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Human VH-antibody-based CAR T cells targeting folate receptor-alpha show enhanced persistence and reduced T-cell exhaustion against ovarian cancer 靶向叶酸受体α的人vh抗体CAR - T细胞对卵巢癌表现出增强的持久性和减少的T细胞耗竭。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1016/j.biopha.2026.119169
Nithidol Sakunrangsit , Kannika Khantasup , Natapol Pornputtipong , Koramit Suppipat , Nattiya Hirankarn , Supannikar Tawinwung
{"title":"Human VH-antibody-based CAR T cells targeting folate receptor-alpha show enhanced persistence and reduced T-cell exhaustion against ovarian cancer","authors":"Nithidol Sakunrangsit ,&nbsp;Kannika Khantasup ,&nbsp;Natapol Pornputtipong ,&nbsp;Koramit Suppipat ,&nbsp;Nattiya Hirankarn ,&nbsp;Supannikar Tawinwung","doi":"10.1016/j.biopha.2026.119169","DOIUrl":"10.1016/j.biopha.2026.119169","url":null,"abstract":"<div><h3>Background</h3><div>Folate receptor-alpha (FOLR1) is highly expressed in ovarian cancer and correlates with poor clinical outcomes, making it an attractive target for adoptive cell therapy. Single-domain antibodies (V<sub>H</sub> domains) have gained increasing interest as antigen-binding domains for CAR T-cell engineering.</div></div><div><h3>Methods</h3><div>We generated a second-generation FOLR1-specific CAR incorporating a fully human V<sub>H</sub>-only antibody and compared its <em>in vitro</em> functional activity with a MOv19-derived scFV CAR. CAR expression, memory phenotype, cytotoxicity, cytokine secretion, and exhaustion markers were evaluated following antigen stimulation. Antitumor efficacy was further assessed in 3D spheroids and repeated tumor-rechallenge assays.</div></div><div><h3>Results</h3><div>Both V<sub>H</sub>-based and scFV-based FOLR1 CAR T cells demonstrated potent and antigen-specific cytotoxicity against FOLR1-positive ovarian cancer cells. Intriguingly, FOLR1-V<sub>H</sub> CAR T cells showed lower activation and cytokine release upon initial stimulation, accompanied by reduced expression of exhaustion markers including PD-1 and LAG-3. FOLR1-V<sub>H</sub> CAR T cells preferentially preserved a central-memory phenotype and displayed superior persistence and tumor control during multiple rounds of antigen rechallenge. Both CAR formats achieved comparable cytotoxicity in 3D spheroid models.</div></div><div><h3>Conclusion</h3><div>Human FOLR1-V<sub>H</sub> CAR T cells demonstrated potent antitumor activity with reduced exhaustion and enhanced persistence. These properties highlight the V<sub>H</sub> domain as a promising targeting module for next-generation CAR T-cell therapies in ovarian cancer.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119169"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Nanoparticles as an effective drug delivery system in COVID-19" [Biomedicine & Pharmacotherapy 143 (2021) 112162] “纳米颗粒作为新型冠状病毒有效的给药系统”的撤稿通知[生物医学与药物治疗143(2021)112162]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-20 DOI: 10.1016/j.biopha.2026.119150
Neehasri Kumar Chowdhury , Deepika , Reshma Choudhury , Gaurav Ambadas Sonawane , Shankar Mavinamar , Xiaoming Lyu , Ramendra Pati Pandey , Chung-Ming Chang
{"title":"Retraction notice to \"Nanoparticles as an effective drug delivery system in COVID-19\" [Biomedicine & Pharmacotherapy 143 (2021) 112162]","authors":"Neehasri Kumar Chowdhury ,&nbsp;Deepika ,&nbsp;Reshma Choudhury ,&nbsp;Gaurav Ambadas Sonawane ,&nbsp;Shankar Mavinamar ,&nbsp;Xiaoming Lyu ,&nbsp;Ramendra Pati Pandey ,&nbsp;Chung-Ming Chang","doi":"10.1016/j.biopha.2026.119150","DOIUrl":"10.1016/j.biopha.2026.119150","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119150"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "ATP ion channel P2X purinergic receptors in inflammation response" [Biomedicine & Pharmacotherapy 158 (2023) 114205] 关于“ATP离子通道P2X嘌呤能受体在炎症反应中的作用”的撤回通知[生物医学与药物治疗]158(2023):114205]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-20 DOI: 10.1016/j.biopha.2026.119148
