Biomedicine & Pharmacotherapy最新文献

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Retraction notice to "Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?" [Biomedicine & Pharmacotherapy 154 (2022) 113522] 关于“Omicron变体(B.1.1.529)及其亚谱系:在SARS-CoV-2重组变体的出现中,我们迄今为止知道什么?”的撤回通知?[生物医学与药物治疗][j]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI: 10.1016/j.biopha.2026.119215
Manish Dhawan , AbdulRahman A. Saied , Saikat Mitra , Fahad A. Alhumaydhi , Talha Bin Emran , Polrat Wilairatana
{"title":"Retraction notice to \"Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?\" [Biomedicine & Pharmacotherapy 154 (2022) 113522]","authors":"Manish Dhawan , AbdulRahman A. Saied , Saikat Mitra , Fahad A. Alhumaydhi , Talha Bin Emran , Polrat Wilairatana","doi":"10.1016/j.biopha.2026.119215","DOIUrl":"10.1016/j.biopha.2026.119215","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119215"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fumarate loss destabilizes mitochondria and activates cGAS–STING in OLP 富马酸丢失会破坏线粒体的稳定性,激活OLP中的cGAS-STING。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-02 DOI: 10.1016/j.biopha.2026.119127
Yanxing Hu , Huyan Chen , Chenyun Ding , Shengbo Zhang , Qing Chen , Hongying Sun , Qiaozhen Yang
{"title":"Fumarate loss destabilizes mitochondria and activates cGAS–STING in OLP","authors":"Yanxing Hu ,&nbsp;Huyan Chen ,&nbsp;Chenyun Ding ,&nbsp;Shengbo Zhang ,&nbsp;Qing Chen ,&nbsp;Hongying Sun ,&nbsp;Qiaozhen Yang","doi":"10.1016/j.biopha.2026.119127","DOIUrl":"10.1016/j.biopha.2026.119127","url":null,"abstract":"<div><div>Mitochondrial metabolism and innate immune signaling are increasingly recognized as intersecting pathways in chronic inflammatory disease. Here, we identify a metabolically driven mechanism linking the TCA cycle imbalance to mucosal inflammation in oral lichen planus (OLP). Multi-omics analysis revealed that fumarate hydratase (FH) is upregulated in OLP tissues and cells, leading to significant fumarate depletion. This metabolic shift induces mitochondrial dysfunction, characterized by enhanced oxidative phosphorylation, proton leak, and TFAM downregulation. These changes destabilize the mitochondrial genome, promote mtDNA leakage into the cytosol, and activate the cGAS-STING pathway, resulting in TBK1-IRF3- NF-κB -driven inflammatory responses. Genetic knockdown of FH or pharmacological supplementation with monomethyl fumarate (MMF) restored mitochondrial homeostasis, prevented mtDNA release, and attenuated immune activation. Furthermore, depletion of mtDNA using 2′,3′-dideoxycytidine (ddC) validated the essential role of mtDNA in sustaining cGAS-STING dependent inflammation. Co-treatment with fumarate further suppressed cytosolic mtDNA and enhanced repression of innate signaling. These findings uncover a functional FH-fumarate-mtDNA-cGAS-STING axis in OLP and reveal fumarate as a key metabolic modulator of mitochondrial immune surveillance. Our work provides conceptual and therapeutic insight into the role of mitochondrial metabolism in non-infectious mucosal inflammation.</div></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119127"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Natural flavonoids alleviate glioblastoma multiforme by regulating long non-coding RNA" [Biomedicine & Pharmacotherapy 161 (2023) 114477] “天然黄酮类化合物通过调节长链非编码RNA缓解多形性胶质母细胞瘤”的撤回通知[生物医学与药物治疗]161(2023)114477。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.biopha.2026.119166
Xian Liu , Xinyu Xiao , Xue Han , Lan Yao , Wei Lan
{"title":"Retraction notice to \"Natural flavonoids alleviate glioblastoma multiforme by regulating long non-coding RNA\" [Biomedicine & Pharmacotherapy 161 (2023) 114477]","authors":"Xian Liu ,&nbsp;Xinyu Xiao ,&nbsp;Xue Han ,&nbsp;Lan Yao ,&nbsp;Wei Lan","doi":"10.1016/j.biopha.2026.119166","DOIUrl":"10.1016/j.biopha.2026.119166","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119166"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Interplays between non-coding RNAs and chemokines in digestive system cancers" [Biomedicine & Pharmacotherapy 152 (2022) 113237] “非编码rna与趋化因子在消化系统癌症中的相互作用”的撤回通知[生物医学与药物治疗152(2022)113237]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-12 DOI: 10.1016/j.biopha.2026.119211
