BMC Infectious Diseases最新文献

{"title":"Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial.","authors":"M M B Horstink, D R Geel, C A den Uil, P E Deetman, H Endeman, A Abdulla, T M Bosch, W J R Rietdijk, F W Thielen, J J Haringman, P van Vliet, T A Rijpstra, C Bethlehem, A Beishuizen, A E Muller, B C P Koch","doi":"10.1186/s12879-025-10747-3","DOIUrl":"10.1186/s12879-025-10747-3","url":null,"abstract":"<p><strong>Background: </strong>Sepsis and septic shock are significant global healthcare challenges with high mortality rates. Effective management requires timely and adequate antimicrobial therapy. Beta-lactam antibiotics, commonly used in patients with sepsis, are crucial for treating these infections. However, standard dosing often leads to insufficient plasma levels due to dynamic physiological changes in critically ill patients. Previous randomized controlled trials highlighted the need for timely dose adjustments to improve clinical outcomes. This is the study protocol for the BULLSEYE trial in which we aim to optimize antibiotic treatment during the initial 48 h of sepsis by comparing standard to double dosing of beta-lactam antibiotics.</p><p><strong>Methods: </strong>This open-label, multicenter, randomized controlled trial will compare standard to double dosing of beta-lactam antibiotics (cefuroxime, ceftazidime, ceftriaxone, cefotaxime, amoxicillin, amoxicillin/clavulanic acid, flucloxacillin, meropenem, and piperacillin/clavulanic acid) in critically ill patients with septic shock. Participants will be randomized into two arms: the control arm receiving standard care, and the intervention arm receiving double antibiotic doses for 48 h, irrespective of renal function. Following this period, all patients will receive standard doses as per local protocol. The primary outcome is all cause 28-day mortality, with secondary outcomes including 90-day, 365-day, hospital and ICU mortality, hospital and ICU length of stay, SOFA scores, time to shock reversal, microbiological eradication, clinical cure, pharmacodynamic target attainment, safety, quality of life, and medical consumption.</p><p><strong>Discussion: </strong>The BULLSEYE trial aims to improve sepsis treatment in critically ill patients. Despite anticipated recruitment challenges, its large sample size ensures robust comparability. This pivotal trial could significantly impact sepsis treatment, leading to better clinical outcomes.</p><p><strong>Trial registration: </strong>EU_CT 2024-512950-13-00. Protocol version 2.3, protocol date 09-12-2024. Prospectively registered on 09-01-2025 at Clinicaltrails.gov nr. NCT06766461.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"392"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of septic shock caused by drug-resistant Edwardsiella tarda and literature review.","authors":"Yan Zhou, De Ren, Yin Li, Shuiqing Gui","doi":"10.1186/s12879-025-10789-7","DOIUrl":"10.1186/s12879-025-10789-7","url":null,"abstract":"<p><strong>Background: </strong>Edwardsiella tarda (E. tarda) causes highly mortality, which is rare in septic patients. We herein reported a case of septic shock caused by drug-resistant E. tarda.</p><p><strong>Case presentation: </strong>We herein describe a 32-year-old female with septic shock who had the medical history of abortion 1 month ago and \"systemic lupus erythematosus and rheumatoid arthritis\" presented abdominal pain, diarrhea, and dyspnea as the primary symptoms and rapidly deteriorated to MODS following breakfast (undercooked fish porridge) in the ICU. Sepsis surviving bundle was initiated by collecting pathogen culture (sputum, urine and blood samples), empirically broad-spectrum antibiotics administration (Meropenem), along with fluid resuscitation, vasopressor use. E. tarda was confirmed both in blood culture and mNGS (metagenomics next generation sequencing). Thus, the antibiotics were switched to piperacillin-tazobactam according to the susceptibility test that was susceptible to piperacillin-tazobactam and resistant to ampicillin, quinolones and gentamicin. The patient finally recovered and discharged after 18 days of ICU treatment.</p><p><strong>Conclusions: </strong>Empiric antibiotics should be selected with piperacillin-tazobactam and amikacin, and avoid ampicillin, quinolones and gentamicin for suspecting E. tarda infection in southern China. Bacteremia complicated with septic shock caused by E. tarda requires intensive care to improve survival rates.