BMC Infectious Diseases最新文献

{"title":"Urticaria as a dermatologic manifestation of Giardia infection: a systematic review of clinical, diagnostic, and therapeutic features.","authors":"Javad Mahdavi, Kimiya Ahmadifar, Reza Ghasemikhah","doi":"10.1186/s12879-025-11484-3","DOIUrl":"10.1186/s12879-025-11484-3","url":null,"abstract":"<p><strong>Background: </strong>Giardiasis is recognized as the most prevalent enteric protozoal infection worldwide. Although gastrointestinal symptoms are the most common manifestations of giardiasis, several studies have reported cases of urticaria associated with this infection. Urticaria is a common mast cell-dependent disorder characterized by wheals, angioedema, or both. The aim of this study was to conduct the first systematic review to comprehensively synthesize the clinical, diagnostic, and therapeutic features of urticaria as a dermatologic manifestation in patients with giardiasis.</p><p><strong>Methods: </strong>This review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. PubMed/MEDLINE, Web of Science, Scopus, ScienceDirect, and Google Scholar were searched without language restrictions up to 2025 to identify articles reporting patients with urticaria and giardiasis.</p><p><strong>Results: </strong>Thirteen papers describing a total of 23 patients (14 males and 9 females, aged 4 to 56 years) were included. The locations of urticarial lesions varied, involving the head, trunk, and extremities. The duration of urticaria ranged from 8 h to 8 months. Other clinical manifestations reported in the patients included diarrhea, pruritus, abdominal distension, arthropathy, anorexia, headache, vomiting, abdominal pain, and dysphagia. Increased Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), elevated Immunoglobulin E (IgE), eosinophilia, stool examination, and Enzyme-linked immunosorbent assay (ELISA) were among the diagnostic tests utilized. Metronidazole, tinidazole, and quinacrine hydrochloride were the most commonly prescribed medications for treatment.</p><p><strong>Conclusions: </strong>Our review highlights the diversity of clinical presentations and diagnostic approaches, and, for the first time, provides a consolidated resource for clinicians encountering this uncommon extraintestinal manifestation of giardiasis. In the initial evaluation of patients presenting with urticaria and a history of gastrointestinal symptoms, particularly those residing in areas with poor hygiene, potential exposure to contaminated water, or recent travel to such regions, parasitic infections, especially giardiasis, should be considered among the differential diagnoses. By addressing this under-recognized association, our study fills a significant knowledge gap regarding urticaria associated with giardiasis, ultimately facilitating earlier diagnosis, appropriate treatment, and improved patient prognosis.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1085"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an early prediction model for risk of influenza A and influenza B based on complete blood count examination.","authors":"Xiefei Hu, Chunmei Duan, Huajian Chen, Xun Li, Qianyu Jing, Qin Ma, Shunli Cai, Haiping Fan, Shenshen Zhi, Wei Li","doi":"10.1186/s12879-025-11502-4","DOIUrl":"10.1186/s12879-025-11502-4","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1088"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes and associated influencing factors among elderly patients with rifampicin-resistant tuberculosis: a multicenter, retrospective, cohort study in China.","authors":"Huicong Liu, Liping Zou, JiaJia Yu, Qingdong Zhu, Song Yang, Wanli Kang, Jiaojie Ma, Qing Chen, Zhengyu Shi, Xianzhen Tang, Li Liang, Peijun Tang, Qing Pan, Chunhui Guo, Juan Du, Zhanlin Chang, Zhouli Guo, Guihui Wu, Shenjie Tang","doi":"10.1186/s12879-025-11491-4","DOIUrl":"10.1186/s12879-025-11491-4","url":null,"abstract":"<p><strong>Background: </strong>Rifampicin-resistant tuberculosis (RR-TB) remains a significant global public health concern. The elderly population is not only at high risk and among the primary victims of RR-TB but also plays a crucial role in the transmission chain of RR-TB. Their biological particularities, treatment complexities, and social vulnerabilities collectively present substantial challenges to global tuberculosis control. This study aimed to evaluate treatment outcomes and identify predictors of unfavorable outcomes among elderly patients with RR-TB in China.</p><p><strong>Methods: </strong>A multicenter retrospective cohort study was conducted, including 248 elderly RR-TB patients treated across eight tertiary hospitals in China from May 2018 to April 2020. Multivariate logistic regression and Propensity Score Matching (PSM) analyses were performed to identify factors associated with unfavorable outcomes. Statistical analyses were performed using SPSS.