BMC Infectious Diseases最新文献

{"title":"Infections among adults hospitalized in intensive care after the 2023 earthquake in the southeastern part of Türkiye: a multi-center observational study.","authors":"Esat Kivanc Kaya, Burcin Halacli, Goksel Guven, Mehmet Yildirim, Asir Eren Seven, Emin Gemcioglu, Meltem Simsek, Begum Erdemir Sullu, Recep Civan Yuksel, Ahmet Safa Kaynar, Aliye Esmaoglu, Banu Kilicaslan, Seda Banu Akinci, Kursat Gundogan, Ebru Ortac Ersoy, Jordi Rello, Arzu Topeli","doi":"10.1186/s12879-024-10416-x","DOIUrl":"10.1186/s12879-024-10416-x","url":null,"abstract":"<p><strong>Background: </strong>Scarce evidence is available on the epidemiology of microbiologically proven clinical infections in patients admitted to the intensive care unit (ICU) after a great earthquake. The main aim of this study was to assess clinical infections and microbiological features in patients admitted to the ICU following the 2023 earthquake in the southeastern region of Türkiye with a focus on the timing of culture positivity during their ICU stay. The secondary objectives included determining antibiotic susceptibility patterns, identifying the types of antibiotics administered upon ICU admission, evaluating the appropriateness of antibiotic usage, assessing patient outcomes, and identifying factors that influence microbiologically confirmed clinical infections.</p><p><strong>Methods: </strong>A retrospective, multicenter, observational study was conducted on adult earthquake victims admitted to the ICU after the 2023 earthquake in southeastern Türkiye. Patients were categorized into four groups on the basis of culture positivity timing at the 72-hour breakpoint and clinical characteristics were compared among these groups. Factors influencing microbiologically proven clinical infections were also analysed.</p><p><strong>Results: </strong>A total of 107 earthquake-affected adults (58 females and 49 males, median [IQR] age: 37 [27-57] years) were analysed. Infection was present in 50.5% of the patients, predominantly with multidrug-resistant pathogens. Amputation (OR 5.30) and intermittent hemodialysis (OR 2.98) before ICU admission were independent predictors of infection.</p><p><strong>Conclusions: </strong>This study demonstrated that half of the patients admitted to the ICU with earthquake-related injuries had microbiologically proven clinical infections, highlighting the early presence of multidrug-resistant pathogens.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"35"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bone mineral density and its influencing factors in patients infected with HIV under antiretroviral therapy.","authors":"Alireza Azarboo, Mahboobeh Hemmatabadi, Noushin Fahimfar, Zahra Faghihi, SeyedAhmad SeyedAlinaghi, Nooshin Shirzad, Ladan Abbasian","doi":"10.1186/s12879-024-10388-y","DOIUrl":"https://doi.org/10.1186/s12879-024-10388-y","url":null,"abstract":"<p><strong>Background: </strong>Reduced Bone Mineral Density (BMD) has been linked to Human Immunodeficiency Virus (HIV) infection and treatment. There is a lack of information regarding the osteoporosis status of middle-aged patients with HIV in Iran, despite the fact that Antiretroviral Therapy (ART) is widely accessible.</p><p><strong>Objective: </strong>The purpose of this cross-sectional study was to assess the BMD status and low BMD risk factors in patients with HIV under ART living in Iran.</p><p><strong>Methods: </strong>Data were collected from individuals diagnosed with HIV aged 30-50, receiving ART for at least 6 months. Dual-energy X-ray absorptiometry scans assessed BMD in femoral neck, total hip, and lumbar regions. Pearson's correlation coefficients identified relationships between BMD and demographic and laboratory predictors. Univariable and multivariable logistic regression models assessed predictors of low lumbar BMD.