BMC Infectious Diseases最新文献

{"title":"Lung and gut microbiota profiling in intensive care unit patients: a prospective pilot study.","authors":"Antonios Kritikos, Eric Bernasconi, Yangji Choi, Valentin Scherz, Jean-Luc Pagani, Gilbert Greub, Claire Bertelli, Benoit Guery","doi":"10.1186/s12879-025-10825-6","DOIUrl":"https://doi.org/10.1186/s12879-025-10825-6","url":null,"abstract":"<p><strong>Background: </strong>The gut and lung microbiomes play crucial roles in host defense and mayserve as predictive markersfor clinical outcomes in critically ill patients. Despite this, the simultaneous dynamics of lung and gut microbiomes during critical illness remain unclear. This study aims to assess the longitudinal changes in lung and gut microbiota among mechanically ventilated ICU patients with and without infection and to identify microbial features predictive of clinical outcomes, including the development of ventilator associated pneumonia (VAP).</p><p><strong>Methods: </strong>In this prospective observational study, we analyzed 73 endotracheal aspirates (ETA) and 93 rectal swabs collected from 38 ICU patients over multiple timepoints (intubation, infection onset, post-antibiotic, and extubation/discharge). Patients were categorized into three groups: (1) VAP, (2) other infections, and (3) uninfected controls. Lung and gut microbiota were characterized using 16S rRNA gene sequencing. Primary outcomes included microbial diversity and community composition; secondary outcomes included ICU length of stay and ventilator-free days.</p><p><strong>Results: </strong>Alpha diversity declined more significantly in infected patients than in controls during the ICU stay, with the most pronounced changes in lung microbiota. We found an enrichment of Enterobacteriaceae and other Proteobacteria in the lung microbiome of pneumonia patients, while the gut microbiota remained relatively stable. Relative abundances of key taxa such as Mogibacterium were associated with mechanical ventilation duration.</p><p><strong>Conclusions: </strong>This study reveals that distinct microbial patterns in both lung and gut microbiota are associated with infection and clinical outcomes in critically ill patients. Understanding these dynamics is crucial for developing targeted microbiota interventions, potentially improving outcomes such as VAP prevention and management.</p><p><strong>Trial registration: </strong>Ethics Committee of Canton Vaud, Switzerland (2017-01820).</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"468"},"PeriodicalIF":3.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of linezolid in the treatment of tuberculous meningitis: a retrospective analysis and literature review.","authors":"Zhen-Tao Fei, Wei Huang, Dan-Ping Zhou, Yang Yang, Ping Liu, Ning Gan, Ping-Ping He, Dan Ye, Hua-Rui Liu, Xu-Hui Liu, Lu Xia","doi":"10.1186/s12879-025-10874-x","DOIUrl":"https://doi.org/10.1186/s12879-025-10874-x","url":null,"abstract":"<p><strong>Background: </strong>Tuberculous meningitis (TBM) is the most severe form of tuberculosis, with high morbidity and mortality. This retrospective study evaluates the clinical efficacy of linezolid in patients with TBM.</p><p><strong>Methods: </strong>We analyzed 99 TBM patients treated at the Shanghai Public Health Clinical Center from June 2013 to March 2020. Patients were divided into two groups: those receiving standard therapy (n = 43) and those receiving standard therapy plus linezolid (n = 56). Clinical outcomes, cerebrospinal fluid parameters, and adverse events were assessed.</p><p><strong>Results: </strong>Of the included patients, 42.4% were female, and the median age was 24.00 (7.00-44.00) years. Baseline characteristics between the two groups were comparable. After six months of treatment, both groups showed improvements in cerebrospinal fluid parameters, with no significant differences in intracranial pressure, white blood cell count, glucose, or chloride levels (all P > 0.05). Adding linezolid significantly reduced cerebrospinal fluid protein levels compared to the standard therapy group (0.873 [0.228-1.591] g/L vs. 0.172 [-0.691-0.559] g/L, P = 0.018), correlating with better 6-month survival (adjusted OR 1.850, 95% CI 1.111-3.081, P = 0.018), with a stronger effect in critically ill patients (1.010 [0.257-2.019] g/L vs. 0.121 [-0.556-0.510] g/L, P = 0.004). Although intracranial lesion resolution rates were higher in the linezolid group, they were not statistically significant (P > 0.05). Adverse event rates were similar between groups (16.1% vs. 18.6%, P = 0.392).