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"393"},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the extent of intrapulmonary spread on chest CT and false-negative results of T-SPOT.TB in pulmonary tuberculosis: a retrospective study.","authors":"Ryo Sato, Naoki Takasaka, Yusuke Hosaka, Taiki Fukuda, Kyota Shinfuku, Makiko Takatsuka, Tsukasa Hasegawa, Masami Yamada, Yumie Yamanaka, Kai Ryu, Takeo Ishikawa, Jun Araya","doi":"10.1186/s12879-025-10777-x","DOIUrl":"10.1186/s12879-025-10777-x","url":null,"abstract":"<p><strong>Background: </strong>The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can influence the results of the T-SPOT.TB test. However, few previous reports have investigated the association between radiologic pulmonary tuberculosis (PTB) severity and T-SPOT.TB test results.</p><p><strong>Methods: </strong>We retrospectively investigated patients with culture-confirmed pulmonary TB (PTB) at the Jikei University Daisan Hospital between September 2016 and December 2021. We aimed to clarify the association of PTB severity, according to computed tomography (CT), with the false-negative results of the T-SPOT.TB test.</p><p><strong>Results: </strong>Among 193 patients with PTB, 43 (22.3%) had false-negative T-SPOT.TB results. High rates of false-negative results were noted for 7/18 (38.9%) patients with PTB spread in two lung segments (mild PTB) and 16/39 (41.0%) patients with PTB spread in 19 lung segments (severe PTB). Multivariate logistic regression analysis showed that mild or severe PTB (odds ratio [OR]: 3.23; 95% confidence interval [CI]: 1.46-7.13; P = 0.004) and lymphopenia (OR: 3.33; 95% CI: 1.20-9.26; P = 0.02) were statistically significant risk factors for false-negative results.</p><p><strong>Conclusions: </strong>Mild or severe intrapulmonary lesions on chest CT might be associated with the false-negative results of the T-SPOT.TB assay. Additionally, estimating the intrapulmonary spread of PTB using chest CT could serve as a useful supplementary tool in diagnosing patients with PTB who receive false-negative results on the T-SPOT.TB test.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"391"},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral-flow device for the diagnosis of invasive aspergillosis: a systematic review and diagnostic meta-analysis.","authors":"Yuqing Fan, Xue Shang, Yan Wang, Yinghua Zhang, Xiuxia Li, Kehu Yang, Haidi Lv, Kangle Guo","doi":"10.1186/s12879-025-10769-x","DOIUrl":"10.1186/s12879-025-10769-x","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of invasive aspergillosis (IA) can significantly enhance patient survival rates; however, accurately diagnosing IA remains a formidable challenge. Lateral flow device (LFD), as a non-invasive detection method, have been extensively investigated in numerous clinical studies. The objective of this study was to elucidate the diagnostic accuracy of LFD in detecting IA through a meta-analysis.</p><p><strong>Methods: </strong>The PubMed, Embase, and Web of Science database were searched to obtain clinical studies on the diagnosis of IA by LFD. A random-effects meta-analysis with a bivariate hierarchical model was used, the estimates and 95% confidence intervals (CI) were used to present pooled sensitivity, specificity, and summary receiver operating characteristic curves (SROC).</p><p><strong>Results: </strong>Twenty-five cohort or case-control studies were included. The pooled sensitivity of LFD in the diagnosis of IA was 0.67 (95% CI: 0.57-0.75), specificity was 0.90 (95% CI: 0.85-0.93), diagnostic odds ratio was 15.70 (95% CI: 9.69-25.44), the area under the SROC curve (AUC) was 0.87 (95% CI: 0.82-0.93). Subgroup analysis showed that the sensitivity of bronchoalveolar lavage fluid specimen was higher than serum specimen (0.72, 95% CI: 0.67-0.78 vs. 0.49, 95% CI: 0.41-0.56), bronchoalveolar lavage fluid specimens also have higher diagnostic accuracy (AUC = 0.89).</p><p><strong>Conclusions: </strong>LFD is an effective technique for the detection of IA infection, but attention should be paid to the influence of specimen source on the accuracy of this technique.