</p><p><strong>Results: </strong>Among 80 HIV-infected individuals (mean age: 41.1 ± 5.6 years, 60.4% male), 15% exhibited low BMD in the lumbar spine and 3.75% in the femoral neck. Serum phosphate levels were negatively correlated with BMD across the femoral neck, total hip, and lumbar regions (e.g., lumbar BMD: r = -0.24, p = 0.03). Parathyroid hormone (PTH) showed negative correlations with femoral neck and total hip BMD (r = -0.26, p = 0.01; r = -0.29, p = 0.01, respectively). Estradiol positively correlated with lumbar BMD in females (r = 0.36, p = 0.04), and BMI positively correlated with BMD in all regions (e.g., lumbar: r = 0.41, p = 0.001). Testosterone was inversely associated with the odds of lumbar low BMD (OR [95% CI] = 0.79 [0.62-0.96], p = 0.02). Duration of HIV or treatment, CD4 levels, and viral load were not significantly associated with BMD.</p><p><strong>Conclusion: </strong>This study highlights the multifactorial nature of BMD changes in individuals living with HIV. By identifying correlations between metabolic, hormonal, and disease-related factors and bone health, our findings bring attention to an often-overlooked aspect of HIV management, that is patients with HIV may benefit from routine BMD screening, as it could help identify early risks of low BMD.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"33"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on HIV testing in Peru: an interrupted time series analysis from 2014 to 2022.","authors":"Robinson A Yrene-Cubas, Jesus Perez-Castilla, Daniel E Reynaga-Cottle, Maria José Bringas, David R Soriano-Moreno, Daniel Fernandez-Guzman, Jose A Gonzales-Zamora","doi":"10.1186/s12879-024-10407-y","DOIUrl":"https://doi.org/10.1186/s12879-024-10407-y","url":null,"abstract":"<p><strong>Objectives: </strong>Our objective was to evaluate the impact of COVID-19 on the proportion of past-year HIV testing in Peru.</p><p><strong>Methods: </strong>Utilizing data from the National Demographic and Health Survey of Peru from 2014 to 2022, we conducted an interrupted time series analysis. The proportion of past-year HIV testing per quarter of each year was considered our unit of analysis. Statistical analysis involved segmented regression with Newey-West standard errors, dividing each year of evaluation into four quarters. Additionally, we applied an Autoregressive Integrated Moving Average (ARIMA) model.</p><p><strong>Results: </strong>We included 211,359 participants aged 15 to 49 years. The proportion of past-year HIV testing in Peru showed a mean decrease of 8.33% (95%CI: -10.73% to -5.93%) after the COVID-19 lockdown (from August-2020) compared to the previous period (before March-2020). Prior to lockdown, there was a mean quarterly increase of 0.30% (95%CI: 0.21-0.40%) in testing proportion, while after the lockdown, there was a mean quarterly decrease of -0.24% (95%CI: -0.56-0.09%). HIV testing declined in 23 of the 25 regions, ranging from - 23.7% to -3.0%, except in Amazonas and Cajamarca, where increases of 5.3% and 6.8% were observed. Predictions of counterfactual values without the pandemic using the ARIMA model revealed a percentage drop of -9.20% (95%CI: -13.70 to -4.80) in observed compared to predicted values.</p><p><strong>Conclusions: </strong>This study highlights the decrease in proportion of past-year HIV testing in Peru following the COVID-19 lockdown, emphasizing the urgent need for targeted interventions to address disparities and ensure equitable access to testing services.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"39"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences for and acceptability of long-acting HIV prevention products among pregnant and lactating women accessing health services in Kenya: a mixed method cross-sectional analysis.","authors":"Vallery Ogello, Paul Mwangi, Zachary Kwena, Nicholas Thuo, Catherine Makokha, Emmah Owidi, Nelson Muteti, Catherine Kiptinness, Nelly R Mugo, Kenneth Ngure","doi":"10.1186/s12879-024-10414-z","DOIUrl":"https://doi.org/10.1186/s12879-024-10414-z","url":null,"abstract":"<p><strong>Background: </strong>Increased risk of HIV acquisition during pregnancy and lactation among women is evident, necessitating their inclusion in the evaluation of new HIV prevention interventions. Pregnant and postpartum women specifically face challenges with oral PrEP associated with stigma, and the burden of using other tablets. Long-acting products may address challenges related to oral PrEP, however, there is limited data on product-specific preferences and acceptability among pregnant and lactating women.