Biomedicine & Pharmacotherapy最新文献

{"title":"Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate","authors":"Aurora Schiavon ,&nbsp;Carlotta Evaristo ,&nbsp;Laura Saba ,&nbsp;Jessica Petiti ,&nbsp;Ymera Pignochino ,&nbsp;Soraya Puglisi ,&nbsp;Paola Perotti ,&nbsp;Erika Messina ,&nbsp;Claudia Giachino ,&nbsp;Massimo Terzolo ,&nbsp;Marco Lo Iacono","doi":"10.1016/j.biopha.2026.119156","DOIUrl":"10.1016/j.biopha.2026.119156","url":null,"abstract":"<div><h3>Background</h3><div>Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. Mitotane, the only approved drug, has modest efficacy and frequent adverse effects, underscoring the urgent need for new therapeutic approaches. Celastrol, a triterpene compound derived from traditional Chinese medicine, exhibits anti-inflammatory activity and broad anti-tumor effects, including sensitization of cancer cells to chemo- and radiotherapy.</div></div><div><h3>Purpose</h3><div>In this study, we investigated for the first time the anti-cancer potential of celastrol in the ACC H295R cell line.</div></div><div><h3>Methods</h3><div>Using different in vitro biomolecular technologies and biochemical/biophysical experiments, we evaluated celastrol’s effect on ACC cells.</div></div><div><h3>Results</h3><div>Celastrol induced apoptosis in ACC cells and demonstrated efficacy not only in 2D monolayer cultures but also in 3D spheroid models. Importantly, it inhibited spheroid growth and disrupted pre-formed spheroids, highlighting its activity in tumor-like structures. Mechanistic analyses suggested that celastrol triggers apoptosis through induction of endoplasmic reticulum (ER) stress and oxidative stress. These findings parallel our previous observations with mitotane, which also activates the ER stress pathway via the ATF4-ATF3 axis. This partial convergence points to ER stress induction as a potential therapeutic target in ACC.</div></div><div><h3>Conclusion</h3><div>identifying agents capable of complementing or replacing standard therapy remains a central challenge in ACC research. Our findings suggest that celastrol is a potent bioactive compound with activity against both monolayer and 3D ACC models, offering potential translational relevance. By elucidating ER stress as a shared mechanism between celastrol and mitotane, our work supports further exploration of this pathway as a strategy to potentially improve therapeutic outcomes in ACC patients.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119156"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum \"chemical profiling and investigation of molecular mechanisms underlying anti-hepatocellular carcinoma activity of extracts from Polygonum perfoliatum L.\" [Biomedicine & Pharmacotherapy 166 (2023) 115315]","authors":"Xiaolong Tang ,&nbsp;Lin Liu ,&nbsp;Yan Li ,&nbsp;Siyu Hao ,&nbsp;Yueshui Zhao ,&nbsp;Xu Wu ,&nbsp;Mingxing Li ,&nbsp;Yu Chen ,&nbsp;Shuai Deng ,&nbsp;Shuang Gou ,&nbsp;Dan Cai ,&nbsp;Meijuan Chen ,&nbsp;Xiaobing Li ,&nbsp;Yuhong Sun ,&nbsp;Li Gu ,&nbsp;Wanping Li ,&nbsp;Fang Wang ,&nbsp;Zhuo Zhang ,&nbsp;Lei Yao ,&nbsp;Jing Shen ,&nbsp;Fukuan Du","doi":"10.1016/j.biopha.2026.119171","DOIUrl":"10.1016/j.biopha.2026.119171","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119171"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications” [Biomed. Pharmacother. 153 (2022) 113469]","authors":"Urooj Fatima ,&nbsp;Sonam Roy ,&nbsp;Shahnawaz Ahmad ,&nbsp;Lamya Ahmed Al-Keridis ,&nbsp;Nawaf Alshammari ,&nbsp;Mohd Adnan ,&nbsp;Asimul Islam ,&nbsp;Md. Imtaiyaz Hassan","doi":"10.1016/j.biopha.2026.119172","DOIUrl":"10.1016/j.biopha.2026.119172","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119172"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases” [Biomedicine & Pharmacotherapy 164 (2023) 114993]","authors":"Ying Liu ,&nbsp;Wei Ding ,&nbsp;Jianxun Wang ,&nbsp;Xiang Ao ,&nbsp;Junqiang Xue","doi":"10.1016/j.biopha.2026.119192","DOIUrl":"10.1016/j.biopha.2026.119192","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119192"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Moschus exerted protective activity against H2O2-induced cell injury in PC12 cells through regulating Nrf-2/ARE signaling pathways\" [Biomedicine & Pharmacotherapy 159 (2023) 114290]","authors":"Danni Xie ,&nbsp;Ting Deng ,&nbsp;Zhenwei Zhai ,&nbsp;Tao Qin ,&nbsp;Caiyou Song ,&nbsp;Ying Xu ,&nbsp;Tao Sun","doi":"10.1016/j.biopha.2026.119201","DOIUrl":"10.1016/j.biopha.2026.119201","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119201"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Pinostrobin ameliorates lipopolysaccharide (LPS)-induced inflammation and endotoxemia by inhibiting LPS binding to the TLR4/MD2 complex” [Biomed. Pharmacother. 