Biomedicine & Pharmacotherapy最新文献_第3页

Retraction notice to "Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals" [Biomedicine & Pharmacotherapy 164 (2023) 114967] 《乳铁蛋白：对人类和动物的抗菌作用、基因组守护者、治疗用途和临床意义》撤回通知[生物医学与药物治疗164(2023)114967]。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-20 DOI: 10.1016/j.biopha.2026.119147

Mohamed E. Abd El-Hack , Sameh A. Abdelnour , Mahmoud Kamal , Asmaa F. Khafaga , Afnan M. Shakoori , Rehab M. Bagadood , Hind M. Naffadi , Areej Y. Alyahyawi , Hanan Khojah , Saleh Alghamdi , Mariusz Jaremko , Sylwester Świątkiewicz

引用次数: 0

Retraction notice to "Anti-proliferation effects, efficacy of cyasterone in vitro and in vivo and its mechanism" [Biomedicine & Pharmacotherapy 84 (2016) 330-339] 《半雄酮体外、体内抗增殖作用、疗效及其机制》撤稿通知[生物医学与药物治疗84(2016)330-339]。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-23 DOI: 10.1016/j.biopha.2026.119158

XinGang Lu , HongFu Qiu , Liu Yang , JieYing Zhang , ShuJie Ma , Lan Zhen

引用次数: 0

Retraction notice to “Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme” [Biomedicine & Pharmacotherapy 141 (2021) 111928] “天然生物活性分子：多形性胶质母细胞瘤治疗和控制的替代方法”撤回通知[生物医学与药物治疗141(2021)111928]。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119195

Priti Tagde , Pooja Tagde , Sandeep Tagde , Tanima Bhattacharya , Vishal Garg , Rokeya Akter , Md. Habibur Rahman , Agnieszka Najda , Ghadeer M. Albadrani , Amany A. Sayed , Muhammad Furqan Akhtar , Ammara Saleem , Ahmed E. Altyar , Deepak Kaushik , Mohamed M. Abdel-Daim

引用次数: 0

Retraction notice to “Unveiling the potential of FOXO3 in lung cancer: From molecular insights to therapeutic prospects” [Biomedicine & Pharmacotherapy 176 (2024) 116833] “揭示FOXO3在肺癌中的潜力：从分子洞察到治疗前景”[生物医学与药物治疗176(2024)116833]。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119193

Mohammad Ebrahimnezhad , Amir Valizadeh , Maryam Majidinia , Peyman Tabnak , Bahman Yousefi

引用次数: 0

Retraction notice to "Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?" [Biomedicine & Pharmacotherapy 154 (2022) 113522] 关于“Omicron变体（B.1.1.529）及其亚谱系：在SARS-CoV-2重组变体的出现中，我们迄今为止知道什么？”的撤回通知？[生物医学与药物治疗][j]。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI: 10.1016/j.biopha.2026.119215

Manish Dhawan , AbdulRahman A. Saied , Saikat Mitra , Fahad A. Alhumaydhi , Talha Bin Emran , Polrat Wilairatana

引用次数: 0

Fumarate loss destabilizes mitochondria and activates cGAS–STING in OLP 富马酸丢失会破坏线粒体的稳定性，激活OLP中的cGAS-STING。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-02 DOI: 10.1016/j.biopha.2026.119127

Yanxing Hu , Huyan Chen , Chenyun Ding , Shengbo Zhang , Qing Chen , Hongying Sun , Qiaozhen Yang

{"title":"Fumarate loss destabilizes mitochondria and activates cGAS–STING in OLP","authors":"Yanxing Hu , Huyan Chen , Chenyun Ding , Shengbo Zhang , Qing Chen , Hongying Sun , Qiaozhen Yang","doi":"10.1016/j.biopha.2026.119127","DOIUrl":"10.1016/j.biopha.2026.119127","url":null,"abstract":"<div><div>Mitochondrial metabolism and innate immune signaling are increasingly recognized as intersecting pathways in chronic inflammatory disease. Here, we identify a metabolically driven mechanism linking the TCA cycle imbalance to mucosal inflammation in oral lichen planus (OLP). Multi-omics analysis revealed that fumarate hydratase (FH) is upregulated in OLP tissues and cells, leading to significant fumarate depletion. This metabolic shift induces mitochondrial dysfunction, characterized by enhanced oxidative phosphorylation, proton leak, and TFAM downregulation. These changes destabilize the mitochondrial genome, promote mtDNA leakage into the cytosol, and activate the cGAS-STING pathway, resulting in TBK1-IRF3- NF-κB -driven inflammatory responses. Genetic knockdown of FH or pharmacological supplementation with monomethyl fumarate (MMF) restored mitochondrial homeostasis, prevented mtDNA release, and attenuated immune activation. Furthermore, depletion of mtDNA using 2′,3′-dideoxycytidine (ddC) validated the essential role of mtDNA in sustaining cGAS-STING dependent inflammation. Co-treatment with fumarate further suppressed cytosolic mtDNA and enhanced repression of innate signaling. These findings uncover a functional FH-fumarate-mtDNA-cGAS-STING axis in OLP and reveal fumarate as a key metabolic modulator of mitochondrial immune surveillance. Our work provides conceptual and therapeutic insight into the role of mitochondrial metabolism in non-infectious mucosal inflammation.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119127"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction notice to "Natural flavonoids alleviate glioblastoma multiforme by regulating long non-coding RNA" [Biomedicine & Pharmacotherapy 161 (2023) 114477] “天然黄酮类化合物通过调节长链非编码RNA缓解多形性胶质母细胞瘤”的撤回通知[生物医学与药物治疗]161(2023)114477。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.biopha.2026.119166

