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Systematic review and meta-analysis of the prevalence and types of health care associated infections in Nigeria. 尼日利亚卫生保健相关感染流行率和类型的系统回顾和荟萃分析。
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11246-1
Chinemerem Daniel Onwuliri, Ifeanyichukwu Uzoma Ezebialu, Adebayo Adebisi, George Uchenna Eleje, Babatunde Akinola, Chinenye Uzoamaka Ezebialu, Kabir Abdullahi, Benedict Okoro, Chinedu Okoroafor, Obed John, Muzzamil Gadanya, Fozo Alombah, Emeka Okechukwu, Homsuk Swomen, Tochi Joy Okwor
{"title":"Systematic review and meta-analysis of the prevalence and types of health care associated infections in Nigeria.","authors":"Chinemerem Daniel Onwuliri, Ifeanyichukwu Uzoma Ezebialu, Adebayo Adebisi, George Uchenna Eleje, Babatunde Akinola, Chinenye Uzoamaka Ezebialu, Kabir Abdullahi, Benedict Okoro, Chinedu Okoroafor, Obed John, Muzzamil Gadanya, Fozo Alombah, Emeka Okechukwu, Homsuk Swomen, Tochi Joy Okwor","doi":"10.1186/s12879-025-11246-1","DOIUrl":"10.1186/s12879-025-11246-1","url":null,"abstract":"<p><strong>Background: </strong>HealthCare-Associated Infections (HCAIs) are those infections that patients acquire while receiving treatment for other health conditions within the health facility. There is a paucity of data on HCAIs in Nigeria.</p><p><strong>Objectives: </strong>To evaluate the prevalence and types of as well as the common organisms causing HCAIs in Nigeria.</p><p><strong>Materials and methods: </strong>A systematic review, with meta-analysis was conducted, and the results were presented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, AJOL, Google Scholar and Cochrane electronic databases were searched in April 2024. Studies describing prevalence of HCAIs in Nigeria were included. Data extraction was done using pre-specified data extraction form. We performed a meta-analysis on prevalence of HCAIs and subgroup analysis on types of HCAIs in Nigeria using the random-effects model. A risk of bias tool from Hoy and colleagues was used to assess risk of bias.</p><p><strong>Results: </strong>Out of 1899 articles searched, we included 16 studies involving 86772 participants. The pooled prevalence of HCAIs in Nigeria was 15.75% (95% CI 14.39, 17.11) and the commonest type was urinary tract infections (32.54%; 95% CI 29.44-35.64) followed by surgical site infections (22.17%; 95% CI 19.96-24.38) and skin and soft tissue infection (16.43%; 95% CI 9.42-23.43). The commonest organisms reported were Proteus species and Staphylococcus aureus, followed closely by Escherichia coli, Klebsiella and Pseudomonas. One study reported on multidrug resistance. The commonest associated risk factors were surgery, Human Immunodeficiency Virus infection, prior use of antibiotics and endotracheal intubation.</p><p><strong>Conclusions: </strong>The findings of this research unveil a significant prevalence of HCAIs in Nigeria, standing at 15.75%. Urinary tract infections, surgical site infections, and skin and soft tissue infections were the most prevalent. Proteus species and Staphylococcus aureus were identified as the predominant organisms. This review indicates a scarcity of data concerning the risk factors for HCAIs and associated multidrug-resistant infections. Included studies mainly used isolation of microbial organisms to define HCAIs. These gaps underscore the need for further research in these critical areas within the country's healthcare settings.</p><p><strong>Trial registration: </strong>This systematic review was registered in PROSPERO (CRD42023439338).</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"836"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of common respiratory viruses in children: insights from post-pandemic surveillance. 儿童常见呼吸道病毒的流行:来自大流行后监测的见解。
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11201-0