</p><p><strong>Results: </strong>Among 248 patients, 65.7% (163/248) achieved treatment success (cured or completed treatment), while 34.3% (85/248) experienced unfavorable outcomes, including treatment failure (10.5%), death (2.4%), loss to follow-up (15.7%), and non-evaluation (5.6%). Adverse events (AEs) were reported in 56.0% (139/248) of patients, among which anemia was the most common (25.8%). And the use of bedaquiline and linezolid was significantly associated with the occurrence of QT interval prolongation and optic neuritis (p < 0.05). Multivariate analysis revealed that BMI < 18.5 kg/m²(aOR: 3.66, 95% CI: 1.89-7.08, p < 0.01), advanced drug resistance (aOR: 2.25, 95% CI: 1.14-4.45, p = 0.020), pre-treatment anemia (aOR: 4.16, 95% CI: 2.01-8.61, p < 0.001) were independent predictors of unfavorable outcomes. Adjunctive immunotherapy was associated with favorable outcomes (aOR: 0.23, 95% CI: 0.09-0.55, p < 0.001). After PSM, pre-treatment anemia remained significantly correlated with unfavorable outcomes (aOR: 3.5; 95% CI: 1.41-8.67, p = 0.007).</p><p><strong>Conclusion: </strong>A relatively low rates of treatment success were achieved for RR-TB patients in the elderly at tertiary tuberculosis hospitals in China. Low BMI, advanced drug resistance, and pre-treatment anemia were independent prognostic factors for unfavorable treatment outcomes. Adjunctive immunotherapy was prognostic factors for unfavorable treatment outcomes of elderly RR-TB patients. In tuberculosis management, special consideration should be given to elderly patients.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1086"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term impact of national tuberculosis program interventions on incidence and disparities by age and geography.","authors":"Yuan-Shan Chien, Ting-Yu Lin, Chao-Chih Lai, Chen-Yang Hsu, Yu-Chu Hsieh, Shin-Yi Lin, Hsiao Chi Wang, Hung-Pin Chen, Hsiu-Hsi Chen, Dih-Ling Luh, Yen-Po Yeh","doi":"10.1186/s12879-025-11449-6","DOIUrl":"10.1186/s12879-025-11449-6","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1087"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of artificial liver plasma perfusion combined with plasma exchange therapy on clinical efficacy and short-term prognosis of hepatitis B virus-related acute-on-chronic liver failure with or without HIV infection.","authors":"Ming Zhou, Yan Jin, Yixin Mou, Zhu Chen, Bin Wan, Chuangjie Mao, Bei Wu","doi":"10.1186/s12879-025-11496-z","DOIUrl":"https://doi.org/10.1186/s12879-025-11496-z","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of plasma perfusion combined with plasma exchange (PP + PE) artificial liver support system in patients with hepatitis B virus-associated acute-on-chronic liver failure with and without HIV infection (HBV-ACLF/HIV(+) and HBV-ACLF/HIV(-), respectively) and to assess the clinical value and safety of the artificial liver support system.</p><p><strong>Methods: </strong>This study involved 162 patients diagnosed with HBV-ACLF and hospitalized at Chengdu Public Health Clinical Medical Center from January 2020 to January 2025, in accordance with the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute-on-Chronic Liver Failure (2025 edition). Seventeen patients with tumors, severe underlying diseases, or other hepatitis virus infections were excluded. Patients were divided into the HBV-ACLF/HIV(+) and HBV-ACLF/HIV(-) groups. Propensity score matching (PSM) was used to correct baseline bias. Laboratory indices, Model for End-stage Liver Disease score (MELDs), and 28- and 90-day cumulative survival or mortality rates before and after artificial liver therapy were used as effectiveness indicators. Kaplan-Meier analysis was used to plot survival curves, and the log rank test was used to assess survival differences. Cox proportional hazards regression modeling was used for multifactorial analysis to further evaluate the effectiveness of PP + PE therapy and prognostic factors.</p><p><strong>Results: </strong>In total, 145 patients with HBV-ACLF were included, with 64 in the HBV-ACLF/HIV(+) group and 81 in the HBV-ACLF/HIV(-) group. After 1:1 PSM, 29 patients remained in each group. Alanine aminotransferase, glutamate transferase, total bilirubin, indirect bilirubin, international normalized ratio, prothrombin time activity, and MELDs significantly improved in both groups after PP + PE treatment (P < 0.05). Before and after PSM, there was no statistically significant difference in 28- or 90-day cumulative survival between the HBV-ACLF/HIV(+) and HBV-ACLF/HIV(-) groups (after PSM: log rank, P = 0.572). Multifactorial Cox regression analysis showed that improvements in total bilirubin, creatinine, leukocytes, blood ammonia, MELDs, international normalized ratio, and prothrombin time activity were associated with better short-term prognosis in patients with HBV-ACLF/HIV(+) (P < 0.005).</p><p><strong>Conclusion: </strong>The PP + PE artificial liver treatment model effectively promotes liver function recovery and improves clinical status in HBV-ACLF patients, including those with HIV co-infection. This provides a valuable basis for clinical management of co-infected cases. Multicenter prospective studies are needed to confirm its long-term efficacy.