BJU International最新文献

{"title":"External validation of a nomogram for unilateral pelvic lymph node dissection in prostate cancer","authors":"Gernot Ortner, Fabian Falkenbach, Mykyta Kachanov, Tim Inderhees, Tobias Maurer, Sophie Knipper, Markus Graefen, Lars Budäus","doi":"10.1111/bju.16687","DOIUrl":"https://doi.org/10.1111/bju.16687","url":null,"abstract":"ObjectivesTo explore the rationale of unilateral extended pelvic lymph node dissection (ePLND) during radical prostatectomy (RP) by external validation of a nomogram for unilateral ePLND (unilat‐NG) and comparison to the Briganti 2019 nomogram.Patients and methodsPatients with magnetic resonance imaging‐fusion biopsy and consecutive RP with bilateral ePLND were identified within an institutional database. The primary endpoint was the detection rate of lymph node invasion (LNI) contralateral to the prostatic lobe with adverse cancer characteristics. The performance of the unilat‐NG and the Briganti 2019 nomogram to detect contralateral LNI was assessed using descriptive analysis, the receiver operating characteristic curve–derived area under the curve (AUC), and multivariable logistic regression analyses.ResultsOf the overall 406 consecutive patients, 68/406 (16.7%) presented with pathological (p)N1 disease at RP. The AUC for the unilat‐NG with a 1%, 2% and 2.5% cut‐off was 0.58 (95% confidence interval [CI] 0.53–0.63), 0.67 (95% CI 0.59–0.75), and 0.69 (95% CI 0.60–0. 77), respectively; compared to an AUC of 0.72 (95% CI 0.66–0.78) for the Briganti 2019 nomogram with a 7% cut‐off. Applying the unilat‐NG with a 2.5% cut‐off, contralateral ePLND could be omitted in 303/406 (74.6%) patients, misclassifying 10/406 (2.5%) patients with pN0 disease.ConclusionThe Briganti 2019 nomogram outperformed the novel unilat‐NG in contralateral LNI prediction. Yet, a significant proportion of patients undergoing unilateral ePLND would be falsely classified with pN0 disease using any of the nomograms. Therefore, bilateral ePLND should remain the standard of care if PLND is indicated.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"2 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of invasive penile cancer after treatment of penile intraepithelial neoplasia","authors":"Inessa Bjartmar, Axel Gerdtsson, Christian Torbrand, Sinja Kristiansen","doi":"10.1111/bju.16674","DOIUrl":"https://doi.org/10.1111/bju.16674","url":null,"abstract":"ObjectivesTo examine the risk of progression and time to progression from penile intraepithelial neoplasia (PeIN) to invasive penile cancer in patients treated for PeIN with either surgery, laser ablation or topical treatment, and to examine recurrence risk after treatment of PeIN.Patients and MethodsData on patients diagnosed with PeIN (<jats:italic>n</jats:italic> = 1122) between 2000 and 2020 were extracted from the Swedish National Penile Cancer Registry (NPECR). Progression was defined as a second registration of invasive penile cancer in this registry. Additionally, patient charts from the three largest cities in Sweden (Stockholm, Gothenburg and Malmö) were analysed with regard to both progression of PeIN to invasive cancer and recurrence risk after treatment.ResultsThe NPECR included 1122 patients with PeIN, of whom 23 were re‐registered as having invasive penile cancer. In the 927 PeIN patients for whom data on treatment were available, re‐registration of invasive cancer was seen in 13 patients after surgery, six after laser ablation, and one after topical treatment. The progression‐free probabilities at 24 months in these treatment groups were 99.3% (95% confidence interval [CI] 0.987; 0.999), 100% (95% CI 1.000; 1.000) and 98.8% (95% CI 0.965; 1.000), respectively (log‐rank test <jats:italic>P</jats:italic> = 0.192). In the Stockholm, Gothenburg and Malmö cohort, 253 patients with PeIN were followed and 14 developed invasive penile cancer. Of the 247 PeIN cases with data on treatment, four progressed after surgery, eight after laser ablation, and one after topical treatment. The progression‐free probabilities at 24 months in these treatment groups were 98.2% (95% CI 0.956; 1.000), 86.2% (95% CI 0.744; 0.997) and 100% (95% CI 1.000; 1.000), respectively (log‐rank test <jats:italic>P</jats:italic> &lt; 0.001).ConclusionWe found that PeIN has a low risk of progressing into invasive penile cancer regardless of treatment modality. However, laser ablation therapy is not recommended due to a higher risk of progression after such treatment compared to surgical and topical treatment. We recommend individualised follow‐up protocols of PeIN based on treatment and lesion location.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"15 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of high-risk localised muscle invasive bladder cancer","authors":"","doi":"10.1111/bju.16672","DOIUrl":"https://doi.org/10.1111/bju.16672","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"364-365"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term multicentre analysis of robot-assisted radical cystectomy for non-muscle-invasive bladder cancer","authors":"Neeraja Tillu, Reuben Ben-David, Viktor Skokic, Jordan M. Rich, Kaushik P. Kolanukuduru, Linda Dey, Juhana Rautiola, Johan Björklund, Mohammed Almoflihi, Ahmed Eraky, Gus Miranda, Giovanni Cacciamani, Mihir Desai, Reza Mehrazin, John P. Sfakianos, Peter Wiklund","doi":"10.1111/bju.16686","DOIUrl":"https://doi.org/10.1111/bju.16686","url":null,"abstract":"To evaluate the 12-year survival outcomes of patients with non-muscle-invasive bladder cancer (NMIBC) who underwent robot-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD), focusing on those upstaged to ≥pT2 or with node-positive disease.