Constance Adu-Gyamfi, Jesse Addo Asamoah, James Opoku Frimpong, Richard Larbi, Richard Owusu Ansah, Sherihane Naa Ayeley Aryeetey, Richmond Gorman, Henry Kyeremateng Acheampong, Emmanuella Nyarko-Afriyie, Manuella Hayford, Henrietta Dede Tetteh, Kwadwo Boampong, Veronica Barnor, Peter K Brenya, Frederick Ayensu, Nana Kwame Ayisi-Boateng, Philip El-Duah, Christian Drosten, Richard Odame Phillips, Augustina Angelina Sylverken, Michael Owusu
{"title":"Prevalence of common respiratory viruses in children: insights from post-pandemic surveillance.","authors":"Constance Adu-Gyamfi, Jesse Addo Asamoah, James Opoku Frimpong, Richard Larbi, Richard Owusu Ansah, Sherihane Naa Ayeley Aryeetey, Richmond Gorman, Henry Kyeremateng Acheampong, Emmanuella Nyarko-Afriyie, Manuella Hayford, Henrietta Dede Tetteh, Kwadwo Boampong, Veronica Barnor, Peter K Brenya, Frederick Ayensu, Nana Kwame Ayisi-Boateng, Philip El-Duah, Christian Drosten, Richard Odame Phillips, Augustina Angelina Sylverken, Michael Owusu","doi":"10.1186/s12879-025-11201-0","DOIUrl":"10.1186/s12879-025-11201-0","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has significantly affected healthcare systems worldwide, impacting the occurrence and management of respiratory illnesses. This has also influenced respiratory infections' role in childhood mortality. Surveillance of common respiratory viruses in Ghana is limited, making it crucial to assess the prevalence of respiratory viral infections, particularly in children, in the post-pandemic era. This study provides data on the prevalence of respiratory viruses and the associated risk factors in symptomatic children aged 5 or younger in an urban paediatric hospital setting.</p><p><strong>Methods: </strong>The study was a cross-sectional study with a convenience sampling method, conducted in four health facilities: Asokwa Children's Hospital, HopeXchange Medical Centre, University Health Services-KNUST, and Kumasi South Hospital in Kumasi, Ghana, between August 2022 and June 2023. Recruitment was not done in parallel in each hospital. Oropharyngeal swabs were collected from 303 children ≤ 5 years old and screened by RT-qPCR for common respiratory viruses.</p><p><strong>Results: </strong>Out of the 303 patients enrolled in the study, 165 (54.4%) were male, and 122 (40.3%) were aged from 13 to 36 months. The median age of the patients was 19 months. The most common symptoms reported were cough (87.0%), runny nose (87.0%), and fever (72.0%). Respiratory viruses were detected in 100 (33.0%) of the samples, with 36 (12.0%) testing positive for Human metapneumovirus (HMPV), 27 (8.9%) for Respiratory syncytial virus (RSV), and 20 (6.6%) for Human Adenovirus (HAdV). In 8.0% of the cases, multiple viruses were detected, with HAdV being the most common (75.0%). Children under 6 months (AOR: 4.81, 95% CI: 1.20-24.60) had a higher risk of RSV detection compared to children aged 37 to 60 months. Furthermore, it was found that caregivers with tertiary education had higher odds of HMPV detection (AOR: 6.91, 95% CI: 1.71-47.3).</p><p><strong>Conclusion: </strong>The detection of multiple viruses with a higher prevalence of HMPV and RSV in our study emphasises the need for a scaled-up and sustained surveillance of respiratory viruses in Ghana in the post-pandemic era. Such an establishment in respiratory virus surveillance systems in Ghana would help in the timely detection and education on viral seasonal patterns, which will inform public health responses.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"824"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial susceptibility patterns of bacteria isolated from wound infections in Al-Bayda Governorate -Yemen. 也门贝达省伤口感染分离细菌的抗菌药物敏感性模式
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11250-5
Kamal Saleh Hussien, Gamil Taher Abdulmughni, Arwa Mohammed Othman, Huda Zaid Al-Shami, Naif Mohammed Al-Haidary, Rowa Mohammed Assayaghi, Kamal Hamoud Jahzer
