BMC Infectious Diseases最新文献

{"title":"Submandibular gland abscess and bacteremia caused by Dialister micraerophilus in a patient with Sjögren's syndrome: a case report.","authors":"Tinghua Ye, Bin Lu, Sipei Wang, Lulu Jin, Xinling Pan","doi":"10.1186/s12879-025-11563-5","DOIUrl":"10.1186/s12879-025-11563-5","url":null,"abstract":"<p><strong>Background: </strong>Infection caused by Dialister micraerophilus (D. micraerophilus), a slow-growing, anaerobic or microaerophilic, small gram-negative coccobacillus, has been rarely reported, and its clinical characteristics remain insufficiently defined.</p><p><strong>Case presentation: </strong>A 59-year-old woman presented with a submandibular gland abscess and bacteremia caused by D. micraerophilus. The underlying etiology of this infection was salivary gland dysfunction associated with Sjögren's syndrome (SS), which led to submandibular gland abscess formation and subsequent hematogenous dissemination, resulting in bacteremia. Identification of D. micraerophilus was achieved using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16 S rRNA gene sequencing. The patient achieved complete clinical recovery following intravenous piperacillin-tazobactam (4.5 g every 8 h) during hospitalization, followed by a 10-day course of oral amoxicillin-clavulanic (0.375 g every 8 h) after discharge.</p><p><strong>Conclusions: </strong>This case describes bacteremia with D. micraerophilus in a patient with SS complicated by a submandibular gland abscess. Clinical management of such patients should emphasize oral hygiene education and rigorous aseptic techniques during dental procedures to reduce the risk of infection.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1185"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology of hepatitis b virus infection in Uganda after two decades of vaccination: a meta-analysis and meta-regression.","authors":"Hussein Mukasa Kafeero, Hakim Sendagire, Dorothy Ndagire, Abdul Walusansa, Ali Kudamba, Fahad Muwanda, Mariam Namusoke, Ponsiano Ocama","doi":"10.1186/s12879-025-11582-2","DOIUrl":"10.1186/s12879-025-11582-2","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1174"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mental health symptoms and autoimmunity in patients with long COVID.","authors":"Hernan F Guillen-Burgos, Mauricio Sarmiento, Juan F Gálvez-Flórez, Catalina Rojas, Yaneth Beatriz Lora, Ivan David Lozada-Martinez, María C Diazgranados-Garcia, Gibacus, Manuel Rojas, Juan Carlos Salazar-Uribe, Juan-Manuel Anaya","doi":"10.1186/s12879-025-11536-8","DOIUrl":"10.1186/s12879-025-11536-8","url":null,"abstract":"<p><strong>Background: </strong>Neuropsychiatric symptoms are common features in long COVID. The pathogenesis of neuropsychiatric manifestations in both acute COVID-19 and long COVID remains unclear. This study aimed to examine mental health symptoms-depressive, anxiety, and insomnia symptoms-in COVID-19 survivors with long COVID, and to explore their potential association with autoimmune activity.</p><p><strong>Methods: </strong>We conducted an observational, cross-sectional study of 228 adults recruited from a long COVID program in Cartagena, Colombia. Participants underwent clinician-administered interviews and completed validated psychometric scales to assess depressive (PHQ-9), anxiety (GAD-7), and insomnia (ISI) symptoms. Sociodemographic, clinical, and biological data were collected. The autoantibody panel included antinuclear antibodies (ANA), anti-SSA/Ro, anti-SSB/La, anti-RNP, anti-Smith (Sm), rheumatoid factor (RF), anti-thyroglobulin (Tg), and anti-thyroid peroxidase (TPO), measured via ELISA and immunofluorescence. Robust logistic regression models were used to evaluate associations between long COVID, autoantibody positivity, and mental health symptoms, adjusting for age, sex, and relevant covariates.</p><p><strong>Results: </strong>57% of participants with a history of COVID-19 acute infection reported long COVID. In participants with long COVID, we reported high proportions of depressive (21.2%), anxiety (31.2%), and insomnia (28.7%) symptoms. Moreover, an association of all three mental health symptoms with autoantibody positivity (particularly antinuclear antibodies [ANA] isolated or co-occurring with anti-TPO antibodies) was observed in individuals with long COVID. Our findings suggest a potential association between psychopathological symptoms, autoantibody positivity, and distinct clinical profiles of long COVID, warranting further longitudinal investigation.</p><p><strong>Conclusions: </strong>Mental health symptoms (MHS) should be considered one of the main targets involved in translational research in long COVID. There is an urgent need for consultation-liaison physicians to work closely with immunologists, rheumatologists, and pain medicine physicians in clinical settings as well as in research. This will contribute to a better understanding of the impact of MHS during illness in long COVID variants.