</p><p><strong>Methods: </strong>We conducted a mixed-method study to assess the preferences and acceptability of long-acting PrEP modalities either under development or already established among pregnant and lactating women. We conducted quantitative surveys (n = 434) and in-depth interviews (n = 80) in central and western Kenya. We used descriptive statistics and categorical variables to summarize frequencies and proportions. Inductive and deductive content analytic approaches were used for in-depth interviews.</p><p><strong>Results: </strong>The median age of respondents was 25 years (IQR 19.3-31.0). Majority were married (263/434, 61%), had completed high school (222/434, 51%), with no condoms use in the prior 3 months (348/434, 80%). The most preferred PrEP formulations were injectable (251/434, 57%) and implantable (175/434, 40%) options. Participants who preferred injectable PrEP had 8.56 times higher odds of considering ease of use as a reason. (aOR = 8.56, 95% CI [3.81-20.48]) and 3.71 odds of choosing perceived discreteness (aOR = 3.71, 95% CI (1.57-9.97)) as their preference reasons. Participants who preferred Implant for HIV prevention had 2.31 odds of considering it due to perceived effectiveness in preventing HIV as a preference reason (aOR = 2.31, 95% CI (1.21-4.66)) and 2.53-fold of considering discreteness as a preference reason (aOR = 2.53, 95% CI (1.46-4.59)). From the in-depth interviews, women reported prospective acceptability due to the perceived convenience of LA products, perceived effectiveness, reduced cost, improved privacy, and reduced stigma. Women had concerns regarding the safety and efficacy of the products during pregnancy and lactation.</p><p><strong>Conclusion: </strong>Acceptability of LA products underscores the importance of considering the unique needs of pregnant and breastfeeding women in the development of future prevention interventions. Aligning preferences and needs would enhance the uptake and adherence outcomes of HIV prevention products.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"37"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended antibiotic treatment agreement between infectious diseases specialists and ChatGPT^®.","authors":"Santiago Montiel-Romero, Sandra Rajme-López, Carla Marina Román-Montes, Alvaro López-Iñiguez, Héctor Orlando Rivera-Villegas, Eric Ochoa-Hein, María Fernanda González-Lara, Alfredo Ponce-de-León, Karla María Tamez-Torres, Bernardo Alfonso Martinez-Guerra","doi":"10.1186/s12879-024-10426-9","DOIUrl":"https://doi.org/10.1186/s12879-024-10426-9","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance is a global threat to public health. Chat Generative Pre-trained Transformer (ChatGPT^®) is a language model tool based on artificial intelligence. ChatGPT^® could analyze data from antimicrobial susceptibility tests in real time, especially in places where infectious diseases (ID) specialists are not available. We aimed to evaluate the agreement between ChatGPT^® and ID specialists regarding appropriate antibiotic prescription in simulated cases.</p><p><strong>Methods: </strong>Using data from microbiological isolates recovered in our center, we fabricated 100 cases of patients with different infections. Each case included age, infectious syndrome, isolated organism and complete antibiogram. Considering a precise set of instructions, the cases were introduced into ChatGPT^® and presented to five ID specialists. For each case, we asked, (1) \"What is the most appropriate antibiotic that should be prescribed to the patient in the clinical case?\" and (2) \"According to the interpretation of the antibiogram, what is the most probable mechanism of resistance?\". We then calculated the agreement between ID specialists and ChatGPT^®, as well as Cohen's kappa coefficient.</p><p><strong>Results: </strong>Regarding the recommended antibiotic prescription, agreement between ID specialists and ChatGPT^® was observed in 51/100 cases. The calculated kappa coefficient was 0.48. Agreement on antimicrobial resistance mechanisms was observed in 42/100 cases. The calculated kappa coefficient was 0.39. In a subanalysis according to infectious syndromes and microorganisms, Agreement (range 25 - 80%) and kappa coefficients (range 0.21-0.79) varied.