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"388"},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Isolation, genetic, and biological characterization of human adenovirus type 55 positive isolates from Wuhan, China.","authors":"Jing Xie, Yan Wang, Huan Li, Bingxiu Tan, Zhengying Yu, Lizhong Li, Wei Zhang, Hongbin Song, Leili Jia","doi":"10.1186/s12879-025-10798-6","DOIUrl":"10.1186/s12879-025-10798-6","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"389"},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study.","authors":"Wei Bu, Chengyu Wang, Yuan Wu, Peng Zhang, Nengfang Zhang, Ying Han, Xiaona Xu, Sha Li, Yan Cai","doi":"10.1186/s12879-025-10773-1","DOIUrl":"10.1186/s12879-025-10773-1","url":null,"abstract":"<p><strong>Background: </strong>Despite the widespread use of colistin sulfate (CS) in clinical settings in China over recent years, supported by several studies demonstrating its clinical efficacy, there remains a lack of comparative data on the efficacy and safety of polymyxin B sulfate (PMB) versus CS, specifically for carbapenem-resistant Acinetobacter baumannii (CRAB)-caused nosocomial pneumonia.</p><p><strong>Objective: </strong>To compare the efficacy and safety of PMB and CS in intensive care unit (ICU) patients with nosocomial pneumonia caused by CRAB.</p><p><strong>Methods: </strong>We conducted a multicenter retrospective cohort study, including patients diagnosed with CRAB-caused nosocomial pneumonia and treated with intravenous PMB or CS in the ICU of the study hospitals between January 1, 2020, and June 30, 2024. Propensity score matching (PSM) was employed to adjust for potential baseline confounders between cohorts. Multivariate logistic regression analysis and Cox logistic regression analyses were performed to identify for factors potentially influencing the clinical outcomes and adverse events.</p><p><strong>Results: </strong>Following matching, a total of 190 patients were analyzed. There was no statistical significance in the rates of clinical success, microbiological eradication and 28-day mortality between the PMB and CS cohorts. While the incidence of acute kidney injury (AKI) and hepatotoxicity were comparable in both cohorts, but dermal toxicity was significantly higher in patients receiving PMB compared to those receiving CS (18.9% vs. 0%, P < 0.05). Among all the patients, hypertension, baseline renal insufficiency, usage of vasoactive drugs and in combination with three or more antibiotics were independent risk factors associated with AKI; while age, duration of polymyxins ≤ 7 days and Sequential Organ Failure Assessment (SOFA) score were risk factors associated with 28-day all-cause mortality.</p><p><strong>Conclusion: </strong>This study establishes that PMB and CS have similar efficacy in treating CRAB induced nosocomial pneumonia in the ICU settings. The incidence of AKI and hepatotoxicity of both polymyxins are comparable for both polymyxins, although PMB is associated with a significantly higher incidence of skin toxicity. Ensuring adequate therapy duration is key to better outcomes in the treatment of CRAB-induced nosocomial pneumonia in ICU patients, regardless of the type of polymyxins.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"390"},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of infection prevention and control management in obstetrics departments in secondary and tertiary hospitals : A cross-sectional study from Guiyang city, China, 2023.","authors":"Rui Tu, Tao Zhao, Xin Yu, Zuyan Xiao, Jiamin Zhou, Juan Tian, Guiqin Du","doi":"10.1186/s12879-025-10598-y","DOIUrl":"10.1186/s12879-025-10598-y","url":null,"abstract":"<p><strong>Background: </strong>Coinfection in pregnancy can lead to serious adverse consequences for maternal and neonatal health. How to timely and effectively control the occurrence of Healthcare-associated Infections (HAI) during maternal hospitalization is one of the critical challenges facing obstetrics department. To evaluate the current status of infection prevention and control management in obstetrics departments in secondary and tertiary medical institutions in Guiyang City. The findings will serve as a basis future improvement.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Guiyang city, Guizhou Province, China, from July to December 2023. The Guiyang Nosocomial Infection Control and Quality Improvement Center collaborated with 33 medical institutions to collect online survey data. The survey contained five sections, including information about the participating hospitals, basic information on the obstetric department, surveillance of HAIs, the building environment and equipment, and cleaning and disinfection.