates, and PFS were similar in the R‐RPLND and O‐RPLND groups. R‐RPLND had advantages in terms of a shorter hospital stay as a surrogate for less morbidity.ConclusionIn selected patients and selected surgical indications, R‐RPLND represents a minimally invasive alternative to O‐RPLND in the management of patients with testicular germ cell tumours.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"46 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot‐assisted MRI/US fusion transperineal prostate biopsy using the Biobot system: a single‐centre experience","authors":"Gabriele Bignante, David O. Katz, William A. Langbo, Angelo Orsini, Francesco Lasorsa, Edward E. Cherullo, Riccardo Autorino, Srinivas Vourganti","doi":"10.1111/bju.16742","DOIUrl":"https://doi.org/10.1111/bju.16742","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"49 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long‐term follow‐up reveals complexity of urinary and faecal continence outcomes in patients with classic bladder exstrophy","authors":"Mao Liao, Molan Li","doi":"10.1111/bju.16752","DOIUrl":"https://doi.org/10.1111/bju.16752","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"28 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of current quality care metrics after radical nephroureterectomy","authors":"Igor Duquesne, Pierre-Etienne Gabriel, Mohamad Abou Chakra, Mohamad Moussa, Raymond Mansour, Mihnea Bogdan Borz, Louise Duffaut, Benoit Mesnard, Said Ourfali, Jeremy Mercier, Michaël Peyromaure, Alexandre de la Taille, Jérôme Rigaud, Alain Ruffion, Frédéric Panthier, Evanguelos Xylinas, Alexandra Masson-Lecomte, Morgan Rouprêt, Thomas Seisen, Mathieu Roumiguié","doi":"10.1111/bju.16741","DOIUrl":"https://doi.org/10.1111/bju.16741","url":null,"abstract":"To externally validate the tetrafecta and pentafecta frameworks for assessing the quality of radical nephroureterectomy (RNU) and their correlation with oncological outcomes in patients with localised upper tract urothelial carcinoma (UTUC).","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"34 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}