BMC Infectious Diseases最新文献

{"title":"Clinical and immunological predictors of severe pertussis in children: a nomogram-based prediction model.","authors":"Shiying Zhang, Na Shan, Junfang Qin, Ying Li, Chang Liu, Yuejie Yang","doi":"10.1186/s12879-025-11366-8","DOIUrl":"10.1186/s12879-025-11366-8","url":null,"abstract":"<p><strong>Background: </strong>Despite widespread vaccination, pertussis remains a significant health concern, especially for infants and young children. Severe pertussis can lead to severe complications, but the specific risk factors, particularly immunological markers, are not fully understood.</p><p><strong>Methods: </strong>This retrospective case analysis was conducted from January to December 2023 at the Department of Infection, Tianjin Second People's Hospital. Data were collected from 249 children with pertussis (209 common and 40 severe cases) who met the inclusion criteria. Clinical and immunological parameters were compared between severe and common pertussis groups. Lasso regression and multivariate logistic regression were used to identify independent risk factors, and a nomogram prediction model was constructed and validated.</p><p><strong>Results: </strong>Key findings included demographic and clinical differences between severe and common pertussis, such as higher rates of pneumonia, longer hospital stays, and delayed vaccination in the severe group. Immunological differences showed that children with severe pertussis had altered levels of humoral and cellular immune markers. Risk factors for severe pertussis included premature birth, incomplete vaccination, high white blood cell count, and altered lymphocyte profiles. The nomogram prediction model showed excellent performance with a C-index of 0.899 and strong discriminatory ability (AUC = 0.899). Decision curve analysis demonstrated substantial clinical utility.</p><p><strong>Conclusions: </strong>This study highlights the clinical and immunological markers that contribute to severe pertussis in children. The nomogram prediction model developed provides a reliable tool for early identification of high-risk children, improving clinical decision-making and potential outcomes for pertussis management.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"959"},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria vector control strategies in Pakistan: a scoping review.","authors":"Hammad Atif Irshad, Hamzah Jehanzeb, Ayesha Yaseen, Umair Saleem, Muhammad Daniyal Javaid, Hafsa Khan Tareen, Muhammad Mukhtar, Henrique Silviera, Mohammad Asim Beg","doi":"10.1186/s12879-025-11347-x","DOIUrl":"10.1186/s12879-025-11347-x","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains a significant public health concern in Pakistan due to its subtropical climate and diverse array of vectors, which contribute to periodic outbreaks and challenges in disease control. Recent outbreaks-particularly in 2022-along with the rising incidence of Plasmodium falciparum and growing resistance of Anopheles mosquito vector to existing control methods, highlight a critical gap in understanding the effectiveness of current malaria vector control strategies. This article is a scoping review of published literature on malaria prevention methods with a focus on World Health Organization (WHO) outlined interventions in the endemic region of the lower middle-income country, Pakistan.</p><p><strong>Methods: </strong>Relevant articles published in all languages before September 2023 were reviewed. All the articles were obtained from PubMed, Scopus, CINAHL, Embase and Google Scholar. Four independent reviewers performed the selection and characterization of articles based on defined inclusion criteria. The data collected were extracted and analyzed by province, vector, and vector control methods according to WHO recommendations.</p><p><strong>Results: </strong>A total of 46 articles reporting surveillance findings on vector control methods in Pakistan were found. Based on WHO recommendations, the reported strategies included insecticide-treated nets (ITN) (29.79%), indoor residual spraying (IRS) (29.79%), spatial spraying (12.77%), spatial/airborne repellents (4.26%), larval source management (4.26%) and house modifications (4.26%). In contrast to Khyber Pakhtunkhwa, which employs ITN (55%) as the primary vector control method, Punjab was found to use IRS as the main method of vector control (50%).</p><p><strong>Conclusion: </strong>This review highlights the current strategies for controlling malaria vectors and the strategies used in the past for outbreaks in Pakistan. This review identifies a notable increase in the use of insecticide-treated nets (ITNs) over time and highlights differences in the implementation of vector control strategies across provinces in Pakistan. Current practices and their contrast to WHO guidelines are illustrated. It helps us understand the need for improved research and development with precise reporting. These findings can serve as a reference for guiding policy decisions and improving malaria control efforts in endemic regions.