</p><p><strong>Conclusion: </strong>We found poor agreement between ID specialists and ChatGPT^® regarding the recommended antibiotic management in simulated clinical cases.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"38"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the risk of acute kidney injury and mortality associated with concomitant use of vancomycin with piperacillin/tazobactam or meropenem in critically ill and non-critically ill patients: a systematic review and meta-analysis.","authors":"Abdulmajeed M Alshehri, Majed S Al Yami, Atheer Aldairem, Lama Alfehaid, Abdulaali R Almutairi, Omar A Almohammed, Amal Mohammad Badawoud","doi":"10.1186/s12879-024-10227-0","DOIUrl":"10.1186/s12879-024-10227-0","url":null,"abstract":"<p><strong>Background: </strong>There are conflicting findings regarding the risk of acute kidney injury (AKI) and mortality with vancomycin/piperacillin-tazobactam combination (VPT) and vancomycin/meropenem (VM). The aim of this meta-analysis was to compare the risk of AKI and mortality between VPT and VM.</p><p><strong>Methods: </strong>Observational studies reporting the incidence of AKI and mortality in patients receiving VPT or VM between January 2017 and September 2024 were retrieved from PubMed, the Cochrane Library, and Web of Science. The primary outcome of the analysis was the risk of AKI, and the secondary outcomes were the mortality rate, need for renal replacement therapy (RRT), and hospital length of stay (LOS). This meta-analysis was conducted using a random-effects model to estimate the odds ratios (OR) and 95% confidence intervals (CI) for AKI, mortality, and RRT or mean difference and 95% CI for the LOS.</p><p><strong>Results: </strong>Seventeen studies involving a total of 80,595 patients were included in the analysis. The odds of developing AKI were higher among patients who received the VPT versus those who received the VM combination (OR = 2.02; 95%CI 1.56-2.62). There were no differences between VPT and VM in the mortality and hospital length of stay; however, the odds of requiring RRT were higher among VPT group versus VM group (OR = 1.55; 95%CI 1.23-1.96).</p><p><strong>Conclusion: </strong>The findings suggest that the use of VPT is associated with a higher risk of AKI compared to VM and highlight the need for cautious antibiotic selection and monitoring of renal function in patients receiving these combinations.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"36"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical diagnostic performance of droplet digital PCR for pathogen detection in patients with Escherichia coli bloodstream infection: a prospective observational study.","authors":"Hiroki Kitagawa, Masato Kojima, Kayoko Tadera, Shuta Kogasaki, Keitaro Omori, Toshihito Nomura, Norifumi Shigemoto, Eiso Hiyama, Hiroki Ohge","doi":"10.1186/s12879-024-10396-y","DOIUrl":"10.1186/s12879-024-10396-y","url":null,"abstract":"<p><strong>Background: </strong>Droplet digital PCR (ddPCR) is a highly sensitive tool for detecting bacterial DNA in bacterial bloodstream infections (BSI). This study aimed to examine the sensitivity and specificity of ddPCR and the association between bacterial DNA load in whole blood and the time-to-positivity (TTP) of blood culture (BC) in patients with Escherichia coli BSI.</p><p><strong>Methods: </strong>This prospective study enrolled patients with E. coli BSI confirmed via BC at the Hiroshima University Hospital from June 2023 to August 2024. The E. coli DNA load in whole blood, which was simultaneously obtained from two BC sets, was measured using ddPCR with E. coli specific primer and probe. Whole blood samples from 50 patients with BC positive for pathogens other than E. coli (n = 25) and BC negative (n = 25) were also evaluated using ddPCR.</p><p><strong>Results: </strong>A total of 131 patient samples were analyzed in this study. Of the 81 patients with E. coli BSI, ddPCR detected E. coli DNA in 67 (82.7%). The results of ddPCR for E. coli had a sensitivity of 82.7% (95% CI: 73.1-89.4%), specificity 100% (95% CI: 93.0-100%). Patients with positive ddPCR results had significantly shorter TTP than those with negative results (median, 8.8 h vs. 10.7 h, p < 0.001). The positivity rate for both BC sets was significantly higher in patients with positive ddPCR results than in those with negative results (89.6% vs. 35.1%, p < 0.001). Among ddPCR-positive patients, septic shock was significantly associated with intestinal perforation, higher E. coli DNA load, higher 28-d mortality, shorter TTP, and higher positivity rate for four bottles of BC than those without septic shock. The E. coli DNA load in whole blood negatively correlated with TTP (p < 0.001, R² = 0.38).