BMC Infectious Diseases最新文献

{"title":"Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunction.","authors":"Xuemei Shi, Zhonghan Yan, Ruilin Ding, Fenfen Xia, Yan Du, Xiaojie Wang, Qing Peng","doi":"10.1186/s12879-025-10822-9","DOIUrl":"10.1186/s12879-025-10822-9","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-induced myocardial dysfunction (SIMD) is a serious sepsis complication with high mortality, yet current diagnostic and therapeutic approaches remain limited. The lack of early, specific biomarkers and effective treatments necessitates exploration of novel mechanisms. Recently, cuproptosis has been implicated in various diseases, but its role in SIMD is unclear. This study aimed to identify cuproptosis-related biomarkers and potential therapeutic agents, supported by animal model validation.</p><p><strong>Methods: </strong>Four GEO datasets (GSE79962, GSE267388, GSE229925, GSE229298) were analyzed using Limma and WGCNA to identify overlapping genes from differentially expressed genes (DEGs), cuproptosis-related DEGs (DE-CRGs), and module-associated genes. Gene Set Enrichment Analysis (GSEA) and single-sample GSEA (ssGSEA) were performed to assess biological functions and immune cell infiltration, respectively. ceRNA and transcription factor networks were constructed to explore gene regulatory mechanisms, while consensus clustering was employed to define cuproptosis-related subtypes. Diagnostic genes were selected through SVM-RFE, LASSO, and random forest models. Additionally, potential gene-targeting agents were predicted using drug-gene interaction analysis. The findings were validated in SIMD animal models through qPCR and immunohistochemical analysis to confirm gene expression.</p><p><strong>Results: </strong>PDHB and DLAT emerged as key cuproptosis-related biomarkers. GSEA indicated upregulation of oxidative phosphorylation and downregulation of chemokine signaling. ssGSEA revealed negative correlations with several immune cell types. A ceRNA network (51 nodes, 56 edges) was constructed. Machine learning identified PDHB, NDUFA9, and TIMMDC1 as diagnostic genes, with PDHB showing high accuracy (AUC = 0.995 in GSE79962; AUC = 0.960, 0.864, and 0.984 in external datasets). Using the DSigDB database, we predicted six drugs that exhibit significant binding activity with PDHB. qPCR and immunohistochemistry confirmed reduced PDHB and DLAT expression in SIMD animal models.</p><p><strong>Conclusion: </strong>This study identifies PDHB and DLAT as cuproptosis-related biomarkers, addressing the diagnostic and therapeutic gaps in SIMD by unveiling novel molecular insights for early intervention and targeted treatment.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"445"},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of colistin-resistant Enterobacteriaceae isolated from clinical samples in Africa: a systematic review and meta-analysis.","authors":"Yalewayker Gashaw, Zelalem Asmare, Mitkie Tigabie, Asefa Sisay, Ermias Getatachew, Selamyhun Tadesse, Getachew Bitew, Agenagnew Ashagre, Tadesse Misganaw, Muluken Gashaw, Woldeteklehaymanot Kassahun, Zelalem Dejazimach, Abdu Jemal, Solomon Gedfie, Getinet Kumie, Marye Nigatie, Wagaw Abebe, Atitegeb Abera Kidie, Biruk Beletew Abate, Melese Abate Reta, Baye Gelaw","doi":"10.1186/s12879-025-10826-5","DOIUrl":"10.1186/s12879-025-10826-5","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance among Enterobacteriaceae poses a significant global threat, particularly in developing countries. Colistin, a critical last-resort treatment for infections caused by carbapenem-resistant and multidrug-resistant strains, is increasingly facing resistance due to inappropriate use of colistin and the spread of plasmid-mediated resistance genes. Despite the significance of this issue, comprehensive and updated data on colistin resistance in Africa is lacking. Thus, the current study was aimed to determine the pooled prevalence of colistin-resistant Enterobacteriaceae in Africa.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, Scopus, ScienceDirect, and Google Scholar to identify relevant studies. Forty-one studies reporting on the prevalence of colistin resistance in Enterobacteriaceae isolates from clinical specimens in Africa were included in the analysis. Stata 17 software was used to calculate the pooled prevalence of colistin resistance, employing a random-effects model to determine the event rate of resistance. Heterogeneity across studies was assessed using the I² statistic, and publication bias was evaluated using Egger's test. Subgroup analyses were performed to address any identified heterogeneity.