</p><p><strong>Conclusion: </strong>Linezolid appears to offer clinical benefits in managing TBM, particularly in critically ill patients, warranting further prospective studies to optimize treatment protocols.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"467"},"PeriodicalIF":3.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of urinary tract infections among females at a tertiary hospital in Malawi: a retrospective study.","authors":"Pizga Kumwenda, Precious Semu","doi":"10.1186/s12879-025-10842-5","DOIUrl":"https://doi.org/10.1186/s12879-025-10842-5","url":null,"abstract":"<p><strong>Background: </strong>Urinary tract infections (UTIs) are among the most common infections in females, with many experiencing at least one episode in their lifetime. About 150 million cases of UTIs occur each year. Lately, the prognosis of UTIs has been poor, largely due to a rise in antimicrobial resistance among common uropathogens. The present study was conducted to describe UTIs in female clients at Zomba Central Hospital in Malawi.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional study where 340 records of women suffering from UTIs were evaluated. Records were analysed for demographic characteristics, the causative agent of UTIs and their antimicrobial susceptibility profile. Data were cleaned and analysed in Excel 2016.</p><p><strong>Results: </strong>The overall prevalence of UTIs was 48.53%, with age group 15-45 having a higher frequency (53.33%) than other age groups. The most frequently isolated bacteria were Escherichia coli (27.2%), Staphylococcus species (26.5%), Enterobacter species (19.2%), Citrobacter freundii (11.9%), Proteus species (6.0%), Enterococcus species, and Serratia marcescens (4.6%). Comparatively, meropenem and amikacin were effective against most pathogens showing average sensitivity rates of 51% and 56% respectively. Nevertheless, high levels of resistance to ampicillin (87%), ceftriaxone (77%) ciprofloxacin (70%), gentamicin (77%), and cefoxitin (64%) were observed.</p><p><strong>Conclusion: </strong>UTIs remain a significant health concern among females at Zomba Central Hospital, particularly in the reproductive age group. The high prevalence of multidrug-resistant uropathogens, especially against commonly used antibiotics like ampicillin and ceftriaxone, underscores the urgent need for regular antimicrobial resistance surveillance and evidence-based antibiotic stewardship to guide effective treatment strategies.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"466"},"PeriodicalIF":3.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher prevalence of pulmonary tuberculosis revealed by Xpert MTB/RIF ultra among drug users in Kinshasa, Democratic Republic of Congo.","authors":"Guillaume Bandjondo Nkisi, Doudou Malekita Yobi, Bive Bive Zono, Pius Zakayi Kabututu, Tite Minga Mikobi, Serge Fueza Bisuta","doi":"10.1186/s12879-025-10853-2","DOIUrl":"https://doi.org/10.1186/s12879-025-10853-2","url":null,"abstract":"<p><strong>Introduction: </strong>The Democratic Republic of Congo (DRC) is one of the eight countries with the highest burden of tuberculosis (TB) in the world. The public health system is inadequate and the screening for TB in the key and vulnerable population (KVP), including drug users (DU) is not currently done. The present study aimed to determine the prevalence of pulmonary TB among DU in Kinshasa by comparing molecular tests with microscopic techniques.</p><p><strong>Methods: </strong>A cross-sectional study covering 22 townships (out of 24) of Kinshasa was conducted from October to December 2023. Sputum samples were collected from DUs aged ≥ 18 years, clinically suspected of TB, and attending drug consumption sites. The samples were analyzed by both the Acid-fast bacilli (AFB)-Nelseen hot staining and Xpert MTB/RIF Ultra for TB and rifampin-resistance diagnosis.</p><p><strong>Results: </strong>For 399 DUs included in the study, the age range was from 18 to 77 years old, with a median of 31 (IQR: 25-39). Among these DUs, 359 (89%; 95% CI: 86.64- 92.55%) were male. TB prevalence was 3.5% (95% CI: 1.9-5.8%) when the AFB-Nelseen hot staining was used for diagnosis. However, the prevalence was significantly higher at 13.8% (95% CI: 10.6-17.6%) with the Xpert MTB/RIF test (p = 0.000). Xpert MTB-RIF Ultra contributed with an added value of 82% (95% IC: 79.25- 86.47%) to the diagnosis of TB in DUs. The KAPPA test showed a low concordance at 25%. Alcohol, diazepam and tobacco consumption have been identified as practical risks associated with the onset of pulmonary TB (p < 0.05).