三甲胺n -氧化物（TMAO）和癌症风险：对可能联系的见解

IF 7.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2025-09-22 DOI:10.1016/j.biopha.2025.118592

Biki Saha , Antara Banerjee , Rupak Pathak , Asim K. Duttaroy , Surajit Pathak

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引用次数: 0

摘要

肠道微生物群在癌症发病中起着至关重要的作用，部分是通过饮食成分或宿主化合物的代谢物产生的。其中，三甲胺n -氧化物（TMAO）是一种次级肠道微生物衍生的代谢物，因其与癌症的潜在联系而受到关注。当肠道微生物将饮食中的胆碱、肉碱和甜菜碱转化为三甲胺（TMA）时，TMAO就形成了，然后三甲胺在肝脏被FMO3氧化。虽然TMAO在心血管、肾脏和代谢性疾病中的研究已经很好，但越来越多的证据表明，TMAO水平升高与结直肠癌（CRC）和肝细胞癌（HCC）的风险增加有关。虽然确切的机制尚不清楚，但TMAO似乎通过促进炎症、氧化应激、内质网应激和胰岛素抵抗来促进癌症的进展。这篇综述讨论了TMAO合成中涉及的饮食和微生物途径，它在癌症进展中的作用，并批判性地评估了目前关于它对癌症的潜在贡献的文献。了解氧化三甲胺的作用可以为针对肠道微生物群及其代谢物的癌症预防和治疗提供新的策略。

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Trimethylamine N-Oxide (TMAO) and cancer risk: Insights into a possible link

The gut microbiota play a crucial role in cancer pathogenesis, partly through metabolites derived from dietary components or host compounds. Among these, trimethylamine N-oxide (TMAO), a secondary gut microbiota-derived metabolite has gained attention for its potential link to cancer. TMAO is formed when gut microbes convert dietary choline, carnitine, and betaine into trimethylamine (TMA), which is then oxidized in the liver by FMO3. While TMAO has been well studied in cardiovascular, kidney, and metabolic diseases, growing evidence links elevated TMAO levels to increased risks of colorectal cancer (CRC) and hepatocellular carcinoma (HCC). Although the exact mechanisms remain unclear, TMAO appears to contribute to cancer progression by promoting inflammation, oxidative stress, endoplasmic reticulum stress, and insulin resistance. This review discusses the dietary and microbial pathways involved in TMAO synthesis, its role in cancer progression, and critically evaluates the current literature on its potential contribution to cancer. Understanding the role of TMAO could offer new strategies for cancer prevention and therapy that target the gut microbiota and their metabolites.

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.