Characteristics of Klebsiella pneumoniae and carbapenem-resistant Klebsiella pneumoniae clinical isolates from COVID-19 patients: a single-center retrospective analysis in a tertiary hospital, China.

IF 3 3区医学 Q2 INFECTIOUS DISEASES

BMC Infectious Diseases Pub Date : 2025-09-26 DOI:10.1186/s12879-025-11526-w

Dandan Shi, Zijie Zhou, Liqing Hu, Danying Yan, Chuwen Wang, Jinming Ye, Guoqing Qian

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引用次数: 0

Abstract

Background: The COVID-19 pandemic has exacerbated the complexity of antimicrobial resistance (AMR) challenges. This study aimed to quantify risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) acquisition in COVID-19 patients, compare resistance profiles and laboratory biomarkers between carbapenem-susceptible K. pneumoniae (CS-KP) and CRKP strains, and identify clinical indicators predictive of CRKP co-infection.

Methods: We conducted a retrospective analysis of COVID-19 patients with KP-positive cultures admitted to a tertiary hospital in China between January 2020 and May 2024. Antimicrobial susceptibility testing and multivariable logistic regression were employed to evaluate resistance patterns and risk factors.

Results: Among 342 COVID-19 patients with KP-positive, 262 (76.6%) were CSKP and 80 (23.4%) CRKP. Hypertension, prolonged hospitalization, and ICU admission were identified as independent risk factors for CRKP acquisition. CRKP group patients exhibited significantly worse laboratory tests, including elevated inflammatory markers, coagulopathy, and renal dysfunction, providing clinical markers for suspecting the presence of multi-drug resistant bacteria.

Conclusions: Our findings reveal KP resistance profiles under COVID-19 pressures and underscore the necessity of early microbiological confirmation and precision antibiotic use.

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新型冠状病毒肺炎克雷伯菌和耐碳青霉烯肺炎克雷伯菌临床分离株的特征：中国某三级医院单中心回顾性分析

背景：2019冠状病毒病大流行加剧了抗菌素耐药性挑战的复杂性。本研究旨在量化COVID-19患者耐碳青霉烯肺炎克雷伯菌（CRKP）获得的危险因素，比较碳青霉烯敏感肺炎克雷伯菌（CS-KP）和CRKP菌株的耐药谱和实验室生物标志物，并确定预测CRKP联合感染的临床指标。方法：对2020年1月至2024年5月在中国某三级医院住院的新冠肺炎kp阳性患者进行回顾性分析。采用药敏试验和多变量logistic回归评估耐药模式和危险因素。结果：342例新冠肺炎患者中，CSKP阳性262例（76.6%），CRKP阳性80例（23.4%）。高血压、长期住院和ICU住院被确定为获得CRKP的独立危险因素。CRKP组患者的实验室检查明显更差，包括炎症标志物升高、凝血功能障碍和肾功能障碍，为怀疑存在多重耐药细菌提供了临床标志物。结论：我们的研究结果揭示了在COVID-19压力下KP的耐药概况，并强调了早期微生物学确认和精确使用抗生素的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Infectious Diseases 医学-传染病学

CiteScore

6.50

自引率

0.00%

发文量

860

审稿时长

3.3 months

期刊介绍： BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.