</p><p><strong>Conclusion: </strong>DUs are a population at risk of TB that should not be neglected among all KVPs in Kinshasa. In this specific population, the determination of TB prevalence was significantly improved with the use of Xpert MTB/RIF Ultra compared to hot AFB-Neelsen staining. Among the DU included in the present study, those who habitually consumed alcohol in its different forms, diazepam for non-medical purposes, and tobacco, were significantly more infected than the others. DUs should be considered for systemic screening for pulmonary TB alongside other key populations such as people living with HIV and Xpert should be maintained as a first-line test instead of microscopy. Further studies also including asymptomatic participants are needed to assess the burden due to pulmonary TB in DUs as well as in their living environment.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"464"},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming HPV vaccine hesitancy: insights from a successful school-based vaccination campaign in the Saa health district of Cameroon.","authors":"Eposi C Haddison, Doris B Engoung, Carole B Bodo, Victor M Njie","doi":"10.1186/s12879-025-10864-z","DOIUrl":"https://doi.org/10.1186/s12879-025-10864-z","url":null,"abstract":"<p><strong>Background: </strong>Vaccination against human papillomavirus (HPV) represents a critical strategy in the global effort to eradicate cervical cancer. Nonetheless, the uptake of HPV vaccination in Cameroon has been slow, resulting in vaccine wastage during a period of constrained global supply. In the Saa health district, factors such as concerns about infertility, fears of COVID-19 infection, and restrictions on HPV awareness initiatives in Catholic churches and schools have been identified as contributors to vaccine hesitancy. This report outlines the observations from a successful impromptu HPV vaccination campaign conducted in the context of this hesitancy within the Saa health district.</p><p><strong>Methods: </strong>The campaign took place from the 9th to 25th of May 2023 and targeted 853 adolescents aged 9-13 years. A single-dose schedule with Gardasil was used mainly through the school strategy. Community health workers, teachers and priests participated in sensitization activities via door-to-door sensitization for parents, sensitization in schools for students and in churches for faithfuls respectively. Health facilities vaccinated schools in their catchment area. Vaccination data were recorded in routine vaccination registers.</p><p><strong>Results: </strong>A total of 1321 adolescents (154%) were vaccinated, 48.9% (n = 646) of whom were boys. Thirty-four primary and two secondary schools participated in the campaign. Health workers, teachers and Catholic priests all participated in sensitization activities. No backlash was reported from parents after vaccination.</p><p><strong>Conclusion: </strong>The successful execution of the campaign can be attributed to the active involvement of key stakeholders within the health district. Continuous advocacy for HPV vaccination, even in a climate of vaccine hesitancy, plays a significant role in positively altering perceptions. Recognizing stakeholders and their influence is essential for tailoring strategies aimed at enhancing HPV vaccine uptake.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"465"},"PeriodicalIF":3.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"After the program ends: HIV testing behavior among men who have sex when men after the conclusion of a program providing regular home delivery of HIV self-testing kits.","authors":"Tyler B Wray, Philip A Chan, Jeffrey D Klausner, Lori M Ward, Erik M S Ocean","doi":"10.1186/s12879-025-10784-y","DOIUrl":"10.1186/s12879-025-10784-y","url":null,"abstract":"<p><p>Testing for HIV continues to play a key role in prevention, especially among at-risk populations such as gay, bisexual, and other men who have sex with men (MSM). Incorporating HIV self-testing (HIVST) into testing programs encourages more frequent screening and likely facilitates earlier diagnosis, but little is known about how testing behavior changes after self-testing programs end. In this study, a subset of MSM in the eTest trial who were randomized to receive regular HIVST or clinic testing every three months for 12 months were followed for an additional 12 months. We compared testing rates during the intervention period to