BJU International最新文献

{"title":"Indirect evidence and cautious sequencing in indeterminate testicular lesions.","authors":"Lei Wang, Chao Wang, Yukun Pan, Dongxiang Zheng","doi":"10.1111/bju.70348","DOIUrl":"10.1111/bju.70348","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":"734-735"},"PeriodicalIF":4.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Caution in interpreting the diagnostic superiority of digital Uromonitor in NMIBC surveillance\".","authors":"José Rubio-Briones","doi":"10.1111/bju.70335","DOIUrl":"10.1111/bju.70335","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":"731-732"},"PeriodicalIF":4.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological concerns on prostate-specific membrane antigen (PSMA) immunohistochemistry for predicting PSMA-PET avidity.","authors":"Yukun Liu, Zhangming Lei, Penglei Mao","doi":"10.1111/bju.70328","DOIUrl":"10.1111/bju.70328","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":"732-733"},"PeriodicalIF":4.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: 'Indirect evidence and cautious sequencing in indeterminate testicular lesions'.","authors":"Muhammed Arif Ibis, Fabio Castiglione","doi":"10.1111/bju.70349","DOIUrl":"10.1111/bju.70349","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":"735-736"},"PeriodicalIF":4.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"A deep-learning model using automatedperformance metrics and clinical features topredict urinary continence recovery afterrobot-assisted radical prostatectomy\".","authors":"","doi":"10.1111/bju.70338","DOIUrl":"10.1111/bju.70338","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":"738"},"PeriodicalIF":4.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: 'Methodological concerns on prostate-specific membrane antigen (PSMA) immunohistochemistry for predicting PSMA-PET avidity'.","authors":"Jonathon Carll, Henry Yen-Cheng Pan, Nathan Lawrentschuk, Andrew Ryan","doi":"10.1111/bju.70327","DOIUrl":"10.1111/bju.70327","url":null,"abstract":"","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":"733-734"},"PeriodicalIF":4.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13550804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT urography and urinary cytology in surveillance of endoscopically managed UTUC","authors":"Pietro Scilipoti, Raffaele La Mura, Federico Zorzi, Marie Chicaud, Nicola Nannola, Carlos Gonzalez Gonzalez, Andrea Folcia, Angelo Occhi, Andrea Cosenza, Eugenio Ventimiglia, Luigi Candela, Giuseppe Rosiello, Marco Moschini, Francesco Montorsi, Alberto Briganti, Andrea Salonia, Steeve Doizi, Frederic Panthier, Luca Villa, Olivier Traxer","doi":"10.1111/bju.70469","DOIUrl":"https://doi.org/10.1111/bju.70469","url":null,"abstract":"Objective Our objective was to assess whether non‐invasive surveillance with computed tomography (CT) urography and urinary cytology could safely reduce the need for ureteroscopy (URS) in patients with upper tract urothelial carcinoma treated with endoscopic kidney‐sparing surgery (eKSS). Patients and Methods We performed a retrospective multicentre analysis of patients undergoing eKSS for upper tract urothelial carcinoma at two tertiary centres (2006–2025). Surveillance included second‐look URS at 4–6 weeks, then every 6 months for 2 years and annually thereafter. CT urography and urinary cytology were performed within 3 months before each URS, and this served as the reference standard. Four trigger strategies were evaluated for diagnostic performance. Analysis started from the third URS. Recurrence over time was analysed using annualized rates per person‐year, accounting for multiple recurrences and treating radical nephroureterectomy as a competing event, overall and by risk group. Results A total of 133 patients and 256 ureteroscopic assessments were included. Combined CT and/or cytology showed sensitivity of 35.5%, specificity of 75.0%, a positive predictive value of 64.1% (95% confidence interval [CI] 52.4–74.7), and a negative predictive value of 48.0% (95% CI 40.4–55.7), avoiding 69.2% of URS (95% CI 63.1–74.8) but missing 64.5% of recurrences (95% CI 56.0–72.4). Cytology alone was highly specific (97%) but poorly sensitive (11%); CT alone showed moderate sensitivity (27%) and good specificity (78%); requiring both to be positive yielded near‐perfect specificity but near‐zero sensitivity (2.8%). Recurrence rates were stable across follow‐up years at 0.34, 0.35, 0.35, and 0.28 events/person‐year at years 1–4 in the low‐risk group, and 0.33, 0.38, 0.32, and 0.32 in the high‐risk group. Conclusions CT urography and urinary cytology may reduce the frequency of URS but cannot safely replace endoscopic surveillance because of the high rate of missed recurrences. Stable recurrence rates over time support the need for continued long‐term endoscopic follow‐up after eKSS.