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"953"},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of sexually transmitted infections among pregnant women attending antenatal care in public hospitals in Addis Ababa, Ethiopia.","authors":"Endale Haile, Amanuel Tebabal Nega, Fentahun Yenealem, Simachew Kassa Limenih, Fentahun Alemnew Chekole, Wendu Feysa Balcha, Tadele Emageneh Goshu","doi":"10.1186/s12879-025-11388-2","DOIUrl":"10.1186/s12879-025-11388-2","url":null,"abstract":"<p><strong>Background: </strong>Sexually transmitted infections (STIs), primarily spread through sexual contact, remain a major public health concern. The high prevalence of STIs among pregnant women in Africa contributes to significant maternal and perinatal morbidity. Despite documented adverse pregnancy outcomes, research on STI prevalence and associated factors among pregnant women in Ethiopia, particularly in public hospitals of Addis Ababa, Ethiopia, remains limited. Therefore, this study aimed to determine the prevalence and contributing factors of STIs among pregnant women attending antenatal care at public hospitals in Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among 302 pregnant women attending antenatal care at selected public hospitals in Addis Ababa from August 1 to September 1, 2022. Participants were selected through systematic random sampling, and data were collected through face-to-face interviews, supplemented with chart reviews. Data entry and processing were performed using Epi Info version 7.2.2.2, and analysis was conducted with SPSS version 25. A range of demographic, behavioral, and obstetric factors were assessed for their association with STI outcomes. Crude odds ratios (COR) with 95% confidence intervals (CI) were initially calculated to evaluate these associations. Variables with a P-value of < 0.2 in the bivariate logistic regression were then included in the multivariable logistic regression model, and adjusted odds ratios (AOR) with 95% CIs were computed. Statistical significance was considered at P < 0.05.</p><p><strong>Results: </strong>The prevalence of STIs in this study was 27.5% (95% CI: 22.5%-33.1%). Significant associations were observed with a history of abortion (AOR = 3.59, 95% CI: 1.72-5.45), history of stillbirth (AOR = 2.41, 95% CI: 1.61-4.06), multiple sexual partners (AOR = 3.97, 95% CI: 1.99-5.95), and alcohol consumption (AOR = 2.09, 95% CI: 1.89-3.28).</p><p><strong>Conclusion: </strong>The higher STI prevalence observed in this study, compared to previous Ethiopian findings, underscores the need for targeted public health interventions. Significant associations with abortion, stillbirth, multiple sexual partnerships, and alcohol consumption highlight the importance of integrated strategies, including routine antenatal STI screening, behavioral risk counseling, and community education addressing alcohol use and multiple sexual partnerships.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"956"},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norwegian scabies hid in advanced AIDS-associated talaromycosis misdiagnosed as atopic dermatitis: a case report.","authors":"Mengyan Wang, Hu Wan","doi":"10.1186/s12879-025-11390-8","DOIUrl":"10.1186/s12879-025-11390-8","url":null,"abstract":"<p><strong>Background: </strong>Crusted scabies (Norwegian scabies), a rare variant of scabies infestation, typically manifests in immunocompromised hosts or institutionalized patients with characteristic hyperkeratosis and fissured plaques. In AIDS patients with concurrent opportunistic infections like talaromycosis, scabies diagnosis may be obscured by overlapping cutaneous manifestations, potentially delaying appropriate management. This case highlights the diagnostic challenges in differentiating crusted scabies from treatment-refractory dermatitis in advanced HIV patients.</p><p><strong>Case presentation: </strong>A 46-year-old male with advanced AIDS (the absolute CD4 + count is 3 cells/ul) presented to the emergency department with persistent fever and progressive hyperkeratotic lesions. Two months prior, the patient had been misdiagnosed with atopic dermatitis and treated with dupilumab therapy. Subsequently, talaromycosis-associated febrile symptoms and lymphadenopathy had resolved following liposomal amphotericin B and antiretroviral therapy. Dermatological manifestations, however, remained refractory. Upon readmission, physical examination demonstrated coalescing gray-brown hyperkeratotic plaques with fissures and erythematous denuded areas distributed on the trunk, extremities, and thighs. Histopathologic analysis of biopsy identified Sarcoptes scabiei mites embedded in the stratum corneum, with microscopy of skin scrapings confirming motile mites. Treatment included topical sulfur ointment and oral ivermectin. Gradual resolution of crusts occurred over 4 weeks.