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1220"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent loss of anti-HBc antibodies in people with multiple sclerosis undergoing disease-modifying therapies.","authors":"Patrizia Pasculli, Yann Collins Fosso Ngangue, Maria Antonella Zingaropoli, Federica Dominelli, Federica Ciccone, Michele Antonacci, Gina Ferrazzano, Roberta Campagna, Ombretta Turriziani, Guido Antonelli, Claudio Maria Mastroianni, Antonella Conte, Maria Rosa Ciardi","doi":"10.1186/s12879-025-11586-y","DOIUrl":"10.1186/s12879-025-11586-y","url":null,"abstract":"<p><strong>Background: </strong>Disease-modifying therapies (DMTs) are widely used in the treatment of multiple sclerosis (MS). A mounting body of evidence suggests that the risk of hepatitis B virus (HBV) reactivation is primary associated with anti-CD20 therapies. HBV infection leads to the development of anti-HBc antibodies, which typically persist for life. However, the existing literature also highlights the intermittent loss of anti-HBc antibodies in certain immunocompromised individuals. The present study aims to gather real-world evidence on the risk of infection in people with MS (pwMS) prior to the initiation or modification of DMTs, with a particular focus on HBV reactivation and the dynamics of anti-HBc antibody levels in this population.</p><p><strong>Materials and methods: </strong>At the Neuroinfectious Unit, pwMS were longitudinally evaluated for infectious risk before starting, switching, or during DMTs, with a particular focus on the course of anti-HBc antibodies over time during anti-CD20 treatment.</p><p><strong>Results: </strong>A seven-year retrospective and observational study was conducted, with 318 pwMS enrolled (183 females and 135 males, with a median age [interquartile range, IQR] of 51 [41-60] years). Among 110 anti-CD20 treated pwMS, 15 were anti-HBc positive, with negative or positive HBsAg, and positive or negative anti-HBs antibodies. In 2/15 of pwMS HBsAg was positive, detectable HBV-DNA was found in blood and start specific antiviral therapy before DMT. During anti-CD20 therapy, four out of the fifteen pwMS showed a transient loss of anti-HBc following the start of anti-CD20 treatment. Moreover, during this seven-year retrospective and observational study, two pwMS showed HBV reactivation.</p><p><strong>Conclusions: </strong>The findings of this observational cohort study demonstrated the intermittent loss of anti-HBc antibodies in pwMS during anti-CD20 therapy. It is imperative that infectious disease screening is performed on pwMS before starting DMTs to define the serological profile and to mitigate the risk of infection, allowing for the avoidance of discontinuing MS therapy and guaranteeing a higher degree of safety.</p><p><strong>Trial registration: </strong>Clinical trial number: not applicable.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1179"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of toxoplasmosis by serology and nested-PCR in kidney transplant recipients and patients on hemodialysis from Sri Lanka.","authors":"Gpc Weerasooriya, A Manamperi, Bmha Banneheke","doi":"10.1186/s12879-025-11353-z","DOIUrl":"10.1186/s12879-025-11353-z","url":null,"abstract":"<p><p>Toxoplasmosis, the parasitic disease caused by Toxoplasma gondii (T.gondii) affects approximately one-third of the global population. In immunocompromised patients who had been previously infected with T.gondii, the parasite can reactivate to cause infection. This study aimed to determine the seroprevalence of T.gondii among kidney transplant recipients (KTR) and hemodialysis patients (HD) by enzyme-linked immunosorbent assay (ELISA) and to detect T.gondii Deoxyribonucleic Acid (DNA) by nested-Polymerase Chain Reaction (nPCR). Of the 342 patients (114 KTR and 228 HD), 64 (18.7%) and 123 (36%) showed evidence of acute and past infection, respectively, by ELISA, while two (0.6%) had indeterminate results and 153 (44.7%) were negative. In nPCR, there were 28 (8.2%) positives, of which 6.1% only IgG positives, 1.2% only IgM positives, 0.6% both IgM and IgG positives, and 0.3% were indeterminates. The importance of using a combination of serology and molecular methods to determine toxoplasmosis status before commencing treatment in patients awaiting KTR and undergoing HD is indicated by these results. This is the first study that determined toxoplasmosis seroprevalence and targeted the B1 gene using nPCR method to detect toxoplasmosis among KTR and HD patients in Sri Lanka.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1207"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomegalovirus infection contributes to acute rejection in solid organ transplant recipients: a systematic review and meta-analysis.","authors":"Amirreza Keyvanfar, Shabnam Tehrani, Mahdi Falah Tafti, Niki Talebian, Zahra Mohammadi, Mahsa Hojabri, Sepehr Ramezani, Mehrdad Yasaei, Setareh Khorrami, Shiva Nezami, Negar Ghaedi, Davood Yadegarynia, Elahe Eghbal, Hanieh Najafiarab","doi":"10.1186/s12879-025-11648-1","DOIUrl":"10.1186/s12879-025-11648-1","url":null,"abstract":"<p><strong>Background: </strong>Solid organ transplant (SOT) recipients receive immunosuppressive drugs that predispose them to opportunistic infections, including cytomegalovirus (CMV) infection. In these patients, CMV infection can lead to life-threatening consequences, such as transplant rejection. This systematic review and meta-analysis investigated the role of CMV infection in the development of acute rejection in SOT recipients.