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"63 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient‐reported outcomes as non‐muscle‐invasive bladder cancer clinical trial endpoints","authors":"Kimberly Toumazos, Spencer Bell, Katelyn Spencer, Darrell Nakagawa, Kelly K. Bree, Ashish M. Kamat, Sarah P. Psutka, Patrick J. Hensley","doi":"10.1111/bju.70461","DOIUrl":"https://doi.org/10.1111/bju.70461","url":null,"abstract":"Objective To evaluate the frequency at which patient‐reported outcomes (PROs) are incorporated as nonmuscle‐invasive bladder cancer (NMIBC) clinical trial endpoints. Patients and Methods Interventional trials limited to patients with NMIBC were queried from clinicaltrials.gov from 1994 to 2025 (start of trial). Observational studies or those without a discrete intervention were excluded. The incorporation of all PROs as primary and secondary endpoints was recorded. PROs were not limited to validated tools. They were defined according to United States Food and Drug Administration (FDA) guidance as any information about a patient's health/experience coming directly from the patient without interpretation by a provider/investigator. Categorical variables were analysed with chi‐square and Fisher's exact tests, when applicable, and continuous variables were analysed with the Mann–Whitney <jats:italic>U</jats:italic> test. Results A total of 94 clinical trials were included, of which 21 (22%) incorporated PROs. PROs were included in 3% and 20% of trials as primary and secondary endpoints, respectively. The most commonly used PROs include the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 (EORTC QLQ‐C30) and EORTC QLQ‐Nonmuscle‐Invasive Bladder Cancer 24 module (incorporated in 48% and 43% of NMIBC trials using PROs, respectively). Trials that incorporated PROs as endpoints included higher median anticipated patient enrolments (median [interquartile range] number of patients 166 [461] vs 46 [101], <jats:italic>P</jats:italic> = 0.002) and were more likely to be randomised controlled trials (62% vs 41%, <jats:italic>P</jats:italic> = 0.057). There was no difference in funding mechanism (industry‐sponsored vs cooperative group/federally funded) between trials that did and did not incorporate PROs. There was little change in PRO incorporation as trial endpoints over time. Conclusion Despite recent emphasis from the FDA, patient advocacy groups, and the scientific community on the use of PRO measurements to capture the holistic, lived experience of patients on investigational cancer therapeutics, there is limited incorporation of PROs in NMIBC interventional trials. These data serve as a call to action for PRO tool harmonisation and universal incorporation in NMIBC clinical trial design.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"6 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of time to nephrectomy on cancer‐specific mortality in pathological T stage ( pT)1b –2 renal cancer","authors":"Michele Nicolazzini, Federico Polverino, Leonardo Quarta, Maximilian Filzmayer, Michele Petix, Calogero Catanzaro, Nick Lee, Jordan A. Goyal, Nicola Longo, Gennaro Musi, Felix K. H. Chun, Alberto Briganti, Riccardo Schiavina, Shahrokh F. Shariat, Carlotta Palumbo, Alessandro Volpe, Fred Saad, Pierre I. Karakiewicz","doi":"10.1111/bju.70468","DOIUrl":"https://doi.org/10.1111/bju.70468","url":null,"abstract":"Objective To assess the impact of prolonged time to surgery on cancer‐specific mortality (CSM) in patients with pathological T stage (pT)1b–2 N0M0 renal cell carcinoma (RCC) treated with nephrectomy (either partial [PN] or radical [RN]). Within the Surveillance, Epidemiology and End Results (SEER) database (2004–2021), we tested the effect of time to surgery &gt;3 vs ≤3 months on CSM