</p><p><strong>Conclusions: </strong>This case underscores the imperative for comprehensive dermatological evaluation in immunocompromised hosts with atypical cutaneous presentations.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"955"},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare-Seeking behavior for acute respiratory infections in a community population in Southwest China during the 2021-2023 influenza seasons.","authors":"Qing Wang, Mingyue Jiang, Tingting Li, Yuhua Ren, Jiang Long, Jia Li, Yunshao Xu, Yanlin Cao, Jie Qian, Weizhong Yang, Mengmeng Jia, Li Qi, Luzhao Feng","doi":"10.1186/s12879-025-11301-x","DOIUrl":"10.1186/s12879-025-11301-x","url":null,"abstract":"<p><strong>Background: </strong>The healthcare-seeking behavior for acute respiratory infection (ARI) is a crucial denominator in estimating the respiratory disease burden. This study aimed to assess the healthcare-seeking behaviors among community residents with ARI and identify key factors influencing their healthcare preference.</p><p><strong>Methods: </strong>A cross-sectional community questionnaire survey was carried out in Wanzhou, a district in southwest China, following the winter-spring influenza peaks in the 2021-2022 and 2022-2023 seasons. Employing post-stratified estimation and chi-square tests, we adjusted and compared healthcare-seeking rates. We used multinomial logistic regression to discern the factors influencing medical behaviors.</p><p><strong>Results: </strong>We collected questionnaires from 9,702 residents of 52 communities. Following demographic adjustment, approximately 19% of the community population had ARI symptoms, with 45% of those infected seeking medical assistance. Compared with the 2021-2022 season, the survey in the 2022-2023 season showed ARI prevalence had an upsurge in individuals aged ≥ 60 (from 21.48 to 26.33%) and among those earning a monthly income below 1000 RMB (from 19.91 to 35.51%), while healthcare-seeking rate showed a significant downtrend for the above groups (from 61.11 to 49.05% for the elderly and 48.45 to 34.17% for low-income individuals). ARI cases had the highest preference of primary healthcare institutions in the 2021-2022 and 2022-2023 seasons (16.58% and 22.06%). The key factors influencing the ARI inclination towards primary healthcare institutions included geographical proximity, familiarity with doctors, educational qualification at or below the primary school, and being a designated facility under medical insurance.</p><p><strong>Conclusions: </strong>Prioritizing the enhancement of geographical convenience and economic measures for particularly vulnerable groups, especially the elderly and low-income populations, is an essential public health strategy in promoting more equitable and timely access to health services. Enhancing the professional capabilities of primary medical institutions in managing acute respiratory infections, specifically through an expanded range of pharmaceuticals, advanced treatment equipment, and a well-trained medical workforce, will help to ease the burden on secondary or tertiary hospitals during the seasonal peaks of ARI.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"957"},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of dengue virus infection among febrile patients visiting healthcare facilities in the selected districts of Afar region, Northeast Ethiopia.","authors":"Biruk Zerfu, Tesfu Kassa, Gezahegne Mamo, James W Larrick, Mengistu Legesse","doi":"10.1186/s12879-025-11406-3","DOIUrl":"10.1186/s12879-025-11406-3","url":null,"abstract":"<p><strong>Background: </strong>Dengue fever (DF) is caused by dengue virus (DENV) and is primarily spread through bites of infected Aedes mosquitoes in tropical and subtropical regions, including Ethiopia. In the Afar region, DF is often misdiagnosed as malaria due to limited diagnostic capabilities. This study assessed the seroprevalence of DENV infection among febrile patients in healthcare facilities in the Afar region.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from September 2022 to March 2023 in Amibara, Harunka and Awash Sebat city administration districts, involving febrile patients suspected of having malaria. Sociodemographic data, clinical features and blood samples were collected from participants after obtaining informed consent or assent. Following blood film examination for Plasmodium infection, sera were tested for anti-DENV IgM and IgG antibodies using enzyme-linked immunosorbent assay (ELISA). Data were entered into Epi Data 3.1 and analyzed with Stata/SE 14.2. A p-value < 0.05 was considered significant.