Xian Liu , Xinyu Xiao , Xue Han , Lan Yao , Wei Lan

引用次数: 0

Retraction notice to "Interplays between non-coding RNAs and chemokines in digestive system cancers" [Biomedicine & Pharmacotherapy 152 (2022) 113237] “非编码rna与趋化因子在消化系统癌症中的相互作用”的撤回通知[生物医学与药物治疗152(2022)113237]。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-12 DOI: 10.1016/j.biopha.2026.119211

Abdollah Jafarzadeh , Seyedvahid Seyedmoalemi , Amirreza Dashti , Maryam Nemati , Sara Jafarzadeh , Najmeh Aminizadeh , Massoud Vosough , Ali Rajabi , Ali Afrasiabi , Hamed Mirzaei

引用次数: 0

Editorial for Brazilian papers 巴西报纸社论。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-10 DOI: 10.1016/j.biopha.2026.119198

Daniel Cristian, André Luis Branco de Barros

引用次数: 0

Amlodipine mitigates Cisplatin- and acetaminophen-induced nephrotoxicity associated with alterations in renal gamma-glutamyl transpeptidase and oxidative stress 氨氯地平减轻顺铂和对乙酰氨基酚引起的与肾γ -谷氨酰转肽酶和氧化应激改变相关的肾毒性。

IF 7.5 2区医学

Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-03 DOI: 10.1016/j.biopha.2026.119187

Majdi Ali Al-Somat , Hassan Mohammed Al-Mahbashi , Afif Saeed Al-Nabehi

{"title":"Amlodipine mitigates Cisplatin- and acetaminophen-induced nephrotoxicity associated with alterations in renal gamma-glutamyl transpeptidase and oxidative stress","authors":"Majdi Ali Al-Somat , Hassan Mohammed Al-Mahbashi , Afif Saeed Al-Nabehi","doi":"10.1016/j.biopha.2026.119187","DOIUrl":"10.1016/j.biopha.2026.119187","url":null,"abstract":"<div><div>Gamma-glutamyl transpeptidase (GGT) plays a pivotal role in renal glutathione metabolism and redox regulation, and its excessive activation contributes to oxidative stress and tubular injury. Cisplatin (CP) and acetaminophen (Aceta) are well-known nephrotoxic agents primarily inducing renal damage through oxidative mechanisms, whereas amlodipine (Amlo) has been suggested to exert nephroprotective effects. This study aimed to evaluate the protective effect of Amlo against CP- and Aceta-induced nephrotoxicity in rats, with particular emphasis on renal GGT activity and oxidative stress. Fifty-six male albino rats were randomly allocated into seven groups receiving normal saline, CP, Aceta, Amlo, or their respective combinations. Treatments were administered for 14 days, with a single intraperitoneal dose of CP (8 mg/kg) on day 10. Renal GGT activity, oxidative stress markers Reduced Glutathione (GSH), Glutathione Peroxidase (GPx), Catalase (CAT), Superoxide Dismutase (SOD), Malondialdehyde (MDA), and Nitric Oxide (NO), kidney function indices blood urea nitrogen (BUN), serum creatinine (SC), and urea, and histopathological alterations were assessed. Cisplatin markedly elevated renal GGT activity, oxidative stress parameters, and renal dysfunction markers, whereas Aceta induced a milder but significant renal injury. Amlodipine treatment attenuated GGT overactivation, reduced oxidative stress, and improved renal functional and histological integrity, while Aceta co-administration exacerbated CP-induced renal damage. Collectively, these findings indicate that CP induces more pronounced renal GGT activation and oxidative injury than Aceta, and that Amlo confers significant nephroprotection, underscoring the critical role of GGT in drug-induced nephrotoxicity.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119187"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0