</p><p><strong>Methods: </strong>PubMed, Embase, Scopus, and Web of Science databases were systematically searched for eligible publications until Jan 31, 2025. English-language studies reporting the association between CMV infection and acute rejection in adult SOT recipients were included. Baseline characteristics, transplanted organs, and CMV infection and acute rejection status in SOT recipients were independently extracted by two reviewers. The pooled odds ratio (ORs) with a 95% confidence interval (CI) was calculated using the random effect model.</p><p><strong>Results: </strong>Overall, 27 studies with 6308 SOT recipients entered the meta-analysis. Acute rejection was significantly higher in SOT recipients with CMV infection than those without CMV infection (OR = 2.02, 95%CI 1.64-2.49, I² = 40.44%). Acute rejection was significantly higher in recipients of liver (OR = 4.43, 95%CI 2.20-8.92, I² = 0.00%), kidney (OR = 2.22, 95%CI 1.70-2.89, I² = 48.72%), and lung (OR = 1.38, 95%CI 1.01-1.90, I² = 0.00%), if they were infected with CMV. While acute rejection was not significantly associated with CMV infection in heart transplant recipients (OR = 1.49, 95%CI 0.54-4.12, I² = 18.83%). Furthermore, Egger's test did not indicate any evidence of publication bias (P = 0.7440).</p><p><strong>Conclusions: </strong>CMV infection approximately doubles the risk of acute rejection in SOT recipients. This association differs between various organs, with liver transplants indicating the highest risk, followed by kidney and lung transplants.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1205"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the AIDS scale among the system of quality of life instruments for chronic diseases (QLICD-HIV V2.0).","authors":"Xiaoyuan Sun, Liyuan Qiao, Haifeng Ding, Jianming Jiang, Ying Chen, Chonghua Wan","doi":"10.1186/s12879-025-11613-y","DOIUrl":"10.1186/s12879-025-11613-y","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1190"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of biofire blood culture identification 2 (BCID2) panel versus a matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) rapid incubation protocol on time to optimal therapy in patients with positive blood cultures.","authors":"Alexandria Baum, Jessica L Miller, Victoria Gavaghan, Eric T Beck, Jill Argotsinger","doi":"10.1186/s12879-025-11354-y","DOIUrl":"10.1186/s12879-025-11354-y","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1208"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking the evolution of emerging serotypes and antibiotic resistance patterns in Streptococcus pneumoniae among Indian adults using high-throughput genome sequencing.","authors":"Geetha Nagaraj, Varun Shamanna, Harshitha Gangaiah Krishnappa, Vandana Govindan, Mettingal Ramakrishnan Shincy, Ravikumar Kadahalli Lingegowda","doi":"10.1186/s12879-025-11587-x","DOIUrl":"10.1186/s12879-025-11587-x","url":null,"abstract":"","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1181"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative clinical features of COVID-19 in Non-elderly adult and elderly populations of Kermanshah province in Iran: a retrospective study.","authors":"Mohadeseh Yari, Sana Veisinezhad, Maryam Ahmadi, Parvin Abbasi, Mina Berimavandi","doi":"10.1186/s12879-025-11589-9","DOIUrl":"10.1186/s12879-025-11589-9","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19, caused by the SARS-CoV-2, emerged as a lethal infectious disease with viral pneumonia-like symptoms, and was first identified in Wuhan, China, in December 2019. This study aimed to compare the epidemiological characteristics and clinical manifestations of COVID-19 between elderly and non-elderly adult populations in Kermanshah Province, Iran.</p><p><strong>Methods: </strong>This retrospective study included 20,943 COVID-19 patients diagnosed between March 2020 and July 2021. Data were collected from the Medical Care Monitoring Center (MCMC) and comprised demographic information, comorbidities, clinical symptoms, hospitalization duration, and outcomes (discharge or mortality). Statistical analyses were performed using chi-square tests, Kaplan-Meier survival analysis, and multivariate Cox regression.</p><p><strong>Results: </strong>Of the 20,943 patients, 7,174 (34.3%) were aged 65 years or older. Elderly patients exhibited a higher prevalence of comorbidities such as diabetes (11.5% vs. 6.5%), heart disease (11.7% vs. 3.6%), and COPD (1.8% vs. 0.7%) compared to younger adults (P < 0.001). Additionally, elderly patients had a significantly higher mortality rate (19.4% vs. 6.0%) and shorter median survival time (18 days vs. 36 days) (P < 0.001). Severe symptoms, including hypoxemia (SpO2 < 93%) and altered mental status, were also more common in the elderly.</p><p><strong>Conclusion: </strong>This study showed that elderly COVID-19 patients are at a higher risk of severe illness and mortality compared to younger adults. The presence of comorbidities and more severe clinical manifestations in this age group led to increased hospitalization duration and mortality. These findings underscore the importance of targeted clinical management and public health policies for the elderly population in the context of COVID-19.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"1200"},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}