</p><p><strong>Conclusion: </strong>The E. coli DNA load in whole blood is inversely correlated with TTP. Notably, a higher E. coli DNA load is associated with septic shock.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"22"},"PeriodicalIF":3.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue fever in Yemen: a five-year review, 2020-2024.","authors":"Wadhah Hassan Edrees, Wadee Abdullah Al-Shehari, Ahmed Mohammed Al-Haddad, Lutf Mohammed Alrahabi, Osama Saleh Al-Haddad, Ali Ahmed Al-Halani","doi":"10.1186/s12879-024-10429-6","DOIUrl":"https://doi.org/10.1186/s12879-024-10429-6","url":null,"abstract":"<p><strong>Background: </strong>Dengue fever (DF) is a mosquito-borne viral infection that has recently become a burden worldwide, particularly in low-income countries, such as Yemen. There have been no epidemiological studies on DF in recent years in Yemen. Therefore, based on secondary data, this study aimed to shed light on the epidemiology of DF in Yemen between 2020 and 2024.</p><p><strong>Methods: </strong>This was a retrospective analysis using secondary data recorded between January 2020 and August 2024 in the Surveillance Center of the Ministry of Health and Population in Aden. The data was gathered in a Microsoft Excel file and descriptively analyzed.</p><p><strong>Results: </strong>A total of 104,562 dengue cases, aged between 1 and 80 years (SD = 24.93±17.02), were enrolled in this retrospective analysis. A higher proportion of DF cases was recorded among males (58.10%), the age group of 15-24 years (26.11%), in 2020 (30.65%), in the Taiz governorate (39.17%), and in the autumn (28.9%). The total incidence of DF was 103.09 per 10,000 individuals. Additionally, the incidence rate of DF per 10,000 individuals was significantly higher among males (118.3 cases), aged 25-34 years (91.73 cases), in 2020 (31.39 cases), and in the Shabwah governorate (176.96 cases). In general, the total fatality rate was 217 (0.21%), with a high rate among females (0.23%), aged ≥ 65 years (0.75%), in 2020 (0.37%), and the Aden governorate (0.82%).</p><p><strong>Conclusion: </strong>These findings indicate that the rates of DF cases have increased in Yemen over the last few years. Therefore, it is critical to introduce an effective program to prevent DF and control dengue vector transmission in Yemen.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"28"},"PeriodicalIF":3.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of Helicobacter pylori infection with the risk of anemia in children: systematic review and meta-analysis.","authors":"Muluken Walle, Addisu Tesfaye, Melaku Mekonnen Agidew, Muluken Semaw, Surafel Mekuria, Fasil Getu","doi":"10.1186/s12879-024-10427-8","DOIUrl":"https://doi.org/10.1186/s12879-024-10427-8","url":null,"abstract":"<p><strong>Background: </strong>Children are among the most vulnerable groups for Helicobacter pylori (H. pylori) infection, which was linked with an increased risk of anemia. H. pylori infection may cause the development of anemia through affecting the absorption of different micronutrients and increasing hepcidin production from hepatocytes. This study aimed to assess the effect of H. pylori infection on the occurrence of anemia in children.</p><p><strong>Methodology: </strong>Previously published articles were systematically searched on major databases including Science Direct, PubMed, Embase, Scopus, Cochrane Library, and Science Citation Index using search terms. The search results were imported into EndNote X9 to organize and remove duplicates. Then, relevant data was extracted and analyzed using STATA version 16.0. The pooled odds ratio (OR) was calculated to evaluate the associations of H. pylori infection with Anemia. Moreover, pooled standardized mean difference (SMD) of Hemoglobin (Hgb) and Serum ferritin (SF) levels between cases and controls were calculated for group comparisons.