</p><p><strong>Results: </strong>This systematic review analyzed the colistin resistance profile of 9,636 Enterobacteriaceae isolates. The overall pooled prevalence of colistin resistance was 26.74% (95% CI: 16.68-36.80). Subgroup analysis by country revealed significant variability in resistance rates, ranging from 0.5% in Djibouti to 50.95% in South Africa. Species-specific prevalence of colistin resistance was as follows: K. pneumoniae 28.8% (95% CI: 16.64%-41.05%), E. coli 24.5% (95% CI: 11.68%-37.3%), Proteus spp. 50.0% (95% CI: 6.0%-106.03%), and Enterobacter spp. 1.22% (95% CI: -0.5%-3.03%). Analysis based on AST methods revealed significant differences in colistin resistance rates (p = 0.001). The resistance rates varied between 12.60% for the disk diffusion method and 28.0% for the broth microdilution method. Additionally, a subgroup analysis of clinical specimens showed significant variation (p < 0.001) in colistin resistance. Stool specimen isolates had the highest resistance rate at 42.0%, while blood specimen isolates had a much lower resistance rate of 3.58%.</p><p><strong>Conclusions: </strong>Colistin resistance in Enterobacteriaceae is notably high in Africa, with significant variation across countries. This underscores the urgent need for effective antimicrobial stewardship, improved surveillance, and the development of new antibiotics.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"437"},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence trends of Trichomonas vaginalis infection among women in Jingzhou, central of China, 2019-2023.","authors":"Yan Yang, Yue Qu, Bin Yan, Changzheng Wang, Shun Liu","doi":"10.1186/s12879-025-10815-8","DOIUrl":"https://doi.org/10.1186/s12879-025-10815-8","url":null,"abstract":"<p><strong>Background: </strong>Trichomonas vaginalis (T. vaginalis) is one of the most prevalent sexually transmitted infections globally, with significant regional variations in its prevalence. This study aimed to examine the epidemiological characteristics of T. vaginalis infection in Jingzhou, Hubei Province, China.</p><p><strong>Methods: </strong>To obtain the prevalence of T. vaginalis infection among age groups and different years, a total of 115,775 patients from 2019 to 2023 were included in this study. Two detection methods including immunochromatographic assay and wet mount microscopy were used to detect the pathogens in vaginal swabs samples including T. vaginalis with other vaginal pathogens, such as Candida albicans (C. albicans) and Gardnerella Vaginalis (G. vaginalis).</p><p><strong>Results: </strong>The overall prevalence of T. vaginalis in Jingzhou was 3.41%, demonstrating a decreasing trend from 2019 to 2023, with a particularly significant decrease during the COVID-19 pandemic in 2020-2022 (P < 0.001). The highest positive rate of T. vaginalis was observed in the 45-54 years age group (4.87%), while the lowest rate was observed in the 25-34 years age group (2.37%). The prevalence of T. vaginalis in pregnant women (0.83%) was lower than that in non-pregnant women (1.87%), with a statistically significant difference (P < 0.001). T. vaginalis had co-infection with other pathogens (2.76%) compared to single infection (0.65%), and the most common co-infection pattern was T. vaginalis and G. vaginalis (2.09%). The results showed that there was relative high consistency (Kappa: 0.841) between the immunochromatographic assay and wet mount microscopy method for the detection of T. vaginalis. Additionally, elevated leukocyte levels were associated with a higher prevalence of T. vaginalis.</p><p><strong>Conclusion: </strong>The overall infection rate of T. vaginalis was 3.41%, showing a decreasing trend in prevalence in Jingzhou from 2019 to 2023. The prevalence was the highest in the 45-54 years age group. The study suggested that the immunochromatographic assay should be widely implemented as a screening method for T. vaginalis in primary healthcare facilities.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"435"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of high-risk HPV and cervical abnormalities in HIV-positive women in Bali, Indonesia.","authors":"I Ketut Agus Somia, Made Lady Adelaida Purwanta, Ni Wayan Winarti, Ida Bagus Nyoman Putra Dwija, Desak Made Putri Pidari, Anak Agung Sagung Sawitri, Anak Agung Ayu Yuli Gayatri, I Nyoman Gede Budiana, Komang Januartha Putra Pinatih, Ketut Tuti Parwati Merati","doi":"10.1186/s12879-025-10827-4","DOIUrl":"https://doi.org/10.1186/s12879-025-10827-4","url":null,"abstract":"<p><strong>Background: </strong>Women living with Human Immunodeficiency Virus (HIV) are at higher risk of cervical cancer, particularly in regions like Indonesia where cervical cancer screening programs are limited. Bali has seen a rise in both HIV and cervical cancer cases, prompting the need for targeted interventions. This study investigates the prevalence of cervical cytological abnormalities and associated risk factors among women with HIV in Bali, focusing on their relationship with high-risk Human Papillomavirus (HR-HPV) types.