</p><p><strong>Results: </strong>A total of 411 febrile patients (55.5% female, aged 5-80 years, with a mean age of 27.3 ± 13.8 years) participated in the study. Among those tested for anti-DENV antibodies, 101/410 (24.6%) were positive for anti-DENV IgM, indicating an acute DENV infection, and 142/367 (38.7%) were positive for anti-DENV IgG, revealing previous exposure. Only 44/411 (10.7%) were positive for Plasmodium infection, while 18/410 (4.4%) were co-infected with malaria and acute DENV infection and 18/367 (4.9%) were positive for both malaria and previous exposure to DENV. Those diagnosed with malaria were nearly 2.5 times more likely to test positive for acute DENV infection than those without malaria (AOR = 2.37; 95% CI 1.14-4.92). The odds of positivity for previous exposure were about two times higher in females than in males (AOR = 2.24; 95% CI 1.32-3.26) and in government and private sector employees than in pastoralists and agro-pastoralists (AOR = 1.90; 95% CI 1.03-8.15), while patients aged 11-20 years had lower odds of previous exposure than those aged 5-10 years (AOR = 0.35; 95% CI 0.14-0.88). Experiencing muscle pain was associated with twice the odds of previous exposure (AOR = 1.90; 95% CI 1.04-3.49).</p><p><strong>Conclusion: </strong>The study reveals a high seroprevalence of DENV infection among febrile patients in the study area, highlighting the need for routine diagnosis and management of DF in this setting. Improving vector control, disease surveillance and public awareness would be crucial for combating DF and other mosquito-borne diseases.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"948"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"May bacterial meningitis pave the way for a toxoplasmosis flare-up: a cross-sectional study from Egypt.","authors":"Rania Y Shash, Enas A El Saftawy, Basma Emad Aboulhoda, Mohamed F Farag, Asmaa Ibrahim, Mansour A Alghamdi, Nahla Yassin Sahloul","doi":"10.1186/s12879-025-11314-6","DOIUrl":"10.1186/s12879-025-11314-6","url":null,"abstract":"<p><strong>Background: </strong>The probable association of Toxoplasma gondii (T.gondii) flare-up/co-existence with bacterial meningitis is yet to be elucidated. This study aimed to investigate the possible incidence of T.gondii flare-ups in the cerebrospinal fluid (CSF) suspected of bacterial meningitis as a hidden co-morbid factor. The causative organisms of bacterial meningitis, antibiotic resistance patterns, and physiological aspects of CSF among various age groups were all assessed.</p><p><strong>Methods: </strong>A cross-sectional study in Almaza Military Hospital, Emergency Department, involved 300 Egyptian patients with symptoms suggestive of meningitis, out of whom 51/ 300 (17.0%) were confirmed by chemical and physiological parameters and microbiological analysis to have bacterial meningitis. Based on age, the patients were divided into Group-1 (< 30 years old) and Group-2 (> 30 years old). The obtained CSF samples were assessed for bacterial growth, antibiotic sensitivity, physiological criteria, and chemical parameters (protein, glucose, and chloride). Toxoplasma was detected using both immune and molecular assays.</p><p><strong>Results: </strong>Overall, 51 (17%) out of 300 patients were confirmed for bacterial meningitis. Males constituted 66.7%. Group-1 consisted of 41 patients (80.4%) distributed as infants (n = 30, 58.8%), children (n = 7, 13.7%), and neonates (n = 4, 7.8%) (P < 0.001) (males 63.4% and females 36.6%). Group-2 involved 10 patients (19.6%), (males 80% and females 20%). Overall, 49% of the patients received empirical antibiotics, and bacterial growth was present in 51% of the cases. Enterobacter spp. was the most prevalent type of bacteria (15.7%), whereas Pseudomonas and Acinetobacter spp. were the least (2% each). Neonates and children (in subgroup-1) predominantly showed Methicillin-resistant Staphylococcus aureus. 73.7% of infants (subgroup-1) and 80% of group-2 had multidrug-resistant bacteria. Bacterial growth was associated with higher neutrophil count and lower glucose and chloride levels. In group-1, females had a significant increase in neutrophils. The CSF glucose was negatively correlated with neutrophils (r=-0.467) and positively correlated with chloride (r = 0.4). The CSF protein level was positively correlated with neutrophils (r = 0.308), while the chloride level was negatively correlated with neutrophils (r=-0.416) and protein (r = -0.601). The anti-Toxoplasma IgG was positive in 23.5% of cases, indicating exposure to Toxoplasma gondii. All patients were negative for anti-Toxoplasma IgM and the Repeat element (RE) gene. Chronic cerebral toxoplasmosis was higher in the female patients (P = 0.0016).</p><p><strong>Conclusions: </strong>Despite the variable demographic data, bacterial species, antibiotic resistance, and altered CSF physiological and chemical parameters, toxoplasmosis flare-ups and bacterial meningitis lacked association.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"952"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual diagnosis of neurobrucellosis and Anti-LGI1 encephalitis: a rare case report.","authors":"Chuyan Yang, Ying Liu, Yongzhong Lin, PeiYu Shi, Jing Tan","doi":"10.1186/s12879-025-11361-z","DOIUrl":"10.1186/s12879-025-11361-z","url":null,"abstract":"<p><strong>Background: </strong>Anti-LGI1 encephalitis is a subtype of autoimmune encephalitis characterised by cognitive dysfunction, psychiatric disorders, faciobrachial dystonic seizures, and hyponatraemia. However, its precise pathogenesis remains unclear. Brucellosis, a zoonotic disease prevalent globally, poses a significant threat to public health; nevertheless, the nonspecific nature of its clinical symptoms often results in diagnostic delays.