BJU International最新文献

Active surveillance in prostate cancer: when to exit and what are the options? 前列腺癌的主动监测：何时退出？有哪些选择？

IF 4.5 2区医学

BJU International Pub Date : 2025-05-19 DOI: 10.1111/bju.16744

Jianliang Liu,Dixon T S Woon,Marlon Perera,Nathan Lawrentschuk

引用次数: 0

Bridging the gap: the role of large language model refinement in readability in urology research. 弥合差距：大语言模型细化在泌尿学研究可读性中的作用。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-19 DOI: 10.1111/bju.16774

Giovanni E Cacciamani,Ethan Layne,Maria Giovanna Asmundo,Giorgio Ivan Russo

引用次数: 0

Robot-assisted PSMA-radioguided surgery for local recurrence in the prostatic bed. 机器人辅助psma放射引导前列腺床局部复发手术。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-19 DOI: 10.1111/bju.16770

Fabian Falkenbach,Giovanni Mazzucato,Marie-Lena Schmalhofer,Zhe Tian,Pierre I Karakiewicz,Markus Graefen,Lars Budäus,Philipp Mandel,Fijs W B van Leeuwen,Matthias N van Oosterom,Anne-Claire Berrens,Henk G van der Poel,Farzad Shenas,Daniel Koehler,Sophie Knipper,Tobias Maurer

引用次数: 0

What is lost in an average? Identifying distinct post-radical prostatectomy functional recovery profiles. 平均损失了什么？明确根治性前列腺切除术后不同的功能恢复概况。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-15 DOI: 10.1111/bju.16773

Patrick Lewicki,Kevin Ginsburg,Nnenaya Mmonu,Corinne Labardee,Anna Johnson,James Peabody,Adam Gadzinski,Alice Semerjian,Tudor Borza,Brian R Lane,Andrew E Krumm,

{"title":"What is lost in an average? Identifying distinct post-radical prostatectomy functional recovery profiles.","authors":"Patrick Lewicki,Kevin Ginsburg,Nnenaya Mmonu,Corinne Labardee,Anna Johnson,James Peabody,Adam Gadzinski,Alice Semerjian,Tudor Borza,Brian R Lane,Andrew E Krumm,","doi":"10.1111/bju.16773","DOIUrl":"https://doi.org/10.1111/bju.16773","url":null,"abstract":"OBJECTIVETo describe, via latent variable mixture modelling, distinct post-radical prostatectomy (RP) patient-reported outcome (PRO) recovery profiles, which are positioned to complement currently disseminated statistical averages for shared decision-making.PATIENTS AND METHODSPatients undergoing RP and completing the 26-item Expanded Prostate Cancer Index Composite 12 months after surgery were identified from the Michigan Urological Surgery Improvement Collaborative data registry. Hierarchical cluster analysis and latent variable mixture modelling was applied to urinary incontinence (UI) and sexual function (SF) recovery scores, and final models chosen based on optimal performance.RESULTSA total of 3956 patients comprised the study cohort. Three distinct UI profiles were identified with prevalence of 49%, 37% and 14% from best to worst recovery, respectively. Four distinct SF profiles were identified with prevalence of 14%, 24%, 42%, and 20%, from best to worst recovery, respectively. The last two SF profiles had similar function scores but differed based on perception of function being bothersome. Limitations include incomplete PRO capture, which may introduce bias.CONCLUSIONSWe identify distinct UI and SF recovery profiles and their prevalence from a large, prospectively maintained registry, potentially improving interpretability of PRO data for decision making.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"25 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostate cancer active surveillance in solid organ transplant: a matched study and literature review. 前列腺癌在实体器官移植中的主动监测：一项匹配研究和文献综述。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-14 DOI: 10.1111/bju.16777

Mark N Alshak,Michelle I Higgins,Aurora J Grutman,Jack Campbell,Joseph G Cheaib,Carlos A Rivera Lopez,Marcus Spann,Yuezhou Jing,Christian P Pavlovich