{"title":"Antimicrobial susceptibility patterns of bacteria isolated from wound infections in Al-Bayda Governorate -Yemen.","authors":"Kamal Saleh Hussien, Gamil Taher Abdulmughni, Arwa Mohammed Othman, Huda Zaid Al-Shami, Naif Mohammed Al-Haidary, Rowa Mohammed Assayaghi, Kamal Hamoud Jahzer","doi":"10.1186/s12879-025-11250-5","DOIUrl":"10.1186/s12879-025-11250-5","url":null,"abstract":"<p><strong>Background: </strong>Wounds compromise the skin's protective barrier, providing a favorable environment for bacterial colonization and proliferation. The rising incidence of multidrug-resistant pathogens poses a major global healthcare challenge, hindering effective infection management.</p><p><strong>Aim: </strong>To identify bacterial pathogens associated with wound infections and assess their antimicrobial susceptibility patterns.</p><p><strong>Methods: </strong>This cross-sectional study included 139 patients with clinically suspected wound infections. Wound swabs were collected and processed using standard microbiological techniques. Isolated bacteria were identified and tested for antimicrobial susceptibility using the disc diffusion method according to CLSI guidelines.</p><p><strong>Results: </strong>The majority of patients (27.3%) were aged 26-35 years, with 46 (33.1%) males and 93 (66.9%) females. Of 139 specimens, 108 (77.7%) yielded positive cultures. The most frequently isolated organisms were Escherichia coli (20.4%), Pseudomonas aeruginosa (19.4%), Staphylococcus aureus (17.6%), and Citrobacter freundii (16.7%). A high level of resistance to commonly used antibiotics was observed among most isolates.</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of bacterial wound infections in Al-Bayda Governorate, Yemen, and the alarming rates of antimicrobial resistance among the isolates. The observed resistance, particularly to first-line antibiotics, underscores the urgent need for robust antimicrobial stewardship programs to guide effective treatment strategies.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"868"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and diagnostic process of liver abscess secondary to chemotherapy by mucor indicus in a patient with acute leukemic disease: case report. 急性白血病患者化疗继发肝脓肿的检测与诊断过程:1例报告。
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11192-y
Hong Liu, Junjie Xia, Ming Guan
{"title":"Detection and diagnostic process of liver abscess secondary to chemotherapy by mucor indicus in a patient with acute leukemic disease: case report.","authors":"Hong Liu, Junjie Xia, Ming Guan","doi":"10.1186/s12879-025-11192-y","DOIUrl":"10.1186/s12879-025-11192-y","url":null,"abstract":"<p><p>Mucormycosis is a rare opportunistic fungal infection usually seen in patients with diabetic ketoacidosis or severe immunocompromise. It is difficult to diagnose, progresses rapidly, and has a high morbidity and mortality rate. Clinical adult hepatic mucormycosis is very rare.A 60-year-old male patient was diagnosed with acute leukemia. Lung and liver infections developed during myelosuppression after induction of chemotherapy. Direct microscopic examination and histopathologic examination of the punctured liver tissue revealed mucormycosis fungi. The patient was given antifungal treatment with amphotericin B in combination with posaconazole and liver function improved. We report this clinical case with the intention of improving the clinical detection and diagnosis of hepatic mucormycosis secondary to chemotherapy for leukemia. It also aims to deepen the understanding of this disease and to reduce the occurrence of missed diagnosis and misdiagnosis when encountering hepatic mucormycosis infection in future clinical work.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"859"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia. 亚基因型C4乙型肝炎感染的疾病进展和治疗需求:澳大利亚北部地区的一项回顾性队列研究
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11213-w
Genevieve E Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y C Tong, David Boettiger, Benjamin Cowie, Joshua S Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies