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1081"},"PeriodicalIF":3.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A national report on 2024 dengue fever outbreak in Iran: has the game changed?","authors":"Davood Yadegarynia, Amirreza Keyvanfar, Amirahmad Keramati, Hanieh Najafiarab, Shayan Norouzi, Shiva Soleimani, Ali Bodaghi, Shahnam Arshi, Shabnam Tehrani, Faezeh Sharafi, Azar Darvishi, Ghobad Moradi","doi":"10.1186/s12879-025-11453-w","DOIUrl":"https://doi.org/10.1186/s12879-025-11453-w","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1077"},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of flexible and navigable suction combined with retrograde flexible ureteroscopy in the management of infectious stones.","authors":"Deheng Cui, Qinghong Ma, Guangzhi Wang, Jianbin Luo, Guoqiang Chen","doi":"10.1186/s12879-025-11508-y","DOIUrl":"https://doi.org/10.1186/s12879-025-11508-y","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1079"},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of pt-NGS technology on antimicrobial use and outcomes in patients with lower respiratory tract infections: a hospital-based real-world study.","authors":"Ziyi Wang, Wanyi Yin, Yupei Hao, Shuai Liu, Shizhao Yuan, Yanjing Zhang, Jing Wang, Shuying Li, Yan Liu, Jing Yu","doi":"10.1186/s12879-025-11494-1","DOIUrl":"https://doi.org/10.1186/s12879-025-11494-1","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1076"},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-tuberculous mycobacterial infections among pulmonary tuberculosis suspected and confirmed patients in Ethiopia - A systematic review and meta analyses.","authors":"Deresse Daka, Belay Tessema, Awelani Mutshembele, Amir Alelign, Wubet Birhan, Baye Gelaw","doi":"10.1186/s12879-025-11497-y","DOIUrl":"https://doi.org/10.1186/s12879-025-11497-y","url":null,"abstract":"<p><strong>Introduction: </strong>Nontuberculous mycobacteria (NTM) are environmental pathogens found in soil, water, and various environments, causing chronic pulmonary infections. They are resistant to chlorine and extreme temperatures but not typically transmissible. NTM infections are often misdiagnosed as tuberculosis (TB), especially in Ethiopia, where data on prevalence is scarce. This research aims to analyze NTM isolation from pulmonary samples and other specimens used in pulmonary tuberculosis (PTB) diagnosis among patients suspected or confirmed as PTB cases in Ethiopia.</p><p><strong>Objective: </strong>This study systematically reviews and synthesizes published studies that report NTM isolation from sputum and other clinical samples in Ethiopia to estimate the overall prevalence of NTM isolation, identify the common species, and analyze regional variations in their occurrence.</p><p><strong>Methods: </strong>This systematic review and meta-analysis aimed to determine NTM prevalence in infected individuals in Ethiopia. Using PubMed, Scopus, Web of Science, Google Scholar, and African Journals Online, we conducted a comprehensive literature search. Data extraction and quality assessment used the Newcastle-Ottawa Scale. Meta-analysis employed STATA-18 software with a random-effects model and included subgroup analysis. PROSPER registration: CRD420251000131.</p><p><strong>Results: </strong>In this review a total of 5,415 participants were involved and 53.8% were TB suspected patients, 37.6% were PTB patients, 4.0% were Multidrug resistance-tuberculosis (MDR-TB) patients, and 4.6% were Human Immunodeficiency virus (HIV) positive. The NTM prevalence was 3.8%, showing high heterogeneity and regional species variability. The meta-analysis highlighted differences in NTM prevalence across age groups and diagnostic tools, emphasizing the need for enhanced diagnostics and continuous surveillance to improve patient outcomes and inform public health strategies.</p><p><strong>Conclusion: </strong>The review summarizes the epidemiology and geographical distribution of NTM infections and common NTM species isolated among PTB suspected patients in Ethiopia, revealing regional variations and clinical implications. Despite limited data, Ethiopia has a lower prevalence of NTM compared to other African regions and the worldwide average.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1078"},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromoblastomycosis in Peru: a retrospective review of 13 cases.","authors":"Mercedes Sanchez-Diaz, Nicolas Antunez de Mayolo, Cesar Ramos, Omayra Chincha, Beatriz Bustamante","doi":"10.1186/s12879-025-11475-4","DOIUrl":"https://doi.org/10.1186/s12879-025-11475-4","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1075"},"PeriodicalIF":3.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144941626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}