</p><p><strong>Results: </strong>Out of the 33 hospitals invited to participate, 28 (85.00% response rate) accepted and completed the online survey. There were significant differences in the type and educational backgrounds of infection preventionists between tertiary care and secondary care hospitals (P < 0.001). No other variables showed significant differences.</p><p><strong>Conclusion: </strong>The configuration of full-time Infection Preventionists (IPs) in both tertiary and secondary hospitals in Guiyang City, Guizhou Province, is insufficient, with the situation being particularly severe in secondary hospitals. Additionally, in terms of personnel configuration, secondary hospitals have a high proportion of nursing professionals and lack highly educated talent. Therefore, it is recommended that secondary medical institutions should staff sufficient, professional, and well-structured IPs. Furthermore, secondary hospitals should actively establish a nosocomial infection monitoring system and enhance their information monitoring capabilities. Moreover, establishing LDR (labor, delivery, and recovery) rooms with a focus on comfort can help improve the experience of maternal care, but its role in preventing hospital infections requires further research.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"383"},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional difference on rotavirus vaccine coverage in children with diarrhea in Mozambique, before and during COVID-19 pandemic: a cross-sectional analysis.","authors":"Marta Cassocera, Adilson Fernando Loforte Bauhofer, Assucênio Chissaque, Benilde Munlela, Esperança Guimarães, Telma Isaías, Carolina Conjo, Braiton Maculuve, Sérgio Chicumbe, Nilsa de Deus","doi":"10.1186/s12879-025-10750-8","DOIUrl":"10.1186/s12879-025-10750-8","url":null,"abstract":"<p><strong>Background: </strong>Immunization coverage is a global concern for the Immunization Agenda 2030 due to the Coronavirus disease (COVID-19) pandemic. Prior to the pandemic, Mozambique had a positive impact on reducing all-cause diarrhea hospitalization and rotavirus positivity due to vaccination with the monovalent vaccine against rotavirus (Rotarix^®). We evaluated rotavirus vaccine coverage in Mozambican children with diarrhea in four sentinel sites before and during the COVID-19 pandemic.</p><p><strong>Methods: </strong>A cross-sectional analysis between January 2016 and April 2023 was performed using the National Diarrhea Surveillance data from four sentinel sites for children under five years old. The cut-off before and during the COVID-19 period was the date of the first COVID-19 case reported in Mozambique on March 22, 2020. Vaccination cards were used to verify rotavirus immunization status. A two-sample test for equality of proportions of rotavirus coverage before and during the COVID-19 pandemic was performed.</p><p><strong>Results: </strong>During the COVID-19 pandemic, the rotavirus vaccine coverage was 77.3% (133/172), significantly higher than the 68.6% (771/1124) before the pandemic [difference: 8.7% (95% CI: 1.6 to 15.9); p-value = 0.026]. The two sample test for equality of proportions indicates that at the sentinel site in Zambézia province in the center region of the country, the rotavirus vaccine coverage reduced significantly during the pandemic period compared to the pre COVID-19 pandemic period (difference: -28.1%; 95% CI: -47.8 to -8.3; p-value = 0.028).</p><p><strong>Conclusion: </strong>Despite national level increase of the rotavirus vaccine coverage, during the COVID-19 pandemic, there was a significant reduction in the sentinel site in the center region of the country. Future rotavirus interventions should target areas with lowest rotavirus vaccine coverage, also, rotavirus diarrheal cases and severity should be monitored in those settings to evaluate the interventions impact.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"382"},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of strongyloidiasis prevalence in immunocompromised patients referred to hospitals: a case study of Iran's capital.","authors":"Zahra Arab-Mazar, Tahereh Kanani, Mahdi Toulabi, Arian Karimi Rouzbahani, Shirzad Fallahi, Anahita Behzadi, Maysam Yousefi, Seyyed Javad Seyyed Tabaei","doi":"10.1186/s12879-024-10431-y","DOIUrl":"10.1186/s12879-024-10431-y","url":null,"abstract":"<p><strong>Background: </strong>Strongyloidiasis is a parasitic disease commonly caused by S. stercoralis. It can lead to serious consequences in immunocompromised patients. This study aimed to investigate the prevalence of S. stercoralis infection in immunocompromised patients referred to selected hospitals.