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from July to December 2023, recruiting 245 women from HIV outpatient clinics in Bali. Demographic and clinical data were collected via interviews and physical examinations, including cervical swabs and blood samples. HPV genotyping was performed using ThinPrep cytology followed by a two-stage PCR process. The first stage utilized universal primers (MY09/11) for HPV detection, while the second stage employed type-specific primers to identify high-risk strains, (16,18,31,33,35,39,45,51,52,56,58,59,66 and 68. Blood samples were analyzed to determine CD4 and CD8 T-cell counts.</p><p><strong>Results: </strong>Of 239 participants, 26 (10.87%) had abnormal cytology (6 cases (2.5%) of atypical squamous cells with high risk (ASC-H), 9 cases (3.8%) of atypical squamous cells of undetermined significance (ASC-US), 4 cases (1.7%) of high-grade squamous intraepithelial lesions (H-SIL), and 7 cases (2.9%) of low-grade squamous intraepithelial lesions (L-SIL)). Furthermore, 58 participants (24%) were tested positive for HPV DNA, with HPV type 18 being the most prevalent (28% in all HPV-positive samples). HPV-positive women had a seven-fold higher risk of abnormal cytology (PR = 7.022, 95% CI = 3.223-15.295). Multivariate analysis revealed HPV 18 as an independent risk factor (ExpB = 9.029, p = 0.007) and a history of pap smear screening reduced HR-HPV risk (ExpB = 0.358, p = 0.013).</p><p><strong>Conclusion: </strong>This study highlights that 10.87% of HIV-positive women in Bali had abnormal cytology, with HPV 18 significantly linked to higher risk. A history of pap smear screening reduced HR-HPV risk. These findings underscore the need for robust cervical cancer screening and HPV vaccination, particularly for younger women, to improve health outcomes in Indonesia.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"432"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bayesian spatiotemporal modelling and mapping of malaria risk among children under five years of age in Ghana.","authors":"Wisdom Kwami Takramah, Yaw Asare Afrane, Justice Moses K Aheto","doi":"10.1186/s12879-025-10787-9","DOIUrl":"10.1186/s12879-025-10787-9","url":null,"abstract":"<p><strong>Background: </strong>Malaria is a significant public health problem, particularly among children aged 6-59 months who bear the greatest burden of the disease. Malaria transmission is high and more pronounced in poor tropical and subtropical areas of the world. Climate change is positively correlated with the geographical distribution of malaria vectors. There is substantial evidence of spatial and temporal differences in under-five malaria risk. Thus, the study aimed to create intelligent maps of smooth relative risk of malaria in children under-5 years in Ghana that highlight high and low malaria burden in space and time to support malaria prevention, control, and elimination efforts.</p><p><strong>Method: </strong>The study extracted and merged data on malaria among children aged 6-59 months from the 2014 Ghana Demographic and Health Surveys (GDHS), 2016 and 2019 Ghana Malaria Indicator Surveys (GMIS). The outcome variable of interest was the count of children aged 6-59 months with a positive test on the rapid diagnostic test (RDT) result. Bayesian Hierarchical spatiotemporal models were specified to estimate and map spatiotemporal variations in the relative risk of malaria. The existence of local clustering was assessed using the local indicator of spatial association (LISA), and the points were mapped to display significant local clusters, hotpot, and cold spot communities.