156 (2022) 113874]","authors":"Athapaththu Mudiyanselage Gihan Kavinda Athapaththu ,&nbsp;Kyeong Tae Lee ,&nbsp;Mirissa Hewage Dumindu Kavinda ,&nbsp;Seunghun Lee ,&nbsp;Sanghyuck Kang ,&nbsp;Mi-Hwa Lee ,&nbsp;Chang-Hee Kang ,&nbsp;Yung Hyun Choi ,&nbsp;Gi-Young Kim","doi":"10.1016/j.biopha.2026.119108","DOIUrl":"10.1016/j.biopha.2026.119108","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119108"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rise in double-strand breaks sensitizes tumors to oxidative metabolism inhibitors","authors":"Ferran Medina-Jover ,&nbsp;Agnès Figueras ,&nbsp;Núria Gendrau-Sanclemente ,&nbsp;Emilio Racionero-Andrés ,&nbsp;Meritxell Sociats-Font ,&nbsp;Álvaro Lahiguera ,&nbsp;Pau Guillén ,&nbsp;María Tormo-Fabios ,&nbsp;Roderic Espín ,&nbsp;Miguel Ángel Pardo-Cea ,&nbsp;Andrés Mendez-Lucas ,&nbsp;Edurne Berra ,&nbsp;Josep Maria Piulats ,&nbsp;Álvaro Aytés ,&nbsp;Alberto Villanueva ,&nbsp;Adrià Bernat-Peguera ,&nbsp;Margarita Romeo ,&nbsp;Miquel Angel Pujana ,&nbsp;José Carlos Perales ,&nbsp;Francesc Viñals","doi":"10.1016/j.biopha.2026.119184","DOIUrl":"10.1016/j.biopha.2026.119184","url":null,"abstract":"<div><div>Double-strand breaks (DSBs) accumulate in tumoral DNA due to deficiencies in homologous recombination (HR) repair, such as mutations in BRCA genes, or following antitumoral treatments. In the present study, we show that DSB accumulation, irrespective of origin, triggers an adaptive shift toward oxidative metabolism. We demonstrate that DSBs downregulate the glycolytic transcription factor HIF-1α. This downregulation reduces PDHK1 expression, thereby activating the pyruvate dehydrogenase complex, a key mitochondrial gatekeeper of cellular metabolism. We establish that the induction of oxidative metabolism represents a therapeutically actionable vulnerability across diverse cancer types, independent of HR proficiency. Targeting this metabolic switch in combination with DSB-inducing chemotherapies synergizes <em>in vivo</em>, resulting in significantly reduced tumor growth. Collectively, our findings reveal a critical feedback loop linking DSBs to cancer cell metabolism that constrains metabolic plasticity and creates a compelling therapeutic opportunity for rational combination strategies.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119184"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147387826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Protective effect of sargahydroquinoic acid against Aβ25–35-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system” [Biomed. Pharmacother., vol. 144, (2021), 112271]","authors":"Jeong-Hyun Yoon ,&nbsp;Kumju Youn ,&nbsp;Mira Jun","doi":"10.1016/j.biopha.2026.119146","DOIUrl":"10.1016/j.biopha.2026.119146","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119146"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Chronic citalopram effects on the brain neurochemical profile and perfusion in a rat model of depression detected by the NMR techniques – Spectroscopy and perfusion” [Biomed. Pharmacother. 181 (2024) 117656]","authors":"Iveta Harastova-Pavlova ,&nbsp;Eva Drazanova ,&nbsp;Lucie Kratka ,&nbsp;Petra Amchova ,&nbsp;Maria Hrickova ,&nbsp;Ondrej Macicek ,&nbsp;Jiri Vitous ,&nbsp;Radovan Jirik ,&nbsp;Jana Ruda-Kucerova","doi":"10.1016/j.biopha.2026.119170","DOIUrl":"10.1016/j.biopha.2026.119170","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119170"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to: \"Current status and future therapeutic perspectives of glioblastoma multiforme (GBM) therapy: A review\" [ Biomedicine & Pharmacotherapy 92 (2017) 681-689]","authors":"Komal Anjum ,&nbsp;Bibi Ibtesam Shagufta ,&nbsp;Syed Qamar Abbas ,&nbsp;Seema Patel ,&nbsp;Ishrat Khan ,&nbsp;Sayed Asmat Ali Shah ,&nbsp;Najeeb Akhter ,&nbsp;Syed Shams ul Hassan","doi":"10.1016/j.biopha.2026.119164","DOIUrl":"10.1016/j.biopha.2026.119164","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119164"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}