{"title":"Prostate cancer active surveillance in solid organ transplant: a matched study and literature review.","authors":"Mark N Alshak,Michelle I Higgins,Aurora J Grutman,Jack Campbell,Joseph G Cheaib,Carlos A Rivera Lopez,Marcus Spann,Yuezhou Jing,Christian P Pavlovich","doi":"10.1111/bju.16777","DOIUrl":"https://doi.org/10.1111/bju.16777","url":null,"abstract":"OBJECTIVESTo evaluate outcomes of prostate cancer (PCa) active surveillance (AS) in patients with versus without solid organ transplant (SOT), as the safety of PCa AS in patients with SOT remains understudied. We also performed a literature review to identify all studies describing PCa AS in patients with SOT.PATIENTS AND METHODSA retrospective study was conducted for patients with SOT (kidney, liver, heart, lung) with a diagnosis of PCa enrolled into AS either before or after SOT. Using prospectively collected information, they were matched with non-SOT AS patients at PCa diagnosis by age, race, prostate-specific antigen, and Gleason Grade Group (GGG). A scoping review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.RESULTSA total of 32 SOT AS patients were matched with 99 non-SOT AS patients. After matching, there was no significant difference in baseline demographics. 34% were enrolled into AS before SOT. The median time on AS for patients with and without SOT was 4.7 and 4.98 years, respectively (P = 0.87). In all, 53% of patients with SOT and 54.5% those without SOT were still on AS (P = 0.99). In all, 28.1% of patients with and 39.4% without SOT progressed to definitive treatment (P = 0.30), and there were no differences in rates of grade re-classification or GGG at definitive treatment. No systemic disease progression or PCa-specific deaths occurred. In the literature, we identified and reviewed 11 studies and found 99 patients enrolled into AS either before (n = 33) or after (n = 66) SOT. We did not identify a safety signal.CONCLUSIONWe present the largest series of patients with PCa on AS with SOT. In patients with SOT and PCa on AS, a surveillance strategy appears safe and has similar outcomes as those without SOT on AS. Our review found a paucity of AS data in the SOT setting suggesting that further research is warranted.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"17 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re: metabolic syndrome and postoperative risks - a need for proactive BPH treatment. 代谢综合征和术后风险——前列腺增生需要积极治疗。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-14 DOI: 10.1111/bju.16781

Yu-Hsiang Lin,Kuo-Jen Lin,Hsin-Ho Liu

引用次数: 0

Routine prostate biopsies not needed after cryotherapy if surveillance MRI is normal. 如果监测MRI正常，冷冻治疗后不需要常规前列腺活检。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-14 DOI: 10.1111/bju.16772

Herbert Lepor,Jesse Persily,Samuel Parry,Eli Rapoport,Majlinda Tafa,James S Wysock

{"title":"Routine prostate biopsies not needed after cryotherapy if surveillance MRI is normal.","authors":"Herbert Lepor,Jesse Persily,Samuel Parry,Eli Rapoport,Majlinda Tafa,James S Wysock","doi":"10.1111/bju.16772","DOIUrl":"https://doi.org/10.1111/bju.16772","url":null,"abstract":"OBJECTIVESTo compare the clinically significant prostate cancer detection rate (csPCaDR) and pathological characteristics of magnetic resonance imaging (MRI) visible (MRIv) and MRI invisible (MRIi) cancers among men undergoing surveillance after ablative focal therapy (AFT) for intermediate-risk PCa.PATIENTS AND METHODSA total of 305 five men enrolled in an Institutional Review Board-approved primary partial gland cryoablation (PPGCA) outcomes registry meeting the following inclusion criteria: an MRI region of interest (ROI) Prostate Imaging-Reporting and Data System 2-5 concordant with unilateral intermediate-risk disease (Gleason Grade Group [GGG] 2 or 3 disease), no gross extraprostatic extension on MRI, no GGG ≥2 contralateral to the ROI, and at least 6 months of follow-up. Protocol MRI was performed at 6, 24, 42 and 60 months. Biopsy indications evolved over time. Any Gleason pattern 4 (GP4) represented a clinically significant PCa recurrence (csPCaR). Pathological disease characteristics, csPCaDR, and salvage treatments were compared for MRIv and MRIi disease. Baseline and post-treatment characteristics were compared between MRIv and MRIi csPCaR. Ordinal and binary measures were compared with Mann-Whitney rank-sum test. Categorical testing for differences was performed with chi-square testing.RESULTSOf 665 post-treatment MRIs, 87 (13.1%) and 578 (86.9%) were positive (+ve) and negative (-ve) for csPCaR, respectively. Biopsies were taken in 62 of the 87 +ve MRIs and 179 of the 578 -ve MRIs, with a csPCaDR of 43.5% and 10.6% for +ve and -ve MRI, respectively. Of the 46 csPCaRs, 28 (61%) and 18 (39%) were associated with +ve and -ve MRI, respectively. The median linear length of GP4 for MRIv and MRIi csPCaR was 2.6 and 0.6 mm, respectively (P = 0.08). Four (14%) and eight (44%) MRIv and MRIi csPCaRs were managed with continued active surveillance (P = 0.03).CONCLUSIONThe cost and morbidity of surveillance following PPGCA can be safely reduced by avoiding biopsy in most cases with -ve MRI.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"25 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Lin et al. 对Lin等人的回应。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-14 DOI: 10.1111/bju.16782

Victoria S. Edmonds, Mitchell R. Humphreys

引用次数: 0

Response to Chen et al. 对Chen等人的回应。

IF 4.5 2区医学

BJU International Pub Date : 2025-05-10 DOI: 10.1111/bju.16778

Nicolas A. Soputro, Jihad Kaouk

引用次数: 0

Precision medicine in genitourinary oncology: are we pivoting towards imprecision? 泌尿生殖肿瘤学的精准医学：我们是否正在转向不精准？