Abdollah Jafarzadeh , Seyedvahid Seyedmoalemi , Amirreza Dashti , Maryam Nemati , Sara Jafarzadeh , Najmeh Aminizadeh , Massoud Vosough , Ali Rajabi , Ali Afrasiabi , Hamed Mirzaei
{"title":"Retraction notice to \"Interplays between non-coding RNAs and chemokines in digestive system cancers\" [Biomedicine & Pharmacotherapy 152 (2022) 113237]","authors":"Abdollah Jafarzadeh ,&nbsp;Seyedvahid Seyedmoalemi ,&nbsp;Amirreza Dashti ,&nbsp;Maryam Nemati ,&nbsp;Sara Jafarzadeh ,&nbsp;Najmeh Aminizadeh ,&nbsp;Massoud Vosough ,&nbsp;Ali Rajabi ,&nbsp;Ali Afrasiabi ,&nbsp;Hamed Mirzaei","doi":"10.1016/j.biopha.2026.119211","DOIUrl":"10.1016/j.biopha.2026.119211","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119211"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147461399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial for Brazilian papers 巴西报纸社论。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-10 DOI: 10.1016/j.biopha.2026.119198
Daniel Cristian, André Luis Branco de Barros
{"title":"Editorial for Brazilian papers","authors":"Daniel Cristian,&nbsp;André Luis Branco de Barros","doi":"10.1016/j.biopha.2026.119198","DOIUrl":"10.1016/j.biopha.2026.119198","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119198"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "The pharmacological and biological importance of EZH2 signaling in lung cancer" [Biomedicine & Pharmacotherapy 160 (2023) 114313] 《EZH2信号在肺癌中的药理生物学意义》撤稿通知[生物医学与药物治疗160(2023)114313]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-20 DOI: 10.1016/j.biopha.2026.119151
Maliheh Entezari , Afshin Taheriazam , Mahshid Deldar Abad Paskeh , Eisa Sabouni , Mohammad Arad Zandieh , Maryam Aboutalebi , Amirabbas Kakavand , Shamin Rezaei , Elahe Sadat Hejazi , Hamidreza Saebfar , Shokooh Salimimoghadam , Sepideh Mirzaei , Mehrdad Hashemi , Saeed Samarghandian
{"title":"Retraction notice to \"The pharmacological and biological importance of EZH2 signaling in lung cancer\" [Biomedicine & Pharmacotherapy 160 (2023) 114313]","authors":"Maliheh Entezari ,&nbsp;Afshin Taheriazam ,&nbsp;Mahshid Deldar Abad Paskeh ,&nbsp;Eisa Sabouni ,&nbsp;Mohammad Arad Zandieh ,&nbsp;Maryam Aboutalebi ,&nbsp;Amirabbas Kakavand ,&nbsp;Shamin Rezaei ,&nbsp;Elahe Sadat Hejazi ,&nbsp;Hamidreza Saebfar ,&nbsp;Shokooh Salimimoghadam ,&nbsp;Sepideh Mirzaei ,&nbsp;Mehrdad Hashemi ,&nbsp;Saeed Samarghandian","doi":"10.1016/j.biopha.2026.119151","DOIUrl":"10.1016/j.biopha.2026.119151","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119151"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146777045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "An update on the role of miR-124 in the pathogenesis of human disorders" [Biomedicine & Pharmacotherapy 135 (2021) 111198] 《关于miR-124在人类疾病发病机制中的作用的最新进展》[生物医学与药物治疗135(2021)111198]的撤回通知。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.biopha.2026.119167
Soudeh Ghafouri-Fard , Hamed Shoorei , Zahra Bahroudi , Atefe Abak , Jamal Majidpoor , Mohammad Taheri
{"title":"Retraction notice to \"An update on the role of miR-124 in the pathogenesis of human disorders\" [Biomedicine & Pharmacotherapy 135 (2021) 111198]","authors":"Soudeh Ghafouri-Fard ,&nbsp;Hamed Shoorei ,&nbsp;Zahra Bahroudi ,&nbsp;Atefe Abak ,&nbsp;Jamal Majidpoor ,&nbsp;Mohammad Taheri","doi":"10.1016/j.biopha.2026.119167","DOIUrl":"10.1016/j.biopha.2026.119167","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119167"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes" [Biomedicine & Pharmacotherapy 155 (2022) 113727] “双氢槲皮素复合纳米纤维膜通过调节人表皮角质形成细胞的MAPKs/Nrf2信号来预防UVA辐射介导的炎症、细胞凋亡和氧化应激”[生物医学与药物治疗]155(2022)113727]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-02-26 DOI: 10.1016/j.biopha.2026.119165