{"title":"Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia.","authors":"Genevieve E Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y C Tong, David Boettiger, Benjamin Cowie, Joshua S Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies","doi":"10.1186/s12879-025-11213-w","DOIUrl":"10.1186/s12879-025-11213-w","url":null,"abstract":"<p><strong>Background: </strong>In the Northern Territory (NT) of Australia, First Nations people with chronic hepatitis B (CHB) are infected with a unique sub-genotype, C4, which contains mutations linked to progressive fibrosis and hepatocellular carcinoma. This cohort study aimed to investigate disease progression in C4 sub-genotype infection and estimate how many untreated individuals may benefit from antiviral therapy with broadening treatment indications.</p><p><strong>Methods: </strong>Included individuals were part of Hep B PAST, a co-designed program to improve the cascade of care for people living with CHB in the NT. Disease phase and cirrhotic status were determined algorithmically using clinical and laboratory data at two time points. Loss of HBV antigens was assessed longitudinally. Treatment need was assessed cross-sectionally in the cohort at study completion. Key outcomes were estimated rates of HBsAg/HBeAg loss in sub-genotype C4 infection and quantification of how many untreated individuals qualify for therapy under current Australian and expanded global treatment guidelines.</p><p><strong>Results: </strong>HBsAg and HBeAg loss occurred at a rate of 1·04 and 8·06 events/100 person-years respectively (7342·6 and 545·6 years follow up). 783 people living with CHB were included (40% female, median age 48 years). Of these, 16% had cirrhosis (an additional 6% having FibroScan > 7 kPa, meaning 22% had cirrhosis or significant fibrosis) and 25% were prescribed antivirals. Only 6·7% of untreated individuals were treatment eligible under current guidelines. Using the 2024 World Health Organisation guidelines, this increased to 50% due mostly to fibrosis and population prevalence of diabetes.</p><p><strong>Conclusions: </strong>Despite advanced liver disease in people living with CHB in the NT, rates of antigen loss in sub-genotype C4 hepatitis B infection are similar to other genotypes. Further work is needed to understand drivers of cirrhosis and significant fibrosis in this population.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"881"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of inhaled ambroxol hydrochloride solution in patients with lower respiratory tract infectious diseases: a randomized, double-blind, placebo-controlled, multicentre clinical trial. 盐酸氨溴索吸入治疗下呼吸道感染性疾病的疗效和安全性:一项随机、双盲、安慰剂对照的多中心临床试验
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11194-w
Di Wu, Xiuhua Fu, Faguang Jin, Hui Li, Zhiqiang Qin, Haoyan Wang, Hongmei Yue, Jie Zhang, Zhaolong Cao
{"title":"Efficacy and safety of inhaled ambroxol hydrochloride solution in patients with lower respiratory tract infectious diseases: a randomized, double-blind, placebo-controlled, multicentre clinical trial.","authors":"Di Wu, Xiuhua Fu, Faguang Jin, Hui Li, Zhiqiang Qin, Haoyan Wang, Hongmei Yue, Jie Zhang, Zhaolong Cao","doi":"10.1186/s12879-025-11194-w","DOIUrl":"10.1186/s12879-025-11194-w","url":null,"abstract":"<p><strong>Background: </strong>Ambroxol is a widely used mucoactive agent, but the efficacy of inhaled ambroxol in patients with lower respiratory tract infectious (LRTI) disease is poorly understood. This trial aimed to compare the efficacy and safety of inhaled ambroxol with those of placebo in patients with LRTI diseases.</p><p><strong>Methods: </strong>In this randomized, double-blind, placebo-controlled, multicentre clinical trial, 240 patients with LRTI diseases were randomized to receive inhaled ambroxol hydrochloride solution (ambroxol group, N = 120) or placebo (placebo group, N = 120) twice daily for 7 days.