</p><p><strong>Methods and materials: </strong>This was a cross-sectional study in which demographic information, including age, sex, occupation, place of residence, and type of underlying disease, was collected from patients with cancer or who were treated with high doses of corticosteroids for rheumatic diseases. Serum immunoglobulin G (IgG) antibodies against S. stercoralis were measured via enzyme-linked immunosorbent assay (ELISA). For patients with positive antibody tests, stool culture was performed, and the data were analyzed with SPSS software ver. 25.</p><p><strong>Results: </strong>There were included 93 patients in this study, in 11.8% there was administered high doses of corticosteroids due to rheumatic disease and 88.2% had cancer. S. stercoralis-IgG ELISA was positive in 30 patients (32.3%). There was a significant association between the type of disease and a positive IgG antibody test (P ≤ 0.015). Among seropositive patients, only one patient (3.3%) was positive in the stool culture. There was a significant association between the IgG antibody test score and occupation (P ≤ 0.002). Positive IgG antibodies were most common among employees (75%).</p><p><strong>Conclusion: </strong>Although positive S. stercoralis-IgG antibody tests are common among immunocompromised patients, stool culture results are negative for most seropositive patients, indicating previous infections.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"381"},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes of patients with uncomplicated malaria and associated factors in Northwest Ethiopia: a prospective follow-up study, 2024.","authors":"Tilahun Bizuayehu Demass, Mulat Addis Beshaw, Getasew Mulat Bantie, Belay Bezabih Beyene, Melaku Tadege, Agumas Alemu Alehegn, Abraham Amsalu Berneh, Mulat Yimer, Amare Alemu Melese, Wondwossen Amogne Degu","doi":"10.1186/s12879-025-10791-z","DOIUrl":"10.1186/s12879-025-10791-z","url":null,"abstract":"<p><strong>Background: </strong>Malaria is the major public health problem in low-income countries like Ethiopia. Despite extensive interventional studies being conducted to attain the 2030 malaria elimination goals, there is limited data on the treatment outcomes of uncomplicated malaria in Ethiopia. Thus, this study aimed to assess the treatment outcomes and associated factors of uncomplicated malaria in Northwest Ethiopia.</p><p><strong>Methods: </strong>This study was conducted in two health centers, Kolla Diba and Forhe-Sankira, located in Dembia and North Achefer Districts, from April to June 2024. Data was collected from 460 study participants who presented with signs and symptoms and from parasitologically confirmed patients. Malaria was confirmed using microscopy and rapid diagnostic tests (RDT). The parasitologically confirmed patients were appointed on the 3rd, 7th, 14th, and 28th days to determine treatment outcomes for those who were parasitemic on the preceding visit or symptomatic at each visit. The collected longitudinal data was entered and cleaned by Epi-data 4.1 and then analyzed using SPSS 25 software. Descriptive statistics were computed. A binary logistic regression model was fitted to identify factors associated with unsuccessful treatment outcomes at a 95% CI, and a p-value ˂ 0.05 was considered significant.</p><p><strong>Results: </strong>Of the 460 study participants, 234 (50.9%) were parasitologically confirmed. Treatment outcomes were determined for 224 (95.7%) patients. Ten patients were lost to follow-up. The overall unsuccessful treatment rate was 18.8%. No previous malaria attack (AOR = 18.62, 95% CI: 5.15, 67.25), being infected by Plasmodium vivax (AOR = 8.58; 95% CI: 2.85, 25.83), and coartem two times for 3 days plus primaquine for 14 days (AOR = 4.84; 95% CI: 1.83, 12.79) were the identified factors for unsuccessful treatment outcomes.</p><p><strong>Conclusions and recommendations: </strong>This study revealed that a higher proportion of patients had an unsuccessful treatment outcome. No previous malarial attack, being infected by Plasmodium vivax, and coartem plus primaquine were the identified factors for unsuccessful treatment outcomes. We recommend that healthcare providers prescribe first-line antimalarial therapy and appoint patients for follow-up evaluation according to the national guidelines to identify treatment failure early.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"387"},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}