</p><p><strong>Case presentation: </strong>We report the case of a middle-aged male patient diagnosed with anti-LGI1 antibody encephalitis through antibodies in serum and CSF combined with neurobrucellosis through serum antibodies and CSF NGS. Additional testing for paraneoplastic-related and demyelinating-related antibodies, CSF and blood culture yielded negative results, helping rule out other pathogens and etiologies. The patient exhibited symptom improvement after effective antimicrobial and immunomodulatory therapies.</p><p><strong>Conclusions: </strong>This case raises awareness of autoimmune encephalitis following Brucella infection, revealing a potential association between Brucella infection and anti-LGI1 antibody encephalitis. Brucella may be a triggering factor for anti-LGI1 antibody encephalitis; however, more cases are needed to confirm our findings.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"949"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-genome sequencing for analyzing the transmission characteristics of drug-resistant Mycobacterium tuberculosis in Ganzhou, China.","authors":"Juexin Wang, Chan Chen, Huan Fang, Yong Liao, Qiong Lei, De'an Feng, Meng Wang, Baisheng Li","doi":"10.1186/s12879-025-11356-w","DOIUrl":"10.1186/s12879-025-11356-w","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"950"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV/AIDS-related stigma and discrimination among healthcare providers in Western China: a population-based cross-sectional study.","authors":"Siyan Jia, Cen Yue, Lili Zhang, Li Liu, Maoling Yang, Yanqing Zhang, Jiaxin Liu, Min Luo, Jing Zhang, Xing Qu, Junmei Wu, Qin Jiang, Tingting Luo, Yan Zhang, Weixin Liu","doi":"10.1186/s12879-025-11311-9","DOIUrl":"10.1186/s12879-025-11311-9","url":null,"abstract":"<p><strong>Background: </strong>The persistence of Human Immunodeficiency Virus (HIV) and/or Acquired Immune Deficiency Syndrome (AIDS)-related stigma and discrimination in healthcare settings remains a critical issue that urgently requires attention to effectively control HIV/AIDS epidemic. This study aimed to evaluate the extent of HIV/AIDS-related stigma and discrimination and explore the influencing factors among healthcare providers in western China, in order to inform decision-making regarding the reduction of stigma and discrimination intervention.</p><p><strong>Methods: </strong>A cross-sectional study was conducted between October 2023 and July 2024, and 24,646 (with a response rate of 98.6%) healthcare providers completed the survey using a concise and standardized instrument, including sociodemographic and work-related characteristics, healthcare institutional policies and guidelines, attitudes and opinions about people living with Human Immunodeficiency Virus (PLHIV), as well as discriminatory behaviors. Multivariate linear regression analysis was performed to assess the influencing factors of HIV/AIDS-related stigma and discrimination among healthcare providers.</p><p><strong>Results: </strong>The proportions of healthcare providers expressing concerns about dressing wounds and drawing blood were 65.1% and 60.3%, respectively. Approximately 40% of the participants believed that most PLHIV did not care if they infected others and had multiple sexual partners. Healthcare providers experienced more secondary stigma and discrimination in the provision of services to PLHIV than direct stigma and discrimination against PLHIV. 67.1% of the respondents agreed that PLHIV should be allowed to have babies if they wish. 71-98% indicated that their institutions had related policies and guidelines to protect HIV/AIDS patients from discrimination. HIV/AIDS-related discriminatory behaviors were higher among healthcare providers who had lower levels of education and training, worked in private or infectious disease hospitals or hospitals with inadequate policies, provided face to face services to PLHIV, and had higher levels of stigmatizing attitudes (P < 0.05).</p><p><strong>Conclusions: </strong>HIV/AIDS-related stigma and discrimination among healthcare providers were prevalent in western China. The factors identified in the study which were associated with higher HIV/AIDS-related stigma and discrimination may provide valuable insights for mitigating these negative associations, and more coordinated and multifaceted approaches and interventions need to be implemented to effectively reduce HIV/AIDS-related stigma and discrimination in healthcare settings.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"951"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144727752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}