</p><p><strong>Results: </strong>Compared with the placebo group, the ambroxol group had lower sputum trait scores and greater changes in sputum trait scores from Day 2 to Day 8. Compared with the placebo group, the ambroxol group presented lower expectoration difficulty scores and greater changes in expectoration difficulty scores on Days 2, 3, and 6. The sputum volume scores on Days 6, 7, and 8 were lower in the ambroxol group than in the placebo group, but the change in the sputum volume score was not different between the groups. Compared with the placebo group, the ambroxol group had lower cough scores on Days 3, 5, 6, and 7, as well as greater changes in cough scores on Days 2, 3, and 5. The incidences of adverse events (10.8% versus 6.7%), serious adverse events (0.8% versus 0.0%), and adverse reactions (4.2% versus 3.3%) were not different between the ambroxol group and the placebo group.</p><p><strong>Conclusions: </strong>Inhaled ambroxol is better at ameliorating respiratory symptoms and has comparable safety to placebo in patients with LRTI diseases.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"830"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virulence and biological characteristics of Talaromyces wortmannii isolated from deep-seated dermatomycosis by in vitro and in vivo evaluation. 深层皮菌病中分离的沃特曼Talaromyces wortmannii的毒力和生物学特性的体外和体内评价。
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1186/s12879-025-11261-2
Yong Zhang, Fangfang Bao, Feifan Dong, Gongqi Yu, Hongqing Tian
{"title":"Virulence and biological characteristics of Talaromyces wortmannii isolated from deep-seated dermatomycosis by in vitro and in vivo evaluation.","authors":"Yong Zhang, Fangfang Bao, Feifan Dong, Gongqi Yu, Hongqing Tian","doi":"10.1186/s12879-025-11261-2","DOIUrl":"10.1186/s12879-025-11261-2","url":null,"abstract":"<p><strong>Background: </strong>Talaromyces wortmannii is a ubiquitous saprophytic fungus found in soil, plants, and marine organisms. Infections caused by T. wortmannii in humans are rarely reported, however, a recent case of skin mycosis attributed to this fungus highlights its potential to cause infections under certain conditions. Therefore, studying the biological characteristics of T. wortmannii is crucial for the prevention and control of dermatomycosis.</p><p><strong>Methods: </strong>T. wortmannii was incubated on different medium and at various temperatures, gathered pertinent data on colony growth and conduct an analysis of its growth characteristics. The Sensititre YeastOne<sup>®</sup> and CLSI M38 method was used to determine the minimum inhibitory concentrations (MICs) of amphotericin B, 5-flucytosine, anidulafungin, caspofungin, micafungin, fluconazole, itraconazole, posaconazole, voriconazole and Terbinafine. Finally, the in vivo virulence of T. wortmannii were investigated using Galleria mellonella as an infection model.</p><p><strong>Results: </strong>The characteristic of T.wortmannii included septate hyphae, occasionally fragmented with varying diameters. Velvety colonies with dense sporulation were observed, grow fastest at 32 °C and displayed a radial growth pattern with a centrally elevated morphology and a slightly depressed margin. The MICs of amphotericin B, itraconazole, posaconazole and voriconazole were relatively low, suggesting potential clinical efficacy. A greater number of deaths occurred at higher inoculum levels. Both the T.wortmannii clinical strain F22-1-C5 and standard strain CGMCC3.17703 exhibits virulence towards the larvae.</p><p><strong>Conclusions: </strong>T. wortmannii can cause human infections. Amphotericin B, itraconazole, posaconazole, and voriconazole may be effective for treatment of such infectoins.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"884"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Cytomegalovirus and Epstein-Barr virus infections among Jordanians: seroprevalence and associated factors. 校正:约旦人巨细胞病毒和eb病毒感染:血清阳性率和相关因素。
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-06-30 DOI: 10.1186/s12879-025-11245-2
Hassan M Kofahi, Jordan F Swedan, Maen Aljezawi