in patients with pT1b‐2N0M0 RCC. Patients and Methods Propensity score matching (PSM) and multivariable competing risks regression (CRR) were performed. Subgroup analyses stratified patients according to time to surgery interval (≤1 vs 1–3 months, ≤3 vs 3–6 months, ≤3 vs &gt;6 months), histotype, and grade. Results Of 16 322 patients with pT1b–2 RCC treated with nephrectomy, time to surgery &gt;3 months was recorded in 3023 (18%) patients. These patients were older (median age 64 vs 62 years) and harboured a smaller proportion of pT2 patients (19% vs 30%). After one‐to‐one PSM, 3023 (100%) patients with a time to surgery &gt;3 months exhibited a 60‐month CSM of 7.6% vs 5.9% in 3023 (23%) patients with a time to surgery ≤3 months. In CRR time to surgery &gt;3 months independently predicted 1.3‐fold higher CSM ( <jats:italic>P</jats:italic> = 0.02). Subgroup analyses revealed a dose–response effect, with a CSM increase in 1.3‐fold fashion when time to surgery was 3–6 months vs 1.6‐fold fashion when time to surgery was &gt;6 months. The detrimental effect of time to surgery&gt;3 months was consistent across all grades but was not evidenced among patients with a non‐clear cell RCC. Conclusion In patients with pT1b‐2N0M0 treated with either PN or RN, prolonged time from diagnosis to surgery was associated with higher CSM. This association was not observed among patients with non‐clear cell RCC.","PeriodicalId":8985,"journal":{"name":"BJU International","volume":"9 1","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive photoacoustic imaging maps collagen and muscle remodelling in bladder outlet obstruction.","authors":"Alexander Koven, Xiaolin He, Tianzhou Zhang, Shukai Huang, Monica Farcas, Eno Hysi, Darren A Yuen","doi":"10.1111/bju.70444","DOIUrl":"https://doi.org/10.1111/bju.70444","url":null,"abstract":"<p><strong>Objectives: </strong>Our objective was to characterize regional bladder remodelling in a rat model of partial bladder outlet obstruction (pBOO) and to evaluate collagen-specific photoacoustic (PA) imaging as a noninvasive tool for detecting early structural and collagen remodelling of the bladder wall.</p><p><strong>Materials and methods: </strong>Female Sprague-Dawley rats underwent nerve-sparing midurethral obstruction or sham surgery and were evaluated at 4 and 8 weeks. Two independent cohorts of 30 rats each were studied. Cohort 1 bladders underwent ex vivo multispectral PA imaging (680-970 nm, 40 MHz) and histologic analysis. A custom spectral unmixing algorithm quantified collagen density across bladder regions (dome, midsection, and neck) and compared it with histologic collagen-to-muscle area ratios. Cohort 2 underwent molecular and biochemical analyses, including hydroxyproline quantification and assessment of collagen- and matrix-associated gene expression.</p><p><strong>Results: </strong>pBOO resulted in significant bladder enlargement, with increased absolute bladder mass and bladder-to-body mass ratios at 4 and 8 weeks (P < 0.05). Metabolic cage analysis demonstrated an increased frequency of small-volume voids at 8 weeks, despite preserved mean, maximum, and total voided volumes. Region-specific analysis identified the midsection as the site of greatest collagen accumulation with even greater detrusor muscle expansion, leading to a reduction in the collagen-to-muscle ratio. Molecular markers of collagen and matrix remodelling, along with hydroxyproline content, were significantly elevated, particularly in the midsection. Ex vivo PA imaging quantitatively mapped collagen distribution and demonstrated a strong correlation with histologic collagen-to-muscle ratios (r = 0.75), supporting its validity as a quantitative marker of regional remodelling.</p><p><strong>Conclusion: </strong>Bladder remodelling in pBOO is spatially heterogeneous, involving coordinated alterations in collagen deposition and detrusor muscle architecture that are most pronounced in the midsection. Collagen-specific PA imaging enables quantitative assessment of these structural changes and represents a promising noninvasive tool for early detection and longitudinal monitoring of obstruction-associated bladder wall remodelling.</p>","PeriodicalId":8985,"journal":{"name":"BJU International","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}