this 12-month post-intervention period. Results of a Poisson mixed model showed a significant condition by time interaction (IRR=0.91, SE=0.04, p=.019, %95CI=0.84-0.98). The average marginal predicted probability of testing in a given follow-up among controls was 30.4% during the intervention period and 28.2% post-intervention, versus 70.0% among HIVST condition participants during the intervention period but 23.6% by the end of the post-intervention period. Although regular mail delivery of HIVST increased HIV testing considerably while tests are actively being delivered, testing rates declined to a level similar to those who had not received HIVST after regular delivery stops. These results suggest that regularly delivering HIVST does not encourage longer-term regular testing habits in MSM who typically test infrequently.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"462"},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Comparative analysis of clinical features of brucellosis in Kashi and Guangzhou: a retrospective multicentre study.","authors":"Shufang Pan, Shuru Chen, Zhanlian Huang, Kaixiang Zhou, Guofen Zeng, Maimaitiaili Tuerxun, Jianyun Zhu, Yutian Chong","doi":"10.1186/s12879-025-10744-6","DOIUrl":"10.1186/s12879-025-10744-6","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"459"},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin and Iinterlukin-6 relationship and influence of mortality in sepsis.","authors":"Yi-Hsuan Tsai, Kai-Yin Hung, Wen-Feng Fang","doi":"10.1186/s12879-025-10829-2","DOIUrl":"10.1186/s12879-025-10829-2","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is a severe and life-threatening disease involving multiple risk factors. Leptin has been suggested to play a role in modulating the inflammatory response in sepsis and improving outcomes; however, there are conflicting results regarding the outcome of sepsis. The present study aims to clarify the expression of leptin in patients with sepsis, and its association with other cytokines.</p><p><strong>Method: </strong>The retrospective study enrolled 165 adults with sepsis from medical intensive care units (ICU)s, and collected leptin, glucose levels, and cytokines such as IL-6, IL-1RA, IL-10, IL-17, TNF-α, IFN-γfor analysis. Leptin levels were divided into three groups based on concentration: Low (≤ 3.78 ng/mL), Medium (3.78 < leptin ≤ 23.2 ng/mL), and High (> 23.2 ng/mL). Survival curve analysis and comparisons among groups were performed. A subgroup analysis by sex (male and female) was also conducted. Finally, a multiple-factor logistic regression model was used to evaluate the interaction between leptin and other factors.</p><p><strong>Result: </strong>The high leptin groups were the oldest (low vs. medium vs. high: 60 vs. 66 vs. 78, p < 0.0001) and had the highest body mass index (BMI) (19.8 vs. 23.9 vs. 24.2, p < 0.0001), the highest percentages of women (28.6 vs. 34.1 vs. 65.9 p = 0.001), and the most comorbidities (1 vs. 1 vs. 2, p = 0.001). After controlling IL-6, day 1 leptin had a trend associated with lower mortality in the hospital (β = 0.984, p = 0.062). The highest IL-6 group had a significantly higher mortality rate among three IL-6 level patients (p = 0.015), but in the high leptin subgroup analysis, the significant effect of high IL-6 on mortality disappeared. Besides, the subgroup analysis of men, the high leptin group had a trend of better survival than the medium and low leptin groups.</p><p><strong>Conclusion: </strong>High leptin levels may mitigate the adverse prognostic impact of elevated IL-6 on septic mortality. At comparable IL-6 levels, leptin could serve as a predictor of septic outcomes. Leptin might act as a protective factor in men. Future research should explore leptin's role in IL-6-mediated inflammation and its potential protective effect in high IL-6 sepsis cases.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"460"},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of an online peer support group as a strategy to improve antiretroviral therapy adherence among young people in Kampala district, Uganda: qualitative findings.","authors":"Yerusa Kiirya, Sabrina Kitaka, Joan Kalyango, Joseph Rujumba, Gloria Adobea Odei Obeng-Amoako, Mathew Amollo, Joan Nangendo, Charles Karamagi, Philipa Musooke, Anne Katahoire","doi":"10.1186/s12879-025-10831-8","DOIUrl":"10.1186/s12879-025-10831-8","url":null,"abstract":"<p><strong>Introduction: </strong>Peer support groups may contribute to adherence and play a role in decreasing the stigma of antiretroviral therapy (ART) adherence among young people living with HIV (YPLHIV). However, peer support activities usually occur face-to-face in Uganda and elsewhere in Sub-Saharan Africa and thus have structural limitations and may not be readily available when young people need them. Online peer support has the potential to help YPLHIV access regular psychosocial support without significant effort or cost. We assessed the acceptability of a WhatsApp peer support group as a strategy to improve ART adherence among Ugandan YPLHIV.