{"title":"Correction: Cytomegalovirus and Epstein-Barr virus infections among Jordanians: seroprevalence and associated factors.","authors":"Hassan M Kofahi, Jordan F Swedan, Maen Aljezawi","doi":"10.1186/s12879-025-11245-2","DOIUrl":"10.1186/s12879-025-11245-2","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"810"},"PeriodicalIF":3.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of foodborne parasitic infections in market-sold aquatic products and high-risk populations in Shanghai, China: surveillance between 2022 and 2024. 中国上海市售水产品和高危人群食源性寄生虫感染流行情况:2022 - 2024年监测
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-06-26 DOI: 10.1186/s12879-025-11203-y
Simin Dai, Jun Feng, Min Chen, Huanyu Wu, Yujuan Shen, Qing Yu, Jian Chen
{"title":"Prevalence of foodborne parasitic infections in market-sold aquatic products and high-risk populations in Shanghai, China: surveillance between 2022 and 2024.","authors":"Simin Dai, Jun Feng, Min Chen, Huanyu Wu, Yujuan Shen, Qing Yu, Jian Chen","doi":"10.1186/s12879-025-11203-y","DOIUrl":"10.1186/s12879-025-11203-y","url":null,"abstract":"<p><strong>Background: </strong>Substantial achievements have been made in preventing and treating human parasitic diseases in China over the past six decades. However, with the recent progression of economic globalization and food diversification, foodborne parasitic diseases have become a significant public health challenge. Here, we investigated and analyzed the characteristics of foodborne parasitic infections arising from market-sold aquatic food products and in key populations.</p><p><strong>Methods: </strong>Freshwater, seawater, and pickled products were randomly obtained from agricultural trade markets, restaurants, supermarkets, and retail stores in four districts of Shanghai from 2022 to 2024. Parasite metacercariae or larvae were subsequently detected in these aquatic products via artificial digestion or dissection methods. Fecal samples from 698 diarrhea outpatients from the intestinal clinics of hospitals were analyzed via molecular methods.</p><p><strong>Results: </strong>Of the 1,914 aquatic samples, 163 (8.52%) tested positive for parasites. Nine out of 1,086 freshwater products tested positive for parasites, including Clonorchis sinensis (7; 0.64%) and Gnathosotoma spinigerum (2; 0.18%). Anisakis was detected only in 7 of 27 seawater fish species, with contamination rates ranging from 6.00 to 100.00%. Echinostoma metacercariae was found only in marinated mud snails (20.43%). The prevalence of Clonorchis sinensis metacercariae in freshwater fish was highest in the second quarter (April-June), and catering samples presented the highest contamination rate, at 12.96%. In the sequence analysis, only one outpatient sample tested positive for parasitic infection, identified as Cryptosporidium meleagridis. No Giardia lamblia was found in the participants.</p><p><strong>Conclusions: </strong>Foodborne parasite contamination occurs in market-sold aquatic food products in Shanghai Municipality, although the incidence of parasite infection was low in the key populations tested. Further studies are needed to establish more comprehensive information that could improve public health and human food safety awareness.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"807"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Two cases of Talaromyces Marneffei tracheobronchial infection in HIV-negative patients. 更正:2例hiv阴性患者发生马尔尼菲氏Talaromyces Marneffei气管支气管感染。
IF 3.4 3区 医学
BMC Infectious Diseases Pub Date : 2025-06-26 DOI: 10.1186/s12879-025-11239-0
Xingbing Lu, Juan Chen, Shiqi Miao, Yi Xie
{"title":"Correction: Two cases of Talaromyces Marneffei tracheobronchial infection in HIV-negative patients.","authors":"Xingbing Lu, Juan Chen, Shiqi Miao, Yi Xie","doi":"10.1186/s12879-025-11239-0","DOIUrl":"10.1186/s12879-025-11239-0","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"809"},"PeriodicalIF":3.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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