Jinping Zhang , Yongchun Zheng , Bo Hong , Lina Ma , Yingchun Zhao , Shuai Zhang , Shuwen Sun , Qiteng Ding , Yue Wang , Wencong Liu , Chuanbo Ding
{"title":"Retraction notice to \"Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes\" [Biomedicine & Pharmacotherapy 155 (2022) 113727]","authors":"Jinping Zhang ,&nbsp;Yongchun Zheng ,&nbsp;Bo Hong ,&nbsp;Lina Ma ,&nbsp;Yingchun Zhao ,&nbsp;Shuai Zhang ,&nbsp;Shuwen Sun ,&nbsp;Qiteng Ding ,&nbsp;Yue Wang ,&nbsp;Wencong Liu ,&nbsp;Chuanbo Ding","doi":"10.1016/j.biopha.2026.119165","DOIUrl":"10.1016/j.biopha.2026.119165","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119165"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to "Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology" [Biomedicine & Pharmacotherapy 150 (2022) 113041] 《肺部疾病的天然疗法和营养品:传统意义、植物化学和药理学》撤稿通知[生物医学与药物治疗150(2022)113041]。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-06 DOI: 10.1016/j.biopha.2026.119188
Md. Mominur Rahman , Shabana Bibi , Md. Saidur Rahaman , Firoza Rahman , Fahadul Islam , Muhammad Saad Khan , Mohammad Mehedi Hasan , Anwar Parvez , Md. Abid Hossain , Saila Kabir Maeesa , Md. Rezaul Islam , Agnieszka Najda , Hamdan S. Al-malky , Hanan R.H. Mohamed , Hussah I.M. AlGwaiz , Aeshah A. Awaji , Mousa O. Germoush , Osama A. Kensara , Mohamed M. Abdel-Daim , Mohd Saeed , Mohammad Amjad Kamal
{"title":"Retraction notice to \"Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology\" [Biomedicine & Pharmacotherapy 150 (2022) 113041]","authors":"Md. Mominur Rahman ,&nbsp;Shabana Bibi ,&nbsp;Md. Saidur Rahaman ,&nbsp;Firoza Rahman ,&nbsp;Fahadul Islam ,&nbsp;Muhammad Saad Khan ,&nbsp;Mohammad Mehedi Hasan ,&nbsp;Anwar Parvez ,&nbsp;Md. Abid Hossain ,&nbsp;Saila Kabir Maeesa ,&nbsp;Md. Rezaul Islam ,&nbsp;Agnieszka Najda ,&nbsp;Hamdan S. Al-malky ,&nbsp;Hanan R.H. Mohamed ,&nbsp;Hussah I.M. AlGwaiz ,&nbsp;Aeshah A. Awaji ,&nbsp;Mousa O. Germoush ,&nbsp;Osama A. Kensara ,&nbsp;Mohamed M. Abdel-Daim ,&nbsp;Mohd Saeed ,&nbsp;Mohammad Amjad Kamal","doi":"10.1016/j.biopha.2026.119188","DOIUrl":"10.1016/j.biopha.2026.119188","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119188"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Molecular insights to in vitro biocompatibility of endodontic Pulpotec with macrophages determined by oxidative stress and apoptosis” [Biomedicine & Pharmacotherapy 176 (2024) 116921] “氧化应激和细胞凋亡对牙髓牙髓与巨噬细胞体外生物相容性的影响”[生物医学与药物治疗]176(2024)116921。
IF 7.5 2区 医学
Biomedicine & Pharmacotherapy Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.biopha.2026.119197
Ankita Mohanty , Swadheena Patro , Ealisha Jha , Paritosh Patel , Aditya Nandi , Adrija Sinha , Shaikh Sheeran Naser , Antarikshya Das , Pritam Kumar Panda , Prabhat Kumar Rout , Richa Mishra , Nagendra Kumar Kaushik , Deobrat Singh , Mrutyunjay Suar , Suresh K. Verma
{"title":"Retraction notice to “Molecular insights to in vitro biocompatibility of endodontic Pulpotec with macrophages determined by oxidative stress and apoptosis” [Biomedicine & Pharmacotherapy 176 (2024) 116921]","authors":"Ankita Mohanty ,&nbsp;Swadheena Patro ,&nbsp;Ealisha Jha ,&nbsp;Paritosh Patel ,&nbsp;Aditya Nandi ,&nbsp;Adrija Sinha ,&nbsp;Shaikh Sheeran Naser ,&nbsp;Antarikshya Das ,&nbsp;Pritam Kumar Panda ,&nbsp;Prabhat Kumar Rout ,&nbsp;Richa Mishra ,&nbsp;Nagendra Kumar Kaushik ,&nbsp;Deobrat Singh ,&nbsp;Mrutyunjay Suar ,&nbsp;Suresh K. Verma","doi":"10.1016/j.biopha.2026.119197","DOIUrl":"10.1016/j.biopha.2026.119197","url":null,"abstract":"","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":"197 ","pages":"Article 119197"},"PeriodicalIF":7.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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