Ji-peng Liu , Si-cheng Liu , Shi-qi Hu , Jia-feng Lu , Chang-lei Wu , Dong-xia Hu , Wen-jun Zhang
{"title":"Retraction notice to \"ATP ion channel P2X purinergic receptors in inflammation response\" [Biomedicine & Pharmacotherapy 158 (2023) 114205]","authors":"Ji-peng Liu ,&nbsp;Si-cheng Liu ,&nbsp;Shi-qi Hu ,&nbsp;Jia-feng Lu ,&nbsp;Chang-lei Wu ,&nbsp;Dong-xia Hu ,&nbsp;Wen-jun Zhang","doi":"10.1016/j.biopha.2026.119148","DOIUrl":"10.1016/j.biopha.2026.119148","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119148"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “Narciclasine suppresses oral cancer metastasis by modulating cathepsin B and extracellular signal-related kinase pathways” [Biomed. Pharmacother. 158 (2023) 114159] “水仙素通过调节组织蛋白酶B和细胞外信号相关激酶途径抑制口腔癌转移”的更正[生物医学杂志]。中国药理学杂志，2015(5):391 - 391。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119189
Mu-Kuei Shieu , Hsin-Yu Ho , Chia-Chieh Lin , Yu-Sheng Lo , Yi-Ching Chuang , Ming-Ju Hsieh , Mu-Kuan Chen
{"title":"Corrigendum to “Narciclasine suppresses oral cancer metastasis by modulating cathepsin B and extracellular signal-related kinase pathways” [Biomed. Pharmacother. 158 (2023) 114159]","authors":"Mu-Kuei Shieu ,&nbsp;Hsin-Yu Ho ,&nbsp;Chia-Chieh Lin ,&nbsp;Yu-Sheng Lo ,&nbsp;Yi-Ching Chuang ,&nbsp;Ming-Ju Hsieh ,&nbsp;Mu-Kuan Chen","doi":"10.1016/j.biopha.2026.119189","DOIUrl":"10.1016/j.biopha.2026.119189","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119189"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Diclofenac and metformin synergistic dose dependent inhibition of hamster fibrosarcoma, rescued with mebendazole” [Biomedicine & Pharmacotherapy 167 (2023) 115528] “双氯芬酸与二甲双胍协同剂量依赖性抑制甲苯达唑拯救仓鼠纤维肉瘤”撤回通知[生物医药与药物治疗167(2023)115528]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119194
Dušica J. Popović , Kosta J. Popović , Dejan Miljković , Jovan K. Popović , Dušan Lalošević , Mihalj Poša , Zana Dolićanin , Ivan Čapo
{"title":"Retraction notice to “Diclofenac and metformin synergistic dose dependent inhibition of hamster fibrosarcoma, rescued with mebendazole” [Biomedicine & Pharmacotherapy 167 (2023) 115528]","authors":"Dušica J. Popović ,&nbsp;Kosta J. Popović ,&nbsp;Dejan Miljković ,&nbsp;Jovan K. Popović ,&nbsp;Dušan Lalošević ,&nbsp;Mihalj Poša ,&nbsp;Zana Dolićanin ,&nbsp;Ivan Čapo","doi":"10.1016/j.biopha.2026.119194","DOIUrl":"10.1016/j.biopha.2026.119194","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119194"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Adult hippocampal neurogenesis (AHN) controls central nervous system and promotes peripheral nervous system regeneration via physical exercise" [Biomedicine & Pharmacotherapy 165 (2023) 115078] 关于“成人海马神经发生（AHN）通过体育锻炼控制中枢神经系统并促进周围神经系统再生”的撤回通知[生物医学与药物治疗165(2023)115078]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-12 DOI: 10.1016/j.biopha.2026.119212
Vahideh Zalouli , Hosnieh Rajavand , Mahdi Bayat , Jalil Khaleghnia , Fariborz Sharifianjazi , Farzad Jafarinazhad , Nima Beheshtizadeh
{"title":"Retraction notice to \"Adult hippocampal neurogenesis (AHN) controls central nervous system and promotes peripheral nervous system regeneration via physical exercise\" [Biomedicine & Pharmacotherapy 165 (2023) 115078]","authors":"Vahideh Zalouli ,&nbsp;Hosnieh Rajavand ,&nbsp;Mahdi Bayat ,&nbsp;Jalil Khaleghnia ,&nbsp;Fariborz Sharifianjazi ,&nbsp;Farzad Jafarinazhad ,&nbsp;Nima Beheshtizadeh","doi":"10.1016/j.biopha.2026.119212","DOIUrl":"10.1016/j.biopha.2026.119212","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119212"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals" [Biomedicine & Pharmacotherapy 164 (2023) 114967] 《乳铁蛋白：对人类和动物的抗菌作用、基因组守护者、治疗用途和临床意义》撤回通知[生物医学与药物治疗164(2023)114967]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-20 DOI: 10.1016/j.biopha.2026.119147