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"209 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"March's reviewers of the month","authors":"","doi":"10.1111/bju.16673","DOIUrl":"https://doi.org/10.1111/bju.16673","url":null,"abstract":"&lt;p&gt;Like most journals, BJUI relies on the hard work and dedication of its peer reviewers and we are grateful to them all. Each month the Editorial Team nominates peer reviewers whose reviews have stood out for their quality and timeliness and those selected as the best are highlighted on this page in recognition of their exceptional work.&lt;/p&gt;&lt;p&gt;Dr Hemal has done pioneering work in the field of laparoscopic urology venturing in the field since 1992 and has been associated with initial development of robotic urologic surgery since 2001 developing several techniques. His unique contribution has been in training of Fellows, residents, urologists (worldwide) in addition performing live demonstration of endourological, laparoscopic and Robotic Urologic Surgical procedures in over 350 scientific conferences all across the world for educational purposes and disseminating the knowledge, Proctoring, Mentoring and Preceptorship in Laparoscopic, Endourology and Robotic Urologic Surgery during entire career spanning over 35 years. He helped developing robotic program and Team at several centres all across the world since 2001. Dr Hemal has seven books and over 450 scientific papers in peer-reviewed journals and another 200 papers and book chapters to his credit. He has been the recipient of many academic distinctions and awards to name a few prestigious BC Roy Award, UGC Hari Om Ashram award and “Padma-Shree” by the president of India. He is also recipient of several other prestigious award such as Urologist of the Decade award, Guest Scholar of the American College of Surgeons, SIU- scholar, Fulbright scholar, and Health Hero award given by Business Journal of USA. He has also received Sushruta award by Indian, American Urology association. He has been nominated as Best Doctor of America, Top Doctor of America and Top Prostate Cancer doctor since 2008 every year till the date. He was also featured as Top Prostate Cancer doctor of USA in New York Times, USA.&lt;/p&gt;&lt;p&gt;Dr Usher-Smith is a GP and Associate Professor of General Practice at the University of Cambridge. Her main research interest focuses on optimising the implementation of risk-stratified medicine to promote prevention and early detection of cancer and cardiovascular disease. This includes quantitative and qualitative research covering the development and validation of risk models, evaluation of the societal, psychological, behavioural and system-level aspects associated with implementation, and conducting feasibility and pilot studies within clinical practice. Alongside research on breast cancer risk assessment and risk-stratified bowel cancer screening, she co-led the Yorkshire Kidney Screening Trial, the first study to assess the feasibility of incorporating an additional abdominal CT-scan within risk-based lung cancer screening programmes, and is currently leading a feasibility study of incorporating a newly developed PREDICT Kidney risk communication tool into clinical care for patients who have ","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 3","pages":"363"},"PeriodicalIF":3.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16673","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any difference between cognitive and fusion transrectal biopsies if performed by residents?","authors":"Jordi Stira, Riccardo Lombardo, Carmen Gravina, Giorgia Tema, Antonio Nacchia, Antonio Franco, Alessandro Guercio, Antonio Cicione, Alessandra Fegiz, Ferdinando Fusco, Giorgio Franco, Antonio Luigi Pastore, Yazan Al Salhi, Andrea Fuschi, Andrea Tubaro, Cosimo De Nunzio","doi":"10.1111/bju.16681","DOIUrl":"https://doi.org/10.1111/bju.16681","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"421 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistics in clinical urology research: fundamental concepts in comparative research","authors":"Melissa Assel,&nbsp;Sigrid V. Carlsson","doi":"10.1111/bju.16685","DOIUrl":"10.1111/bju.16685","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"135 5","pages":"714-716"},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urology residency - a demographic cross-sectional study by the Swiss Society of Residents in Urology.","authors":"Silvan Sigg, Luca Afferi, Fabienne Lehner, Sarah Dugas, Madlen Kasten, Julien Blanc, Andres Affentranger, Fabian Aschwanden","doi":"10.1111/bju.16684","DOIUrl":"https://doi.org/10.1111/bju.16684","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Google infodemiology and temporal trends in benign prostatic hyperplasia surgery in Australia.","authors":"Brian Ng Hung Shin, Liang Qu, Samuel X Tan, Handoo Rhee, Eric Chung","doi":"10.1111/bju.16650","DOIUrl":"https://doi.org/10.1111/bju.16650","url":null,"abstract":"<p><strong>Objective: </strong>To contextualise the national population-based temporal surgical trends in the management of benign prostatic hyperplasia (BPH) in Australia.