</p><p><strong>Results: </strong>The number of positive malaria cases in children aged 6-59 months decreased marginally from 946.7 (36.4%) in 2014 to 603.6 (22.9) in 2019 DHS survey periods. Smooth relative risk of malaria among children aged 6-59 months has consistently increased in the Northern and Eastern regions between 2014 and 2019. Socioeconomic and climatic factors such as household size [Posterior Mean: -0.198 (95% CrI: 3.52, 80.95)], rural area [Posterior Mean: 1.739 (95% CrI: 0.581, 2.867)], rainfall [Posterior Mean: 0.003 (95% CrI: 0.001, 0.005)], and maximum temperature [Posterior Mean: -1.069 (95% CrI: -2.135, -0.009)] were all shown as statistically significant predictors of malaria risk in children aged 6-59 months. Hot spot DHS clusters (enumeration areas) with a significantly high relative risk of malaria among children aged 6-59 months were repeatedly detected in the Ashanti region between 2014 and 2019.</p><p><strong>Conclusion: </strong>The findings of the study would provide policymakers with practical and insightful information for the equitable distribution of scarce health resources targeted at reducing the burden of malaria and its associated mortality among children under five years.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"430"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lactate-to-albumin ratio and mortality in hepatic failure: a retrospective cohort study.","authors":"Huan Wu, Long Wu, Li Luo, Hai-Yang Li, Bao-Fang Zhang","doi":"10.1186/s12879-025-10783-z","DOIUrl":"https://doi.org/10.1186/s12879-025-10783-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Liver failure has a high mortality rate, and currently, there is no convenient risk predictor. The lactate-to-albumin ratio (LAR) has emerged as a promising predictor in various critical illnesses. However, its potential role in predicting all-cause mortality in patients with liver failure remains unexplored. Therefore, this study aims to investigate the correlation between LAR and all-cause mortality in patients suffering from liver failure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We retrospectively analyzed data from patients with liver failure who were admitted to the intensive care unit (ICU) between 2008 and 2019, which were gathered from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. LAR was calculated from the ratio obtained from the first measurement taken within 24 h of admission. The optimal LAR threshold was determined using the Youden index. With LAR categorized into low, middle, and high groups based on tertiles, Kaplan - Meier analysis was employed to compare mortality risks among three patient groups. Multivariate Cox proportional hazards regression models were utilized to evaluate the association between LAR and all-cause mortality in hepatic failure patients within hospital admission. Additionally, receiver operating characteristic (ROC) and smoothing curve analysis were used to assess the predictive ability, sensitivity, and specificity of LAR for all-cause mortality in patients with liver failure, and the area under the curve (AUC) was calculated. A smooth curve fitting approach and threshold effect analysis were employed to detect the potentially non-linear relationship between the LAR and the risk of all-cause mortality in patients with hepatic failure. Finally, subgroup analyses were performed to assess the relationship between LAR and prognosis across different types of liver failure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 902 patients with hepatic failure were included in this study. They were divided into survivors group (611 patients) and non-survivors group (291 patients) according to whether they survived during hospitalization, and the mortality rate of patients was 32.26%. The Kaplan-Meier survival curves illustrating patients in hepatic failure with elevated LAR showed a significantly heightened risk of in-hospital mortality (P &lt; 0.001). We identified a non-linear relationship between LAR and the risk of hospital mortality after adjusting for potential confounders and the inflection point of LAR to be 1.33. LAR was shown to be an independent predictor of all-cause mortality within hospitalization in patients with hepatic failure by multivariate COX regression analysis (HR, 1.66; 95% CI, 1.35-2.05; P &lt; 0.0001). The optimal cutoff value for separating the survival and death groups according to ROC was found to be 0.97. The AUC value for LAR was 0.755 (95% CI: 0.721, 0.789), which was higher than that for arterial blood lactate (AUC = 0.725) and serum albumin (AUC = ","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"433"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Google Trends to forecast acute febrile illness outbreaks in North India reported through the Integrated Disease Surveillance Program.","authors":"Madhur Verma, Kamal Kishore, Pragyan Paramita Parija, Soumya Swaroop Sahoo, Dolly Gambhir, Usha Gupta, Rakesh