</p><p><strong>Results: </strong>A total of nine published articles were included in this study. The result showed that H. pylori-infected children had 2.68 times more risk of developing anemia compared to H. pylori-negative children (OR: 2.68:95% CI:1.44-4.99, p = 0.002). Subgroup analyses based on study design showed an increased significant association between H. pylori infection and anemia among case-control studies (OR:3.792:95%CI;1.767, 8.142, p = 0.001). Subgroup analyses based on the H. pylori detection method indicated an increased significant association between H. pylori infection and anemia when the stool antigen test method was used (OR:3.801;95%CI:1.090,13.250, p = 0.036). Moreover, there was a significant decrement of Hgb and SF levels in the H. pylori positive group compared to the negative group with SMD of -0.54(95%CI: -0.65, -0.42, p < 0.001) and - 0.49(95% CI: -0.91, -0.08, p < 0.020), respectively.</p><p><strong>Conclusions: </strong>This study revealed that children with H. pylori infection are at a higher risk of developing anemia as compared to non-infected children. Moreover, the observed decrease in Hgb and SF levels in infected children suggests that H. pylori may contribute to the development of anemia. Future research need to focus on the mechanisms by which H. pylori infection contributes to anemia, as well as the potential benefits of targeted interventions in reducing both H. pylori prevalence and anemia rates in children.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"23"},"PeriodicalIF":3.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual screening assisted identification of a phytocompound as potent inhibitor against Candida lusitaniae; an in-silico study.","authors":"Rimsha Timotheous, Habiba Naz, Usman Arif, Momna Toqeer Dar, Muhammad Farhan Sarwar, Mudassar Fareed Awan, Sajed Ali, Safia Obaidur Rab","doi":"10.1186/s12879-024-10400-5","DOIUrl":"https://doi.org/10.1186/s12879-024-10400-5","url":null,"abstract":"<p><p>Candida lusitaniae is one of the fungal species which causes serious health illnesses including peritonitis, vaginitis and fungemia, among others. Several antifungal drugs have been designed to tackle its infections but their efficacy is still questionable due to their associated side effects. Hence, there is a need to design those drugs which possess comparatively higher degree of therapeutic potential. Phytochemicals were selected in this regard because these compounds which satisfactorily follow this criteria as, their therapeutic index is comparatively larger than the synthetic drugs. Considering this fact, different phyto-compounds were opted in this research work to estimate their therapeutic efficiency against the secreted aspartyl proteinase (SAP) of C. lusitaniae since, it assists this pathogen in developing the infections. Initially, the structure of SAP was modelled for subsequent docking analysis. The results of molecular docking suggested that three compounds, opelconazole, daidzin 4'0-glucuronide and naringin exhibited better docking scores. Afterwards, ADME analysis of all these four compounds was performed to comprehend their drug-likeness attributes. The results of ADME analysis revealed that only the daidzin 4'0-glucuronide followed all the required parameters. Lastly, MD simulations were conducted in which top three compounds in context of docking scores along three approved anti-fungal drugs in complex with SAP were incorporated for the comparative analysis. The overall results of MD simulations suggested that daidzin 4'0-glucuronide exhibited comparatively better results. This outcome indicated that this particular compound not only showed better binding affinity with SAP during docking analysis and fulfilled all of the drug-likeness moieties among other compounds but also, displayed better simulation results, leading to a conclusion that daidzin 4'0-glucuronide could be a potential drug candidate against C. lusitaniae. However, its real-time efficacy could only be validated in clinical settings.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"24"},"PeriodicalIF":3.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}