</p><p><strong>Methods: </strong>Google Trends (GT) was used to analyse the level of patients' online interest in various surgical options for the treatment of BPH. Analysis of variance was performed and the average rates of change in GT popularity score was calculated for the period from 1 January 2010 to 31 October 2022. Data regarding surgical volume were extracted from the Medicare Benefits Schedule and the Australian Institute of Health and Welfare databases, and population-adjusted rates of BPH procedures performed were calculated accordingly.</p><p><strong>Results: </strong>The level of online interest in Australia was highest for transurethral resection of the prostate (TURP) and population data also showed that TURP remained the most utilised procedure across the study period. Nationwide, there was an increased uptake of photovaporisation of the prostate, accounting for 7.6% of BPH procedures in 2020-2021, with correspondingly lower rates of TURP and simple prostatectomies performed. Holmium laser enucleation of the prostate (HoLEP) appeared to be underutilised and had the lowest mean popularity score, while prostatic urethral lift (PUL) and transurethral water vapour ablation (TUWA) showed strong uptake in the more recent years. The average rates of change were highest for TURP at +1.59/year (P < 0.001), followed by PUL at +0.56/year (P < 0.001) and TUWA at +0.50/year (P = 0.004), while the lowest was for HoLEP at +0.09/year (P = 0.116).</p><p><strong>Conclusion: </strong>Differences were found between GT analysis and actual BPH procedures performed at a population level. This study highlights that clinicians need to adapt and provide better patient counselling to ensure a shared decision-making process when choosing the treatment procedure for BPH/male LUTS.</p>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of BCG vs upfront radical cystectomy for high-risk non-muscle-invasive bladder cancer.","authors":"Pietro Scilipoti, Mattia Longoni, Mario de Angelis, Paolo Zaurito, Aleksander Ślusarczyk, Francesco Soria, Benjamin Pradere, Wojciech Krajewski, David D'Andrea, Andrea Mari, Francesco Del Giudice, Renate Pichler, José Daniel Subiela, Gautier Marcq, Andrea Gallioli, Luca Afferi, Riccardo Mastroianni, Giuseppe Simone, Simone Albisinni, Laura S Mertens, Ekaterina Laukhtina, Katharina Oberneder, José Luis Rodríguez Elena, Javier Aranda, Alfonso Lafuente Puentedura, Jorge Caño Velasco, Roberto Contieri, Rodolfo Hurle, Keiichiro Mori, Piotr Radziszewski, Shahrokh F Shariat, Paolo Gontero, Andrea Necchi, Morgan Rouprêt, Francesco Montorsi, Andrea Salonia, Alberto Briganti, Marco Moschini","doi":"10.1111/bju.16675","DOIUrl":"https://doi.org/10.1111/bju.16675","url":null,"abstract":"<p><strong>Objective: </strong>To assess the oncological outcomes of patients with high-risk (HR) and very high-risk (VHR) non-muscle-invasive bladder cancer (NMIBC) treated with upfront radical cystectomy (RC) vs Bacillus Calmette-Guérin (BCG) instillations from a contemporary European multicentre cohort.</p><p><strong>Patients and methods: </strong>We conducted a retrospective analysis of 1491 patients diagnosed with HR- or VHR-NMIBC from a European multicentre database between 2015 and 2024. Patients were included if they received either upfront RC or at least five doses of BCG. A 1:1 propensity score matching (PSM) according to clinically relevant variables was applied. Progression was defined as muscle-invasive or metastatic disease. Cumulative incidence plots and multivariable competing risk regression models addressing cancer-specific mortality (CSM) were fitted.</p><p><strong>Results: </strong>Among the 1221 patients with HR- (n = 1221 [90%]) or VHR-NMIBC (n = 121 [10%]), 87 (7.1%) underwent upfront RC. The median follow-up was 2.6 years. After PSM (87 vs 87 patients), the 5-year CSM rate was similar in patients treated with BCG (13%) vs their upfront RC counterparts (16%) (hazard ratio: 1.77, 95% confidence interval [CI] 0.66-4.73; P = 0.3). Of the 1134 patients who initially received BCG, 73 (6.6%) eventually required delayed RC, with 34 (47%) progressing to muscle-invasive bladder cancer before delayed RC. The 3-year CSM rate was comparable in upfront RC (13%) vs delayed RC (11%) among non-progressing patients (P = 0.3). However, patients who progressed before delayed RC had worse 3-year CSM relative to those who did not (13% vs 31%, hazard ratio: 0.32, 95% CI 0.13-0.83; P = 0.018).</p><p><strong>Conclusion: </strong>Within a European cohort of patients with HR- and VHR-NMIBC, upfront RC was rarely performed. Patients treated with BCG did not exhibit a CSM disadvantage relative to their upfront RC counterparts. After matching, long-term CSM was similar between BCG therapy and upfront RC. Delayed RC, led to worse outcomes if performed after progression, but matched upfront RC when performed before progression, underscoring importance of timely surgery.</p>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}