Kakkar","doi":"10.1186/s12879-025-10801-0","DOIUrl":"https://doi.org/10.1186/s12879-025-10801-0","url":null,"abstract":"<p><strong>Background: </strong>Acute Febrile Illness (AFI) like Malaria, Dengue, Chikungunya, and Enteric fever still remain the most common cause of seeking healthcare in low-middle-income countries and need to be constantly monitored for any impending outbreak. Digital epidemiology promises to assist traditional health surveillance. The health data (including AFI) collated by Google using specialised platforms like Google Trends (GT) is known to correlate with actual disease trends. The present study thus aims to assess the potential of GT to support routine surveillance system and forecast AFI outbreaks reported through the Indian Integrated Disease Surveillance Programme (IDSP).</p><p><strong>Methods: </strong>We utilised Haryana's IDSP portal to retrieve the weekly data of the most commonly reported infectious diseases causing AFI between 2011 and 2020. Internet search trends were downloaded using GT. Descriptive statistics estimated the burden of the AFI and Bland-Altman's plot depicted statistical agreement between the two. We adopted the Box-Jenkins approach to attain the final SARIMA model and explain the time-dependent weekly incidence of AFI.</p><p><strong>Results: </strong>The time series plot of the reported AFI displayed trends. Martin- Bland plots depicted acceptable agreement between two datasets for all Chikungunya and Dengue. Among the models evaluated, the Malaria model [SARIMA(1,1,1)(1,1,1)] demonstrated the best performance with a balanced fit and reasonable accuracy, while the Enteric Fever model [SARIMA(0,1,0)(1,1,1)] exhibited low prediction error but weak seasonal significance. In contrast, the Dengue [SARIMA(1,1,0)(1,1,0)] and Chikungunya [ARIMA(1,0,0)(0,0,0)] models had high forecast errors, limiting their predictive reliability. Overall, GT supplemented the prediction performance of the SARIMA models with adjusted R² of 46%, 50%, 50%, and 52% compared to the original 43%, 49%, 20%, and 48%.</p><p><strong>Conclusions: </strong>Our study observed modest improvements in GT-based SARIMA forecasting models compared to routine IDSP mechanisms for predicting AFI outbreaks in Haryana, highlighting the potential for further enhancement. As more granular GT data becomes available, its integration with traditional surveillance systems could significantly enhance forecasting accuracy for AFI and other infectious disease outbreaks. At no additional cost to the health system, GT can serve as a valuable, real-time digital epidemiology tool, strengthening public health preparedness and enabling timely interventions for the early containment of emerging diseases.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"431"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late lymphocele infection with Parvimonas micra in a kidney allograft recipient.","authors":"Rihab Dkhissi, Gabriel Ouellet, Xavier Charmetant, Fanny Buron, Florent Valour, Olivier Rouviere, Xavier Matillon, Emmanuel Morelon","doi":"10.1186/s12879-025-10759-z","DOIUrl":"https://doi.org/10.1186/s12879-025-10759-z","url":null,"abstract":"<p><strong>Background: </strong>Lymphocele infection is a frequent and usually early complication following renal transplantation. We report the case of a transplanted patient with a chronic lymphocele that became infected six years after transplantation Parvimonas micra, a commensal of the human oral cavity.</p><p><strong>Case presentation: </strong>The patient had a stable lymphocele for six years post-transplantation, as observed through several medical imaging studies, without the need for intervention due to the absence of any impact on graft function. Regarding a six-month progressive decline in general condition, a persistent inflammatory syndrome and a deterioration of renal function, a PET scan revealed a hypermetabolic infiltration behind the lymphocele adjacent to the graft. Bacterial superinfection with Parvimonas micra was diagnosed by an exploratory puncture. The patient had a history of dental periodontal treatments. The initial attempt at treatment with radiological drainage and three months of antibiotic therapy was unsuccessful. Faced with radiological deterioration despite treatment, the patient underwent surgical intervention for lavage with necessary antibiotic therapy for an additional six weeks. He achieved clinical remission, but metabolic activity persists within the site of a residual collection, and the patient remains closely observed.