</p><p><strong>Methods: </strong>We conducted a formative qualitative study in three health facilities in Kampala, Uganda, between July and August 2022. We held four focus group discussions with twenty-six YPLHIV seeking services at the study facilities. We also conducted six key informant interviews with health providers attached to adolescent HIV care clinics. Data was analyzed using thematic analysis guided by Sekhon's theoretical framework of acceptability (2017), which conceptualizes acceptability through multiple constructs, including affective attitudes, burden, intervention coherence, and perceived effectiveness. Our analysis examined these dimensions in the context of WhatsApp-based peer support groups for HIV care.</p><p><strong>Results: </strong>Overall, WhatsApp peer support groups were acceptable for use among YPLHIV. The young people regarded it as convenient because it would save time and would be more cost-effective compared to the transport costs of in-person meetings. Health providers revealed that the WhatsApp peer support group could reduce the stigma associated with community follow-up and empower YPLHIV to overcome stigma. Both young people and health providers suggested that online peer support could enhance emotional support, psychosocial well-being, and ART adherence. However, participants raised concerns about privacy and the cost of internet bundles and smartphones, especially for younger adolescents.</p><p><strong>Conclusion: </strong>Online peer support groups are acceptable to Ugandan YPLHIV and hold promise in enhancing psychosocial support and improving treatment adherence in this sub-population. In implementing online support groups, due consideration should be given to software tools with high privacy standards and zero-rated data use for new apps. Research is needed to evaluate the feasibility and effectiveness of this peer support model in Uganda.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"461"},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central line-associated bloodstream infections (CLABSI) in critical care: understanding incidence, and risk factors in Palestine.","authors":"Sameer Alomari, Mohammad Yahya, Nadeem Alabadlah, Khader Thiab, Walid Basha, Haneen Dhaidel, Razan Rabi, Dina Abugaber, Ahmad Enaya","doi":"10.1186/s12879-025-10855-0","DOIUrl":"10.1186/s12879-025-10855-0","url":null,"abstract":"<p><strong>Introduction: </strong>Central line-associated bloodstream infections (CLABSIs) represent a major source of morbidity and mortality, particularly in developing countries. Central venous catheters (CVCs) are an essential part of managing critically ill patients. This study seeks to describe the epidemiology of central line-associated bloodstream infections CLABSI among ICU patients in Palestine and to identify the specific organism involved.</p><p><strong>Methods: </strong>This retrospective descriptive study included 323 ICU patients with 490 central venous catheters. The electronic medical records were reviewed to identify patients with CLABSIs hospitalized from January 2018 through December 2021. Comparative analysis was conducted to assess associations between various variables and the incidence of CLABSI.</p><p><strong>Result: </strong>A total of 19 CLABSI episodes in 323 patients yielded an incidence of CLABSI of approximately 5.9%, with a rate of 8.91 per 1,000 device days. CLABSI patients had significantly more CVC utilization ratio and insertions compared to non-CLABSI patients. No significant differences were observed in age, gender, or overall mortality. The most predominant bacteria was Acinetobacter baumannii (21%).</p><p><strong>Conclusion: </strong>This study highlights the importance of minimizing CVC use and limiting the number of insertions to reduce CLABSI risk. Effective management strategies should focus on reducing CVC duration and frequency.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"463"},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}