Mohamed E. Abd El-Hack , Sameh A. Abdelnour , Mahmoud Kamal , Asmaa F. Khafaga , Afnan M. Shakoori , Rehab M. Bagadood , Hind M. Naffadi , Areej Y. Alyahyawi , Hanan Khojah , Saleh Alghamdi , Mariusz Jaremko , Sylwester Świątkiewicz
{"title":"Retraction notice to \"Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals\" [Biomedicine & Pharmacotherapy 164 (2023) 114967]","authors":"Mohamed E. Abd El-Hack ,&nbsp;Sameh A. Abdelnour ,&nbsp;Mahmoud Kamal ,&nbsp;Asmaa F. Khafaga ,&nbsp;Afnan M. Shakoori ,&nbsp;Rehab M. Bagadood ,&nbsp;Hind M. Naffadi ,&nbsp;Areej Y. Alyahyawi ,&nbsp;Hanan Khojah ,&nbsp;Saleh Alghamdi ,&nbsp;Mariusz Jaremko ,&nbsp;Sylwester Świątkiewicz","doi":"10.1016/j.biopha.2026.119147","DOIUrl":"10.1016/j.biopha.2026.119147","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119147"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism" [Biomedicine & Pharmacotherapy 84 (2016) 330-339] 《半雄酮体外、体内抗增殖作用、疗效及其机制》撤稿通知[生物医学与药物治疗84(2016)330-339]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI: 10.1016/j.biopha.2026.119158
XinGang Lu , HongFu Qiu , Liu Yang , JieYing Zhang , ShuJie Ma , Lan Zhen
{"title":"Retraction notice to \"Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism\" [Biomedicine & Pharmacotherapy 84 (2016) 330-339]","authors":"XinGang Lu ,&nbsp;HongFu Qiu ,&nbsp;Liu Yang ,&nbsp;JieYing Zhang ,&nbsp;ShuJie Ma ,&nbsp;Lan Zhen","doi":"10.1016/j.biopha.2026.119158","DOIUrl":"10.1016/j.biopha.2026.119158","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119158"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme” [Biomedicine & Pharmacotherapy 141 (2021) 111928] “天然生物活性分子：多形性胶质母细胞瘤治疗和控制的替代方法”撤回通知[生物医学与药物治疗141(2021)111928]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119195
Priti Tagde , Pooja Tagde , Sandeep Tagde , Tanima Bhattacharya , Vishal Garg , Rokeya Akter , Md. Habibur Rahman , Agnieszka Najda , Ghadeer M. Albadrani , Amany A. Sayed , Muhammad Furqan Akhtar , Ammara Saleem , Ahmed E. Altyar , Deepak Kaushik , Mohamed M. Abdel-Daim
{"title":"Retraction notice to “Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme” [Biomedicine & Pharmacotherapy 141 (2021) 111928]","authors":"Priti Tagde ,&nbsp;Pooja Tagde ,&nbsp;Sandeep Tagde ,&nbsp;Tanima Bhattacharya ,&nbsp;Vishal Garg ,&nbsp;Rokeya Akter ,&nbsp;Md. Habibur Rahman ,&nbsp;Agnieszka Najda ,&nbsp;Ghadeer M. Albadrani ,&nbsp;Amany A. Sayed ,&nbsp;Muhammad Furqan Akhtar ,&nbsp;Ammara Saleem ,&nbsp;Ahmed E. Altyar ,&nbsp;Deepak Kaushik ,&nbsp;Mohamed M. Abdel-Daim","doi":"10.1016/j.biopha.2026.119195","DOIUrl":"10.1016/j.biopha.2026.119195","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119195"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Unveiling the potential of FOXO3 in lung cancer: From molecular insights to therapeutic prospects” [Biomedicine & Pharmacotherapy 176 (2024) 116833] “揭示FOXO3在肺癌中的潜力：从分子洞察到治疗前景”[生物医学与药物治疗176(2024)116833]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119193
Mohammad Ebrahimnezhad , Amir Valizadeh , Maryam Majidinia , Peyman Tabnak , Bahman Yousefi
{"title":"Retraction notice to “Unveiling the potential of FOXO3 in lung cancer: From molecular insights to therapeutic prospects” [Biomedicine & Pharmacotherapy 176 (2024) 116833]","authors":"Mohammad Ebrahimnezhad ,&nbsp;Amir Valizadeh ,&nbsp;Maryam Majidinia ,&nbsp;Peyman Tabnak ,&nbsp;Bahman Yousefi","doi":"10.1016/j.biopha.2026.119193","DOIUrl":"10.1016/j.biopha.2026.119193","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119193"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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