</p><p><strong>Conclusions: </strong>Infected lymphoceles should be considered in the differential diagnosis for patients presenting with nonspecific infectious and inflammatory symptoms, regardless of the time elapsed since renal transplantation. The treatment of this complication can be complex.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"434"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment completion and safety profile of once-weekly 3HP regimen for tuberculosis preventive treatment in children and adolescents: a systematic review.","authors":"Sipang Pangprasertkul, Nida Buawangpong, Kanokporn Pinyopornpanish, Wichuda Jiraporncharoen, Chaisiri Angkurawaranon","doi":"10.1186/s12879-025-10832-7","DOIUrl":"https://doi.org/10.1186/s12879-025-10832-7","url":null,"abstract":"<p><strong>Background: </strong>Children and adolescents are at increased risk of progressing from latent to active tuberculosis (TB). The 3-month, once-weekly isoniazid and rifapentine (3HP) regimen offers a shorter tuberculosis preventive treatment (TPT) option. However, evidence regarding its completion rates and safety in these populations remains limited.</p><p><strong>Objective: </strong>To evaluate treatment completion rates and adverse events associated with the 3HP regimen in children and adolescents.</p><p><strong>Methods: </strong>A systematic review of studies evaluated the 3HP regimen in children and adolescents with LTBI was conducted. Databases including PubMed, Embase, Cochrane Library, and CINAHL were searched to identify relevant studies. Data on treatment completion rates and adverse events were extracted and analyzed descriptively.</p><p><strong>Results: </strong>Ten studies involving children and adolescents aged 0-20 years were reviewed. Treatment completion rates were higher with 3HP regimen ranged from 70.9 to 100%, with a favorable safety profile. Mild adverse events, including nausea, vomiting, and abdominal pain, were reported, with no serious adverse events or hepatotoxicity observed.</p><p><strong>Conclusions: </strong>The 3HP regimen demonstrates high completion rates and safety profile in children and adolescents with LTBI, highlighting its suitability for this population. Expanding its implementation in programmatic settings is crucial to advancing global TB elimination.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"436"},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-driven pathogen replacement events in a kidney transplant recipient with ADPKD: a case report.","authors":"Ziyan Yan, Yuchen Wang, Wenli Zeng, Jialiang Hui, Bin Yang, Jian Xu, Yun Miao, Renfei Xia","doi":"10.1186/s12879-025-10804-x","DOIUrl":"10.1186/s12879-025-10804-x","url":null,"abstract":"<p><strong>Background: </strong>Retaining the native bilateral kidneys after transplantation is a common treatment for patients with end-stage autosomal dominant polycystic kidney disease. However, this strategy poses the risks of potential complications from polycystic kidney infection. The efficiency of antibiotic therapy and the optimal time for native nephrectomy in managing these infections remain uncertain.</p><p><strong>Case presentation: </strong>We report a case of a kidney transplant recipient with retained bilateral polycystic kidneys who experienced recurrent cyst and bloodstream infections, accompanied by antibiotic-driven pathogen replacement. After multiple failed attempts at antibiotic therapy, the patient subsequently underwent unilateral polycystic kidney resection. Subsequently, a new infection episode occurred, leading to the other native nephrectomy. Cystic tissue and fluid samples were collected from both shallow and deep layers of the polycystic kidneys, along with peripheral blood and urine samples. These samples were analyzed using microbial culture, metagenome sequencing, and digital polymerase chain reaction to identify infectious pathogens. Pathogen replacement occurred across different infection episodes, with the dominant bacterial species being Escherichia coli, Klebsiella aerogenes, and Enterococcus faecium, in succession.</p><p><strong>Conclusions: </strong>This case highlights the replacement of dominant pathogens under antibiotic selection pressure in polycystic kidney infections, primarily involving gram-negative bacilli. When initial and subsequent antibiotic therapy fail, re-evaluation of the cyst infection definition is necessary, and preemptive native nephrectomy should be considered.</p>","PeriodicalId":8981,"journal":{"name":"BMC Infectious Diseases","volume":"25 1","pages":"423"},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}